Urgent Catheter Ablation in Octogenarians with Serious Tachyarrhythmias.
This study included consecutive octogenarians who underwent urgent radiofrequency catheter ablation (RFCA) for various serious tachyarrhythmias (urgent group, n=28) that were life-threatening, hemodynamically deleterious, or provoking ischemia, and consecutive octogenarians who underwent elective RFCA (control group, n=36). The rate of a successful RFCA, complications, later arrhythmia recurrences, and mortality were compared between the groups. RESULTS: There was no significant difference in the breakdown of the targeted arrhythmias between the groups, and common-type atrial flutter was most often targeted in both th...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Takahashi K, Hayashi M, Iwasaki YK, Miyauchi Y, Yodogawa K, Tsuboi I, Hayashi H, Oka E, Hagiwara K, Fujimoto YH, Shimizu W Tags: J Nippon Med Sch Source Type: research

Usefulness of Single Photon Emission Computed Tomography/Computed Tomography Fusion-Hybrid Imaging to Evaluate Coronary Artery Disorders in Patients with a History of Kawasaki Disease.
CONCLUSION: Fusion imaging was capable of accurately evaluating myocardial ischemia/infarction as cardiovascular sequelae of Kawasaki disease and confirming the culprit coronary arteries. In addition, analysis of fusion images confirmed that small-range infarct lesions were concomitantly present directly under giant coronary artery aneurysms in the anterior descending coronary artery. PMID: 27180792 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Abe M, Fukazawa R, Ogawa S, Watanabe M, Fukushima Y, Kiriyama T, Hayashi H, Itoh Y Tags: J Nippon Med Sch Source Type: research

Combining Fulvestrant with Low-Dose Capecitabine is Effective and Tolerable in Woman with Metastatic Breast Cancer.
Abstract Although the use of endocrine therapy in combination with intravenous chemotherapy has not been standardized, the combination of fulvestrant and chemotherapy may be promising. A 62-year-old woman came to our hospital's outpatient clinic with extensive ascites. Approximately 10 years earlier, she had undergone mastectomy and sentinel lymph node biopsy. Pathologically invasive lobular carcinoma, with a maximum diameter of 28 mm, had been diagnosed in the left breast. The cancer had a histological grade of 2, was positive for estrogen receptor (95% or more positive cells), and was negative for both progester...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Nakai M, Takei H, Yanagihara K, Yamashita K, Uchida E Tags: J Nippon Med Sch Source Type: research

Homonymous Hemianopsia Associated with Probable Alzheimer's Disease.
We describe a case of PCA in which a combination of imaging methods, in conjunction with symptoms and neurological and neuropsychological examinations, led to its being diagnosed and to AD being identified as its probable cause. Treatment with donepezil for 6 months mildly improved alexia symptoms, but other symptoms remained unchanged. A 59-year-old Japanese woman with progressive alexia, visual deficit, and mild memory loss was referred to our neurologic clinic for the evaluation of right homonymous hemianopsia. Our neurological examination showed alexia, constructional apraxia, mild disorientation, short-term memory los...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ishiwata A, Kimura K Tags: J Nippon Med Sch Source Type: research

Right Inguinal Hernia Encompassing the Uterus, Right Ovary and Fallopian Tube in an Elderly Female: Case Report.
We report on an operation to treat just such a rare condition for a right inguinal hernia. An 87-year-old Japanese woman was admitted with swelling in the right inguinal region and a purulent discharge from the vagina. Vital signs were stable, but the mobile mass was irreducible. Computed tomography of the abdomen indicated uterine tissue in a right inguinal hernia. We diagnosed an inguinal hernia with an incarcerated uterus and performed surgery on that basis. An incision approximately 6 cm long was made in the skin above the swollen area to open the inguinal sac, disclosing a tumor enveloped by a hernial sac. Opening the...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ueda J, Yoshida H, Makino H, Maruyama H, Yokoyama T, Hirakata A, Akagi I, Watanabe M, Uchida E, Uchida E Tags: J Nippon Med Sch Source Type: research

