A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
Abstract A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy showed a nodular and morpheic basal cell carcinoma (BCC). A chest computed tomography (CT) scan showed multiple lung tumors. CT-guided biopsy of the lung and the cervical lymph node revealed metastatic basal cell carcinoma (MBCC). The primary skin tumor was resected and a total of 10 courses of cisplatin (25 mg/m2/day×...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kanzaki A, Ansai SI, Ueno T, Kawana S, Shimizu A, Naito Z, Saeki H Tags: J Nippon Med Sch Source Type: research

A Drug Interaction between Crizotinib and Warfarin in Non-Small-Cell Lung Cancer: A Case Report.
We report a case of increased prothrombin time-international normalized ratio (PT-INR) when crizotinib and warfarin were co-administered. A 74-year-old Japanese woman presented to the hospital with dyspnea, and was diagnosed with anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Three years after surgical resection of the tumor, the patient started crizotinib because of the recurrence of NSCLC. She received 2 mg/day warfarin due to a medical history of cerebral infarction and chronic atrial fibrillation. Before crizotinib initiation, the patient's PT-INR was 2.60. After 7 days of daily doses of ...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kubomura Y, Ise Y, Wako T, Katayama S, Noro R, Kubota K Tags: J Nippon Med Sch Source Type: research

Prompt Procedures Have a Great Impact on the Consequences of Asiatic Black Bear Mauling.
CONCLUSIONS: Although the severity and mortality rate following bear-inflicted injuries are not high, these encounters usually take place in remote rural areas, so a delay in rescue and proper care can lead to the incident becoming fatal. Hence, early decisions and arrangements for patient transportation to a tertiary care center and prompt measures to save lives will have a positive impact on the consequences of such incidents. PMID: 29279561 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Akiyama G, Kuwahara H, Asahi R, Tosa R, Yokota H Tags: J Nippon Med Sch Source Type: research

Midterm Result of Arthroscopic Bicruciate Ligament Sutures for Multiligament Knee Injury in an Adolescent Patient.
We present a case report on performing bicruciate ligament sutures arthroscopically in an adolescent patient. PATIENT AND METHODS: The patient was a 14-year-old boy, who was diagnosed with injuries to the anterior cruciate ligament, posterior cruciate ligament, and medial collateral ligament. Single-stage arthroscopic primary suturing of the anterior and posterior cruciate ligaments and open medial collateral ligament suturing were performed 7 days after the injury. RESULTS AND DISCUSSION: The patient returned to routine activities, including high-level competitive sports, at 8 months post-surgery, and currently,...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Oshima Y, Iizawa N, Takai S Tags: J Nippon Med Sch Source Type: research

A Case of Anomalous Congenital Band that Was Difficult to Differentiate from Omphalomesenteric Duct Anomaly.
Abstract Anomalous congenital band (ACB) is rare and difficult to identify preoperatively. Here we report a pediatric ACB case that was preoperatively suspected using computed tomography and was difficult to differentiate from omphalomesenteric duct anomaly. ACB should be considered in the differential diagnosis of acute abdomen. PMID: 29279563 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Miyao M, Takahashi T, Uchida E Tags: J Nippon Med Sch Source Type: research

A Case of a Giant Cell Tumor of the Tendon Sheath of the Middle Phalanx of the Fourth Toe.
Abstract Giant cell tumors of the tendon sheath (GCT-TS) are one of the most common tumors of the hand, along with ganglions. However, occurrence in the toes is far less common. Here we present a rare case of GCT-TS at the middle phalanx level of the flexor digitorum longus tendon sheath. Magnetic resonance imaging showed low intensity both on T1 and T2 weighted images. To the best of our knowledge, our case is the first report of a GCT-TS arising at the middle phalanx level of the flexor digitorum longus tendon sheath of the fourth toe. Although GCT-TS are rare in the toe, they must be included in the differentia...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Okabe K, Hoashi T, Asahara M, Esaki E, Ito M, Otsuka R, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Review on Recent Topics in Hypophysitis.
Abstract The number of cases of lymphocytic hypophysitis is small, although the condition is not rare. For optimal therapy, the correct diagnosis from imaging, immunological studies, and pathological findings from a pituitary biopsy is important. Recently, anti-Rabphilin antibody has been proposed to be a biomarker for lymphocytic infundibulo-neurohypophysitis. Immunological disorders such as anti-Pit-1 antibody syndrome are similar to the pathogenesis of lymphocytic hypophysitis. Moreover, recent immune checkpoint blockade such ipilimumab has been shown to induce anti-CTLA-4-related hypophysitis. In the future, e...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Sugihara H Tags: J Nippon Med Sch Source Type: research

Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis.
Abstract Reflux esophagitis is characterized by excessive esophageal acid exposure. To treat reflux esophagitis, it is necessary to reduce excessive esophageal acid exposure to within the normal range. The first-line drug for the treatment of reflux esophagitis is a standard-dose proton-pump inhibitor (PPI), which is also recommended by the Evidence-based Clinical Practice Guidelines 2015 for gastroesophageal disease of the Japanese Society of Gastroenterology. It has been reported that the response to a standard dose of PPI in patients with mild reflux esophagitis is 90-100%, and that in patients with severe refl...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Iwakiri K Tags: J Nippon Med Sch Source Type: research

A Real-World Retrospective Cohort Study of Combined Therapy with Bevacizumab and Paclitaxel in Japanese Patients with Metastatic Breast Cancer.
CONCLUSIONS: The BP regimen was active and well tolerated in the real-world clinical settings. As many as 28.9% of patients who received the initial dose of 90 mg/m(2) required a dose reduction of paclitaxel by 20 mg/m(2). Therefore, there is a need to find a therapeutic regimen that is less likely to result in dose reductions for patients with MBC who undergo a BP regimen using the initial paclitaxel dose of 90 mg/m(2). PMID: 29142182 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Yamada H, Inoue K, Nagai SE, Nakai M, Arisawa F, Ueda H, Saito T, Ninomiya J, Kuroda T, Sakurai T, Kodama H, Kimizuka K, Hata S, Kai T, Kurosumi M, SBCCSG investigators Tags: J Nippon Med Sch Source Type: research

Worse Preoperative Status Based on Inflammation and Host Immunity Is a Risk Factor for Surgical Site Infections in Colorectal Cancer Surgery.
CONCLUSION: mGPS is an independent risk factor for SSIs. Our results suggest that cachexia before surgery in patients with colorectal cancer might predict the incidence of SSIs. PMID: 29142183 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Sagawa M, Yoshimatsu K, Yokomizo H, Yano Y, Okayama S, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Kato H, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Efficacy of Cell-Free and Concentrated Ascites Reinfusion Therapy for Palliative Care in a Patient with Malignant Pleural Mesothelioma: A Case Report.
We report the case of malignant ascites in a patient with malignant pleural mesothelioma (MPM) whose symptoms were relieved by CART. A 59-year-old Japanese male with MPM who had undergone pleural decortication had pleural and peritoneal recurrence. His general status deteriorated as he developed massive ascites due to peritoneal metastases. With the initiation of CART, he recovered well enough to receive cisplatin-based systemic chemotherapy. Repeated use of CART contributed to the maintenance of his good general condition and enabled him to undergo successive systemic chemotherapy, which might have lengthened his life. Th...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Hisakane K, Ohmatsu H, Umemura S, Kirita K, Matsumoto S, Yoh K, Niho S, Goto K Tags: J Nippon Med Sch Source Type: research

Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case.
In conclusion, despite the absence of pain sensitivity in CIPA syndrome cases, there is an absolute need for the administration of anesthesia in surgical procedures because of tactile hyperesthesia. PMID: 29142185 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Urfalioglu A, Arslan M, Duman Y, Gisi G, Oksuz G, Yildiz H, Oksuz H, Balaban A Tags: J Nippon Med Sch Source Type: research

