Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases.PMID:33455976 | DOI:10.1272/jnms.JNMS.2021_88-410 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Rongjiong Zheng Dina Guo Yongquan Dong Mingming Wang Meiling Hu Yifeng Ren Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-515. Online ahead of print.ABSTRACTIschemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that ...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Toshiyuki Hayashi Koichi Nomura Yasuhiro Nishiyama Kazumi Kimura Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study
J Nippon Med Sch. 2021 Jan 16. doi: 10.1272/jnms.JNMS.2021_88-518. Online ahead of print.ABSTRACTBACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout.METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gou...
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Masaki Wakita Kuniya Asai Yoshiaki Kubota Masahiro Koen Wataru Shimizu Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty.PMID:33455979 | DOI:10.1272/jnms.JNMS.2021_88-519 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 18, 2021 Category: Universities & Medical Training Authors: Yasushi Oshima Norishige Iizawa Shinro Takai Tokifumi Majina Source Type: research

Prognostic Factors in Patients with Brain Metastases of Lung Adenocarcinoma with the Surveillance Epidemiology and End Results Database.
CONCLUSIONS: The nomogram was able to predict a 3-, 6- and 9-month OS rate of patients suffering from LACA with brain metastases. PMID: 33455976 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 16, 2021 Category: Universities & Medical Training Authors: Zheng R, Guo D, Dong Y, Wang M, Hu M, Ren Y Tags: J Nippon Med Sch Source Type: research

Unilateral isolated trochlear nerve palsy due to ipsilateral midbrain infarction.
Abstract Ischemic stroke is a very rare etiology in cases of isolated trochlear nerve palsy, and no reports of ipsilateral trochlear nerve palsy caused by unilateral stroke have so far been published. However, we now report a case of isolated trochlear nerve palsy due to ipsilateral dorsal small midbrain infarction in a 70-year-old woman who presented with acute onset of diplopia. There were no other clinical manifestations, but brain magnetic resonance imaging revealed a small ischemic lesion in the right dorsal midbrain, showing that isolated trochlear nerve palsy can be caused by stroke. PMID: 33455977 [Pu...
Source: Journal of Nippon Medical School - January 16, 2021 Category: Universities & Medical Training Authors: Hayashi T, Nomura K, Nishiyama Y, Kimura K Tags: J Nippon Med Sch Source Type: research

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study.
Abstract BACKGROUND: Various optimal medical therapies have been established for the treatment of heart failure (HF) with a reduced ejection fraction (HFrEF). Like HFrEF, HF with a preserved ejection fraction (HFpEF) too is related to poor prognoses. We aimed to investigate the effect of topiroxostat, an oral xanthine oxidoreductase inhibitor, in HFpEF patients with hyperuricemia or gout. METHODS: In this non-randomized, open-label, single-arm trial, we administered topiroxostat (40-160 mg/day) to HFpEF patients with hyperuricemia or gout to achieve a target uric acid level of 6.0 mg/dl. The primary outcome w...
Source: Journal of Nippon Medical School - January 16, 2021 Category: Universities & Medical Training Authors: Wakita M, Asai K, Kubota Y, Koen M, Shimizu W Tags: J Nippon Med Sch Source Type: research

The Optimal Distraction Force to Evaluate Tibiofemoral Joint Gaps in Posterior Stabilized-Total Knee Arthroplasty.
ConclusionsThese displacement forces were considered optimal loads to evaluate the tibiofemoral joint gaps during surgery and to obtain knee stability post-total knee arthroplasty. PMID: 33455979 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 16, 2021 Category: Universities & Medical Training Authors: Oshima Y, Iizawa N, Takai S, Majina T Tags: J Nippon Med Sch Source Type: research