Errata.
Authors: PMID: 27180796 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Tags: J Nippon Med Sch Source Type: research

Conservative Treatment for Fracture of the Proximal Femur with Complications.
CONCLUSION: This study showed that in patients with hip fractures, severe complications, and poor general conditions, early prognosis after conservative treatment aiming for early transfer to wheelchair is no worse than that following surgical treatment. Thus, conservative treatment should be considered for patients with poor ability for activities of daily living. PMID: 26960582 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Oba R, Takai S Tags: J Nippon Med Sch Source Type: research

Pregnancy-associated Deaths: 31-year Experience.
CONCLUSIONS: Amniotic fluid embolism was the leading cause of maternal deaths and was followed by obstetric hemorrhage. To prevent and reduce the number of maternal deaths in Japan, further basic and clinical research on amniotic fluid embolism is required. PMID: 26960583 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Yoneyama K, Sekiguchi A, Matsushima T, Kawase R, Nakai A, Asakura H, Takeshita T Tags: J Nippon Med Sch Source Type: research

Effect of Dual Therapy with Botulinum Toxin A Injection and Electromyography-controlled Functional Electrical Stimulation on Active Function in the Spastic Paretic Hand.
Abstract BACKGROUND: Many previous studies have demonstrated that botulinum toxin A (BTX-A) injections satisfactorily reduce spasticity. Nevertheless, BTX-A, with or without an adjuvant therapy, effectively improves the direct functional movement in few patients with spastic upper extremity paralysis. Therefore the present study aimed to determine the effectiveness of task-orientated therapy on spasticity and functional movement by using electromyography-triggered functional electrical stimulation (EMG-FES) after BTX-A injections. DESIGN: Open-label, prospective clinical trial Method: The subjects were 15 pat...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Tsuchiya M, Morita A, Hara Y Tags: J Nippon Med Sch Source Type: research

Superior Dislocation of the Patella in a Young Woman without Osteophytes: A Case Report.
Abstract Superior dislocation of the patella without patellar ligament injury is an extremely rare condition. A review of the English-language literature found only 23 reported cases. In addition, the primary factor for dislocation in most of these cases was considered to be osteophytes in the inferior pole of the patella and the anterior surface of the femoral condyle; only 1 case had no osteophytes. We treated a 19-year-old woman who sustained a painful locking of the left knee after colliding with a friend. Plain radiography and computed tomography showed superior-lateral dislocation of the patella and an inter...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Kataoka T, Iizawa N, Takai S Tags: J Nippon Med Sch Source Type: research

Glue Embolization of a Blunt Traumatic Hepatic Arteriovenous Fistula under Inflow and Outflow Control.
We report on a rare case of blunt traumatic hepatic arteriovenous fistula arising from a pseudoaneurysm in a 35-year-old woman. Transarterial embolization was performed with n-butyl-2-cyanoacrylate, under inflow control with loose coil packing within the pseudoaneurysm and outflow control by balloon occlusion of the hepatic vein. A promising therapeutic outcome was achieved without any serious adverse events. Thus, the combination of these techniques to control inflow and outflow was successfully used to treat this rare hepatic vascular injury. PMID: 26960586 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Mine T, Murata S, Yasui D, Yokota H, Tajima H, Kumita S Tags: J Nippon Med Sch Source Type: research

Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine.
CONCLUSION: Our findings indicate that topical tacrolimus should be considered for treating refractory interstitial keratitis in children. PMID: 26960587 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Joko T, Shiraishi A, Ogata M, Ohashi Y Tags: J Nippon Med Sch Source Type: research

Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia.
We report a case of the extremely rare condition Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (LPD) which occurred after umbilical cord blood transplantation. A 25-year-old Japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. Bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. Chronic symptoms of graft-versus-host disease appeared only on the skin and were successfully treated with cyclosporine alone. Three years later, however, the patien...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Yui S, Yamaguchi H, Imadome K, Arai A, Takahashi M, Ohashi R, Tamai H, Moriya K, Nakayama K, Shimizu A, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Rhabdomyosarcoma of the Uterus: A Case Report.
PMID: 26568387 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Kuroki M, Yoneyama K, Watanabe A, Fukami T, Matsushima T, Katsumata N, Takeshita T Tags: J Nippon Med Sch Source Type: research

