Presence of promyelocytes in peripheral blood as a novel predictor of the optimal timing for single-step peripheral blood stem cell collection.
CONCLUSION: The presence of promyelocytes in peripheral blood may be a useful indicator of the optimal timing for single-step PBSC collection. PMID: 32238739 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Marumo A, Yamaguchi H, Hirakawa T, Inai K, Onai D, Omori I, Yamanaka S, Fujiwara Y, Sakaguchi M, Wakita S, Okamoto M, Yui S, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Identification of novel C-terminally truncated estrogen receptor β variant transcripts and their distribution in humans.
CONCLUSION: This study elucidated the complicated genomic organization and splicing patterns of the human ERβ gene that contribute to the distinct heterogeneity of human ERβ mRNAs and proteins. PMID: 32238740 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Ishii H, Hattori Y, Ozawa H Tags: J Nippon Med Sch Source Type: research

Portal venous gas in adults: The clinical significance, management and outcomes of 25 consecutive cases.
ConclusionsClinical, laboratory and radiographic parameters can inform decisions on conservative management. However, 47.1% of patients who underwent surgery for suspected bowel necrosis did not require bowel resection, suggesting that this approach alone may not be sufficient to avoid non-therapeutic laparotomy. A new approach should therefore be developed to improve this situation. PMID: 32238741 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Arai M, Kim S, Ishii H, Takiguchi T, Yokota H Tags: J Nippon Med Sch Source Type: research

Quick arthroscopic repair technique for ulnar-sided triangular fibrocartilage complex tears: a technical note.
Abstract Triangular fibrocartilage complex (TFCC) tears are recognized as a cause of ulnar-sided wrist pain. Nowadays, arthroscopy plays an important role in providing treatment as well as in establishing the diagnosis. Arthroscopic repair of a TFCC tear is indicated after the failure of non-surgical treatments such as cast immobilization, splinting, and administration of nonsteroidal anti-inflammatory drugs for more than 3 months. Several arthroscopic therapeutic methods have been described, including the inside-out, outside-in, and all-arthroscopic techniques. However, these arthroscopic procedures are time-co...
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Takai S Tags: J Nippon Med Sch Source Type: research

Preliminary clinical trial to explore predictive biomarkers of response to sublingual immunotherapy for Japanese cedar pollinosis.
Abstract BACKGROUND: As part of the planning for a future multicenter study, this preliminary clinical trial was performed to explore candidate biomarkers useful for predicting the therapeutic effects of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (JCP) using serum samples from patients. METHODS: This prospective study included patients undergoing SLIT for JCP at our hospital. All enrolled patients (n = 17) started SLIT between June and November of 2015. With informed consent from the patients, in January, March, and June of 2016, blood samples were obtained, and an inquiry was conducted usi...
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Takahara E, Matsune S, Ishida M, Wakayama N, Okubo K Tags: J Nippon Med Sch Source Type: research

Developing a new scale to assess alexithymia-like features in Japanese youth: Investigation of the factor structure and psychometric properties.
CONCLUSIONS: As the correlations between this new alexithymia scale and the related variables were significantly small in accordance with our hypothesis, we could demonstrate that this new scale had acceptable reliability and construct validity and could be useful for measuring alexithymic tendency in young adolescents. PMID: 32074538 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - February 20, 2020 Category: Universities & Medical Training Authors: Kashimura M, Ishizu K, Shimoda Y, Kashimura M Tags: J Nippon Med Sch Source Type: research

Pain relief of arthroscopic rotator cuff repair by nerve block.
CONCLUSION: Interscalene nerve blocks could obtain good pain relief for ARCR easily. In addition, although the continuous interscalenous nerve block can obtain continuous pain relief, we should pay attention about complications. PMID: 32009067 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Iwashita S, Hashiguchi H, Okubo A, Yoneda M, Takai S Tags: J Nippon Med Sch Source Type: research

Novel GUCY2D variant (E843Q) at mutation hotspot associated with macular dystrophy in Japanese patient.
CONCLUSIONS: This is the first report on the findings in a patient with a heterozygous variant, c.2527G>C, p.Glu843Gln in the GUCY2D, presenting with mild macular dystrophy without a general reduction of cone function. Our findings expand the spectrum of the clinical phenotypes of GUCY2D-adCRD and help identify the morphological and functional changes caused by defects of dimerization of GC-E in the phototransduction cascade. PMID: 32009068 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Takeda Y, Kubota D, Oishi N, Maruyama K, Gocho K, Yamaki K, Igarashi T, Takahashi H, Kameya S Tags: J Nippon Med Sch Source Type: research

