Infantile Myofibroma: a case report and review of the literature.
Abstract Herein, we report a case of solitary infantile myofibroma (IM) on the back of a newborn with partial CD34-positivity in neoplastic cells. On ultrasonographic examination, the tumor appeared as a multilocular mass with a hypoechoic center surrounded by an isoechoic rim. Histopathologically, the lesion was composed of tightly packed, uniform, small, round cells with pale, oval nuclei, CD34-positivity, and richly cellular, interlacing fascicles of spindle cells, with features of myofibroblasts with α-smooth muscle actin (α-SMA) positivity. We speculate that neoplastic cells in most cases of IM di...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Ogita A, Ansai SI Tags: J Nippon Med Sch Source Type: research

Novel surgical procedure of the half palmaris longus transfer for the opponensplasty of the thumb in patients with carpal tunnel syndrome: A Technical Note.
Abstract Thumb opposition is an essential movement for daily use of the hand, including precise pinch or grasping as well as fine and complicated hand movement. Although previous studies have reported several donor tendons for opponensplasty, opponensplasty using palmaris longus, Camitz opponensplasty, have been utilized in patients who have loss of opposition function due to long-standing carpal tunnel syndrome, because the procedure involves a simple and useful tendon transfer without causing functional deficits. To obtain enough length to transfer the tendon to the metacarpophalangeal joint of the thumb, the PL...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Kentrao S, Majima T Tags: J Nippon Med Sch Source Type: research

The Latest Strategy for Keloid and Hypertrophic Scar Prevention and Treatment: The Nippon Medical School (NMS) Protocol.
Abstract In 2006, we established a scar/keloid-specialized institution in the Department of Plastic, Reconstructive, and Aesthetic Surgery at Nippon Medical School (NMS) in Tokyo, Japan. In the ensuing 15 years, we treated approximately 2000 new scar/keloid patients annually. This extensive experience has greatly improved the efficacy of the treatments we offer. Therefore, we discuss here the latest NMS protocol for preventing and treating keloids and hypertrophic scars. While this protocol was optimized for Japanese patients, our experiences with a growing body of international patients suggest that it is also ef...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Ogawa R, Dohi T, Tosa M, Aoki M, Akaishi S Tags: J Nippon Med Sch Source Type: research

Secondary Hemochromatosis and Hepatocellular Carcinoma Developed from Immunoglobulin G4-Related Disease with Hepatopathy: A Case Report.
Abstract Immunoglobulin G4 (IgG4) -related disease (IgG4-RD) is a recently characterized entity in which lymphocytes and plasma cells infiltrate various anatomical sites. IgG4-hepatopathy, which is the manifestation of IgG4-RD, is a broader term covering various patterns of liver injury. The clinical course including the malignant potential of IgG4-RD remains unclear. Here we report the first case of secondary hemochromatosis and hepatocellular carcinoma (HCC) developed from IgG4-hepatopathy. A 67-year-old man was admitted to our hospital due to deteriorated glucose tolerance. Blood test results showed hypergammag...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Kanaka S, Kawano Y, Yokomuro S, Ando F, Itokawa N, Hatori T, Matsumoto K, Zen Y, Miyashita M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Bone marrow sarcoidosis with pancytopenia and renal failure presenting as fever of unknown origin: the pivotal role of 18F-FDG-PET/CT in lesion detection.
We describe a case of fever of unknown origin (FUO), renal failure, and pancytopenia. Initially, lymph proliferative disorder was suspected; therefore, bone marrow biopsy and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) were performed. Bronchoscopy and lung biopsy were performed because of abnormal FDG uptake in both lung fields. Taken together with the laboratory and histological results, sarcoidosis with bone marrow invasion was confirmed. The patient was discharged following favorable response to corticosteroid therapy. Sarcoidosis may present as FUO without typical specific...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Matsuda N, Iida S, Ogino Y, Saito N, Yasutake M Tags: J Nippon Med Sch Source Type: research