Ultrasound Evaluation of the Transverse Movement of the Flexor Pollicis Longus Tendon on the Distal Radius during Wrist and Finger Motion in Healthy Volunteers.
CONCLUSIONS: There is a significant relationship between the transverse movement of the FPL at the distal radius and wrist and finger motions. Our findings indicated that the irritation of the FPL caused by the movement of both the FPL itself and of the flexor digitorum superficialis and profundus is most induced with the wrist in dorsal flexion with all 5 fingers at full flexion compared to other wrist positions during finger motion. This wrist position might be the optimum one at which to evaluate the irritation of the FPL from volar locking plates in patients with distal radius fracture. We believe that our transverse u...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Improvements in Signs and Symptoms of Dry Eye after Instillation of 2% Rebamipide.
CONCLUSIONS: The administration of 2% rebamipide 4 times daily for 4 weeks improves the signs and symptoms of dry eye and improves patients' quality of life. PMID: 26568389 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Igarashi T, Fujita M, Yamada Y, Kobayashi M, Fujimoto C, Takahashi H, Igarashi T, Nakano Y, Suzuki H, Takahashi H Tags: J Nippon Med Sch Source Type: research

Ethanol Dose- and Time-dependently Increases α and β Subunits of Mitochondrial ATP Synthase of Cultured Neonatal Rat Cardiomyocytes.
In this study, the effects of ethanol on protein composition was examined with 2-dimensional electrophoresis of protein extracts from cultured neonatal rat cardiomyocytes exposed to 100 mM ethanol for 24 hours. A putative β subunit of mitochondrial ATP synthase was increased, which was confirmed by Western blot. The cellular protein abundances in the α and β subunits of ATP synthase increased in dose (0, 10, 50, and 100 mM) - and time (0.5 hour and 24 hours) -dependent manners. The DNA microarray analysis of total RNA extract demonstrated that gene expression of the corresponding messenger RNAs of these sub...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Mashimo K, Arthur PG, Ohno Y Tags: J Nippon Med Sch Source Type: research

Intraperitoneal Migration of a Mesh Plug from a Hernioplasty Forming a Colocutaneous Fistula with the Cecum: Report of a Case.
This report describes the case of a 57-year-old man who had undergone a right inguinal hernioplasty 13 years previously. Recovery was uneventful until he experienced inflammation of the groin, and required open drainage three times for a refractory abscess in his right groin. Additional colonoscopy and x-ray examinations with contrast medium clearly demonstrated a mesh plug that had migrated and penetrated the cecum, forming a colocutaneous fistula. The mesh was successfully removed under general anesthesia, and the inflammation in the groin resolved. PMID: 26568391 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Sekiguchi K, Mizuguchi Y, Mamada Y, Koizumi M, Uchida E Tags: J Nippon Med Sch Source Type: research

A Girl with Idiopathic Epilepsy Showing Forced Normalization after Levetiracetam Administration.
CONCLUSIONS: To the best of our knowledge, this is the first report of a patient with idiopathic epilepsy but without disabilities in everyday life showing forced normalization associated with LEV administration. PMID: 26568392 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Kawakami Y, Okazaki T, Takase M, Fujino O, Itoh Y Tags: J Nippon Med Sch Source Type: research

Neurosyphilis Mimicking Ramsay Hunt Syndrome.
Abstract A 36-year-old man presented with facial nerve palsy, hearing loss, vertigo and headache. He was initially diagnosed with Ramsay Hunt syndrome and treated with a systemic steroid and valaciclovir; however, his symptoms deteriorated. Serum rapid plasma reagin (RPR) and treponema pallidum hemagglutination tests were positive. Cerebrospinal fluid analysis revealed an elevated white blood cell count and positive RPR, confirming the diagnosis of neurosyphilis. Penicillin G (PCG) was administered, and his facial nerve function and headache improved. However, left-side hearing loss worsened temporarily, which was...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Maeda T, Yoshizawa S, Hirayama T, Saga T, Tateda K, Urita Y Tags: J Nippon Med Sch Source Type: research

