Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery
CONCLUSION: Previous vitrectomy surgery did not affect gene expression in the anterior segment after intravitreal injection of AAV vectors.PMID:33980756 | DOI:10.1272/jnms.JNMS.2021_88-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Kazuhisa Takahashi Tsutomu Igarashi Koichi Miyake Maika Kobayashi Yuko Katakai Hiromi Hayashita-Kinoh Chiaki Fujimoto Shuhei Kameya Hiroshi Takahashi Takashi Okada Source Type: research

Brain-derived Neurotrophic Factor in the Aqueous Humor of Glaucoma Patients
CONCLUSIONS: BDNF level in aqueous humor varies widely.PMID:33980757 | DOI:10.1272/jnms.JNMS.2021_88-305 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Tsutomu Igarashi Kenji Nakamoto Maika Kobayashi Hisaharu Suzuki Takeshi Arima Yutaro Tobita Kazuhiro Takao Toru Igarashi Takahisa Okuda Takashi Okada Hiroshi Takahashi Source Type: research

Clinical Characteristics and Surgical Outcomes for Collision Athletes with Traumatic Posterior Instability
CONCLUSION: Traumatic posterior instability in collision athletes often involves glenoid osseous lesions and is frequently accompanied by anterior apprehension and lesions. Although collision athletes can return to play after arthroscopic repair, such activity is associated with a risk of re-dislocation.PMID:33980758 | DOI:10.1272/jnms.JNMS.2020_88-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Atsushi Tasaki Source Type: research

Changes in the Ganglion Cell Complex after Inner Limiting Membrane Peeling for Epiretinal Membrane in Glaucoma Patients
CONCLUSIONS: The present results suggest that this procedure does not cause structural exacerbation of glaucoma in glaucoma patients. Although further studies of the functional effects of ILM peeling are required, the present results suggest that there is no significant difference between the two groups.PMID:33980759 | DOI:10.1272/jnms.JNMS.2021_88-202 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Yusuke Umemoto Tsutomu Igarashi Kenji Nakamoto Takeshi Arima Maika Kobayashi Yutaro Tobita Hiroshi Takahashi Source Type: research

Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery
CONCLUSION: Previous vitrectomy surgery did not affect gene expression in the anterior segment after intravitreal injection of AAV vectors.PMID:33980756 | DOI:10.1272/jnms.JNMS.2021_88-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Kazuhisa Takahashi Tsutomu Igarashi Koichi Miyake Maika Kobayashi Yuko Katakai Hiromi Hayashita-Kinoh Chiaki Fujimoto Shuhei Kameya Hiroshi Takahashi Takashi Okada Source Type: research

Brain-derived Neurotrophic Factor in the Aqueous Humor of Glaucoma Patients
CONCLUSIONS: BDNF level in aqueous humor varies widely.PMID:33980757 | DOI:10.1272/jnms.JNMS.2021_88-305 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Tsutomu Igarashi Kenji Nakamoto Maika Kobayashi Hisaharu Suzuki Takeshi Arima Yutaro Tobita Kazuhiro Takao Toru Igarashi Takahisa Okuda Takashi Okada Hiroshi Takahashi Source Type: research

Clinical Characteristics and Surgical Outcomes for Collision Athletes with Traumatic Posterior Instability
CONCLUSION: Traumatic posterior instability in collision athletes often involves glenoid osseous lesions and is frequently accompanied by anterior apprehension and lesions. Although collision athletes can return to play after arthroscopic repair, such activity is associated with a risk of re-dislocation.PMID:33980758 | DOI:10.1272/jnms.JNMS.2020_88-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Atsushi Tasaki Source Type: research

Changes in the Ganglion Cell Complex after Inner Limiting Membrane Peeling for Epiretinal Membrane in Glaucoma Patients
CONCLUSIONS: The present results suggest that this procedure does not cause structural exacerbation of glaucoma in glaucoma patients. Although further studies of the functional effects of ILM peeling are required, the present results suggest that there is no significant difference between the two groups.PMID:33980759 | DOI:10.1272/jnms.JNMS.2021_88-202 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Yusuke Umemoto Tsutomu Igarashi Kenji Nakamoto Takeshi Arima Maika Kobayashi Yutaro Tobita Hiroshi Takahashi Source Type: research

Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery
CONCLUSION: Previous vitrectomy surgery did not affect gene expression in the anterior segment after intravitreal injection of AAV vectors.PMID:33980756 | DOI:10.1272/jnms.JNMS.2021_88-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Kazuhisa Takahashi Tsutomu Igarashi Koichi Miyake Maika Kobayashi Yuko Katakai Hiromi Hayashita-Kinoh Chiaki Fujimoto Shuhei Kameya Hiroshi Takahashi Takashi Okada Source Type: research

Brain-derived Neurotrophic Factor in the Aqueous Humor of Glaucoma Patients
CONCLUSIONS: BDNF level in aqueous humor varies widely.PMID:33980757 | DOI:10.1272/jnms.JNMS.2021_88-305 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Tsutomu Igarashi Kenji Nakamoto Maika Kobayashi Hisaharu Suzuki Takeshi Arima Yutaro Tobita Kazuhiro Takao Toru Igarashi Takahisa Okuda Takashi Okada Hiroshi Takahashi Source Type: research