Current status of postoperative infection after colorectal surgery: subanalysis of data from the 2015 Japan Postoperative Infectious Complications Survey.
Abstract BACKGROUND: Most surveillance programs for postoperative infection focus on surgical site infections (SSI). However, remote infections, as postoperative infections, are of emerging clinical importance. We investigated the incidence of both SSI and remote infection following colorectal surgery by performing a subanalysis of a multicenter survey after gastrointestinal surgery. METHODS: From September 2015 to March 2016, 1724 patients underwent colorectal surgery in 28 affiliated institutions in Japan. We retrospectively recorded patients' age, sex, surgical site, surgical approach, wound classification...
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Maruyama H, Kusachi S, Makino H, Kanno H, Yoshida H, Niitsuma T Tags: J Nippon Med Sch Source Type: research

Prognostic impact of hyperbilirubinemia in the early phase after allogeneic hematopoietic stem cell transplantation.
The objective of this study was to identify the unfavorable prognostic factors of liver dysfunction in the early post-transplant period. METHODS: We defined liver dysfunction as the detection within 30 days of transplantation of elevated liver or biliary enzyme levels corresponding to Grade 2 in the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. We retrospectively investigated 82 patients who had undergone allogeneic HSCT at our institution. RESULTS: Elevated liver or biliary enzyme levels were observed in almost half of the patients studied (n=40, 48.7%). Elevated total bilirubin (T-Bil) lev...
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Omori I, Yamaguchi H, Hirakawa T, Inai K, Onai D, Marumo A, Yamanaka S, Sakaguchi M, Fujiwara Y, Wakita S, Okamoto M, Tamai H, Nakayama K, Yui S, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Impact of postoperative respiratory tract infection after gastroenterological surgery on hospitalization period and medical expenses: A sub-set analysis of a multi-center study in Japan.
ConclusionsThe hospitalization period and medical expenses are known to increase in patients that develop surgical site infections. Our findings show that these parameters also increase in patients with PRTI following gastrointestinal surgery. However, further studies are needed to confirm these results. PMID: 32009071 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Maruyama H, Kusachi S, Yoshida H, Makino H, Nishimuta H, Niitsuma T Tags: J Nippon Med Sch Source Type: research

Changes over an 8-year period in Streptococcus pyogenes emm types in pharyngeal isolates from non-invasive infection patients at a pediatric facility.
CONCLUSIONS: In our earlier report, the predominant emm type was emm12, while in the current study, emm1 was the most common. The current study also identified 3 strains of Group G Streptococcus (GGS) among the isolates, which carried a stg245, stg6795, and stg840 gene, respectively. One GAS strain was found to carry stg485, a gene typically associated with GGS rather than GAS. PMID: 32009072 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Okabe T, Norose Y, Hida M, Takeda S, Takase M, Suzuki Y, Ohkuni H Tags: J Nippon Med Sch Source Type: research

The Influence of medial osteophyte removal on correction of varus deformity in total knee arthroplasty.
CONCLUSION: Correlation was found at 30 degrees of knee flexion between the widths of osteophytes and the degree of angle correction in the coronal plane in TKA. We found the degree of angle correction per 1mm width of osteophyte removal to be 0.4 degrees. PMID: 32009073 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Iizawa N, Oshima Y, Kataoka T, Majima T, Takai S Tags: J Nippon Med Sch Source Type: research

Stress Analysis of the Proximal Tibia using Finite Element Method after Unicompartmental Knee Arthroplasty.
CONCLUSIONS: The proper postoperative alignment must be achieved in UKA. The osteotomy level should be set at the cancellous bone close to the joint line, and maximum bone stock should be preserved. PMID: 32009074 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - January 31, 2020 Category: Universities & Medical Training Authors: Sano M, Oshima Y, Murase K, Sasatani K, Takai S Tags: J Nippon Med Sch Source Type: research

Primary Tumor Infiltration and Severe Acute Kidney Injury in Patients With Acute Myeloblastic Leukemia.
In this report, we describe several clinical characteristics of AKI due to primary tumor infiltration. In addition, we emphasize the importance of onconephrology, a new subspecialty concerned with the complex relationship between the kidneys and cancer. PMID: 31902852 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Aratani S, Aburakawa S, Ryotokuji T, Marumo A, Sakai Y, Inokuchi K, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