Effect of Ethanol on Gene Expression of Beating Neonatal Rat Cardiomyocytes - Further Research with Ingenuity Pathway Analysis Software.
CONCLUSIONS: IPA predicted ethanol-induced activation or inhibition of canonical pathways and functions of cardiomyocytes depending on the concentrations of ethanol, and 3 networks related to heart functions of cardiomyocytes exposed to 3 concentrations of ethanol. PMID: 32741906 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Mashimo K, Ohno Y Tags: J Nippon Med Sch Source Type: research

The Role of Community Hospital Pediatric Departments in Counter Measures for Measles Epidemics at Olympic Game Sites.
CONCLUSIONS: Measles outbreaks are possible in Japan as a result of visitors from abroad. Items to mitigate an outbreak were identified as maintenance of high vaccination rates, readily available information regarding the location of negative pressure hospital rooms, the status of measles development, and finally medical staffing issues. There is a continued risk of measles outbreaks occurring in infants and individuals who do not have a measles antibody titer. PMID: 32741907 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Igarashi T, Takeda S, Igarashi T, Narazaki H, Itoh Y Tags: J Nippon Med Sch Source Type: research

Efficacy and long-term prognosis of nerve-sparing radical hysterectomy for cervical cancer.
This study described performance of our nerve-sparing technique and the long-term prognosis of patients.MethodsSixty-one patients underwent radical hysterectomy in a 5-year period during which the nerve-sparing technique was introduced; of these, 31 patients underwent NSRH and 30 underwent conventional RH. We retrospectively examined the medical records and compared postoperative urinary function and treatment outcome between the two groups.ResultsThe median time required for urinary residual volume to fall to ≤50 ml after removal of the urinary catheter was 6 days (range, 2-20 days) in the NSRH group and 13.5 days (ran...
Source: Journal of Nippon Medical School - August 1, 2020 Category: Universities & Medical Training Authors: Yamamoto A, Kamoi S, Ikeda M, Yamada T, Yoneyama K, Takeshita T Tags: J Nippon Med Sch Source Type: research

Photodynamic Therapy Delays Cutaneous Wound Healing in Mice.
CONCLUSIONS: PDT delayed acute wound healing in a murine model of secondary intention wound healing. PMID: 32655090 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2020 Category: Universities & Medical Training Authors: Sun Y, Tosa M, Takada H, Ogawa R Tags: J Nippon Med Sch Source Type: research

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion in an Adult with Cerebellar Ataxia: A Case Report.
Abstract Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinicoradiological syndrome characterized by transient mild encephalopathy and magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of the corpus callosum (SCC). Patients with MERS generally present with central nervous system symptoms such as consciousness disturbance, headache, and seizure; adult-onset MERS with cerebellar ataxia is rare. A 53-year-old man was admitted to our hospital with fever of 1 week's duration, headache, neck stiffness, and gait disturbance. Neurological examination revealed...
Source: Journal of Nippon Medical School - July 15, 2020 Category: Universities & Medical Training Authors: Nakajima M, Suda S, Kimura K Tags: J Nippon Med Sch Source Type: research

Adenocarcinoma and Neuroendocrine Collision Tumor in a Giant Gastric Hyperplastic Polyp.
Abstract Screening esophagogastroduodenoscopy of a 65-year-old man revealed a 4.7-cm polypoid in the gastric high body. Clinical and laboratory findings, including serum gastrin level (460 pg/mL) and biopsy findings, were consistent with a diagnosis of type I neuroendocrine tumor (NET). Histologically, the mass consisted of dilated tortuous glands at the surface and grade 1 NET in deeper tissue. Some hyperplastic glands exhibited a transition to adenocarcinoma, which invaded the NET, simulating a "tumor in tumor" appearance. Next-generation sequencing revealed that the adenocarcinoma component harbored a...
Source: Journal of Nippon Medical School - July 15, 2020 Category: Universities & Medical Training Authors: Park YM, Na K, Sung JY, Jang JY, Kim YW Tags: J Nippon Med Sch Source Type: research

