The relationship between severity of varus osteoarthritic knees and contracture of the medial structures
CONCLUSIONS: The threshold angle for expected correction with medial osteophyte removal was 9.5˚. However, with no differences in correction between those with larger or smaller than this angle, medial structure contracture seemed to be unrelated to severity of deformity.PMID:34526449 | DOI:10.1272/jnms.JNMS.2022_89-113 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Norishige Iizawa Yasushi Oshima Tatsunori Kataoka Hiroshi Watanabe Tokifumi Majima Shinro Takai Source Type: research

Serum interleukin-18 provides a clue to the diagnosis of adult-onset Still's disease: findings from 6 Japanese patients with adult-onset Still's disease
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-114. Online ahead of print.ABSTRACTAdult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder accompanied by skin eruption. However, typical skin eruptions, such as evanescent, salmon-pink erythema, are not specific to AOSD and dermatologists often face difficulty in diagnosing AOSD. Interleukin-18 (IL-18) is believed to be the initiating factor of the inflammatory cascade in AOSD and overproduction of IL-18 contributes to the development of systemic autoinflammatory reactions. Therefore, we examined serum IL-18 levels in the active and inactive ...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Azusa Ogita Shin-Ichi Ansai Hidehisa Saeki Source Type: research

Management of simple hepatic cyst
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-115. Online ahead of print.ABSTRACTSimple hepatic cysts are typically saccular, thin-walled masses with fluid-filled epithelial lined cavities that arise from aberrant bile duct cells during embryonic development. With the development of diagnostic modalities such as ultrasonography, computed tomography and magnetic resonance imaging, simple hepatic cysts are seen with relative frequency in daily clinical examination. US is the most useful and noninvasive tool for the diagnosis of simple hepatic cysts, and can generally differentiate simple hepatic cysts from ab...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tetsuya Shimizu Masato Yoshioka Yohei Kaneya Tomohiro Kanda Yuto Aoki Ryota Kondo Hideyuki Takata Junji Ueda Youichi Kawano Atsushi Hirakata Akira Matsushita Nobuhiko Taniai Yasuhiro Mamada Hiroshi Yoshida Source Type: research

Multiscale aspects of molecular motions: From molecular vibrations, conformational changes of biomolecules to cellular dynamics
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-116. Online ahead of print.ABSTRACTMolecular aspects of living systems are important because it is the most basic aspects of life as exemplified in biochemistry and structural biology. Since molecules move due to interactive forces between atoms, physics plays an important role to understand the dynamic phenomena of living systems. Here we review our multiscale approaches for computationally treating different levels of molecular motions: vibrational dynamics of molecules, conformational change of biomolecules, and cellular dynamics using statistical-mechanics-b...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hiroshi Fujisaki Source Type: research

Development of biomarkers for predicting recurrence by determining the metastatic ability of cancer cells
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-118. Online ahead of print.ABSTRACTAdjuvant chemotherapy has been carried out for patients with cancer who underwent curative resection, but it is basically not needed for patients without micro-metastatic lesions who undergo a perfectly curative surgical operation. The patients who need adjuvant chemotherapy are defined as those whose micro-metastases cannot be detected by imaging modalities in the other sites of the resective areas, despite curative resection for the primary sites. If biomarkers to efficiently evaluate the metastatic potential of each patient ...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kazufumi Honda Source Type: research

Surgical outcomes of coronal shear fractures of the distal humerus in the elderly
CONCLUSION: ORIF yielded satisfactory outcomes for theelderly with noncomminuted CSF of the distal humerus. However, the cases with comminuted articular fragment or complex posterior fractures were still challenging.PMID:34526454 | DOI:10.1272/jnms.JNMS.2022_89-202 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yuji Tomori Mitsuhiko Nanno Kentaro Sonoki Tokifumi Majima Source Type: research