A Case of Pseudo-Meigs Syndrome Caused by a Giant Uterine Leiomyoma with Cystic Degeneration.
Abstract Pseudo-Meigs syndrome is defined as the secondary accumulation of ascites and hydrothorax associated with pelvic tumor other than benign ovarian tumor such as fibroma, which classically resolve upon surgical removal of the tumor. Here we report a case of pseudo-Meigs syndrome caused by a giant uterine leiomyoma, which was initially suspected to be ovarian cancer. A 37-year old nulliparous woman presented with a 5-month history of abdominal distension and anorexia. Abdominal ultrasonography revealed the presence of a giant cystic lesion and solid mass in the peritoneal cavity along with a massive ascites. ...
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Yaguchi A, Ban K, Koshida Y, Fujikami Y, Ogura E, Terada A, Akagi K, Matsumoto H, Tobiume T, Okagaki A, Tatsumi K Tags: J Nippon Med Sch Source Type: research

Intravenous immunoglobulin attenuates cecum ligation and puncture -induced acute lung injury by inhibiting apoptosis of alveolar epithelial cells.
CONCLUSION: IVIG can suppress inflammatory cytokine levels and improve survival. Lung histopathology and alveolar epithelial cell apoptosis were improved by IVIG treatment in a dose-dependent manner. Suppressing apoptosis in alveolar epithelial cells appears to be one of the mechanisms by which IVIG improves survival. PMID: 31902854 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Hagiwara J, Yamada M, Motoda N, Yokota H Tags: J Nippon Med Sch Source Type: research

Comparison of initial experience with two different intrascleral intraocular lens fixation techniques.
CONCLUSIONS: Both techniques showed favorable surgical outcomes. Flanged IOL fixation might be superior because of the shorter intraoperative time, but might initially be technically difficult because of the need to perform angled sclerotomy with a 30-G needle to avoid iris injury. PMID: 31902855 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Kunishige T, Takahashi H Tags: J Nippon Med Sch Source Type: research

Influence of total knee arthroplasty on hip rotational range of motion.
CONCLUSION: TKA was proven to vary the neutral position of hip rotational movement and to increase hip rotational range of motion. PMID: 31902856 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Kataoka T, Oshima Y, Iizawa N, Majima T, Takai S Tags: J Nippon Med Sch Source Type: research

Temporal Dispersion of Atrial Activation causes Postoperative Atrial Fibrillation.
CONCLUSIONS: Dispersion of the atrial activation significantly increased just before the PoAF onset. Temporal dispersion of the atrial activation is one of the precursory variations of PoAF. PMID: 31902857 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 27, 2019 Category: Universities & Medical Training Authors: Kawase Y, Ishii Y, Nishina D, Bessho R, Nitta T Tags: J Nippon Med Sch Source Type: research

Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
CONCLUSIONS: The present findings suggest that activation of TRPV4 channels worsens liver fibrosis and that inhibition of TRPV4 channels may alleviate liver fibrosis in vivo. PMID: 31801932 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 7, 2019 Category: Universities & Medical Training Authors: Fu J, Du H, Zhang X, Xu X Tags: J Nippon Med Sch Source Type: research

Renal Complications after Hematopoietic Stem Cell Transplantation: Role of Graft-Versus-Host Disease in Renal Thrombotic Microangiopathy.
Abstract Hematopoietic stem cell transplantation (HSCT) is a widely accepted treatment for mainly hematopoietic disorders. Recent advances in transplantation techniques have increased the number of long-time survivors with chronic kidney disease (CKD). The presence of CKD affects outcomes and is associated with high mortality rates. Therefore, physicians treating transplant survivors should consider renal complications and optimize management of patients with CKD after HSCT. The pathology of CKD after HSCT is affected by many factors, and the causes of renal thrombotic microangiopathy (TMA) are diverse and complic...
Source: Journal of Nippon Medical School - November 28, 2019 Category: Universities & Medical Training Authors: Mii A, Shimizu A, Yamaguchi H, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Reconstruction of the proximal phalanx head with a costal osteochondral graft for a comminuted fracture of the proximal interphalangeal joint.
Abstract We herein report a case involving a 41-year-old male carpenter who underwent costal osteochondral grafting with a pins and rubbers traction system (PRTS) for a complex cartilage defect of the proximal interphalangeal (PIP) joint. He had inadvertently cut his finger incompletely off with a power saw. The skin laceration extended to the dorsal aspect of his ring finger, and he had incomplete loss of the ulnar condyle and comminution of the radial condyle of the proximal phalanx of the PIP joint. He was diagnosed with an intra-articular PIP joint open fracture of the left ring finger with a 60% defect of the...
Source: Journal of Nippon Medical School - November 28, 2019 Category: Universities & Medical Training Authors: Satake Y, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