Severe Aneurysmal Subarachnoid Hemorrhage after Warning Headache during Pregnancy: A Case Report.
CONCLUSIONS: A pregnant woman with severe headache should undergo brain CT or magnetic resonance imaging to rule out subarachnoid hemorrhage. PMID: 32655093 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2020 Category: Universities & Medical Training Authors: Hironaka K, Suzuki M, Tateyama K, Ozeki T, Adachi K, Morita A Tags: J Nippon Med Sch Source Type: research

A case of Kawasaki disease with intussusception.
Abstract Kawasaki disease is a systemic vasculitis of unknown etiology and is known to be associated with various digestive disorders, though only a few cases of intussusception associated with Kawasaki disease have been reported. The case of a 3-year-old boy with intussusception followed by Kawasaki disease is reported. The patient was admitted to our hospital due to severe abdominal pain. Because the target sign was seen on ultrasonography, intussusception was diagnosed, and hydrostatic reduction was performed. On the second day after admission, he developed a high-grade fever (38 oC) and an irregular rash on th...
Source: Journal of Nippon Medical School - June 30, 2020 Category: Universities & Medical Training Authors: Ueharu K, Asano T, Fukunaga R, Matsui R, Yoshida K, Miyatake-Sudoh C, Abe M, Fujita A, Ito Y Tags: J Nippon Med Sch Source Type: research

Evaluation of a tool that enables cancer patients to participate in the decision-making process during treatment selection.
CONCLUSION: Almost all patients stated that the check sheet used in this study was useful as a decision support tool, and also facilitated the communication between doctors and patients. Before incorporation into general clinical practice, this increased benefit should be weighed against the potential extra administrative workload imposed on clinicians. PMID: 32612013 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 30, 2020 Category: Universities & Medical Training Authors: Chubachi K, Umihara J, Yoshikawa A, Nakamichi S, Takeuchi S, Matsumoto M, Miyanaga A, Minegishi Y, Yamamoto K, Seike M, Gemma A, Kubota K Tags: J Nippon Med Sch Source Type: research

Statistical evaluation of the first year of a neonatal intensive care unit established in a medical school hospital.
CONCLUSION: The comparison of birth weight and gestational age distributions, cases of respiratory disorders, and delivery methods indicate that our new NICU is positioned as an intermediate facility between a high-level NICU and a regular obstetrics facility. PMID: 32612014 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 30, 2020 Category: Universities & Medical Training Authors: Narazaki H, Watanabe M, Migita M, Kurashina R, Shima Y, Mine M, Kumasaka S, Ishikawa G, Yamada T, Itoh Y Tags: J Nippon Med Sch Source Type: research

Treatment for Geriatric Traumatic Brain Injury: A Nationwide Cohort Study.
Abstract BACKGROUND: Due to aging of the Japanese population, traumatic brain injuries (TBI) in elderly individuals have increased. However, the effectiveness and prognosis of intensive treatment in geriatric TBI have not yet been determined. Thus, we analyzed the prognostic factors of intensive and aggressive treatments using nationwide data from Japan Neurotrauma Data Bank (JNTDB) projects. METHODS: We analyzed 1,879 geriatric TBI cases (≥65 years old) registered in four JNTDB projects, Project 1998 (P1998) to Project 2015 (P2015). Clinical features, aggressive treatment usage, and 6-month outcomes on th...
Source: Journal of Nippon Medical School - June 30, 2020 Category: Universities & Medical Training Authors: Yokobori S, Saito K, Sasaki K, Kanaya T, Fujiki Y, Yamaguchi M, Satoh S, Watanabe A, Igarashi Y, Suzuki G, Kaneko J, Nakae R, Onda H, Ishinokami S, Takayama Y, Noae Y, Sato H, Unemoto K, Fuse A, Yokota H Tags: J Nippon Med Sch Source Type: research

Drug resistance in cancer therapy and the possible role of epigenetics.
Abstract Effective leukemia treatment is seriously hampered by drug resistance. The possible roles of epigenetic mechanisms have recently been considered in cancer drug resistance. With conventional anti-cancer drugs, including alkylating drugs, anti-metabolite drugs, topoisomerase inhibitors, and microtubule inhibitors, which have been available for half a century, the drug resistance often occurs due to decreased expression of target enzymes, with increased expression of drug export pumps. The alterations of target gene expression and increased export pump function might be caused by epigenetic changes, such as ...
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Asano T Tags: J Nippon Med Sch Source Type: research