Glucagon responses to glucose challenge in patients with idiopathic postprandial syndrome
CONCLUSIONS: These data suggest that glucagon suppression is stronger in patients with idiopathic postprandial syndrome than in normal subjects previously reported. The present data will contribute to further understanding and future research of this syndrome.PMID:34526455 | DOI:10.1272/jnms.JNMS.2022_89-205 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Minami Kosuda Kentaro Watanabe Masao Koike Ai Morikawa Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research

A case of suspected low-pressure hydrocephalus caused by spinal drainage following subarachnoid hemorrhage
DISCUSSION: LPH is a rare disease caused by various factors and is treated by correcting liquorrhea or overdrainage, if any. Otherwise, drainage at a negative CSF pressure is necessary. Its symptoms and image findings are similar to those of intracranial hypertension and normal-pressure hydrocephalus. This paper reports a suspected LPH case caused by spinal drainage following subarachnoid hemorrhage with literature review.PMID:34526456 | DOI:10.1272/jnms.JNMS.2022_89-209 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tomohiro Ozeki Asami Kubota Yasuo Murai Akio Morita Source Type: research

Machine Learning Prediction for Supplemental Oxygen Requirement in Patients with COVID-19
CONCLUSION: In this study, we developed a machine learning model that can be used as a triage tool by clinicians to detect high-risk patients and disease progression earlier. Prospective validation studies are needed to verify the application of the tool in clinical practice.PMID:34526457 | DOI:10.1272/jnms.JNMS.2022_89-210 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yutaka Igarashi Kan Nishimura Kei Ogawa Nodoka Miyake Taiki Mizobuchi Kenta Shigeta Hirofumi Obinata Yasuhiro Takayama Takashi Tagami Masahiro Seike Hayato Ohwada Shoji Yokobori Source Type: research

A new technique for introduction of a surgical stapler in robot-assisted lobectomy for lung cancer
CONCLUSION: The new total port approach, with three robotic arms, for introducing surgical staplers during RATS using the da Vinci Si robotic system appears to be feasible.PMID:34526458 | DOI:10.1272/jnms.JNMS.2022_89-211 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Jitsuo Usuda Tatsuya Inoue Takumi Sonokawa Mitsuo Matsumoto Yutaka Enomoto Kento Suzuki Yuya Tomioka Source Type: research

A Proposed New Clinical Classification of Metastatic Gastric Cancer - Pyloric and Antral Gastric Cancer
CONCLUSION: Classification by a combination of macroscopic and metastatic form in pyloric/antral metastatic gastric cancer might be useful for diagnosis and treatment.PMID:34526459 | DOI:10.1272/jnms.JNMS.2022_89-212 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tetsuro Kawagoe Go Ikeda Yu Oshiro Keiko Kaneko Katsuhiko Iwakiri Source Type: research

Enhancement of ultraviolet B-induced apoptosis and elimination of DNA damage by pre-irradiation with infrared radiation A does not depend on DNA damage repair
CONCLUSION: These results indicate that the enhancement of UVB-induced apoptosis and acceleration of removal of CPDs by pre-irradiation with IRA does not depend on DNA damage repair.PMID:34526460 | DOI:10.1272/jnms.JNMS.2022_89-213 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Shizuka Okazaki Yoko Funasaka Hidehisa Saeki Source Type: research

The Impact of Childhood Disease on Hospital Visiting: A Survey of Pediatricians
CONCLUSIONS: Caregivers make decisions on when to visit the hospital based on the child's expression of pain and their behavior. The creation of guidelines to give appropriate guidance to caregivers as to when to visit the hospital is essential.PMID:34526461 | DOI:10.1272/jnms.JNMS.2022_89-214 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hanako Tajima Juri Ogawa Izuru Nose Ruby Pawankar Miho Maeda Morihisa Takarabe Yutaka Momota Miki Kakinuma Source Type: research

