Kirschner wires fixation alone or Kirschner wires fixation with tension band wiring in paediatric fractures of the lateral humeral condyle.
CONCLUSIONS: TBW fixation is probably optimal procedure for displaced lateral humeral condyle fractures in children, as it can promote early active range of motion exercise. PMID: 31611504 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Takai S Tags: J Nippon Med Sch Source Type: research

Volar locking plate fixation for intra-articular distal radius fractures with volar lunate facet fragments distal to the watershed line.
CONCLUSIONS: Distally placed volar locking plate fixation effectively treats intra-articular distal radius fractures with VLF fragments distal to the watershed line by stabilizing the fragments. However, small displaced VLF fragments may increase the risk of reduction loss in ulnar variance. PMID: 31611505 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Nanno M, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Complementary use of magnetic resonance imaging and fine needle aspiration cytology in the diagnosis of soft tissue tumors.
CONCLUSIONS: The combined preoperative application of MRI and FNAC improved diagnosis of soft tissue tumors relative to assessment with either modality alone. PMID: 31611506 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Tsunoda R, Nanno M, Arai S, Takai S Tags: J Nippon Med Sch Source Type: research

The optimal alignment of the tibial implant in unicompartmental arthroplasty using 3-dimensional finite analysis.
CONCLUSIONS: In UKA, optimal alignment of the tibial implant might be at the middle position in the coronal plane and at the posterior inclination similar to each patient's original inclination in the sagittal plane to reduce complications. PMID: 31611507 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Sasatani K, Majima T, Murase K, Takeuchi N, Matsumoto T, Oshima Y, Takai S Tags: J Nippon Med Sch Source Type: research

Acute kidney injury in non-intensive care unit and intensive care unit patients treated with vancomycin and piperacillin-tazobactam.
CONCLUSIONS: The combined use of TZP in patients receiving VAN increased the incidence of AKI in both non-ICU and ICU settings. PMID: 31611508 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Inage S, Nakamura S, Isoe Y, Okamoto S, Uetake S, Murakami M, Yamaguchi A, Morishima M, Nei T, Ise Y, Katayama S Tags: J Nippon Med Sch Source Type: research

Impact of Orthopedic Promotional Activities on Multidisciplinary Approaches for Bone Metastases.
CONCLUSION: A high potential demand exists for a multidisciplinary approach for bone metastases, and orthopedic specialists should actively participate in this approach. PMID: 31564687 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Natural progression and tumor growth predictive factors of retroperitoneal schwannoma.
CONCLUSIONS: The growth rates of retroperitoneal schwannomas were various. Additionally, MRI findings and clinical findings that could predict the future growth of retroperitoneal schwannoma could not be clarified. Therefore, careful follow-up is necessary for this tumor, especially for lesions with bone erosion. PMID: 31564688 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Basophil-expressing genes related with the efficacy of sublingual immunotherapy.
Abstract Basophils have been implicated not only in allergy pathogenesis, but also in the efficacy of allergen immunotherapy (AIT). We recently conducted a clinical study of sublingual immunotherapy (SLIT) in patients with Japanese cedar pollinosis using a purified cedar allergen. Patients were stratified into the high-responder (HR) and non-responder (NR) groups, and comprehensive microarray analysis was performed on peripheral basophils in the patients from both groups. A total of 153 genes were found to be differentially expressed in the HR and NR patients. The majority of the differentially expressed genes wer...
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Gotoh M, Kaminuma O, Nakaya A, Saeki M, Nishimura T, Kitamura N, Hiroi T, Kimihiro Okubo A Tags: J Nippon Med Sch Source Type: research

Fetal and Neonatal Circulatory Disorders in Twin to Twin Transfusion Syndrome (The Secondary Publication).
Abstract Twin to twin transfusion syndrome (TTTS) is a major complication of monochorionic diamniotic (MD) twins, and its onset is known to be associated with placental vascular anastomoses and blood flow imbalance. In a typical case of TTTS, the recipient develops polyhydramnios, weight gain, cardiomegaly and hydrops fetalis in the uterus. In contrast, the donor develops oligohydramnios and intrauterine growth restriction. Recently, the significance of the renin-angiotensin-aldosterone system (RAAS) that transfers from the donor to the recipient has attracted interest in the fetal circulation of TTTS. The donor h...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Yoda H Tags: J Nippon Med Sch Source Type: research