A case of simultaneous superficial hypopharyngeal and superficial esophageal cancers treated by endoscopic resection.
Abstract In recent times, the diagnosis and treatment of superficial laryngopharyngeal cancers has been receiving a lot of attention. Here, we present a case of superficial hypopharyngeal cancer and superficial esophageal cancer for which endoscopic laryngo-pharyngeal surgery (ELPS) and endoscopic submucosal dissection (ESD) were performed simultaneously. The patient was a 67-year-old male. During his follow-up for distal gastrectomy performed earlier for stomach cancer, an upper gastrointestinal endoscopy revealed three primary cancers: superficial hypopharyngeal cancer, superficial esophageal cancer, and esophag...
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Miyazawa M, Shimakawa T, Asaka S, Yamaguchi K, Murayama M, Usui T, Yokomizo H, Shiozawa S, Katsube T, Naritaka Y Tags: J Nippon Med Sch Source Type: research

A Patient Required Peritoneal Catheter Removal Caused by Peritoneal Dialysis-related Peritonitis due to Gram-negative Rod-like Pseudomonas aeruginosa During Antibiotic Therapy for Enterococcus faecalis.
In this report, we describe a case in which, during antibiotic therapy for PD-related peritonitis due to Enterococcus faecalis alone, the patient suffered another occurrence of peritonitis due to newly revealed Gram-negative rod-like Pseudomonas aeruginosa. He required catheter removal due to the peritonitis being suspected of relapsing. Although so further investigations are required, it is possible that early catheter removal is effective in cases in which another organism is newly detected during antibiotic therapy for PD-related peritonitis caused by a different responsible organism not meeting the definition of refrac...
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Terada K, Sumi Y, Aratani S, Hirama A, Sakai Y Tags: J Nippon Med Sch Source Type: research

Growth hormone treatment at Nippon Medical School Chiba Hokusoh Hospital.
CONCLUSIONS: Improvement in height standard deviation score was similar when treatment was started before and after the growth spurt. PMID: 32475901 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Kuramochi E, Mae K, Ohtomo Y, Kamada R, Sugano-Tajima H, Asano T Tags: J Nippon Med Sch Source Type: research

Efficacy and safety of miglitol- or repaglinide-based combination therapy with alogliptin in drug-na ïve patients with type 2 diabetes: An open-label, single-center, parallel, randomized control pilot study.
ConclusionsThe addition of alogliptin to repaglinide monotherapy did not cause glucose-independent inappropriate insulin secretion and did not appear to increase the incidence of hypoglycemia. PMID: 32475902 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Okajima F, Sugihara H, Emoto N Tags: J Nippon Med Sch Source Type: research

Factors associated with prolonged surgical duration of laparoscopic radical nephrectomy using retroperitoneal approach by non-expert surgeons.
CONCLUSIONS: Factors associated with prolonged LRN via the retroperitoneal approach implemented by non-expert surgeons are ipsilateral adrenalectomy and specimen weight. PMID: 32475903 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Yanagi M, Kimura G, Sekine T, Takeda H, Akatsuka J, Endo Y, Hayashi T, Hamasaki T, Kondo Y Tags: J Nippon Med Sch Source Type: research

The effect of gonadectomy and angiotensin II receptor blockade in a mouse model of isoproterenol-induced cardiac diastolic dysfunction.
CONCLUSION: These gender differences suggest that sex hormones play a pivotal role in modulating cardiac hypertrophy and diastolic dysfunction induced by chronic beta-adrenoceptor stimulation, thereby affecting the therapeutic potential of angiotensin receptor blockade. PMID: 32475904 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Asai K, Murai M, Shirakabe A, Kamiya M, Noma S, Sato N, Mizuno K, Shimizu W Tags: J Nippon Med Sch Source Type: research