Analysis of Cognitive aging Estimated by the Japanese Version of the Montreal Cognitive Assessment in Patients Aged 75 years or Older with and Without Type 2 diabetes Mellitus
CONCLUSIONS: Patients aged ≥75 years with T2DM might have lower cognition than those without T2DM; the inability to perform delayed recall in T2DM patients might denote a cognitive function decline.Therefore, compared with other patients, patients aged ≥75 years with T2DM need to receive individually tailored explanations about their care, based on their cognition.PMID:34526462 | DOI:10.1272/jnms.JNMS.2022_89-215 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Taeko Saito Takehisa Yamada Yasushi Miyauchi Naoya Emoto Fumitaka Okajima Source Type: research

Iron supplementation for hypoferritinemia-related psychological symptoms in children and adolescents
This study examined the effects of iron administration on psychological state of children and adolescents with reduced serum ferritin concentration.METHODS: This prospective study evaluated 19 participants aged 6-15 years with serum ferritin levels
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Katsunaka Mikami Fumiaki Akama Keitaro Kimoto Hideki Okazawa Yasushi Orihashi Yuichi Onishi Yuki Takahashi Hiromasa Yabe Kenji Yamamoto Hideo Matsumoto Source Type: research

The screening program, incidence, and treatment for tumors in patients with severe motor and intellectual disabilities
CONCLUSIONS: We reported a tumor therapy to the patients with SMID. Our therapy provides satisfactory results for patients with SMID and their families. Further studies are required to clarify the clinical significance of the screening test and the tumor operative method for the patients with SMID.PMID:34526464 | DOI:10.1272/jnms.JNMS.2022_89-217 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kei Ishimaru Satoshi Akita Shunji Matsuda Shungo Yukumi Masamitsu Morimoto Chiya Kikuchi Sayuri Matsui Kazufumi Tanigawa Jun Kuwabara Hironori Matsumoto Satoshi Kikuchi Motohira Yoshida Shigehiro Koga Yuji Watanabe Source Type: research

The influences of obesity in laparoscopic and open distal gastrectomy patients for early gastric cacer
In this study, we examined the effects of obesity on laparoscopic and open distal gastrectomy.METHODS: A totalof 262 patients with gastric cancer (cStageI) who underwent distal gastrectomy were classified into open distal gastrectomy (ODG) (145 patients) and laparoscopic distal gastrectomy (LDG) (117 patients) groups. According to their body mass index (BMI), they were subdivided into obese (BMI ≥ 25) and non-obese patients (BMI
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kentaro Maejima Nobuhiko Taniai Hiroshi Yoshida Source Type: research

Outcome of modified laparoscopic sacrocolpopexy and its effect on voiding dysfunction
CONCLUSIONS: The modified LSC in women with POP provides good functional outcomes in terms of IPSS, post void residual volume (PVR), and urinary storage function.PMID:34526466 | DOI:10.1272/jnms.JNMS.2022_89-219 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yuka Toyama Yasutomo Suzuki Satoko Nakayama Yuki Endo Yukihiro Kondo Masao Ichikawa Shigeo Akira Source Type: research

Intraoperative low-field magnetic resonance imaging-guided tumor resection in glioma surgery: Pros and cons
CONCLUSIONSLow-field intraoperative MRI improves the GTR rate and reduces unintentional reoperation incidence compared to the conventional technique. Our findings showed no operating time prolongation in the MRI group despite intraoperative imaging, which considered that intraoperative MRI helped reduce decision-making time and procedural hesitation during surgery.PMID:34526467 | DOI:10.1272/jnms.JNMS.2022_89-301 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yu Fujii Toshihiro Ogiwara Gen Watanabe Yoshiki Hanaoka Tetsuya Goto Kazuhiro Hongo Tetsuyoshi Horiuchi Source Type: research