Successful Rescue of a Patient with Acute Aconitine Poisoning Complicated by Polycystic Renal Hemorrhage.
CONCLUSIONS: This case significantly advances our understanding of hemoperfusion with reduced heparin for the treatment of ventricular arrhythmia caused by aconitine poisoning. PMID: 26568394 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Chen X, Wu R, Jin H, Gao R, Yang B, Wang Q Tags: J Nippon Med Sch Source Type: research

Idiopathic Intracranial Hypertension: The "Moth-eaten" Skull Base and Encephaloceles.
Idiopathic Intracranial Hypertension: The "Moth-eaten" Skull Base and Encephaloceles. J Nippon Med Sch. 2015;82(4):168-9 Authors: Isshiki S, Tajima H, Wakayama N, Tateyama K PMID: 26328792 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Isshiki S, Tajima H, Wakayama N, Tateyama K Tags: J Nippon Med Sch Source Type: research

Transverse Ultrasound Assessment of the Displacement of the Median Nerve in the Carpal Tunnel during Wrist and Finger Motion in Healthy Volunteers.
Abstract PURPOSE: The purpose of this study was to investigate the displacement of the median nerve in the carpal tunnel during finger motion at varied wrist positions using transverse ultrasound in healthy volunteers, in order to clarify the appropriate position of a wrist splint in treating carpal tunnel syndrome. METHODS: Fifty wrists of 25 asymptomatic volunteers were evaluated by transverse ultrasound. The location of the median nerve in the carpal tunnel was examined at 5 wrist positions (neutral, 60° dorsiflexion, 60° palmar flexion, 40° ulnar flexion, 10° radial flexion) with all 5 fin...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Normative Data and Predictive Equation of Interrupter Airway Resistance in Preschool Children in Japan.
Abstract Measurement of interrupter airway resistance (Rint) is a convenient alternative to standard spirometry for assessing respiratory function in uncooperative young children. The aim of the present prospective study was to establish the normative data and predictive equation of Rint in Japanese preschool children. A total of 214 children were enrolled from a single kindergarten; however, 129 were excluded because they met at least 1 of the exclusion criteria, such as wheezing history or recent common cold. Expiratory Rint values were assessed in 85 of the children, but technically unsatisfactory measurements ...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Imai T, Takase M Tags: J Nippon Med Sch Source Type: research

Too Early Initiation of Enteral Nutrition is Not Nutritionally Advantageous for Comatose Acute Stroke Patients.
CONCLUSION: It is nutritionally disadvantageous not to start nutritional support within 3 days after admission in comatose acute stroke patients. However, starting EN too early is not nutritionally beneficial, and TPN with 20% glucose fed through a tube is recommended as adequate nutrition for these patients. However, TPN should not be employed for longer than 10 days, because switching to EN after this period contributes to better nutritional recovery than continuing TPN. PMID: 26328795 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Yamada SM Tags: J Nippon Med Sch Source Type: research

A Case of Cryoglobulinemic Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus.
Abstract A 61-year-old man with bilateral purpura of the lower limbs and subsequent edema, was hospitalization after renal dysfunction developed. The presence of hepatitis C virus (HCV) RNA and cryoglobulin and the finding of membranoproliferative glomerulonephritis on renal biopsy led to a diagnosis of HCV-related glomerulonephritis due to cryoglobulinemia. Because of the pre-existence of nephrotic syndrome and the continuously increasing serum level of creatinine, treatment with cryofiltration, interferon, and steroids was started. After 5 cryofiltration sessions, the cryocrit level had decreased to 1% and the l...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Otsuka T, Sakai Y, Ohno D, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