Cultured Neonatal Rat Cardiomyocytes Continue Beating Through Upregulation of CTGF Gene Expression.
CONCLUSIONS: The present results suggest that the large increase in CTGF gene expression in beating cardiomyocytes is not a cause but a result of beating, which may provide a putative pathway for controlling beating. Beating is sustained by developed cardiomyofibrils and directly upregulates CTGF gene expression, which is not followed by CTGF protein synthesis. PMID: 33311008 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 16, 2020 Category: Universities & Medical Training Authors: Mashimo K, Ohno Y Tags: J Nippon Med Sch Source Type: research

Bacterial Meningitis Due to Streptococcus pneumoniae in a 7-Month-Old Girl Who Received Three Doses of 13-Valent Pneumococcal Conjugate Vaccine.
We describe a case of pneumococcal meningitis in a 7-month-old girl who had received three doses of 13-valent pneumococcal conjugate vaccine. Brain magnetic resonance imaging showed infarcts in the right frontal region, and she was treated with antibiotics, intravenous immunoglobulin, dexamethasone, and edaravone. On day 27, an enhanced brain CT scan showed improvement of abnormal findings in the frontal region, except for slight atrophy. The S. pneumoniae serotype was 12F, which is not included in the 13-valent pneumococcal conjugate vaccine. A future vaccine is expected to use cross-reactivity to target common antigens. ...
Source: Journal of Nippon Medical School - December 16, 2020 Category: Universities & Medical Training Authors: Yoshida K, Narazaki H, Okada H, Takagi A, Itoh Y Tags: J Nippon Med Sch Source Type: research

Optimal treatment duration of neoadjuvant endocrine therapy in women aged 60 years or older with estrogen receptor-positive, HER2-negative invasive breast cancer.
CONCLUSIONS: Neoadjuvant exemestane therapy is an effective strategy in older women with hormone-sensitive breast cancer. PMID: 33250473 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Hayashi Y, Takei H, Saito T, Kai T, Inoue K, Kurosumi M, Ninomiya J, Saitama Breast Cancer Clinical Study Group (SBCCSG) Tags: J Nippon Med Sch Source Type: research

What are the factors affecting postoperative nausea and vomiting following breast cancer surgery with inhalation anesthesia?
CONCLUSIONS: Although many previous studies have shown that PONV is a multifactorial event, our results indicate that desflurane use can be considered a main cause of ePONV. However, in the delayed phase, a higher Apfel score was the main predictor. In the early and delayed phases, a long duration of anesthesia was related to a high risk of PONV. Accordingly, avoiding a long duration of anesthesia and desflurane use is recommended for patients at a high risk of developing PONV, particularly for those with high Apfel scores. PMID: 33250474 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Morita T, Yamamoto M, Sakamoto A Tags: J Nippon Med Sch Source Type: research

A Case of Segmental Hypoganglionosis of the Colon.
Abstract A 64-year-old female was admitted to the hospital with constant abdominal pain. She had been previously hospitalized five times in 2 years with similar symptoms. Computed tomography revealed dilatation and fecal impaction from the ileum to the transverse colon. A barium enema and simultaneous ileus tube radiography demonstrated a segment of narrow descending-sigmoid colon. Colonoscopy did not show any mucosal change. These symptoms did not improve with conservative therapy when a descending and sigmoid colectomy was performed. In terms of histology, there was a disappearance of ganglion cells, and axon of...
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Yamagishi A, Koyama N, Yamashita N, Suzuki M, Yamada T, Kawashima M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Comparison of IgG antibodies, SARS-CoV-2 load, and prognostic indicators in patients with severe and mild COVID-19 in Japan.
Abstract We assessed the relationship between disease severity and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load, IgG antibody levels, and prognostic indicators. Twenty-one patients hospitalized with COVID-19 were classified as having severe or mild disease based on their average respiratory rate during hospitalization (severe: ≥22 breaths/min; mild:
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Kashiwagi K, Maeda T, Yoshizawa S, Sato T, Aoki K, Ishii Y, Tateda K Tags: J Nippon Med Sch Source Type: research