Learning curve for endoscopic thyroidectomy using video-assisted neck surgery: retrospective analysis of a single surgeon's experience of 100 cases
CONCLUSIONS: In VANS, a certain surgical level was reached after experiencing 30 cases.PMID:34526468 | DOI:10.1272/jnms.JNMS.2022_89-302 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Ryuta Nagaoka Iwao Sugitani Hiroko Kazusaka Mami Matsui Masaomi Sen Marie Saitou Tomoo Jikuzono Ritsuko Okamura Takehito Igarashi Kazuo Shimizu Source Type: research

Long-term Benefits of Treatment with Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
CONCLUSION: This study suggested that long-term administration of tolvaptan may improve renal function and inhibit total kidney volume growth.PMID:34526469 | DOI:10.1272/jnms.JNMS.2022_89-303 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Naoko Shimoda Mariko Ikeda Tomohiro Yan Sayuri Kawasaki Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

A rapidly growing small intestinal metastasis from lung cancer
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-501. Online ahead of print.ABSTRACTSmall intestinal metastasis from lung cancer is a relatively rare occurrence, and often causes intestinal obstruction, gastrointestinal perforation, and/or gastrointestinal bleeding making it is an oncological emergency. Many patients have been reported to undergo emergency surgery owing to the rapid progression of the intestinal metastatic lesion; however, information regarding the changes that occur in such metastases over time remains lacking. Therefore, we analyzed 4 patients who had small intestinal metastases arising from...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Katsuyoshi Ankoh Seiichi Shinji Takeshi Yamada Akihisa Matsuda Ryo Ohta Hiromichi Sonoda Masahiro Hotta Goro Takahashi Yohei Kaneya Takuma Iwai Kohki Takeda Koji Ueda Sho Kuriyama Toshimitsu Miyasaka Kazuhide Yonaga Yoshinobu Shioda Hiroshi Yoshida Ryuji Source Type: research

Maculopapular Drug Eruption Caused by Apalutamide: Case Report and Review of the Literature
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-503. Online ahead of print.ABSTRACTApalutamide, an oral androgen receptor signaling inhibitor, is approved for the treatment of non-metastatic castration-resistant prostate cancer and metastatic prostate cancer. In the international randomized placebo-controlled clinical trials, apalutamide was associated with a higher rate of rash than placebo. However, given that reports from a dermatological perspective are limited, the skin manifestations and histopathology of the skin lesions caused by apalutamide are largely unknown. Here, we report a case of apalutamide-i...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hiroki Katayama Hidehisa Saeki Shin-Ichi Osada Source Type: research

A Risk Reduction Technique for Five Invasive Procedures in the Emergency Room Using a Compact and Lightweight X-ray Unit
CONCLUSIONS: The devised portable X-ray unit could contribute medical safety during invasive procedures frequently performed in the ER.PMID:34526472 | DOI:10.1272/jnms.JNMS.2022_89-504 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yutaka Igarashi Shimpei Ikeda Kunio Hirai Naoki Tominaga Taiki Mizobuchi Kenta Shigeta Hiromoto Ishii Shoji Yokobori Source Type: research

A case of unilateral recurrent nerve palsy with chronic inflammatory demyelinating polyradiculoneuropathy
We report a patient who developed left recurrent nerve palsy with CIDP. The patient was a 48-year-old male. The disease developed as progressive muscle weakness and numbness of the four limbs 3 years before and was diagnosed as CIDP. The symptoms had been improved by high-dose intravenous gamma-globulin therapy. However, from 2 months before he became aware of breathy hoarseness, and bilateral decreased grip strength and sensory disturbance of the upper and lower limbs recurred and progressed. On laryngoscopy disorder of left vocal fold movement and glottal closure incompetence during phonation were observed, and neurogeni...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Taro Komachi Hideto Saigusa Osamu Kadosono Hiroyuki Ito Satoshi Yamaguchi Hiroshi Nagayama Masanori Sakamaki Source Type: research