Second Free Flap Surgery for Skull Base Tumors: Case Report and Literature Review.
In this report, we discuss the results of second free flap surgery after skull base reconstructive surgery. We retrospectively analyzed data from patients treated at our center during the period from 2013 through 2017. All four patients identified had skull base anaplastic meningioma and had undergone radiotherapy. In all cases, the flap and donor blood vessel were sourced from sites that differed from those used in the previous surgeries. No complications developed, such as cerebrospinal fluid leakage, meningitis, wound infection, wound hemorrhage, or flap necrosis. Because the first flap was found to be unviable, it was ...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Kubota A, Murai Y, Umezawa H, Ishisaka E, Tsukiyama A, Nakagawa S, Matano F, Ogawa R, Morita A Tags: J Nippon Med Sch Source Type: research

Central Diabetes Insipidus Associated with Orbital Apex Syndrome.
Abstract Orbital apex syndrome (OAS) manifests as multiple cranial nerve palsies caused by an abnormal nerve response to inflammation or other processes. Central diabetes insipidus (CDI) is characterized by deficient synthesis or secretion of antidiuretic hormone. A 62-year-old woman underwent myringotomy for otitis media with effusion. Two months after the procedure, symptoms of hearing loss had not improved, and she underwent left tympanoplasty and mastoidectomy. After surgery, she presented with left ocular pain and visual loss. Neurologic examination revealed ptosis, total ophthalmoplegia, and a relative affer...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Yoon JH, Cho SH, Lee SH, Ma SK, Kim SW, Bae EH Tags: J Nippon Med Sch Source Type: research

Mechanism of respiratory failure in fatal crowd accidents using a thoracoabdominal compression model of traumatic asphyxia.
CONCLUSIONS: In human women, respiratory failure could occur within 1 h due to respiratory muscle fatigue even when the total thoracoabdominal load is only about 60% of the body weight. Vital capacity ≤1.85 L and modified Borg scale score ≥8.3 can be considered as indices for predicting respiratory failure. PMID: 31434839 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Motomura T, Matsumoto H, Yokota H, Suzuki M, Nishimoto T, Ujihashi S Tags: J Nippon Med Sch Source Type: research

Validity of integrated relaxation pressure cutoff value used in Starlet (high-resolution manometry system).
CONCLUSIONS: It is difficult to determine the IRP cutoff value using the Starlet. In diagnosis of achalasia using the Starlet, it is necessary to comprehensively judge the results other than IRP values. In addition, there was an association between IRP values and achalasia subtypes in the Chicago classification. PMID: 31434840 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Kawami N, Hoshino S, Hoshikawa Y, Takenouchi N, Hanada Y, Tanabe T, Goto O, Kaise M, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Comparison of functional dyspepsia with early chronic pancreatitis.
Abstract Functional dyspepsia (FD) is a common disease that can markedly impair the patients' quality of life. In 2016, Rome IV criteria defined the diagnosis of functional dyspepsia as requiring bothersome FD symptoms. In 2009, a new diagnosis of early chronic pancreatitis (ECP) was proposed as a new strategy to address chronic pancreatitis at the initial phase and prevent it from advancing into chronic pancreatitis. Although chronic pancreatitis was reported to be one of the causes of dyspepsia, there was scant data regarding the relationship between ECP and FD patients. Therefore, we tried to investigate differ...
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Futagami S, Yamawaki H, Agawa S, Ikeda G, Noda H, Kirita K, Higuchi K, Gudis K, Murakami M, Kodaka Y, Ueki N, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Novel modification of abductor pollicis longus suspension arthroplasty with trapeziectomy for thumb carpometacarpal osteoarthritis.
CONCLUSIONS: The modified Thompson procedure is a simple and effective technique that can improve the thumb radial abduction angle compared with the original technique in patients with advanced thumb CMC osteoarthritis. Additionally, this new technique is as useful as the original procedure in early restoring thumb function and relieving pain. PMID: 31308312 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Nanno M, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Urothelial carcinoma of the bladder, lipid cell variant: A case report and literature review.
Abstract Lipid cell variant of urethral carcinoma (UC) is a rare tumor and has been clinicopathologically poorly understood. A nodular tumor was detected in the bladder of an 87-year-old man with asymptomatic gross hematuria; the tumor was transurethrally resected. The patient was pathologically diagnosed with high-grade UC, lipid cell variant. The tumor cells, similar to lipoblasts, commonly contained cytoplasmic vacuoles. Immunohistochemically, the tumor cells were positive for epithelial markers such as CK7, 20, EMA, CAM5.2, and 34betaE12. However, they were negative for vimentin and S100. Moreover, focal posit...
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Takahashi K, Kimura G, Endo Y, Akatsuka J, Hayashi T, Toyama Y, Hamasaki T, Kondo Y Tags: J Nippon Med Sch Source Type: research