Neoadjuvant chemotherapy of capecitabine + epirubicin + cyclophosphamide combination therapy ( 'CEX' therapy) for HER-2 negative breast cancer, as retrospective study in our institute.
CONCLUSIONS: This study suggested that 'CEX' therapy as NAC could be an important option for individualized treatment. In particular, it was effective for TN breast cancer. PMID: 31776320 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 28, 2019 Category: Universities & Medical Training Authors: Yokoyama T, Makino H, Seki N, Ueda J, Hosone M, Katayama H, Takei H, Yoshida H Tags: J Nippon Med Sch Source Type: research

Exosome-derived microRNA-22 ameliorates pulmonary fibrosis by regulating fibroblast-to-myofibroblast differentiation both in vitro and in vivo.
ConclusionsExosomal miR-22 modulates fibroblast-to-myofibroblast differentiation. The present study warrants further investigations to shed light on miR-22 as a novel therapeutic target for patients with IPF. PMID: 31776321 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 28, 2019 Category: Universities & Medical Training Authors: Kuse N, Kamio K, Azuma A, Matsuda K, Inomata M, Usuki J, Morinaga A, Tanaka T, Kashiwada T, Atsumi K, Hayashi H, Saito Y, Seike M, Gemma A Tags: J Nippon Med Sch Source Type: research

Kirschner wires fixation alone or Kirschner wires fixation with tension band wiring in paediatric fractures of the lateral humeral condyle.
CONCLUSIONS: TBW fixation is probably optimal procedure for displaced lateral humeral condyle fractures in children, as it can promote early active range of motion exercise. PMID: 31611504 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Tomori Y, Nanno M, Takai S Tags: J Nippon Med Sch Source Type: research

Volar locking plate fixation for intra-articular distal radius fractures with volar lunate facet fragments distal to the watershed line.
CONCLUSIONS: Distally placed volar locking plate fixation effectively treats intra-articular distal radius fractures with VLF fragments distal to the watershed line by stabilizing the fragments. However, small displaced VLF fragments may increase the risk of reduction loss in ulnar variance. PMID: 31611505 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Nanno M, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Complementary use of magnetic resonance imaging and fine needle aspiration cytology in the diagnosis of soft tissue tumors.
CONCLUSIONS: The combined preoperative application of MRI and FNAC improved diagnosis of soft tissue tumors relative to assessment with either modality alone. PMID: 31611506 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Tsunoda R, Nanno M, Arai S, Takai S Tags: J Nippon Med Sch Source Type: research

The optimal alignment of the tibial implant in unicompartmental arthroplasty using 3-dimensional finite analysis.
CONCLUSIONS: In UKA, optimal alignment of the tibial implant might be at the middle position in the coronal plane and at the posterior inclination similar to each patient's original inclination in the sagittal plane to reduce complications. PMID: 31611507 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Sasatani K, Majima T, Murase K, Takeuchi N, Matsumoto T, Oshima Y, Takai S Tags: J Nippon Med Sch Source Type: research

Acute kidney injury in non-intensive care unit and intensive care unit patients treated with vancomycin and piperacillin-tazobactam.
CONCLUSIONS: The combined use of TZP in patients receiving VAN increased the incidence of AKI in both non-ICU and ICU settings. PMID: 31611508 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 15, 2019 Category: Universities & Medical Training Authors: Inage S, Nakamura S, Isoe Y, Okamoto S, Uetake S, Murakami M, Yamaguchi A, Morishima M, Nei T, Ise Y, Katayama S Tags: J Nippon Med Sch Source Type: research