Endoscopic Treatment of Boerhaave Syndrome Using Polyglycolic Acid Sheets and Fibrin Glue: A Report of Two Cases.
We report the cases of two patients with Boerhaave syndrome who were successfully treated using PGA sheets. The present clinical outcomes suggest that the use of PGA sheets is feasible and safe for treating patients with Boerhaave syndrome, and that they may be another treatment option. PMID: 29142186 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Ishikawa Y, Tagami T, Hirashima H, Fukuda R, Moroe Y, Unemoto K Tags: J Nippon Med Sch Source Type: research

An ATP2A2 Missense Mutation in a Japanese Family with Darier Disease: A Case Report and Review of the Japanese Darier Disease Patients with ATP2A2 Mutations.
Abstract Darier disease (DD) is a rare autosomal dominant skin disorder due to mutations in the ATP2A2 gene, which encodes sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2). The clinical manifestations of DD are characterized by warty papules and plaques in seborrheic areas, and association with neuropsychiatric abnormalities has also been reported in a few families with DD. We herein report a classic Japanese DD case with a previously described mutation (p.C560R) in ATP2A2. In Japan, 26 mutations in the ATP2A2 gene in 7 pedigrees and 19 sporadic cases with DD have been reported, among which one pedigre...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Li M, Higashi N, Nakano H, Saeki H Tags: J Nippon Med Sch Source Type: research

A Case of Microscopic Polyangiitis with Subarachnoid Hemorrhage and Cardiovascular Complications.
We report a very rare case of MPA complicated with cerebral infarction, cardiovascular disease, and fatal subarachnoid hemorrhage in a 54-year-old man. During the first six days of hospitalization the patient was diagnosed with rapid progressive glomerulonephritis (RPGN), cerebral infarction, and unstable angina. According to patient's symptoms and laboratory findings, were consisted with a diagnosis of severe MPA. Steroid pulse therapy was immediately introduced. However, the patient developed massive subarachnoid hemorrhage on the 8th day of hospitalization. The condition progressively deteriorated, and the patient died ...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Aratani S, Sakai Y, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Dynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions.
Abstract Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number of extracellular stimuli and mediators to maintain tissue homeostasis. Accordingly, impaired regulation of endothelial permeability causes various diseases, including chronic inflammation, asthma, edema, sepsis, acu...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Rho SS, Ando K, Fukuhara S Tags: J Nippon Med Sch Source Type: research

Magnetic Resonance Imaging of Neurotransmitter-Related Molecules.
Abstract Molecular imaging implies the method capable of pictorially displaying distribution of target molecules and their relative concentration in space. In clinical medicine, where non-invasiveness is mandatory, diagnostic molecular imaging has been considered virtually identical to positron emission tomography (PET). However, there is another powerful, apparently underutilized molecular imaging, namely, proton magnetic resonance spectroscopic imaging ((1)H-MRSI). The technique can detect target molecules endogenous in brain in virtue of their own specific resonance frequencies (chemical shift) and can create q...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Igarashi H, Ueki S, Ohno K, Ohkubo M, Suzuki Y Tags: J Nippon Med Sch Source Type: research

Actions of Propofol on Neurons in the Cerebral Cortex.
Abstract Propofol is primarily a hypnotic, and is widely used for induction and maintenance of anesthesia, as well as for sedation in various medical procedures. The exact mechanisms of its action are not well understood, although its neural mechanisms have been explored in in vivo and in vitro experiments. Accumulating evidence indicates that one of the major targets of propofol is the cerebral cortex. The principal effect of propofol is considered to be the potentiation of GABAA receptor-mediated inhibitory synaptic currents, but propofol has additional roles in modulating ion channels, including voltage-gated N...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Kobayashi M, Oi Y Tags: J Nippon Med Sch Source Type: research