Improving Mood with Cognitive Behavioral Therapy in a Woman with Mild Cognitive Impairment-a Case Report.
This study investigated the feasibility of a cognitive behavioral therapy (CBT) program for a female patient with mild cognitive impairment (MCI), depression, and anxiety, to improve her mood and quality of life. The program comprised of eight 30-minute weekly sessions with interventions such as behavioral activation, relaxation, and cognitive reconstruction, in which the patient's caregiver also participated. An assessment evaluating the patient's condition were conducted before and immediately after the intervention. After 3 and 12 months, the caregiver reported the patient's behavioral and psychological symptoms using s...
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Kashimura M, Nomura T, Ishiwata A, Kitamura S, Tateno A Tags: J Nippon Med Sch Source Type: research

An Examination of Solitary Deaths in Tokyo Metropolis by Labor Force Status: Characteristics of Unnatural Deaths at Home among Individuals Living Alone.
CONCLUSIONS: We showed that the incidences of solitary death are significantly higher among non-employed than employed individuals for both sexes, and postmortem intervals among non-employed are significantly longer. PMID: 31308315 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Kanawaku Y, Ohno Y Tags: J Nippon Med Sch Source Type: research

Successful treatment of severe lactic acidosis and tumor lysis syndrome related to intravascular lymphoma in the intensive care unit.
We report a rare case in which a patient with intravascular lymphoma involving multiple organ failure survived. PMID: 31308316 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Mase H, Ogawa Y, Takeuchi J, Genda Y, Ichiba S, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Blood Galectin-3 Levels Predict Postoperative Complications after Colorectal Cancer Surgery.
CONCLUSIONS: These results indicate that increased perioperative blood galectin-3 levels may be associated with POC after CRC surgery. PMID: 31292325 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Matsuda A, Yamada M, Matsumoto S, Sakurazawa N, Kawano Y, Sekiguchi K, Yamada T, Matsutani T, Miyashita M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.
CONCLUSIONS: The rs11045879 minor allele in the SLCO1B1 gene is a potential predictor of non-responders to MTX treatment among Japanese RA patients. In future collaborative research, we will investigate whether the association with SLCO1B1 polymorphism is significant by performing statistical analysis with a larger study population. PMID: 31292326 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Takahashi K, Nakamura H, Watanabe A, Majima T, Koiwa M, Kamada T, Takai S Tags: J Nippon Med Sch Source Type: research

Symptoms Related to Moderate Skeletal-Related Events as Clues for the Diagnosis of Bone Metastasis.
CONCLUSION: The results of the present study suggest that symptoms related to SREs can be used to diagnose bone metastasis in the absence of a screening test. Bone metastasis should be diagnosed as often as possible based on symptoms related to moderate SREs and should be treated as soon as possible before patients develop severe SREs. PMID: 31292327 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Multicenter Observational Study of Fulvestrant 500 mg in Postmenopausal Japanese Women with Estrogen Receptor-Positive Advanced or Recurrent Breast Cancer after Prior Endocrine Treatment (SBCCSG29 Study).
CONCLUSION: Fulvestrant 500 mg is an effective and safe treatment for patients with advanced or recurrent breast cancer after prior endocrine treatment. PMID: 31292328 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Kimizuka K, Inoue K, E Nagai S, Saito T, Nakano S, Futsuhara K, Yamada H, Kaneko S, Sakurai T, Hata S, Kurosumi M Tags: J Nippon Med Sch Source Type: research