A Case of Portal Venous Gas after Rectal Surgery without Anastomotic Leakage or Bowel Necrosis.
Abstract Portal venous gas has traditionally been considered an indicator of a poor prognosis due to bowel necrosis. Portal venous gas has recently been detected in patients with various clinical conditions, such as Crohn's disease, chemotherapy, and blunt abdominal injury without bowel necrosis. We herein report the first case of a patient with rectal cancer in whom portal venous gas developed after low anterior resection without anastomotic leakage or bowel necrosis. A 66-year-old man who had undergone low anterior resection started having severe diarrhea the day after the operation. A fever was present for 2 da...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Yamada T, Kan H, Matsumoto S, Machida T, Koizumi M, Shinji S, Matsuda A, Yamagishi A, Yokoyama Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Early Effects of Oral Pulmonary Vasodilators in an Elderly Patient with Critical Thromboembolic Pulmonary Hypertension: A Case Report.
Abstract A 70-year-old woman who had been treated for bipolar disorder and dementia was admitted to the intensive care unit of a university hospital with severe dyspnea; pulmonary arterial hypertension was diagnosed after cardiac catheterization was performed. Computed tomography pulmonary angiography showed typical signs of chronic thrombosis in the proximal pulmonary artery without an adequate amount of fresh thrombi, which appeared to be the cause of the elevation in pulmonary artery pressure, and resulted in severe hypoxemia. Therefore, the pulmonary arterial hypertension was classified as belonging to the chr...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Okazaki H, Hata N, Shirakabe A, Tsurumi M, Shinada T, Shimizu W Tags: J Nippon Med Sch Source Type: research

A Case Report and a Short Literature Review of Pulmonary Sequestration Showing Elevated Serum Levels of Carbohydrate Antigen 19-9.
Abstract Pulmonary sequestration is a type of bronchopulmonary malformation defined as an isolated portion of lung tissue with systemic arterial supply and no bronchial communication. Carbohydrate antigen 19-9 (CA19-9) has been used for diagnosis and follow-up of gastrointestinal tumors. The current study presents a rare case of intralobar pulmonary sequestration associated with the marked elevation of CA19-9. A 39-year-old female patient was admitted to our hospital due to acute liver injury with marked elevation of serum CA19-9 (3,051.1 μmol/mL), and was then diagnosed with intralobar pulmonary sequestration ...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Dong J, Cai Y, Chen R, Du S, Chen Y, Shi K Tags: J Nippon Med Sch Source Type: research

Erratum: Long-term Hemodialysis Corrects Left Ventricular Dyssynchrony in End-stage Renal Disease: A Study with Gated Technetium-99m Sestamibi Myocardial Perfusion Single-photon Emission Computed Tomography.
Abstract UNLABELLED: The first name of Yukinao Sakai was given incorrectly as Naoyuki. WRONG: Naoyuki Sakai → CORRECT: Yukinao Sakai. PMID: 26268464 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 16, 2015 Category: Universities & Medical Training Authors: Takahashi N, Sato N, Ishikawa M, Kikuchi A, Hanaoka D, Ishihara S, Amitani K, Sakai Y, Kumita S, Shimizu W Tags: J Nippon Med Sch Source Type: research

Multispectral Imaging of Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma with Triple-immunoenzyme Staining.
PMID: 26156664 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Yoshimura H, Matsuda Y, Matsushita A, Nakamura Y, Uchida E, Ishiwata T Tags: J Nippon Med Sch Source Type: research

Indwelling Drains Are Not Necessary for Patients Undergoing One-level Anterior Cervical Fixation Surgery.
DISCUSSION: Given the negligible intraoperative and postoperative bleeding observed in both groups, and the lack of difference in PVS increments between the groups, our results suggested that indwelling drains are not required for patients undergoing typical anterior cervical fixation surgery. However, it is important to take care of major vessels such as the superior and inferior thyroid arteries and the external jugular vein as well as the prevertebral venous plexus during surgery. PMID: 26156665 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Kogure K, Node Y, Tamaki T, Yamazaki M, Takumi I, Morita A Tags: J Nippon Med Sch Source Type: research