Solitary chondrosarcoma of the right ring finger: A case report
We present a case of solitary chondrosarcoma arising from the proximal phalanx of the ring finger in an elderly man. The chondrosarcoma developed over a period of 14 years, during which the phalanx became progressively more deformed. Several radiographic investigations were carried out, but the patient declined further suggested diagnostic examinations (computed tomography, magnetic resonance imaging, biopsy). Eventually, the lesion became significantly enlarged, and radiographs showed osteolytic lesions in the phalangeal bone. Ray amputation of the finger was required to establish a wide resection of the chondrosarcoma. M...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yuji Tomori Norio Motoda Ryu Tsunoda Ryuji Ohashi Yasuyuki Kitagawa Tokifumi Majima Source Type: research

Bilobed flap for reconstruction of skin defect after excision of parotid carcinoma: a case report
CONCLUSIONS: The bilobed flap is useful for reconstructing skin defects measuring up to 6 cm in diameter.PMID:34526475 | DOI:10.1272/jnms.JNMS.2022_89-603 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Koji Sakamoto Hiroyuki Ozawa Masayuki Shimoda Masashi Nakaishi Atsuko Sakanushi Takeshi Matsunobu Kimihiro Okubo Takashi Okada Yoichiro Sato Seiichi Shinden Kaoru Ogawa Source Type: research

The relationship between severity of varus osteoarthritic knees and contracture of the medial structures
CONCLUSIONS: The threshold angle for expected correction with medial osteophyte removal was 9.5˚. However, with no differences in correction between those with larger or smaller than this angle, medial structure contracture seemed to be unrelated to severity of deformity.PMID:34526449 | DOI:10.1272/jnms.JNMS.2022_89-113 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Norishige Iizawa Yasushi Oshima Tatsunori Kataoka Hiroshi Watanabe Tokifumi Majima Shinro Takai Source Type: research

Serum interleukin-18 provides a clue to the diagnosis of adult-onset Still's disease: findings from 6 Japanese patients with adult-onset Still's disease
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-114. Online ahead of print.ABSTRACTAdult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder accompanied by skin eruption. However, typical skin eruptions, such as evanescent, salmon-pink erythema, are not specific to AOSD and dermatologists often face difficulty in diagnosing AOSD. Interleukin-18 (IL-18) is believed to be the initiating factor of the inflammatory cascade in AOSD and overproduction of IL-18 contributes to the development of systemic autoinflammatory reactions. Therefore, we examined serum IL-18 levels in the active and inactive ...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Azusa Ogita Shin-Ichi Ansai Hidehisa Saeki Source Type: research

Management of simple hepatic cyst
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-115. Online ahead of print.ABSTRACTSimple hepatic cysts are typically saccular, thin-walled masses with fluid-filled epithelial lined cavities that arise from aberrant bile duct cells during embryonic development. With the development of diagnostic modalities such as ultrasonography, computed tomography and magnetic resonance imaging, simple hepatic cysts are seen with relative frequency in daily clinical examination. US is the most useful and noninvasive tool for the diagnosis of simple hepatic cysts, and can generally differentiate simple hepatic cysts from ab...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tetsuya Shimizu Masato Yoshioka Yohei Kaneya Tomohiro Kanda Yuto Aoki Ryota Kondo Hideyuki Takata Junji Ueda Youichi Kawano Atsushi Hirakata Akira Matsushita Nobuhiko Taniai Yasuhiro Mamada Hiroshi Yoshida Source Type: research

Multiscale aspects of molecular motions: From molecular vibrations, conformational changes of biomolecules to cellular dynamics
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-116. Online ahead of print.ABSTRACTMolecular aspects of living systems are important because it is the most basic aspects of life as exemplified in biochemistry and structural biology. Since molecules move due to interactive forces between atoms, physics plays an important role to understand the dynamic phenomena of living systems. Here we review our multiscale approaches for computationally treating different levels of molecular motions: vibrational dynamics of molecules, conformational change of biomolecules, and cellular dynamics using statistical-mechanics-b...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hiroshi Fujisaki Source Type: research