Long-Term Outcomes of Endovascular Stenting for Blunt Renal Artery Injuries with Stenosis: A Report of Five Consecutive Cases.
CONCLUSIONS: Renal artery stenting for hemodynamically stable blunt renal artery injuries with stenosis is suggested to be safe and helps in avoiding long-term hemodialysis and renovascular hypertension. PMID: 31292329 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Okada I, Inoue J, Kato H, Koido Y, Kiriu N, Hattori T, Morimoto K, Ichinose Y, Yokota H Tags: J Nippon Med Sch Source Type: research

Huge Littoral Cell Angioma of the Spleen: A Case Report.
Abstract Littoral cell angioma (LCA), a rare vascular neoplasm that occurs in the spleen, is difficult to definitively diagnose preoperatively because histological examination is the only accurate means of diagnosing this condition. Thus, the preoperative diagnosis is often incorrect. Splenectomy is the appropriate treatment and can be performed laparoscopically or by open surgery depending on the size of the tumor. Here we present a case of a 38-year-old man who presented with a history of slight non-specific abdominal distension for 2 months. An abdominal CT scan showed a huge spleen measuring 35×18 cm and...
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Lyu S, He Q Tags: J Nippon Med Sch Source Type: research

Recurrent Bowel Obstruction Caused by Cecal Volvulus: A Case Report.
Abstract The preoperative diagnosis of cecal volvulus (CV) is rare and difficult and emergent laparotomy is frequently performed. Here, we report a case of CV that was diagnosed by preoperative computed tomography in a patient with an intellectual disability. In addition, we demonstrate that elective laparoscopic cecopexy can be performed following conservative treatment, such as the use of an ileus tube per anus. PMID: 31292331 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Miyao M, Takahashi T, Okusa M, Kusakabe M, Takano R, Masuda Y, Kawashima M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Atopic Dermatitis-Like Rash During Evolocumab Treatment of Familial Hypercholesterolemia.
We report the first known case of a patient who developed an atopic dermatitis (AD)-like rash during evolocumab therapy. A 43-year-old Japanese man with heterozygous familial hypercholesterolemia was treated with subcutaneous injection of 140 mg evolocumab biweekly, for 16 months. The therapy was then changed to subcutaneous injection of 420 mg evolocumab monthly. A few days after the first dose, the patient experienced pruritus and rash on his extremities. The rash worsened, while the pruritus subsided, then relapsed after the second and third doses. He had erythema and excoriation on his legs, lichenification over his po...
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Kanda N, Okajima F Tags: J Nippon Med Sch Source Type: research

Efficacy of laparoscopic repeat hepatectomy for recurrent liver cancer.
CONCLUSIONS: Our results indicate that LapRH for recurrent liver cancer provides feasible outcomes comparable to those of initial hepatectomy. Further studies, however, are needed to confirm our results. PMID: 31204379 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 15, 2019 Category: Universities & Medical Training Authors: Yoshioka M, Taniai N, Kawano Y, Shimizu T, Kondo R, Kaneya Y, Aoki Y, Yoshida H Tags: J Nippon Med Sch Source Type: research

The current status of laparoscopic hepatectomy.
Abstract Before the first laparoscopic hepatectomy (LH) was described in 1991, open hepatectomy (OH) was the only choice for the surgical treatment of liver tumors. At first, LH was indicated solely by tumor location, size, and type. The use of LH has spread rapidly throughout the world because it reduces the incision size. This review systematically assesses the current status of LH.LH is significantly less complicated, requires a shorter hospital stay, and less blood loss compared with OH. The long-term survival rates with LH and OH are comparable. Developing new techniques and instruments will improve the conve...
Source: Journal of Nippon Medical School - June 15, 2019 Category: Universities & Medical Training Authors: Yoshida H, Taniai N, Yoshioka M, Hirakata A, Kawano Y, Shimizu T, Ueda J, Takata H, Nakamura Y, Mamada Y Tags: J Nippon Med Sch Source Type: research