Serum CA 125 Level after Neoadjuvant Chemotherapy is Predictive of Prognosis and Debulking Surgery Outcomes in Advanced Epithelial Ovarian Cancer.
Abstract Recently, neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) has been recommended for selected patients with International Federation of Gynecology and Obstetrics (FIGO) stage III or IV disease and bulky tumors. The aim of this study was to evaluate associations between post-NACT serum CA 125 levels, surgical outcomes, and clinical outcomes in patients with advanced epithelial ovarian cancer. We retrospectively analyzed 107 patients with FIGO stage III or IV ovarian cancer who were treated with NACT-IDS at the Gynecology Department of Kanagawa Cancer Center between January 2001 and...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Matsuhashi T, Takeshita T, Yamamoto A, Kawase R, Yamada T, Kurose K, Doi D, Konnai K, Onose R, Kato H Tags: J Nippon Med Sch Source Type: research

Therapeutic Drug Monitoring Simulator for Antibiotic Dosage for Methicillin-Resistant Staphylococcus aureus Sepsis in a Patient with Primary Immunodeficiency on Peritoneal Dialysis.
Abstract Bacterial infections often cause fatal systemic infections in patients with primary immunodeficiency. To prevent unfortunate results, the selection, dose, and dosage of antibiotics are extremely important. Here, we report a case of Wiskott-Aldrich syndrome in a patient undergoing peritoneal dialysis because of chronic renal failure in whom methicillin-resistant Staphylococcus aureus sepsis developed. Because of the primary disease and complications, teicoplanin was the only chosen anti-S. aureus drug to prevent side effects. We used parameter estimation and dosage adjustment from a therapeutic drug monito...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Narazaki H, Terada Y, Kaizu K, Jitsukawa T, Ito Y, Asano T Tags: J Nippon Med Sch Source Type: research

Subarachnoid Block-Induced Deafferentation Pain Successfully Treated with Pentazocine.
Abstract Deafferentation pain induced by subarachnoid block (SAB) is rare, but it can appear in the form of recurrent phantom lower limb pain, new acute-onset stump pain in amputees, lower limb pain in patients with tabes dorsalis, and neuropathic pain. We have previously reported that thiopental is an effective treatment for deafferentation pain induced by therapeutic SAB applied to treat neuropathic pain of central origin. Here, we report the case of an amputee who developed new stump pain in his lower limb immediately after subarachnoid tetracaine was administered prior to appendectomy. A 51-year-old man who ha...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Kishikawa H, Wajima Z, Shitara T, Shimizu T, Adachi H, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Subarachnoid Aneurysmal Hemorrhage Associated with Coarctation of the Aorta: Case Report and Review of the Literature.
We report the case of a 50-year-old woman who presented with SAH. On evaluation, six IAs were distributed among the anterior communicating artery (ACoA) (ruptured), distal segments of both anterior cerebral arteries (ACA), the left internal carotid artery (ICA), the bifurcation of the left middle cerebral artery (MCA)/MCA early branch, and the inferior trunk of the left MCA. CoA was also diagnosed. The ruptured ACoA IA, and two other unruptured IAs, were successfully clipped during emergency surgery. Postoperative intensive care was instituted to avoid cerebral vasospasm and renal or spinal cord ischemia. During the same h...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Nakae R, Fujiki Y, Yokobori S, Naoe Y, Yokota H Tags: J Nippon Med Sch Source Type: research

Aortic Valve Replacement for the Management of Heyde Syndrome: A Case Report.
Abstract Heyde syndrome describes the triad of aortic stenosis, acquired coagulopathy, and anemia due to bleeding from intestinal angiodysplasia. An 87-year-old man with iron deficiency anemia due to melena was admitted to our hospital. On examination, a systolic murmur was heard and echocardiography confirmed the presence of aortic stenosis. Esophagogastroduodenoscopy and colonoscopy were unremarkable. Capsule endoscopy and double balloon endoscopy revealed angiodysplasia throughout the small intestine. Laboratory investigations were significant for reduced plasma levels of high molecular weight von Willebrand fa...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Shibamoto A, Kawaratani H, Kubo T, Nishimura N, Sato S, Seki K, Sawada Y, Takaya H, Okura Y, Takeda K, Uejima M, Namisaki T, Moriya K, Mitoro A, Yamao J, Yoshiji H Tags: J Nippon Med Sch Source Type: research

