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Condition: Ataxia

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Total 492 results found since Jan 2013.

Ataxia Associated with CADASIL: a Pathology-Confirmed Case Report and Literature Review.
Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is primarily characterized by migraine, stroke, mood disturbances, and cognitive decline. Ataxia has seldom been reported as a presenting symptom. Here, we review reports of CADASIL presenting as ataxia and compare these to the first pathologically confirmed case of CADASIL presenting with progressive ataxia. A 50-year-old woman presented with progressive truncal ataxia. Brain magnetic resonance imaging (MRI) revealed white matter hyperintensities in the bilateral anterior temporal lobes, external capsules...
Source: Cerebellum - July 29, 2020 Category: Neuroscience Authors: Park DG, Min JH, Sohn SH, Sohn YB, Yoon JH Tags: Cerebellum Source Type: research

Evaluation of Clinical Features and Stroke Etiology in Patients with Bilateral Middle Cerebellar Peduncle Infarction
Conclusion: BMCPI is a rare cerebrovascular disease characterized by vertigo, ataxia, and dysarthria, which may also be accompanied by a hearing deficit or clinical signs of brainstem damage. BMCPI may be associated with hypoperfusion secondary to occlusive disease of the bilateral VA or proximal basilar artery.Eur Neurol
Source: European Neurology - July 24, 2020 Category: Neurology Source Type: research

A novel CACNA1A variant in a child with early stroke and intractable epilepsy
ConclusionWe present the second case of recurrent ischemic strokes in a patient withCACNA1A mutation. Our findings expand the phenotypic heterogeneity related to Cav2.1 (P/Q‐type) calcium channel dysfunction and suggest consideration ofCACNA1A disorder in evaluation of pediatric strokes.
Source: Molecular Genetics & Genomic Medicine - July 20, 2020 Category: Genetics & Stem Cells Authors: Franciska J. Gudenkauf, Mahshid S. Azamian, Jill V. Hunter, Anuranjita Nayak, Seema R. Lalani Tags: CLINICAL REPORT Source Type: research

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion in an Adult with Cerebellar Ataxia: A Case Report.
Abstract Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinicoradiological syndrome characterized by transient mild encephalopathy and magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of the corpus callosum (SCC). Patients with MERS generally present with central nervous system symptoms such as consciousness disturbance, headache, and seizure; adult-onset MERS with cerebellar ataxia is rare. A 53-year-old man was admitted to our hospital with fever of 1 week's duration, headache, neck stiffness, and gait disturbance. Neurological examination revealed...
Source: Journal of Nippon Medical School - July 15, 2020 Category: Universities & Medical Training Authors: Nakajima M, Suda S, Kimura K Tags: J Nippon Med Sch Source Type: research

Misdiagnosis of lamotrigine toxicity as posterior circulation transient ischemic attack or stroke.
CONCLUSION: Emergency departments will frequently call a stroke alert for patients taking LTG and presenting with symptoms consistent with LTG toxicity, particularly in seniors at greater risk of stroke. This adds not only expense but also radiation and contrast exposure from computed tomography (CT) studies. We recommend that a rapid LTG assay be made available and always ordered in patients receiving LTG, avoiding the considerable expense of an unnecessary stroke evaluation. PMID: 32652284 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - July 7, 2020 Category: Neurology Authors: Ramey P, Osborn M, Kirshner H, Abou-Khalil B Tags: Epilepsy Behav Source Type: research

Paradoxical Embolism in a Case of Hereditary Hemorrhagic Telangiectasia: Case Report with Literature Review
We describe a 48-year-old male who presented with acute onset giddiness, mild dysarthria, right hemiparesis, and ataxia. Clinical examinations indicated left cerebellar signs with right hemiparesis. Additionally, the patient had significant clubbing and mild cyanosis. A strong family history of epistaxis and hemoptysis was noted. His Magnetic resonance imaging of the brain showed acute left cerebellar and left frontal cortical infarct with normal vessels. The routine stroke and cardiac workup were normal. Chest X-ray showed bilateral lower zone opacities. Contrast-enhanced computerized tomogram (CT) of the chest showed bil...
Source: Neurology India - July 5, 2020 Category: Neurology Authors: Neena Baby Sabu George Kunnathuparambil Prasanth Varghese Aneesh Mangalasseril Kuriakose Source Type: research

COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions
The present outbreak caused by SARS-CoV-2, an influenza virus with neurotropic potential, presents with neurological manifestations in a large proportion of the affected individuals. Disorders of the central and peripheral nervous system are all present, while stroke, ataxia, seizures, and depressed level of consciousness are more common in severely affected patients. People with these severe complications are most likely elderly with medical comorbidities, especially hypertension and other vascular risk factors. However, postinfectious complications are also expected. Neurological disorders as sequelae of influenza viruse...
Source: Neuroepidemiology - July 1, 2020 Category: Epidemiology Source Type: research

A Case Report of Sporadic Adult Neuronal Intranuclear Inclusion Disease (NIID) With Stroke-Like Onset
Conclusion: This case demonstrates the strong clinical heterogeneity of NIID. NIID can manifest as acute hemiplegia and a stroke-like attack. This case study provides new information for the diagnosis of NIID and the classification of the clinical characteristics.
Source: Frontiers in Neurology - June 9, 2020 Category: Neurology Source Type: research