The effect of continuous field block through intercostal muscles after atrial septal defect closure via a mini-right thoracotomy in pediatric patients.
CONCLUSIONS: Continuous field block via intercostal muscles after ASD closure via a mini-right thoracotomy in children was effective to stabilize the vital signs and reduce the analgesic medication use. PMID: 33250477 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Suzuki K, Sasaki T, Miyagi Y, Mori K, Kishikawa H, Ishii Y, Sakamoto A, Nitta T Tags: J Nippon Med Sch Source Type: research

Successful Case of Thrombo-aspiration Using a 8-Fr Long Sheath into 10-Fr Short Sheath for Subacute Limb Ischemia.
Abstract A 79-year-old man, with a history of atrial fibrillation, presented with a sudden onset of intermittent claudication of the left lower limb. The angiogram revealed a thrombotic total occlusion in the left superficial femoral artery (SFA). A 10-Fr sheath was antegradely inserted into the left common femoral artery (CFA), and the guidewire penetrated the lesion. Thrombo-aspiration using the 8-Fr long sheath into the 10-Fr short sheath was performed repeatedly. Intravenous anticoagulant was administrated immediately after the endovascular treatment. Follow-up angiogram performed 12 days after the procedure c...
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Kiuchi K, Matsushita M, Takano M, Miyauchi Y, Shimizu W Tags: J Nippon Med Sch Source Type: research

Endoscopic detorsion for early postoperative Roux limb torsion after laparoscopic gastrectomy: A case report and literature review.
This study presents a further review of these cases and a summary of the existing literature. PMID: 33250479 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Sakurazawa N, Arai H, Yasuda T, Kuge K, Kuriyama S, Suzuki H, Yoshida H Tags: J Nippon Med Sch Source Type: research

Hypertensive Cardiomyopathy with Congestive Heart Failure in an Infant with Unilateral Wilms Tumor: A Case Report.
This report can help pediatric surgeons become more familiar with cardiomyopathy caused by WT. PMID: 33250480 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Kuwabara J, Akita S, Sato M, Watanabe K, Kawamoto T, Tanigawa K, Matsui S, Matsuno Y, Abe Y, Kikuchi S, Yoshida M, Koga S, Ishimaru K, Egi H, Watanabe Y Tags: J Nippon Med Sch Source Type: research

Usefulness of a colonic stent for colonic obstruction caused by lung cancer metastasis.
This report describes an uncommon case of colonic metastasis from non-small cell lung cancer (NSCLC), in which colonic obstruction was improved with a self-expanding metallic stent.A 62-year-old man was admitted to our hospital for progressively worsening abdominal pain. He had been treated with immunotherapy and chemotherapy after being diagnosed with NSCLC (T4N2M1) 1.5 years earlier. Enhanced computed tomography showed intestinal obstruction and a mass in the colon at the hepatic flexure. Histopathological analysis of a biopsy specimen confirmed NSCLC metastasis. Considering his general condition, endoscopic stenting was...
Source: Journal of Nippon Medical School - November 30, 2020 Category: Universities & Medical Training Authors: Suzuki M, Okada K, Koyama N, Yamashita N, Yamagishi A, Yamada T, Yoshida H Tags: J Nippon Med Sch Source Type: research

Second-generation antipsychotic medications for children and adolescents.
This study aimed to identify the efficacy and tolerability of different antipsychotics in children and adolescents with schizophrenia or bipolar disorder. We conducted a literature review of the empirical evidence for the use of antipsychotics, particularly second-generation antipsychotics, in children and adolescents. The empirical evidence showed that antipsychotic use among children and adolescents was safe and efficacious. The efficacy of antipsychotics in the treatment of children and adolescents with schizophrenia or bipolar disorder was almost similar. When prescribing antipsychotics to children and adolescents, cli...
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Onishi Y, Mikami K, Kimoto K, Watanabe N, Takahashi Y, Akama F, Yamamoto K, Matsumoto H Tags: J Nippon Med Sch Source Type: research