Impact of Orthopedic Promotional Activities on Multidisciplinary Approaches for Bone Metastases.
CONCLUSION: A high potential demand exists for a multidisciplinary approach for bone metastases, and orthopedic specialists should actively participate in this approach. PMID: 31564687 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Natural progression and tumor growth predictive factors of retroperitoneal schwannoma.
CONCLUSIONS: The growth rates of retroperitoneal schwannomas were various. Additionally, MRI findings and clinical findings that could predict the future growth of retroperitoneal schwannoma could not be clarified. Therefore, careful follow-up is necessary for this tumor, especially for lesions with bone erosion. PMID: 31564688 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Basophil-expressing genes related with the efficacy of sublingual immunotherapy.
Abstract Basophils have been implicated not only in allergy pathogenesis, but also in the efficacy of allergen immunotherapy (AIT). We recently conducted a clinical study of sublingual immunotherapy (SLIT) in patients with Japanese cedar pollinosis using a purified cedar allergen. Patients were stratified into the high-responder (HR) and non-responder (NR) groups, and comprehensive microarray analysis was performed on peripheral basophils in the patients from both groups. A total of 153 genes were found to be differentially expressed in the HR and NR patients. The majority of the differentially expressed genes wer...
Source: Journal of Nippon Medical School - September 30, 2019 Category: Universities & Medical Training Authors: Gotoh M, Kaminuma O, Nakaya A, Saeki M, Nishimura T, Kitamura N, Hiroi T, Kimihiro Okubo A Tags: J Nippon Med Sch Source Type: research

Fetal and Neonatal Circulatory Disorders in Twin to Twin Transfusion Syndrome (The Secondary Publication).
Abstract Twin to twin transfusion syndrome (TTTS) is a major complication of monochorionic diamniotic (MD) twins, and its onset is known to be associated with placental vascular anastomoses and blood flow imbalance. In a typical case of TTTS, the recipient develops polyhydramnios, weight gain, cardiomegaly and hydrops fetalis in the uterus. In contrast, the donor develops oligohydramnios and intrauterine growth restriction. Recently, the significance of the renin-angiotensin-aldosterone system (RAAS) that transfers from the donor to the recipient has attracted interest in the fetal circulation of TTTS. The donor h...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Yoda H Tags: J Nippon Med Sch Source Type: research

Second Free Flap Surgery for Skull Base Tumors: Case Report and Literature Review.
In this report, we discuss the results of second free flap surgery after skull base reconstructive surgery. We retrospectively analyzed data from patients treated at our center during the period from 2013 through 2017. All four patients identified had skull base anaplastic meningioma and had undergone radiotherapy. In all cases, the flap and donor blood vessel were sourced from sites that differed from those used in the previous surgeries. No complications developed, such as cerebrospinal fluid leakage, meningitis, wound infection, wound hemorrhage, or flap necrosis. Because the first flap was found to be unviable, it was ...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Kubota A, Murai Y, Umezawa H, Ishisaka E, Tsukiyama A, Nakagawa S, Matano F, Ogawa R, Morita A Tags: J Nippon Med Sch Source Type: research

Central Diabetes Insipidus Associated with Orbital Apex Syndrome.
Abstract Orbital apex syndrome (OAS) manifests as multiple cranial nerve palsies caused by an abnormal nerve response to inflammation or other processes. Central diabetes insipidus (CDI) is characterized by deficient synthesis or secretion of antidiuretic hormone. A 62-year-old woman underwent myringotomy for otitis media with effusion. Two months after the procedure, symptoms of hearing loss had not improved, and she underwent left tympanoplasty and mastoidectomy. After surgery, she presented with left ocular pain and visual loss. Neurologic examination revealed ptosis, total ophthalmoplegia, and a relative affer...
Source: Journal of Nippon Medical School - September 7, 2019 Category: Universities & Medical Training Authors: Yoon JH, Cho SH, Lee SH, Ma SK, Kim SW, Bae EH Tags: J Nippon Med Sch Source Type: research

Mechanism of respiratory failure in fatal crowd accidents using a thoracoabdominal compression model of traumatic asphyxia.
CONCLUSIONS: In human women, respiratory failure could occur within 1 h due to respiratory muscle fatigue even when the total thoracoabdominal load is only about 60% of the body weight. Vital capacity ≤1.85 L and modified Borg scale score ≥8.3 can be considered as indices for predicting respiratory failure. PMID: 31434839 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Motomura T, Matsumoto H, Yokota H, Suzuki M, Nishimoto T, Ujihashi S Tags: J Nippon Med Sch Source Type: research