A Critical Role for ISGylation, Ubiquitination and, SUMOylation in Brain Damage: Implications for Neuroprotection.
Abstract Post-translational modification (PTMs) of proteins by ubiquitin and ubiquitin-like modifiers such as interferon-stimulated gene 15 (ISG15) and small ubiquitin-related modifier (SUMO) play a critical role in the regulation of brain pathophysiology. Protein ISGylation is a covalent attachment of ISG15 to its target proteins, which is a unique PTM among other ubiquitin-like modifiers. Although, ISG15 shares sequence homology to ubiquitin, yet the functional significance of protein ISGylation is distinct from ubiquitination and SUMOylation. Further, ISG15 highly conserved among vertebrate species, unlike the ...
Source: Neurochemical Research - June 3, 2020 Category: Neuroscience Authors: Nakka VP, Mohammed AQ Tags: Neurochem Res Source Type: research

A review of pathophysiology and neuropsychiatric manifestations of COVID-19
ConclusionThe neurological manifestations of the COVID-19 are varied and the data about this continue to evolve as the pandemic continues to progress.
Source: Journal of Neurology - June 2, 2020 Category: Neurology Source Type: research

Medical and Paramedical Care of Patients With Cerebellar Ataxia During the COVID-19 Outbreak: Seven Practical Recommendations of the COVID 19 Cerebellum Task Force
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the cause of the current pandemic coronavirus disease 2019 (COVID-19), primarily targets the respiratory system. Some patients also experience neurological signs and symptoms ranging from anosmia, ageusia, headache, nausea, and vomiting to confusion, encephalitis, and stroke. Approximately 36% of those with severe COVID-19 experience neurological complications. The virus may enter the central nervous system through the olfactory nerve in the nasal cavity and damage neurons in the brainstem nuclei involved in the regulation of respiration. Patients with cerebe...
Source: Frontiers in Neurology - May 21, 2020 Category: Neurology Source Type: research

MEDICAL AND PARAMEDICAL CARE OF PATIENTS WITH CEREBELLAR ATAXIA DURING THE COVID-19 OUTBREAK: 7 PRACTICAL RECOMMENDATIONS The COVID 19 Cerebellum Task Force
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the cause of current coronavirus disease 2019 (COVID-19), primarily targets the respiratory system. Some patients also experience neurologic signs and symptoms ranging from anosmia, ageusia, headache, nausea and vomiting to confusion, encephalitis and stroke. Approximately 36% of those with severe COVID-19 experience neurological complications. The virus may enter the central nervous system through the olfactory nerve in the nasal cavity and damage neurons in the brainstem nuclei involved in the regulation of respiration. Patients with cerebellar ataxia (CA) ...
Source: Frontiers in Neurology - May 21, 2020 Category: Neurology Source Type: research

Cognition assessments to predict inpatient falls in a subacute stroke rehabilitation setting.
Conclusions: Cognition assessments, i.e., one FIM item, one RAVLT item, or a one-minute verbal fluency test are significant falls predictors. PMID: 32431244 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - May 19, 2020 Category: Neurology Authors: García-Rudolph A, García-Molina A, Opisso E, Tormos JM, Bernabeu M Tags: Top Stroke Rehabil Source Type: research

Opalski Syndrome Treated with Intravenous Recombinant Tissue Type Plasminogen Activator —Case Report and Review of Literature
A 65-year-old man with a history of Wallenberg syndrome caused by vertebral artery dissection at 62 years old was admitted to our hospital with nausea, vertigo, right facial dysesthesia, right hemiplegia, crossed sensory disturbance (sensory loss and numbness in the right face and left body below the neck), and right limb ataxia. Magnetic resonance imaging (MRI) performed 80 minutes after onset revealed no acute ischemic stroke lesions, but magnetic resonance angiography (MRA) demonstrated complete occlusion of the right vertebral artery.
Source: Journal of Stroke and Cerebrovascular Diseases - May 16, 2020 Category: Neurology Authors: Daisuke Hara, Masashi Akamatsu, Heisuke Mizukami, Bunta Kato, Takaaki Suzuki, Jun Oshima, Yukari Akasu, Yasuhiro Hasegawa Tags: Case Report Source Type: research

A Case of Multiple Sclerosis —Like Relapsing Remitting Encephalomyelitis Following Allogeneic Hematopoietic Stem Cell Transplantation and a Review of the Published Literature
Complications involving the central nervous system (CNS) occur in 9–14% of patients following allogeneic hematopoietic stem cell transplantation (HSCT), including stroke-like episodes, demyelination, encephalitis, and nonspecific neurological symptoms. Here we report a case of multiple sclerosis (MS) like relapsing remitting encephalomyelitis following allogeneic HSCT, which did not respond to disease modifying therapies (DMTs) and “domino” autologous HSCT. A 53-year-old male was treated with allogeneic HSCT for lymphoid blast transformation of chronic myeloid leukemia. Ten months later he presented with confusion, s...
Source: Frontiers in Immunology - May 4, 2020 Category: Allergy & Immunology Source Type: research