A Case of External Dental Fistula Related to a Fixed Cantilever Bridge.
We report a rare case of external dental fistula associated with a fixed cantilever denture. A 77-year-old Japanese woman presented with an enlarging reddish granulomatous lesion on her right cheek that was diagnosed as an external dental fistula. A fixed cantilever denture had initially been attached to her upper jaw with her seven bona fide teeth. However, six teeth were completely lost and the denture was attached to only one tooth, which showed apical periodontitis. Subsequently, the external dental fistula developed. We should keep in mind that a patient with a fixed cantilever denture can suffer from apical periodont...
Source: Journal of Nippon Medical School - October 7, 2017 Category: Universities & Medical Training Authors: Mizuno M, Hoashi T, Hisano A, Ichiyama S, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

The Complex Structure of the Mouse Placental Labyrinth Revealed by Double Immunofluorescence Labeling of Slc2a1 and Gjb2.
PMID: 28724843 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Kyi-Tha-Thu C, Takizawa T Tags: J Nippon Med Sch Source Type: research

A Review of the Active Treatments for Toxic Epidermal Necrolysis.
Abstract Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with the separation of skin and mucous membranes at the dermal-epidermal junction. Although it is rare, many treatments have been trialed because of its high mortality rate. Active interventions performed to date include the use of systemic corticosteroids, intravenous immunoglobulins (IVIg), cyclosporine, plasmapheresis, anti-tumor necrosis factor drugs and N-acetylcysteine, but none has been established as the most effective therapy. IVIg and short-term high-dose corticosteroids were regarded as the most promising treatments f...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Kinoshita Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Ultrasonography-Based Classification and Reporting System for the Malignant Risk of Thyroid Nodules.
CONCLUSIONS: The TI-RADS classification used in this study is relatively simple and provides a reliable measure of the risk of malignancy of thyroid nodules. PMID: 28724845 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Xue E, Zheng M, Zhang S, Huang L, Qian Q, Huang Y Tags: J Nippon Med Sch Source Type: research

Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects.
CONCLUSION: Nine months of treatment with orlistat and sibutramine not only reduced weight but also significantly improved BMI, WC, BF, VF, FPG, adiponectin, fasting insulin, HOMA%B, HOMA%S, HOMA-IR and hs-CRP. These improvements could prove useful in the reduction of metabolic and cardiovascular risks in obese subjects. PMID: 28724846 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Al-Tahami BAM, Al-Safi Ismail AA, Sanip Z, Yusoff Z, Shihabudin TMT, Singh TSP, Rasool AHG Tags: J Nippon Med Sch Source Type: research

A Case of Primary Bacterial Pericarditis with Recurrent Cardiac Tamponade.
We present a 49-year-old man with bacterial pericarditis and recurrent cardiac tamponade, which was caused by the rupture of an upper part of the left atrium (LA). According to the autopsy findings, bacteremia from Staphylococcus aureus developed on a substrate of poorly controlled diabetes mellitus and spread to the pericardium via the blood. Subsequently, tissue necrosis developed from the pulmonary trunk and aorta to the LA, leading to recurrence of cardiac rupture and cardiac tamponade. PMID: 28724847 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Yoshizane T, Yamamoto T, Hayashi H, Kitamura M, Miyachi H, Hosokawa Y, Akutsu K, Shimizu W Tags: J Nippon Med Sch Source Type: research

Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review.
Abstract Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissu...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Matsuhashi T, Matsui R, Hasegawa C, Hatori T, Kamoi S, Takeshita T Tags: J Nippon Med Sch Source Type: research

The Ilizarov Mini-External Fixator for the Treatment of First Metatarsal Fracture: A Case Report.
Abstract Forefoot fractures are frequently accompanied by severe soft tissue damage. Therefore, treatment should focus not only on fractures but also on soft tissue damage, for which external fixation can be used as a surgical option. A 63-year-old woman presented to the emergency clinic of our hospital with forefoot pain after a motorcycle accident. Comminuted fracture of the proximal part of the metatarsal was diagnosed. Because of the swollen foot and fracture comminution, an operation using the Ilizarov mini external fixator was performed to prevent further damage to the soft tissue. Weight-bearing was permitt...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Kataoka T, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