Effect of robot-assisted surgery on anesthetic and perioperative management for minimally invasive radical prostatectomy under combined general and epidural anesthesia.
CONCLUSIONS: Robot-assisted surgery required varied consumption of anesthetics and infusion management during MIRP under GCEA. It also shortened the postoperative hospital stay without increasing the rates of postoperative complications. PMID: 32475905 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2020 Category: Universities & Medical Training Authors: Kishikawa H, Suzuki N, Suzuki Y, Hamasaki T, Kondo Y, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Lupus Erythematosus Tumidus with Pseudolymphomatous Infiltrates: A Case Report.
Abstract A 39-year-old Japanese woman presented with a pruritic infiltrated erythematous plaque on the right cheek. Histopathologic analysis of the erythema showed dermal edema, separation of collagen bundles, and nodular perivascular and periadnexal infiltration of lymphocytes in the whole dermis, without epidermal changes. Alcian blue staining intensity was elevated between the collagen bundles, indicating dermal mucinosis. The nodular infiltrates consisted of CD3+ T cell clusters and CD20+ B cell clusters (ratio, approximately 3:1) and included numerous CD123+ cells, indicative of plasmacytoid dendritic cells. ...
Source: Journal of Nippon Medical School - May 20, 2020 Category: Universities & Medical Training Authors: Umeda Y, Ito K, Ansai S, Hoashi T, Saeki H, Kanda N Tags: J Nippon Med Sch Source Type: research

Optimal treatment for tenosynovial giant cell tumors of the hand.
Abstract This review aimed to clarify the following aspects of tenosynovial giant cell tumors (TSGCTs): the use of multiple names, the complex relationship between the tumor growth pattern and location, the high postoperative recurrence rates, local invasiveness, and the use of non-surgical therapy with molecular targeted drugs, as well as to discuss the currently available best treatments. This tumor has been called by various names in the past, but it is in the direction of being unified to TSGCT. TSGCT is classified into the localized and diffuse types according to the growth characteristics. Most cases of TSGC...
Source: Journal of Nippon Medical School - April 30, 2020 Category: Universities & Medical Training Authors: Kitagawa Y, Takai S Tags: J Nippon Med Sch Source Type: research

Effect of tranexamic acid in traumatic brain injury: a case report.
Abstract Traumatic brain injury (TBI) often results in coagulopathy, which increases mortality risk. The clinical randomization of an antifibrinolytic in significant head injury (CRASH) -2 and CRASH-3 trials confirmed that tranexamic acid (TXA) was effective after trauma. Herein, we report a unique coagulation change in a patient with TBI given TXA after point-of-care assessment. Coagulation functions were impaired on admission. At 1 hour after TXA administration, clotting time was further prolonged in the extrinsic coagulation pathway but shortened in the intrinsic coagulation system. The results of a total throm...
Source: Journal of Nippon Medical School - April 30, 2020 Category: Universities & Medical Training Authors: Miike T, Sakamoto Y, Inoue S Tags: J Nippon Med Sch Source Type: research

Recurrent dislocation of the extensor carpi ulnaris tendon with ulnar-sided triangular fibrocartilage complex injury in an ice hockey player: A case report.
We present a case of a 21-year-old male university-league ice hockey player with recurrent dislocation of the ECU tendon and ulnar-sided TFCC injury. He initially underwent stabilization of the ECU; however, his ulnar wrist pain persisted, which adversely affected his sports performance. Subsequently, he underwent additional surgery to repair the TFCC, which led to definitive resolution of his symptoms and resulted in his return to competitive level performance 3 months postoperatively. The treatment of symptomatic dislocation of the ECU remains controversial. In our patient, recurrent dislocation of the ECU tendon with co...
Source: Journal of Nippon Medical School - April 30, 2020 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Takai S Tags: J Nippon Med Sch Source Type: research

Efficacy of rhomboid flap reconstruction after mastectomy for locally advanced breast cancer.
CONCLUSIONS: Rhomboid flap reconstruction is effective for covering large defects after mastectomy in patients with LABC. PMID: 32350190 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 30, 2020 Category: Universities & Medical Training Authors: Kubo K, Takei H, Hamahata A Tags: J Nippon Med Sch Source Type: research

