The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes

Conclusions: These results suggest that eNOS activation is required for the neuroprotection of insulin against ischemic stroke in patients with diabetes.Clinical Relevance: Our findings indicate that the impact of insulin in patients with diabetes with acute ischemic stroke is concurrently dependent on both endothelial nitric oxide synthase (eNOS) signaling and antihyperglycemic effects. When eNOS dysfunction (eg, vascular endothelial dysfunction) is developed in patients with diabetes, the beneficial effect of insulin might be diminished in acute ischemic stroke in spite of its preserved antihyperglycemic effect. For diabetic individuals, hyperglycemia must be controlled as early as possible, otherwise diabetes-associated endothelial dysfunction could aggravate the damage of ischemic stroke. It is essential to preserve eNOS/endothelial function that can improve clinical outcomes when diabetic individuals develop acute ischemic stroke.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Basic research studies Source Type: research