A Complicated Case of Pregnancy Involving a Presacral Epidermoid Cyst.
Abstract Although presacral developmental cysts, including epidermoid cysts, are relatively rare diseases, an intrapelvic mass found for the first time in early pregnancy should be followed-up with the possibility of presacral developmental cysts in mind to be alert to the signs of local infection and malignancy. We treated a pregnant patient with presacral cystic disease. During pregnancy, percutaneous fenestration was performed because the cyst caused severe compression symptoms and complicated bacterial infection. Laparoscopic total cyst excision was performed after cesarean section. There is no suggested crite...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Shigemi D, Kamoi S, Matsuda A, Takeshita T Tags: J Nippon Med Sch Source Type: research

Squamous Cell Carcinomas on Bilateral Feet Arising in Long-Standing Eczematous Lesions.
We present a woman with squamous cell carcinomas on both feet in long-standing eczematous lesions. Histopathological examination of biopsies from the both feet revealed highly atypical cells invading the reticular layer of the dermis in the hyperkeratotic lesion and they were associated with surrounding dermatitis with spongiosis. Although the cause and etiology of eczema in our case is unclear, we speculate that the exceptionally long-lasting dermatitis might have induced double SCCs on bilateral feet with an unusual constitution. To the best of our knowledge, this is a first case of SCC on bilateral feet arising in long-...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Yamase A, Funasaka Y, Ueno T, Ito M, Otsuka Y, Kawana S, Saeki H Tags: J Nippon Med Sch Source Type: research

Circulating Anti-Nuclear Antibodies in Systemic Sclerosis: Utility in Diagnosis and Disease Subsetting.
Abstract The presence of circulating anti-nuclear antibodies (ANAs) is a hallmark of immune dysregulation in patients with systemic sclerosis (SSc). Currently, a variety of SSc-specific ANAs, including anticentromere, anti-topoisomerase I, and anti-RNA polymerase III antibodies, have been well characterized, and their commercial kits are available worldwide. Since these autoantibodies are specifically detected in SSc patients and are associated with unique sets of disease manifestations, they are widely used in routine clinical practice for diagnosis, clinical subgrouping, and prediction of future organ involvemen...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Kuwana M Tags: J Nippon Med Sch Source Type: research

Haptoglobin Reduces Inflammatory Cytokine INF- γ and Facilitates Clot Formation in Acute Severe Burn Rat Model.
Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model. J Nippon Med Sch. 2017;84(2):64-72 Authors: Koami H, Sakamoto Y, Miyasho T, Noguchi R, Sato N, Kai K, Chris Yamada K, Inoue S Abstract Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Miyasho T, Noguchi R, Sato N, Kai K, Chris Yamada K, Inoue S Tags: J Nippon Med Sch Source Type: research

Treatment Results of Transurethral Resection of the Prostate by Non-Japanese Board-Certified Urologists for Benign Prostate Hyperplasia: Analysis by Resection Volume.
CONCLUSIONS: In this study, TURP performed by non-Japanese board-certified urologists was relatively safe and achieved sufficient efficacy. Cases with resection volume less than 20 g appear the most appropriate for non-Japanese board-certified urologists. PMID: 28502962 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Suzuki Y, Toyama Y, Nakayama S, Nomura S, Minowa T, Tanabe K, Kondo Y Tags: J Nippon Med Sch Source Type: research

A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest.
We report a case of syringocystadenoma papilliferum (SCAP) combined with tubular papillary adenoma (TPA) arising on the chest of a 45-year-old Japanese woman. Histopathological examination revealed the characteristic findings of SCAP in the superficial part of the lesion and those of TPA in the deeper part. We reviewed the English literature about this combination. SCAP and TPA have the same cellular components, but show differences of the general structure. The combination of these two neoplasms is more frequent than expected by most dermatopathologists or pathologists. This combination is frequently seen in patients with...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Ito K, Ansai SI, Saeki H Tags: J Nippon Med Sch Source Type: research