Development and verification of educational material for the plain radiographic diagnosis of bone metastasis: a preliminary report.
This study included a series of imaging data from 129 patients who had visited our orthopedic clinic from January 2011 to December 2014. First, we prepared a test to measure orthopedic practitioners' reading ability. Second, educational material was created. Third, the effectiveness of the educational material was verified by having orthopedic trainees take a pre-test and post-test. The test contained plain radiographic data of 12 patients with lesions and 6 without lesions. The educational material included plain radiographic data from 30 patients with typical findings of bone metastasis and diagnostic magnetic resonance ...
Source: Journal of Nippon Medical School - June 15, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Yamaoka T, Yokouchi M, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Laparoscopic Excision of Hydrocele of the Canal of Nuck in an Adult Female Using the "Open Posterior Wall Technique": Case Report Describing a Novel Laparoscopic Approach.
Laparoscopic Excision of Hydrocele of the Canal of Nuck in an Adult Female Using the "Open Posterior Wall Technique": Case Report Describing a Novel Laparoscopic Approach. J Nippon Med Sch. 2019 Jun 15;: Authors: Chihara N, Taniai N, Suzuki H, Nakata R, Shioda M, Yoshida H Abstract Complete surgical excision is the standard treatment for hydrocele of the canal of Nuck. Accordingly, we devised a novel open posterior wall technique for laparoscopic transabdominal preperitoneal (TAPP) excision.A 38-year-old woman presented to us with a 5-month history of a painless reducible lump in the right g...
Source: Journal of Nippon Medical School - June 15, 2019 Category: Universities & Medical Training Authors: Chihara N, Taniai N, Suzuki H, Nakata R, Shioda M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Interleukin-1beta Inhibition Attenuates Vasculitis in a Mouse Model of Kawasaki Disease.
CONCLUSIONS: The anti-IL-1β antibody significantly attenuated CAWS-induced vasculitis. The mechanism of inhibiting vasculitis is thought to include inhibition of the IL-1β pathway and additional effects beyond blocking IL-1β signaling. PMID: 31130561 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Hashimoto Y, Fukazawa R, Nagi-Miura N, Ohno N, Suzuki N, Katsube Y, Kamisago M, Akao M, Watanabe M, Hashimoto K, Tsuno K, Matsui R, Itoh Y Tags: J Nippon Med Sch Source Type: research

Sialorrhea Successfully Treated by the Combined Use of Selective M1 and M3 Muscarinic Acetylcholine Receptor Antagonists.
We report the case of a patient with sialorrhea who was successfully treated by the combined use of pirenzepine and solifenacin (M1 and M3 muscarinic receptor antagonists, respectively). The patient was a 51-year-old man with mean unstimulated and stimulated salivary flow rates per 10 min of 6.1 mL and 41.7 mL, respectively (both were measured three times). 99mTcO4- salivary gland scintigraphy revealed characteristic spontaneous saliva secretion without stimulation. He was treated with Scopolia extract, escitalopram, solifenacin succinate, and the combined administration of solifenacin succinate and pirenzepine. A statisti...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Yamamura Y, Nonaka M Tags: J Nippon Med Sch Source Type: research

Tarsal Navicular Stress Fracture in a Young Athlete: A Case Report.
Abstract Approximately 30% of tarsal navicular stress fractures are missed by physicians because plain radiographs often show no diagnostic clues. If early diagnosis and treatment are not obtained, such fractures will become refractory and the patient will no longer be able to actively participate as an athlete. We herein describe our experience treating a 14-year-old female track sprinter with persistent foot pain. Magnetic resonance imaging 6 months after the onset of pain showed a stress fracture of the tarsal navicular bone. Computed tomography showed the tarsal navicular stress fracture as well as sclerosis a...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Abe K, Hashiguchi H, Sonoki K, Iwashita S, Takai S Tags: J Nippon Med Sch Source Type: research