Development of biomarkers for predicting recurrence by determining the metastatic ability of cancer cells
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-118. Online ahead of print.ABSTRACTAdjuvant chemotherapy has been carried out for patients with cancer who underwent curative resection, but it is basically not needed for patients without micro-metastatic lesions who undergo a perfectly curative surgical operation. The patients who need adjuvant chemotherapy are defined as those whose micro-metastases cannot be detected by imaging modalities in the other sites of the resective areas, despite curative resection for the primary sites. If biomarkers to efficiently evaluate the metastatic potential of each patient ...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kazufumi Honda Source Type: research

Surgical outcomes of coronal shear fractures of the distal humerus in the elderly
CONCLUSION: ORIF yielded satisfactory outcomes for theelderly with noncomminuted CSF of the distal humerus. However, the cases with comminuted articular fragment or complex posterior fractures were still challenging.PMID:34526454 | DOI:10.1272/jnms.JNMS.2022_89-202 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yuji Tomori Mitsuhiko Nanno Kentaro Sonoki Tokifumi Majima Source Type: research

Glucagon responses to glucose challenge in patients with idiopathic postprandial syndrome
CONCLUSIONS: These data suggest that glucagon suppression is stronger in patients with idiopathic postprandial syndrome than in normal subjects previously reported. The present data will contribute to further understanding and future research of this syndrome.PMID:34526455 | DOI:10.1272/jnms.JNMS.2022_89-205 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Minami Kosuda Kentaro Watanabe Masao Koike Ai Morikawa Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research

A case of suspected low-pressure hydrocephalus caused by spinal drainage following subarachnoid hemorrhage
DISCUSSION: LPH is a rare disease caused by various factors and is treated by correcting liquorrhea or overdrainage, if any. Otherwise, drainage at a negative CSF pressure is necessary. Its symptoms and image findings are similar to those of intracranial hypertension and normal-pressure hydrocephalus. This paper reports a suspected LPH case caused by spinal drainage following subarachnoid hemorrhage with literature review.PMID:34526456 | DOI:10.1272/jnms.JNMS.2022_89-209 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tomohiro Ozeki Asami Kubota Yasuo Murai Akio Morita Source Type: research

Machine Learning Prediction for Supplemental Oxygen Requirement in Patients with COVID-19
CONCLUSION: In this study, we developed a machine learning model that can be used as a triage tool by clinicians to detect high-risk patients and disease progression earlier. Prospective validation studies are needed to verify the application of the tool in clinical practice.PMID:34526457 | DOI:10.1272/jnms.JNMS.2022_89-210 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yutaka Igarashi Kan Nishimura Kei Ogawa Nodoka Miyake Taiki Mizobuchi Kenta Shigeta Hirofumi Obinata Yasuhiro Takayama Takashi Tagami Masahiro Seike Hayato Ohwada Shoji Yokobori Source Type: research

A new technique for introduction of a surgical stapler in robot-assisted lobectomy for lung cancer
CONCLUSION: The new total port approach, with three robotic arms, for introducing surgical staplers during RATS using the da Vinci Si robotic system appears to be feasible.PMID:34526458 | DOI:10.1272/jnms.JNMS.2022_89-211 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Jitsuo Usuda Tatsuya Inoue Takumi Sonokawa Mitsuo Matsumoto Yutaka Enomoto Kento Suzuki Yuya Tomioka Source Type: research

A Proposed New Clinical Classification of Metastatic Gastric Cancer - Pyloric and Antral Gastric Cancer
CONCLUSION: Classification by a combination of macroscopic and metastatic form in pyloric/antral metastatic gastric cancer might be useful for diagnosis and treatment.PMID:34526459 | DOI:10.1272/jnms.JNMS.2022_89-212 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Tetsuro Kawagoe Go Ikeda Yu Oshiro Keiko Kaneko Katsuhiko Iwakiri Source Type: research