Primary Volvulus of the Small Intestine Exhibiting Chylous Ascites: A Case Report.
Abstract BACKGROUND: Primary volvulus of the small intestine associated with chylous ascites is very rare, with only four reported cases. In this paper, we report a new case of primary volvulus associated with chylous ascites. CASE PRESENTATION: The patient was a 70-year-old man. After experiencing bloating and abdominal pain for several hours, he called an ambulance and underwent an emergency examination at our hospital. Abdominal distension, pressure pain, and rebound tenderness were observed throughout his entire abdomen. The patient had a history of hypertension for which he was receiving oral treatment. ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Hayama T, Shioya T, Hankyo M, Shimizu T, Shibuya H, Komine O, Watanabe Y, Nanbu K, Yamada T Tags: J Nippon Med Sch Source Type: research

Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma with a Nodular Opacity: Report of a Case.
Abstract Herein, we describe our experience in treating a case of primary pulmonary mucosa-associated lymphoid tissue lymphoma detected as a nodular opacity. A 79-year-old man was referred to our hospital. Computed tomography showed a nodular opacity measuring 20 mm in diameter with regular margins in segment 5 of the right middle lobe of the lung. Although the bronchoscopic brush cytology result was class III, the patient was tentatively diagnosed with suspected mucosa-associated lymphoid tissue lymphoma. A thoracoscopic right middle lobectomy was performed. The pathological findings showed nodular proliferation ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Yoshino N, Hirata T, Takeuchi C, Usuda J, Hosone M Tags: J Nippon Med Sch Source Type: research

Laparoscopic Repair of Vaginal Evisceration after Abdominal Hysterectomy for Uterine Corpus Cancer: A Case Report and Literature Review.
Abstract Vaginal cuff dehiscence is a rare but serious complication that can develop after hysterectomy. Emergent surgical intervention is required for vaginal cuff dehiscence due to the potential subsequent vaginal evisceration, which may lead to necrosis of the small bowel. A 62-year-old nulliparous woman with a 30-year history of smoking, diabetes mellitus, and rheumatoid arthritis (treated with oral steroids) presented with a vaginal cuff dehiscence. Thirty-eight days before the admission, she had undergone a radical operation including total abdominal hysterectomy for uterine corpus cancer at another hospital...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Matsuhashi T, Nakanishi K, Hamano E, Kamoi S, Takeshita T Tags: J Nippon Med Sch Source Type: research

Neck and Occipital Pain Caused by Deep Cervical Intramuscular Lipoma: A Surgical Case.
We describe here a patient with a large intramuscular lipoma in the deep cervical tissue. The patient experienced troublesome pain in the neck and occipital area, and surgical treatment was therefore suggested. Particularly in the cervical area, intramuscular lipomas sometimes invade the surrounding muscles and tissue layers and develop into an irregular mass, despite being benign. In addition, the cervical area has one of the most complex muscle structures. Nevertheless, surgical management of intramuscular lipoma in the cervical and cranial area is sometimes indicated, for example, in patients with clinical symptoms or m...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Kogure K, Yamazaki M, Tamaki T, Node Y, Morita A Tags: J Nippon Med Sch Source Type: research

Delayed Expression of Circulating TGF- β1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing.
CONCLUSION: The expression levels of TGF-β1 and BMP-2 appeared to be delayed in nonunion patients which could play an important role in developing an early marker of fracture union condition and facilitate improved patient's management. PMID: 28331138 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Hara Y, Ghazizadeh M, Shimizu H, Matsumoto H, Saito N, Yagi T, Mashiko K, Mashiko K, Kawai M, Yokota H Tags: J Nippon Med Sch Source Type: research

Arthroscopic Removal and Tendon Repair for Refractory Rotator Cuff Calcific Tendinitis of the Shoulder.
CONCLUSION: When treating calcific tendinitis of the shoulder, it is important to accurately determine the size and location of calcific deposit by radiographs and 3-dimensional computed tomography. Satisfactory clinical and radiological outcomes can be expected after reliable removal of calcific deposit through a single longitudinal incision and side-to-side repair with strong sutures, in association with an appropriate rehabilitation program. PMID: 28331139 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Okubo A, Takai S Tags: J Nippon Med Sch Source Type: research