Pseudomyogenic Hemangioendothelioma.
We report a case of PMHE on the left plantar surface of a 28-year-old woman. Histopathological examination of the resected specimen revealed spindle and epithelioid cells with plump and atypical nuclei proliferated in the dermis and subcutaneous fat tissue with marked fibroplasia. Both spindle and epithelioid cells had abundant eosinophilic cytoplasm. Neoplastic cells were diffusely positive for AE1/AE3, CK7, vimentin, CD31, FLI-1, ERG, and INI-1. From those findings, we made the diagnosis of PMHE. We describe the main points of differentiation between PMHE and diseases that have similar clinical and/or histopathological f...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Ansai SI, Morimoto M, Akaishi S Tags: J Nippon Med Sch Source Type: research

Usefulness of the HyperEye Medical System in Obstructive Colitis Proximal to Colon Carcinoma.
We report a case of sigmoid colon carcinoma in which HEMS angiography was used and found to be useful for real-time detection of the OC lesion. PMID: 31130565 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Ishimaru K, Sato M, Akita S, Sugishita H, Kuwabara J, Tanigawa K, Matsuno Y, Abe Y, Yoshida M, Koga S, Watanabe Y Tags: J Nippon Med Sch Source Type: research

Safety of Abiraterone Acetate Administration in Elderly Patients Receiving Peritoneal Dialysis with Castration-Resistant Prostate Cancer: Two Case Reports.
We report two elderly patients receiving peritoneal dialysis with castration-resistant prostate cancer (CRPC). Herein, we show that the patients were safely treated using abiraterone acetate (750 mg/day orally once daily) and prednisolone (5 mg/day orally once daily). Although the prostate-specific antigen (PSA) level increased in both cases, there was no manifestation of disease progression (clinical and radiographic) for 22 months in case 1 and 8 months in case 2. In case 2, the only adverse event was hypokalemia, which was treated using potassium preparations. PMID: 31130566 [PubMed - in process] (Source: Journal o...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Kimata R, Tomita Y, Kondo Y Tags: J Nippon Med Sch Source Type: research

Clinicopathological Significance and Diagnostic Value of DLEC1 Hypermethylation in Lung Cancer: A Meta-analysis.
Abstract BACKGROUND: DLEC1 is a tumor-suppressor gene which plays a role in carcinogenesis. The purpose of the current study was to help establish the diagnostic performance of DLEC1 methylation in lung cancer. METHODS: PubMed, Embase, CNKI, and Wanfang databases were searched to obtain eligible studies. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations. The diagnostic value was assessed by the summary receiver operating characteristics test. RESULTS: A total of 7 articles, with 8 studies that included 673 lung cancer and 581 cont...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Li X, Mao W, Guo D, Xu H Tags: J Nippon Med Sch Source Type: research

Anesthesia Management of Special Patient Populations Undergoing Electroconvulsive Therapy: A Review.
Abstract Electroconvulsive therapy (ECT) is the safe application of electricity to the scalp of a patient, using brief-pulse stimulation techniques under general anesthesia and muscle paralysis, inducing a series of generalized epileptic seizures. Principal indications for ECT are major depression (unipolar or bipolar) with a lack of response to medications, intolerance to medications due to side effects or coexisting conditions, the need for a rapid response because of other conditions such as catatonia, psychosis, suicidality, or clinically significant dehydration or malnutrition, mania, and schizophreniform dis...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Wajima Z Tags: J Nippon Med Sch Source Type: research

Functional Outcome Following Ultra-Early Treatment for Ruptured Aneurysms in Patients with Poor-Grade Subarachnoid Hemorrhage.
CONCLUSIONS: Approximately 40% of patients with poor-grade aSAH became functionally independent, and approximately half of the patients with poor-grade aSAH who had neither intraventricular hemorrhage with obstructive hydrocephalus nor with brain herniation had good functional outcomes. Although further trials are required to confirm our results, ultra-early surgery may be considered for patients with poor-grade aSAH. PMID: 31130569 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Kaneko J, Tagami T, Unemoto K, Tanaka C, Kuwamoto K, Sato S, Tani S, Shibata A, Kudo S, Kitahashi A, Yokota H Tags: J Nippon Med Sch Source Type: research