Cytokine Profile Changes During the Initial Stage of Treatment for Childhood Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis.
We report the case of a 4-year-old boy with EBV-HLH with persistent fever, severe pancytopenia, hypertriglyceridemia, and hypofibrinogenemia. The levels of plasma cytokines and chemokines were measured using a Bio-Plex system on Days 1, 2, 3, 4, 5, and 8 following hospital admission. The administration of steroid and high-dose intravenous immunoglobulin (1 g/kg) did not alleviate the fever or reduce cytokine production; however, following etoposide (a known antineoplastic agent) administration, the fever decreased immediately, and the patient' s general condition improved. The present study revealed that IL-6, IL-10, IL-8,...
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Ueda T, Itabashi T, Yamanishi S, Tanabe Y, Migita M, Itoh Y Tags: J Nippon Med Sch Source Type: research

Efficacy of a new doctor dispatch system for traffic accidents with advanced automatic collision notification technology: A report of the first 4 cases.
DiscussionAccording to 2008 data from Chiba Prefecture, in accidents where victims sustained severe trauma, the time from accidence occurrence to hospital arrival was 67 min, even with doctor dispatch by air ambulance ("Doctor-Heli" [DH]). Accident information for faster doctor dispatch effectively improved survival rates. An algorithm was developed to assess trauma severity (severity probability) based on accident information. DCN dispatches doctors based on information, including accident site and severity probability, that is sent to smartphones of doctors, reducing the time from accident to DH request by appr...
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Motomura T, Matsumoto H, Mashiko K, Ishikawa H, Nishimoto T, Takeyama Y Tags: J Nippon Med Sch Source Type: research

Petrous internal carotid artery aneurysms: A systematic review.
CONCLUSIONS: The systematic review revealed that the onset of secondary aneurysms was generally manifested by bleeding (p
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Murai Y, Shirokane K, Kitamura T, Tateyama K, Matano F, Mizunari T, Morita A Tags: J Nippon Med Sch Source Type: research

Ultrasound modulates fluorescence strength and ABCG2 mRNA response to aminolevulinic acid in glioma cells.
CONCLUSIONS: The ultrasound irradiation of the malignant gliomas contributes to the stronger 5-ALA induced fluorescence by elevating intracellular PpIX levels. The suppression of ABCG2 expression by ultrasound may be one of the factors which contributes to the PpIX accumulation in glioma cells. PMID: 32238732 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Higuchi T, Yamaguchi F, Asakura T, Yoshida D, Oishi Y, Morita A Tags: J Nippon Med Sch Source Type: research

Angioleiomyoma: Correlation between magnetic resonance imaging features and histologic subtypes.
CONCLUSIONS: Our results suggested that MR findings of angioleiomyoma vary depending on histologic subtypes. T2-weighted images of solid and venous types of angioleiomyoma show specific MR findings which allow for differentiation from other soft tissue tumors such as soft tissue sarcomas. These mostly show iso- to slightly high-signal intensity compared to skeletal muscle, while the cavernous type show non-specific findings. Thus, solid and venous types of angioleiomyoma could be diagnosed preoperatively via clinical findings and MR imaging. PMID: 32238733 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Kitagawa Y, Sudo Y, Tsunoda R, Nanno M, Arai S, Takai S Tags: J Nippon Med Sch Source Type: research

New thrombopoietin receptor agonist (Lusutrombopag) is more effective in impaired renal function patients with chronic liver disease.
CONCLUSION: This study revealed that Lusutrombopag was more sufficiently effective in CLD patients compared with platelet transfusion and that renal function is independent predictor of increase. Factors indicative of renal function significantly and negatively correlated with increase in platelets. PMID: 32238734 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Takeuchi H, Furuichi Y, Yoshimasu Y, Kasai Y, Abe M, Sugimoto K, Itoi T Tags: J Nippon Med Sch Source Type: research