Three-dimensional Analysis of the Attachment and Path of the Transverse Carpal Ligament.
CONCLUSIONS: The anatomic 3-D attachment sites of the TCL were visually shown qualitatively, and their areas quantified. This 3-D information offers further knowledge and understanding of the anatomy and biomechanics of the TCL. It could also help in the accurate assessment of radiographic images and treatment of various wrist injuries and diseases when performing such procedures as carpal tunnel release, Guyon's canal release, trapeziectomy, hook of hamate excision, or arthroscopy. PMID: 26156666 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Detection and Evaluation of Pulmonary Hypertension by a Synthesized Right-Sided Chest Electrocardiogram.
Abstract BACKGROUND: Current standard 12-lead electrocardiogram (ECG) criteria for diagnosing pulmonary hypertension (PH) have a low sensitivity. Although the right-sided chest ECG (V3R-V5R) increases the diagnostic accuracy, these additional leads are not routinely recorded. The aim of the present study was to assess the usefulness of the synthesized right-sided chest ECG (Syn-ECG), generated from 12-lead ECG information, in the detection and evaluation of PH. PATIENTS AND METHODS: The Syn-ECG waveforms in 30 patients with PH, defined as an estimated pulmonary arterial systolic pressure (PASP)>35 mmHg, we...
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Nakatsuji A, Miyauchi Y, Iwasaki YK, Tsuboi I, Hayashi H, Uetake S, Takahashi K, Yodogawa K, Hayashi M, Shimizu W Tags: J Nippon Med Sch Source Type: research

Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report.
We describe a case of sellar chondroma with endocrine impairment as an initial manifestation that completely resolved after surgery. A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for the evaluation of high prolactin levels and a tumor in the sella turcica. A biochemical assessment indicated endocrine dysfunction. Magnetic resonance imaging and computed tomography indicated a tumor in the sella turcica. The patient's presentation favored the preoperative diagnosis of pituitary adenoma or Rathke's cleft cyst. However, because calcification wa...
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Hattori Y, Tahara S, Nakakuki T, Takei M, Ishii Y, Teramoto A, Morita A Tags: J Nippon Med Sch Source Type: research

Hobnail Hemangioma: A Case Report.
Abstract Hobnail hemangioma is a small, solitary, benign vascular tumor that shows a biphasic histological pattern of dilated vascular spaces in the superficial dermis and narrow vascular structures in the deeper dermis. In the superficial dermis, dilated, irregular, thin-walled vascular spaces are lined by plump endothelial cells with large nuclei which protrude into the lumina like hobnails. A 43-year-old Japanese man presented with an 11×8-mm bluish-red macule surrounding a 6×3-mm violaceous, slightly elevated papule of the lumbar region of 6 months' duration. Total resection was performed under loc...
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Takayama R, Ueno T, Futagami A, Ansai S, Fukumoto T, Saeki H Tags: J Nippon Med Sch Source Type: research

Placenta with Old, Diffuse Infarction that Was Difficult to Differentiate from a Placental Tumor.
We present a case of fetal growth restriction associated with an old, diffuse placental infarction. Because the placenta had only a single viable cotyledon, the others being atrophic, the lesion appeared to be a placental tumor on prenatal ultrasonography. The patient did not have pregnancy-induced hypertension. At 31 weeks of gestation, a cesarean delivery was performed because of fetal growth arrest and breech presentation. A small-for-gestational age infant was delivered with Apgar scores of 8 at both 1 and 5 minutes, and the infant had cleft palate and cleft lips. Pathological examination of the placenta revealed an ol...
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Miyake H, Miyazaki-Igarashi M, Suzuki S Tags: J Nippon Med Sch Source Type: research

Pulmonary Nocardiosis due to Nocardia asiatica in an Immunocompetent Host.
We describe a case of pulmonary nocardiosis due to Nocardia asiatica in an immunocompent 64-year-old-female. Wadowsky-Yee-Okuda-α-ketoglutarate (WYOα) agar, a selective media for Legionella species, was useful for the detection based on the growth-inhibition of normal oral flora and growth-promotion of Nocardia species. PMID: 26156671 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Okawa S, Sonobe K, Nakamura Y, Nei T, Kamio K, Gemma A Tags: J Nippon Med Sch Source Type: research