Serum Hepcidin-25 Levels Reflect the Presence of Bacteremia in Patients with Systemic Inflammatory Response Syndrome.
Abstract BACKGROUND: Hepcidin-25 is a key regulatory hormone of iron homeostasis in humans, and its production is greatly upregulated by inflammation as well as iron overload. The aim of this study was to investigate the pathophysiological role of hepcidin-25 in patients with systemic inflammatory response syndrome (SIRS). METHODS: We enrolled 113 consecutive patients (aged 63.4±21, 50 men, 63 women), with 2 or more SIRS criteria, who were admitted to our department of general medicine between August 1, 2015 and August 31, 2017. We measured complete blood cell count and serum levels of hepcidin-25, iro...
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Wakakuri H, Hyodo H, Ohara T, Yasutake M Tags: J Nippon Med Sch Source Type: research

Acute Atomoxetine Selectively Modulates Encoding of Reward Value in Ventral Medial Prefrontal Cortex.
CONCLUSIONS: These results suggest that atomoxetine affects reward value encoding through selective modulation of vmPFC activity related to reward outcome. Therefore, such modulatory action may partly contribute to a therapeutic effect of atomoxetine for a group of ADHD patients with increased activity in vmPFC. PMID: 31130571 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Suzuki C, Ikeda Y, Tateno A, Okubo Y, Fukayama H, Suzuki H Tags: J Nippon Med Sch Source Type: research

Anesthetic Considerations of Intraoperative Neuromonitoring in Thyroidectomy.
CONCLUSIONS: This study suggested that anesthesiologists should correct tube dislocation reliably with video laryngoscope. The dose of rocuronium 0.6 mg/kg without sugammadex could be adequate for IONM. PMID: 31105118 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 17, 2019 Category: Universities & Medical Training Authors: Namizato D, Iwasaki M, Ishikawa M, Nagaoka R, Genda Y, Kishikawa H, Sugitani I, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Metastatic pancreatic mucinous carcinoma responding to systemic chemotherapy with modified FOLFIRINOX and undergoing conversion surgery: A case report.
We report a case of metastatic pancreatic-head mucinous carcinoma (with multiple lymph node and bone metastases), as well as a literature review. Endoscopic ultrasound - fine needle aspiration (EUS-FNA) was useful for diagnosis in this patient, and a satisfactory outcome was achieved using systemic chemotherapy with FOLFIRINOX followed by resection of the primary lesion as conversion surgery. The patient was a 55-year-old man. Hematological findings included elevated serum tumor marker levels: CEA at 12.7 ng/ml and DUPAN-2 at 400 U/ml. With several modalities and EUS - FNA, the patient received a clinicopathological diagno...
Source: Journal of Nippon Medical School - May 17, 2019 Category: Universities & Medical Training Authors: Yokoyama T, Makino H, Hirakata A, Ueda J, Takata H, Okusa M, Kawashima M, Tsujino T, Hosone M, Matsushita A, Nakamura Y, Yoshida H Tags: J Nippon Med Sch Source Type: research

Laparoscopic repeat hepatectomy with indocyanine green fluorescence navigation: A case report.
Abstract The indocyanine green (ICG) fluorescence method is reportedly useful for intraoperative visualization of hepatocellular carcinoma and metastatic liver cancer. Herein, we report the case of a 73-year-old man who underwent laparoscopic hepatectomy using an ICG fluorescence navigation system. The patient had a surgical history of two laparotomies for hepatocellular carcinoma resection. During follow-up at our hospital, abdominal computed tomography revealed recurrence of hepatocellular carcinoma in the lateral area of the liver, and so the patient was hospitalized for surgery. Because of his surgical history...
Source: Journal of Nippon Medical School - May 17, 2019 Category: Universities & Medical Training Authors: Yoshioka M, Taniai N, Kawano Y, Shimizu T, Kondo R, Kaneya Y, Aoki Y, Yoshida H Tags: J Nippon Med Sch Source Type: research