Clinical Characteristics and Surgical Outcomes for Collision Athletes with Traumatic Posterior Instability
CONCLUSION: Traumatic posterior instability in collision athletes often involves glenoid osseous lesions and is frequently accompanied by anterior apprehension and lesions. Although collision athletes can return to play after arthroscopic repair, such activity is associated with a risk of re-dislocation.PMID:33980758 | DOI:10.1272/jnms.JNMS.2020_88-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Atsushi Tasaki Source Type: research

Changes in the Ganglion Cell Complex after Inner Limiting Membrane Peeling for Epiretinal Membrane in Glaucoma Patients
CONCLUSIONS: The present results suggest that this procedure does not cause structural exacerbation of glaucoma in glaucoma patients. Although further studies of the functional effects of ILM peeling are required, the present results suggest that there is no significant difference between the two groups.PMID:33980759 | DOI:10.1272/jnms.JNMS.2021_88-202 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 13, 2021 Category: Universities & Medical Training Authors: Yusuke Umemoto Tsutomu Igarashi Kenji Nakamoto Takeshi Arima Maika Kobayashi Yutaro Tobita Hiroshi Takahashi Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research

Risk Factors for Early Peritoneal Dialysis Discontinuation: Importance of Heart Failure
CONCLUSION: Treatment of RASi, LVEF> 50% and eGFR ≥ 6 mL/ min/1.73m2 when the initiation of PD and better volume control to prevent ultrafiltration failure and heart failure may improve technical survival period in patients undergoing PD.PMID:33867425 | DOI:10.1272/jnms.JNMS.2022_89-201 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Kohsuke Terada Yuichiro Sumi Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

Use of molecular targeted therapy for hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer in real-world clinical practice
CONCLUSIONS: Molecular targeted therapy (MTT) was mostly used in ≥ 3rd lines, and PFS of patients receiving 1st/2nd line and ≥ 3rd line treatments was similar; however, this study included heavily treated patients and a limited number of cases. Treatment options should take into consideration the maximal benefit to the patient based on the results of clinical trials.PMID:33867426 | DOI:10.1272/jnms.JNMS.2022_89-203 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Satoko Nakano Yoshimi Imawari Akemi Mibu Shunsuke Kato Shigeo Yamaguchi Masahiko Otsuka Masataka Sano Source Type: research

A Case Report of Squamous Cell Carcinoma of Unknown Primary That Metastasized to an Inguinal Lymph Node
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2022_89-206. Online ahead of print.ABSTRACTThe term carcinoma of unknown primary (CUP) refers to a malignant tumor whose histology suggests strongly that it is a metastasis, yet the primary lesion is unknown despite sufficient whole body evaluation at the time of examination. CUP has similar incidences in men and women and the average age at diagnosis is 60 years. While its overall incidence varies depending on the report, it generally accounts for 1-5% of all cancers. Thus, it is rare. We encountered a case of squamous cell carcinoma of the inguinal region that seemed ...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Atsuko Sugimoto Kanae Nakamura Kousuke Kuwahara Noriko Matsumoto Kotoho Oki Rei Ogawa Source Type: research

Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
CONCLUSIONS: ACCT with thyroid invasion is an extremely rare malignant neoplasm. FNAC was useful for differentiating ACCT from other diagnoses and enabled appropriate surgical treatment.PMID:33867428 | DOI:10.1272/jnms.JNMS.2022_89-207 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tomoo Jikuzono Shigekazu Suzuki Osamu Ishibashi Shoko Kure Atsuko Sakanushi Munenaga Nakamizo Masashi Kawamoto Ryuji Ohashi Tetsu Yamada Iwao Sugitani Source Type: research

Venous thromboembolism in major orthopedic surgery
J Nippon Med Sch. 2021 Apr 19. doi: 10.1272/jnms.JNMS.2021_88-418. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is one of the most important complications in orthopedic surgery. Deep-vein thrombosis occurs frequently after surgery with few clinical symptoms. Formed emboli are thought to cause pulmonary thromboembolism (PTE). It is well known that PTE has a high-mortality rate when it develops. The cost of medical care is doubled when VTE develops after surgery. As a result, it is imperative to focus on the prevention of VTEs following major orthopedic surgeries.The prevention method should be selected in cons...
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Tokifumi Majima Yasushi Oshima Source Type: research

Effects of thrombophilia and antithrombotic therapy on embryonic chromosomal aberration rates in patients with recurrent pregnancy loss
CONCLUSIONS: With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages.PMID:33867424 | DOI:10.1272/jnms.JNMS.2022_89-103 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 19, 2021 Category: Universities & Medical Training Authors: Nozomi Ouchi Toshiyuki Takeshita Sayuri Kasano Ryoko Yokote Mirei Yonezawa Ryuhei Kurashina Tomoko Ichikawa Ikuno Kawabata Yoshimitsu Kuwabara Source Type: research