Habitual Alcohol Consumption during Pregnancy and Perinatal Outcomes.
Abstract We investigated perinatal outcomes in pregnant Japanese women who habitually consumed alcohol during pregnancies managed at our hospital. Of the 4,791 Japanese women with singleton deliveries at ≥22 weeks' gestation, 44 (0.9%) were found to have habitually consumed alcohol during pregnancy. Multiple logistic regression analyses suggested that habitual alcohol consumption during pregnancy was not associated with adverse perinatal outcomes. However, 64% of the women who habitually consumed alcohol during pregnancy also habitually smoked; smoking leads to increased risks of a low birth weight and placenta...
Source: Journal of Nippon Medical School - July 14, 2015 Category: Universities & Medical Training Authors: Ikeda M, Suzuki S Tags: J Nippon Med Sch Source Type: research

Clinical pictures in pelizaeus-merzbacher disease: a report of a case.
PMID: 25959197 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Miyatake C, Koizumi S, Narazaki H, Asano T, Osaka H, Kurosawa K, Takanashi J, Fujino O Tags: J Nippon Med Sch Source Type: research

Long-term Hemodialysis Corrects Left Ventricular Dyssynchrony in End-stage Renal Disease: A Study with Gated Technetium-99m Sestamibi Myocardial Perfusion Single-photon Emission Computed Tomography.
Abstract INTRODUCTION: Left ventricular (LV) dyssynchrony is common in patients with end-stage renal disease (ESRD), and echocardiographic assessment has shown that it can be improved by a single session of hemodialysis (HD). The aim of this study was to assess the effects of chronic HD on LV dyssynchrony in patients ESRD by means of gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography (GSPECT) with phase analysis. MATERIALS AND METHODS: Twelve patients with ESRD underwent GSPECT and echocardiography before the start of long-term HD (baseline) and 3 months later. In a...
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Takahashi N, Sato N, Ishikawa M, Kikuchi A, Hanaoka D, Ishihara S, Amitani K, Sakai N, Kumita S, Shimizu W Tags: J Nippon Med Sch Source Type: research

Beraprost Sodium Protects Against Diabetic Nephropathy in Patients with Arteriosclerosis Obliterans: A Prospective, Randomized, Open-label Study.
This study was a prospective, randomized, open-label study. Twenty-six Japanese patients (age>30 years) with diabetic nephropathy and arteriosclerosis obliterans were randomly assigned to the BPS group (n=13), which received the combination of an RAS inhibitor and BPS (120 μg/day) therapy, or the control group (n=13), which received only an RAS inhibitor. Patients were followed up for 1 year. The primary endpoint was the effect of BPS on renal function. RESULTS: In the control group, serum creatinine (1.64±0.87 to 2.34±1.53 mg/dL, p
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Shima A, Miyamoto M, Kubota Y, Takagi G, Shimizu W Tags: J Nippon Med Sch Source Type: research

Altered Microglia in the Amygdala Are Involved in Anxiety-related Behaviors of a Copy Number Variation Mouse Model of Autism.
CONCLUSIONS: Perinatal microglia in the basolateral amygdala may play a pathogenic role in the anxiety observed in a mouse model of ASD with duplication of human chromosome 15q11-q13. PMID: 25959200 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Shigemori T, Sakai A, Takumi T, Itoh Y, Suzuki H Tags: J Nippon Med Sch Source Type: research