A possible, non-invasive method of measuring dynamic lung compliance in patients with interstitial lung disease using photoplethysmography.
CONCLUSIONS: We demonstrated a significant reduction in Cdyn in subjects with ILD using photoplethysmography. This non-invasive method might be a novel, promising tool for evaluating fibrosis progression in ILD. PMID: 32999175 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Atsumi K, Saito Y, Tanaka T, Kashiwada T, Hayashi H, Kamio K, Seike M, Osaki R, Sakai K, Kurosawa S, Gemma A, Azuma A Tags: J Nippon Med Sch Source Type: research

Capecitabine plus bevacizumab as first-line therapy for metastatic colorectal cancer patients with poor performance status.
CONCLUSION: This limited study indicated that chemotherapy using capecitabine and bevacizumab for patients with poor PS may provide favorable OFS and OS. Needless to say, we should be careful not to impose extra burden to patients with poor PS. PMID: 32999176 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Yamada Y, Yoshimatsu K, Yokomizo H, Okayama S, Satake M, Ida A, Maeda H, Shiozawa S Tags: J Nippon Med Sch Source Type: research

Intratendinous Ganglion in the Extensor Pollicis Longus: A Case Report and Review of Literature.
We present the case of a 73-year-old woman with an intratendinous ganglion cyst occurring in the extensor pollicis longus (EPL) tendon of her right hand. The subcutaneous mass moved according to the movement of the EPL tendon of her right thumb. Magnetic resonance imaging showed a space-occupying lesion in the EPL tendon. Biochemical and hematoimmunological examinations ruled out diabetes mellitus, rheumatoid arthritis and other connective tissue diseases. She complained of a motion pain during thumb extension, and she had desired surgery. Intraoperatively, an intratendinous cyst was identified within the tendon substance ...
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Tomori Y, Motoda N, Nanno M, Majima T Tags: J Nippon Med Sch Source Type: research

Clinical Outcome of Lentis Comfort Intraocular Lens Implantation.
CONCLUSION: Lentis Comfort IOLs provided better visual function at far and intermediate distances. PMID: 32999178 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Nakajima D, Takahashi H, Kobayakawa S Tags: J Nippon Med Sch Source Type: research

Efficacy of a deep thermal therapy system for osteoarthritis of the knee.
This study sought to assess the efficacy of a deep-tissue thermal therapy system with a resonant cavity applicator (DTT-RCA), which safely heats deep joint tissue for treating osteoarthritis (OA) of the knee. METHODS: Two groups of participants were recruited. The DTT-RCA group comprised 20 knees. Kellgren-Lawrence (K-L) grade was I and II in 8 knees (DTT-RCA I/II group) [mean age 73.3 years (standard deviation 11.4) ], III and VI in 12 knees (DTT-RCA III/IV group) [75.4 (8.6) years]. The control group comprised 13 knees [68.2 (10.8) years]. K-L grade was I in 7 knees and II in 6 knees. This group received exercise th...
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Harada K, Takahashi K, Ikuta F, Shindo Y, Kato K, Iseki Y, Oshima Y, Majima T Tags: J Nippon Med Sch Source Type: research

Serum glucose-to-potassium ratio as a prognostic predictor of severe traumatic brain injury.
We examined whether biomarkers at admission could be useful prognostic predictors. We focused on electrolytes and blood glucose, which can be measured easily at any facility and for which the results can be obtained promptly before those of other biomarkers, such as D-dimer. METHODS: All trauma patients with head injury treated at Chiba Hokusoh Hospital between 2014 and 2017 were investigated. Multiple trauma cases accompanied by fatal trauma, hemorrhagic shock, and cardiopulmonary arrest, and pediatric cases were excluded from this study. The blood gas data at the initial hospital visit were reviewed retrospectively....
Source: Journal of Nippon Medical School - September 29, 2020 Category: Universities & Medical Training Authors: Shibata A, Matano F, Saito N, Fujiki Y, Matsumoto H, Mizunari T, Morita A Tags: J Nippon Med Sch Source Type: research