Interfacility neonatal transfer for convalescent care -efforts toward achieving better regionalized care.
CONCLUSIONS: Interfacility neonatal transport for, both accepting and transferring infants for convalescent care has become an integral part of NICU practice to bridge the gaps between higher level care facility and home. Establishment of well-defined transfer criteria and appropriate allocation of medical and staff resources among relevant facilities is desirable. PMID: 32238735 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Shima Y, Matsukawa S, Yashiro K, Migita M Tags: J Nippon Med Sch Source Type: research

Serum brain-derived neurotrophic factor in glaucoma patients in Japan: An observational study.
CONCLUSION: This is the first study to have investigated serum BDNF concentrations in glaucoma patients in Japan. Further investigations are needed to evaluate the role of BDNF as a potential biomarker of glaucoma. PMID: 32238736 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Igarashi T, Nakamoto K, Kobayashi M, Suzuki H, Tobita Y, Igarashi T, Okuda T, Okada T, Takahashi H Tags: J Nippon Med Sch Source Type: research

Types of pedicle signs indicating symptomatic spinal metastases and their associated clinical and radiological features.
CONCLUSION: Understanding of the various types of pedicle sign is required to properly diagnose bone metastases. PMID: 32238737 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Kitagawa Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Representation of the circumferential distribution of small lower esophageal lesions by defining the position of the right wall in the esophageal hiatus.
CONCLUSIONS: Using this method, the circumferential position of small lower esophageal lesions may be reliably represented as a clock face. PMID: 32238738 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Hoshihara Y, Yamada A, Hoshino S, Hoshikawa Y, Kawami N, Aida J, Takubo K, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Presence of promyelocytes in peripheral blood as a novel predictor of the optimal timing for single-step peripheral blood stem cell collection.
CONCLUSION: The presence of promyelocytes in peripheral blood may be a useful indicator of the optimal timing for single-step PBSC collection. PMID: 32238739 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Marumo A, Yamaguchi H, Hirakawa T, Inai K, Onai D, Omori I, Yamanaka S, Fujiwara Y, Sakaguchi M, Wakita S, Okamoto M, Yui S, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Identification of novel C-terminally truncated estrogen receptor β variant transcripts and their distribution in humans.
CONCLUSION: This study elucidated the complicated genomic organization and splicing patterns of the human ERβ gene that contribute to the distinct heterogeneity of human ERβ mRNAs and proteins. PMID: 32238740 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Ishii H, Hattori Y, Ozawa H Tags: J Nippon Med Sch Source Type: research

Portal venous gas in adults: The clinical significance, management and outcomes of 25 consecutive cases.
ConclusionsClinical, laboratory and radiographic parameters can inform decisions on conservative management. However, 47.1% of patients who underwent surgery for suspected bowel necrosis did not require bowel resection, suggesting that this approach alone may not be sufficient to avoid non-therapeutic laparotomy. A new approach should therefore be developed to improve this situation. PMID: 32238741 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Arai M, Kim S, Ishii H, Takiguchi T, Yokota H Tags: J Nippon Med Sch Source Type: research

Quick arthroscopic repair technique for ulnar-sided triangular fibrocartilage complex tears: a technical note.
Abstract Triangular fibrocartilage complex (TFCC) tears are recognized as a cause of ulnar-sided wrist pain. Nowadays, arthroscopy plays an important role in providing treatment as well as in establishing the diagnosis. Arthroscopic repair of a TFCC tear is indicated after the failure of non-surgical treatments such as cast immobilization, splinting, and administration of nonsteroidal anti-inflammatory drugs for more than 3 months. Several arthroscopic therapeutic methods have been described, including the inside-out, outside-in, and all-arthroscopic techniques. However, these arthroscopic procedures are time-co...
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Takai S Tags: J Nippon Med Sch Source Type: research

Preliminary clinical trial to explore predictive biomarkers of response to sublingual immunotherapy for Japanese cedar pollinosis.
Abstract BACKGROUND: As part of the planning for a future multicenter study, this preliminary clinical trial was performed to explore candidate biomarkers useful for predicting the therapeutic effects of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (JCP) using serum samples from patients. METHODS: This prospective study included patients undergoing SLIT for JCP at our hospital. All enrolled patients (n = 17) started SLIT between June and November of 2015. With informed consent from the patients, in January, March, and June of 2016, blood samples were obtained, and an inquiry was conducted usi...
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Takahara E, Matsune S, Ishida M, Wakayama N, Okubo K Tags: J Nippon Med Sch Source Type: research