Incidence of nausea and vomiting induced by oxycodone administered with prochlorperazine in Japanese cancer patients.
CONCLUSIONS: The incidence of nausea induced by oxycodone with prochlorperazine was 18.1% in opioid-naïve Japanese inpatients. Female sex may be a risk factor for oxycodone-induced nausea. These results suggest that a clinical study would require 314 participants (157 in each group) to decrease the incidence from 18% to 8% (10% decrease) with a new preventive treatment (alpha error=0.05, beta error=0.2). PMID: 25959201 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Yamada T, Kanazawa Y, Aoki Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Unilateral femoral fracture in a low birth weight infant: a case report.
Abstract Femoral fractures due to birth trauma are an extremely rare but important birth injury. While vaginal breech delivery, although rare, can cause femur fracture, abdominal breech delivery is not expected to cause fracture. Here we report on a low birth weight infant who was delivered by cesarean section for breech presentation at 30 1/7 weeks of gestation and sustained a unilateral fracture of the femoral shaft. PMID: 25959202 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Kim YS, Han HS, Sang JH Tags: J Nippon Med Sch Source Type: research

Stress fracture of the radial styloid process in a judo player: a case report.
Abstract Stress fractures of the upper limbs are uncommon, and are most often reported as individual cases or small series. In particularly, stress fractures around the wrist are even less common. A stress fracture of the radial styloid process in a judo player was surgically treated, and a favorable treatment outcome was obtained. A 16-year-old adolescent boy experienced pain in the right wrist, with no apparent trigger, while playing judo. Stress fracture of the radial styloid process was diagnosed with plain radiographs and was treated conservatively with cast immobilization. Although bone union was achieved, t...
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Ohkubo A, Sawaizumi T, Takai S Tags: J Nippon Med Sch Source Type: research

Spontaneous rupture of a simple hepatic cyst: report of a case.
We describe the spontaneous rupture of a simple hepatic cyst. A 62-year-old woman was admitted for right upper quadrant pain of sudden onset. The patient denied a history of abdominal trauma. Computed tomography of the abdomen showed a 13-cm-diameter solitary hepatic cyst in the right lobe. Part of the cyst surface was irregular, and the internal echo was heterogeneous. Retained fluid was detected under the liver capsule. Ten days after admission, computed tomography revealed that the volume of fluid retained under the liver capsule had decreased but that the hepatic cyst had enlarged again. The patient was referred to our...
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Hotta M, Yoshida H, Makino H, Yokoyama T, Maruyama H, Uchida E Tags: J Nippon Med Sch Source Type: research

Seronegative Antiphospholipid Syndrome with Anti-phosphatidylethanolamine Antibody in a Boy.
Abstract Antiphospholipid syndrome (APS) is an autoimmune disease caused by antiphospholipid antibodies. At our institution, APS is diagnosed on the basis of the Sapporo criteria, which consist of thrombosis and recurrent pregnancy-related complications and the following laboratory findings: the presence of lupus anticoagulant, anticardiolipin antibody, or anti-β2 glycoprotein 1 antibody. However, we sometimes treat patients we strongly suspect of having APS but who do not satisfy the laboratory criteria. To accommodate such suspected cases, a subtype of APS termed seronegative APS has been proposed. Here, we...
Source: Journal of Nippon Medical School - May 12, 2015 Category: Universities & Medical Training Authors: Asano T, Narazaki H, Kaizu K, Kuwabara K, Fujino O, Itoh Y Tags: J Nippon Med Sch Source Type: research

Intrathyroidal Epithelial Thymoma: Carcinoma Showing Thymus-like Differentiation Mimicking Squamous Cell Carcinoma of the Thyroid.
PMID: 25797868 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Ebina A, Sugitani I, Motoi N Tags: J Nippon Med Sch Source Type: research

Brain plasticity and rehabilitation in stroke patients.
Abstract In recent years, our understanding of motor learning, neuroplasticity and functional recovery after the occurrence of brain lesion has grown significantly. Novel findings in basic neuroscience have provided an impetus for research in motor rehabilitation. The brain reveals a spectrum of intrinsic capacities to react as a highly dynamic system which can change the properties of its neural circuits. This brain plasticity can lead to an extreme degree of spontaneous recovery and rehabilitative training may modify and boost the neuronal plasticity processes. Animal studies have extended these findings, provid...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Hara Y Tags: J Nippon Med Sch Source Type: research