A case of severe pneumonitis with alveolar hemorrhage associated with herbal medicines.
We report a case of pneumonitis with alveolar hemorrhage induced by herbal medicines. A 73-year-old female was admitted to our hospital due to dyspnea and the presence of an abnormal shadow on the chest roentgenogram. She had received treatment with numerous drugs, including the following herbal medicines: Seisin-renshi-in, Chotosan, Rikkunshi-to, and Shakuyakukannzo-to. Chest radiography revealed diffuse ground-glass shadows in both lungs. The bronchoalveolar lavage fluid was progressively bloody. In addition, culture did not show the presence of microorganisms in the fluid. Moreover, there were no findings suggestive of ...
Source: Journal of Nippon Medical School - May 17, 2019 Category: Universities & Medical Training Authors: Omori M, Saito Y, Miura Y, Tanaka T, Kashiwada T, Atsumi K, Hayashi H, Minegishi Y, Fujita K, Azuma A, Seike M, Gemma A Tags: J Nippon Med Sch Source Type: research

A Case of Gitelman's Syndrome that was difficult to distinguish from Hypokalemic Periodic Paralysis due to Graves' Disease.
Abstract A 21-year-old man presented with hyperthyroidism and hypokalemia and was treated for thyrotoxic hypokalemic periodic paralysis (THPP) due to Graves' disease. Thyroid function soon normalized, but hypokalemia persisted. Laboratory data revealed hyperreninemic hyperaldosteronism and metabolic alkalosis consistent with Gitelman's Syndrome (GS). He was found to have a previously unreported compound heterozygous mutation of T180K and L858H in the SLC12A3 gene and was diagnosed with GS. He was started on eplerenone to control serum potassium levels. It is important to consider other diagnoses when electrolyte i...
Source: Journal of Nippon Medical School - May 17, 2019 Category: Universities & Medical Training Authors: Oba T, Kobayashi S, Nakamura Y, Nagao M, Nozu K, Fukuda I, Iijima K, Sugihara H Tags: J Nippon Med Sch Source Type: research

Therapy-related secondary malignancies after treatment for childhood malignancy: Cases from a single institution.
CONCLUSIONS: Our results revealed that the type of secondary malignancy depends on the number of years that have elapsed since treatment for primary malignancy was concluded. Meningioma, especially, develops many years after completion of primary malignancy treatment. It is therefore necessary to strive for early detection during long-term follow-up. PMID: 31061250 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Ueda T, Migita M, Itabashi T, Tanabe Y, Uchimura R, Gocho Y, Yamanishi M, Kobayashi F, Yoshino M, Fujita A, Yamanishi S, Kaizu K, Hayakawa J, Asano T, Maeda M, Itoh Y Tags: J Nippon Med Sch Source Type: research

Increased H19 long non-coding RNA expression in Schwann cells in the peripheral neuropathic pain.
CONCLUSION: H19 lncRNA increase in Schwann cells might be involved in neuropathic pain. PMID: 31061251 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Iwasaki H, Sakai A, Maruyama M, Ito T, Sakamoto A, Suzuki H Tags: J Nippon Med Sch Source Type: research

Closed fracture diagnosed by bedside ultrasonography during hemodialysis session: A first report of seven cases in hemodialysis patients and evaluations of their clinical characteristics.
CONCLUSIONS: To our knowledge, this is the first report of closed fractures of superficial bone diagnosed by bedside ultrasonography during a hemodialysis session. Ultrasonography is especially useful for diagnosis in these cases because it is non-invasive and highly accurate. Doctors should determine a differential diagnosis for closed fractures in patients undergoing dialysis, especially in older, diabetic, and malnourished patients with recent contusions and sustained pain. PMID: 31061252 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Yamazaki T, Hagiwara S, Kawara N, Arai K, Oyoshi K, Oshima M, Koike S, Miyauchi A, Hayasaka T, Saito T, Tsuruoka S Tags: J Nippon Med Sch Source Type: research