Developing a new scale to assess alexithymia-like features in Japanese youth: Investigation of the factor structure and psychometric properties.
CONCLUSIONS: As the correlations between this new alexithymia scale and the related variables were significantly small in accordance with our hypothesis, we could demonstrate that this new scale had acceptable reliability and construct validity and could be useful for measuring alexithymic tendency in young adolescents. PMID: 32074538 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Kashimura M, Ishizu K, Shimoda Y, Kashimura M Tags: J Nippon Med Sch Source Type: research

Pain relief of arthroscopic rotator cuff repair by nerve block.
CONCLUSION: Interscalene nerve blocks could obtain good pain relief for ARCR easily. In addition, although the continuous interscalenous nerve block can obtain continuous pain relief, we should pay attention about complications. PMID: 32009067 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Iwashita S, Hashiguchi H, Okubo A, Yoneda M, Takai S Tags: J Nippon Med Sch Source Type: research

Novel GUCY2D variant (E843Q) at mutation hotspot associated with macular dystrophy in Japanese patient.
CONCLUSIONS: This is the first report on the findings in a patient with a heterozygous variant, c.2527G>C, p.Glu843Gln in the GUCY2D, presenting with mild macular dystrophy without a general reduction of cone function. Our findings expand the spectrum of the clinical phenotypes of GUCY2D-adCRD and help identify the morphological and functional changes caused by defects of dimerization of GC-E in the phototransduction cascade. PMID: 32009068 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Takeda Y, Kubota D, Oishi N, Maruyama K, Gocho K, Yamaki K, Igarashi T, Takahashi H, Kameya S Tags: J Nippon Med Sch Source Type: research

Current status of postoperative infection after colorectal surgery: subanalysis of data from the 2015 Japan Postoperative Infectious Complications Survey.
Abstract BACKGROUND: Most surveillance programs for postoperative infection focus on surgical site infections (SSI). However, remote infections, as postoperative infections, are of emerging clinical importance. We investigated the incidence of both SSI and remote infection following colorectal surgery by performing a subanalysis of a multicenter survey after gastrointestinal surgery. METHODS: From September 2015 to March 2016, 1724 patients underwent colorectal surgery in 28 affiliated institutions in Japan. We retrospectively recorded patients' age, sex, surgical site, surgical approach, wound classification...
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Maruyama H, Kusachi S, Makino H, Kanno H, Yoshida H, Niitsuma T Tags: J Nippon Med Sch Source Type: research

Prognostic impact of hyperbilirubinemia in the early phase after allogeneic hematopoietic stem cell transplantation.
The objective of this study was to identify the unfavorable prognostic factors of liver dysfunction in the early post-transplant period. METHODS: We defined liver dysfunction as the detection within 30 days of transplantation of elevated liver or biliary enzyme levels corresponding to Grade 2 in the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. We retrospectively investigated 82 patients who had undergone allogeneic HSCT at our institution. RESULTS: Elevated liver or biliary enzyme levels were observed in almost half of the patients studied (n=40, 48.7%). Elevated total bilirubin (T-Bil) lev...
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Omori I, Yamaguchi H, Hirakawa T, Inai K, Onai D, Marumo A, Yamanaka S, Sakaguchi M, Fujiwara Y, Wakita S, Okamoto M, Tamai H, Nakayama K, Yui S, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Impact of postoperative respiratory tract infection after gastroenterological surgery on hospitalization period and medical expenses: A sub-set analysis of a multi-center study in Japan.
ConclusionsThe hospitalization period and medical expenses are known to increase in patients that develop surgical site infections. Our findings show that these parameters also increase in patients with PRTI following gastrointestinal surgery. However, further studies are needed to confirm these results. PMID: 32009071 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Maruyama H, Kusachi S, Yoshida H, Makino H, Nishimuta H, Niitsuma T Tags: J Nippon Med Sch Source Type: research