Enhancement of ultraviolet B-induced apoptosis and elimination of DNA damage by pre-irradiation with infrared radiation A does not depend on DNA damage repair
CONCLUSION: These results indicate that the enhancement of UVB-induced apoptosis and acceleration of removal of CPDs by pre-irradiation with IRA does not depend on DNA damage repair.PMID:34526460 | DOI:10.1272/jnms.JNMS.2022_89-213 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Shizuka Okazaki Yoko Funasaka Hidehisa Saeki Source Type: research

The Impact of Childhood Disease on Hospital Visiting: A Survey of Pediatricians
CONCLUSIONS: Caregivers make decisions on when to visit the hospital based on the child's expression of pain and their behavior. The creation of guidelines to give appropriate guidance to caregivers as to when to visit the hospital is essential.PMID:34526461 | DOI:10.1272/jnms.JNMS.2022_89-214 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hanako Tajima Juri Ogawa Izuru Nose Ruby Pawankar Miho Maeda Morihisa Takarabe Yutaka Momota Miki Kakinuma Source Type: research

Analysis of Cognitive aging Estimated by the Japanese Version of the Montreal Cognitive Assessment in Patients Aged 75 years or Older with and Without Type 2 diabetes Mellitus
CONCLUSIONS: Patients aged ≥75 years with T2DM might have lower cognition than those without T2DM; the inability to perform delayed recall in T2DM patients might denote a cognitive function decline.Therefore, compared with other patients, patients aged ≥75 years with T2DM need to receive individually tailored explanations about their care, based on their cognition.PMID:34526462 | DOI:10.1272/jnms.JNMS.2022_89-215 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Taeko Saito Takehisa Yamada Yasushi Miyauchi Naoya Emoto Fumitaka Okajima Source Type: research

Iron supplementation for hypoferritinemia-related psychological symptoms in children and adolescents
This study examined the effects of iron administration on psychological state of children and adolescents with reduced serum ferritin concentration.METHODS: This prospective study evaluated 19 participants aged 6-15 years with serum ferritin levels
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Katsunaka Mikami Fumiaki Akama Keitaro Kimoto Hideki Okazawa Yasushi Orihashi Yuichi Onishi Yuki Takahashi Hiromasa Yabe Kenji Yamamoto Hideo Matsumoto Source Type: research

The screening program, incidence, and treatment for tumors in patients with severe motor and intellectual disabilities
CONCLUSIONS: We reported a tumor therapy to the patients with SMID. Our therapy provides satisfactory results for patients with SMID and their families. Further studies are required to clarify the clinical significance of the screening test and the tumor operative method for the patients with SMID.PMID:34526464 | DOI:10.1272/jnms.JNMS.2022_89-217 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kei Ishimaru Satoshi Akita Shunji Matsuda Shungo Yukumi Masamitsu Morimoto Chiya Kikuchi Sayuri Matsui Kazufumi Tanigawa Jun Kuwabara Hironori Matsumoto Satoshi Kikuchi Motohira Yoshida Shigehiro Koga Yuji Watanabe Source Type: research

The influences of obesity in laparoscopic and open distal gastrectomy patients for early gastric cacer
In this study, we examined the effects of obesity on laparoscopic and open distal gastrectomy.METHODS: A totalof 262 patients with gastric cancer (cStageI) who underwent distal gastrectomy were classified into open distal gastrectomy (ODG) (145 patients) and laparoscopic distal gastrectomy (LDG) (117 patients) groups. According to their body mass index (BMI), they were subdivided into obese (BMI ≥ 25) and non-obese patients (BMI
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Kentaro Maejima Nobuhiko Taniai Hiroshi Yoshida Source Type: research