Management of Atopic Dermatitis in Japan.
Abstract The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and...
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Saeki H Tags: J Nippon Med Sch Source Type: research

Characteristics and Outcomes of Laparoscopic Surgery in Patients with Gastroesophageal Reflux and Related Disease: A Single Center Experience.
CONCLUSIONS: The characteristics of the patients who underwent LARS at our hospital differed according to pathophysiology and from those in western countries. Satisfactory outcomes depended on the pathophysiology of individual patients. PMID: 28331141 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Nomura T, Iwakiri K, Matsutani T, Hagiwara N, Fujita I, Nakamura Y, Kanazawa Y, Makino H, Kawami N, Miyashita M, Uchida E Tags: J Nippon Med Sch Source Type: research

Usefulness of Color Coding Resected Samples from a Pancreaticoduodenectomy with Tissue Marking Dyes for a Detailed Examination of Surgical Margin Surrounding the Uncinate Process of the Pancreas.
CONCLUSION: By subclassifying the MUP with tissue marking dyes of different colors, we could confirm regional characteristics of MUP (+). As a result, circumferential superior mesenteric arterial nerve plexus-preserving pancreticoduodenectomy was able to be performed in R0 operations in selected patients while a better postoperative quality of life was maintained. Furthermore, Area D (+) represents an extension beyond the limit of the local disease and may indicate the need for early aggressive adjuvant chemotherapy. PMID: 28331142 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Mizutani S, Suzuki H, Aimoto T, Yamagishi S, Mishima K, Watanabe M, Kitayama Y, Motoda N, Isshiki S, Uchida E Tags: J Nippon Med Sch Source Type: research

Chopstick Injury: Successful Stent-Graft Therapy for Traumatic Left Subclavian Artery Aneurysm.
We present an unusual case of a 19-year-old man who presented at the emergency department after being stabbed with a chopstick by his elder brother. Computed tomography revealed a left subclavian artery pseudoaneurysm, which increased from 4 mm to 7 mm in diameter within 47 days. We successfully deployed a Niti-S stent graft for the increasing aneurysm, thereby avoiding a surgical operation. Balloon angioplasty was added for re-stenosis 8 months after the first intervention. PMID: 28331143 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Ueda T, Tajima H, Murata S, Takagi R, Yokota H, Kumita SI Tags: J Nippon Med Sch Source Type: research

Totally Extraperitoneal (TEP) Removal of an Infected Mesh by Laparoscopy after Open Preperitoneal Repair: Initial Case Report.
Abstract Prosthetic mesh infection after open or laparoscopic hernia repair is a rare complication. Superficial wound infection can be resolved by treatment with a combination of antibiotics and wound drainage, whereas deep-seated mesh infection, which can lead to chronic groin sepsis, usually requires removal of the mesh. A 56-year-old Japanese man was admitted to our hospital for the treatment of deep-seated mesh infection. The patient had undergone inguinal hernia repair at another hospital 18 months earlier. The operation was prosthetic mesh repair via an anterior approach. The patient developed deep-seated me...
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Chihara N, Mishima K, Suzuki H, Watanabe M, Toyoda T, Uchida E Tags: J Nippon Med Sch Source Type: research

Modified Marionette Technique for Laparoscopic Colorectal Surgery.
CONCLUSION: The "modified marionette technique" using IOR introduced here is an easy, economical, effective and safe traction technique for colorectal surgeries. This technique will be a useful tool for performing both reduced port and multiport laparoscopic colorectal surgeries. PMID: 28331145 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Shinji S, Kan H, Yamada T, Koizumi M, Yamagishi A, Yokoyama Y, Takahashi G, Iwai T, Hara K, Takeda K, Ohta K, Uchida E Tags: J Nippon Med Sch Source Type: research

Perivascular Hematoma along Pulmonary Artery Complicating Aortic Dissection.
PMID: 27890890 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Wakakuri H, Hyodo H, Ohara T, Yasutake M Tags: J Nippon Med Sch Source Type: research