Outcome of modified laparoscopic sacrocolpopexy and its effect on voiding dysfunction
CONCLUSIONS: The modified LSC in women with POP provides good functional outcomes in terms of IPSS, post void residual volume (PVR), and urinary storage function.PMID:34526466 | DOI:10.1272/jnms.JNMS.2022_89-219 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yuka Toyama Yasutomo Suzuki Satoko Nakayama Yuki Endo Yukihiro Kondo Masao Ichikawa Shigeo Akira Source Type: research

Intraoperative low-field magnetic resonance imaging-guided tumor resection in glioma surgery: Pros and cons
CONCLUSIONSLow-field intraoperative MRI improves the GTR rate and reduces unintentional reoperation incidence compared to the conventional technique. Our findings showed no operating time prolongation in the MRI group despite intraoperative imaging, which considered that intraoperative MRI helped reduce decision-making time and procedural hesitation during surgery.PMID:34526467 | DOI:10.1272/jnms.JNMS.2022_89-301 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Yu Fujii Toshihiro Ogiwara Gen Watanabe Yoshiki Hanaoka Tetsuya Goto Kazuhiro Hongo Tetsuyoshi Horiuchi Source Type: research

Learning curve for endoscopic thyroidectomy using video-assisted neck surgery: retrospective analysis of a single surgeon's experience of 100 cases
CONCLUSIONS: In VANS, a certain surgical level was reached after experiencing 30 cases.PMID:34526468 | DOI:10.1272/jnms.JNMS.2022_89-302 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Ryuta Nagaoka Iwao Sugitani Hiroko Kazusaka Mami Matsui Masaomi Sen Marie Saitou Tomoo Jikuzono Ritsuko Okamura Takehito Igarashi Kazuo Shimizu Source Type: research

Long-term Benefits of Treatment with Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
CONCLUSION: This study suggested that long-term administration of tolvaptan may improve renal function and inhibit total kidney volume growth.PMID:34526469 | DOI:10.1272/jnms.JNMS.2022_89-303 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Naoko Shimoda Mariko Ikeda Tomohiro Yan Sayuri Kawasaki Akio Hirama Tetsuya Kashiwagi Yukinao Sakai Source Type: research

A rapidly growing small intestinal metastasis from lung cancer
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-501. Online ahead of print.ABSTRACTSmall intestinal metastasis from lung cancer is a relatively rare occurrence, and often causes intestinal obstruction, gastrointestinal perforation, and/or gastrointestinal bleeding making it is an oncological emergency. Many patients have been reported to undergo emergency surgery owing to the rapid progression of the intestinal metastatic lesion; however, information regarding the changes that occur in such metastases over time remains lacking. Therefore, we analyzed 4 patients who had small intestinal metastases arising from...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Katsuyoshi Ankoh Seiichi Shinji Takeshi Yamada Akihisa Matsuda Ryo Ohta Hiromichi Sonoda Masahiro Hotta Goro Takahashi Yohei Kaneya Takuma Iwai Kohki Takeda Koji Ueda Sho Kuriyama Toshimitsu Miyasaka Kazuhide Yonaga Yoshinobu Shioda Hiroshi Yoshida Ryuji Source Type: research

Maculopapular Drug Eruption Caused by Apalutamide: Case Report and Review of the Literature
J Nippon Med Sch. 2021 Sep 14. doi: 10.1272/jnms.JNMS.2022_89-503. Online ahead of print.ABSTRACTApalutamide, an oral androgen receptor signaling inhibitor, is approved for the treatment of non-metastatic castration-resistant prostate cancer and metastatic prostate cancer. In the international randomized placebo-controlled clinical trials, apalutamide was associated with a higher rate of rash than placebo. However, given that reports from a dermatological perspective are limited, the skin manifestations and histopathology of the skin lesions caused by apalutamide are largely unknown. Here, we report a case of apalutamide-i...
Source: Journal of Nippon Medical School - September 16, 2021 Category: Universities & Medical Training Authors: Hiroki Katayama Hidehisa Saeki Shin-Ichi Osada Source Type: research