Validity of integrated relaxation pressure cutoff value used in Starlet (high-resolution manometry system).
CONCLUSIONS: It is difficult to determine the IRP cutoff value using the Starlet. In diagnosis of achalasia using the Starlet, it is necessary to comprehensively judge the results other than IRP values. In addition, there was an association between IRP values and achalasia subtypes in the Chicago classification. PMID: 31434840 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Kawami N, Hoshino S, Hoshikawa Y, Takenouchi N, Hanada Y, Tanabe T, Goto O, Kaise M, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Comparison of functional dyspepsia with early chronic pancreatitis.
Abstract Functional dyspepsia (FD) is a common disease that can markedly impair the patients' quality of life. In 2016, Rome IV criteria defined the diagnosis of functional dyspepsia as requiring bothersome FD symptoms. In 2009, a new diagnosis of early chronic pancreatitis (ECP) was proposed as a new strategy to address chronic pancreatitis at the initial phase and prevent it from advancing into chronic pancreatitis. Although chronic pancreatitis was reported to be one of the causes of dyspepsia, there was scant data regarding the relationship between ECP and FD patients. Therefore, we tried to investigate differ...
Source: Journal of Nippon Medical School - August 20, 2019 Category: Universities & Medical Training Authors: Futagami S, Yamawaki H, Agawa S, Ikeda G, Noda H, Kirita K, Higuchi K, Gudis K, Murakami M, Kodaka Y, Ueki N, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Novel modification of abductor pollicis longus suspension arthroplasty with trapeziectomy for thumb carpometacarpal osteoarthritis.
CONCLUSIONS: The modified Thompson procedure is a simple and effective technique that can improve the thumb radial abduction angle compared with the original technique in patients with advanced thumb CMC osteoarthritis. Additionally, this new technique is as useful as the original procedure in early restoring thumb function and relieving pain. PMID: 31308312 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Nanno M, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Urothelial carcinoma of the bladder, lipid cell variant: A case report and literature review.
Abstract Lipid cell variant of urethral carcinoma (UC) is a rare tumor and has been clinicopathologically poorly understood. A nodular tumor was detected in the bladder of an 87-year-old man with asymptomatic gross hematuria; the tumor was transurethrally resected. The patient was pathologically diagnosed with high-grade UC, lipid cell variant. The tumor cells, similar to lipoblasts, commonly contained cytoplasmic vacuoles. Immunohistochemically, the tumor cells were positive for epithelial markers such as CK7, 20, EMA, CAM5.2, and 34betaE12. However, they were negative for vimentin and S100. Moreover, focal posit...
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Takahashi K, Kimura G, Endo Y, Akatsuka J, Hayashi T, Toyama Y, Hamasaki T, Kondo Y Tags: J Nippon Med Sch Source Type: research

Improving Mood with Cognitive Behavioral Therapy in a Woman with Mild Cognitive Impairment-a Case Report.
This study investigated the feasibility of a cognitive behavioral therapy (CBT) program for a female patient with mild cognitive impairment (MCI), depression, and anxiety, to improve her mood and quality of life. The program comprised of eight 30-minute weekly sessions with interventions such as behavioral activation, relaxation, and cognitive reconstruction, in which the patient's caregiver also participated. An assessment evaluating the patient's condition were conducted before and immediately after the intervention. After 3 and 12 months, the caregiver reported the patient's behavioral and psychological symptoms using s...
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Kashimura M, Nomura T, Ishiwata A, Kitamura S, Tateno A Tags: J Nippon Med Sch Source Type: research

An Examination of Solitary Deaths in Tokyo Metropolis by Labor Force Status: Characteristics of Unnatural Deaths at Home among Individuals Living Alone.
CONCLUSIONS: We showed that the incidences of solitary death are significantly higher among non-employed than employed individuals for both sexes, and postmortem intervals among non-employed are significantly longer. PMID: 31308315 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Kanawaku Y, Ohno Y Tags: J Nippon Med Sch Source Type: research

Successful treatment of severe lactic acidosis and tumor lysis syndrome related to intravascular lymphoma in the intensive care unit.
We report a rare case in which a patient with intravascular lymphoma involving multiple organ failure survived. PMID: 31308316 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 15, 2019 Category: Universities & Medical Training Authors: Mase H, Ogawa Y, Takeuchi J, Genda Y, Ichiba S, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Blood Galectin-3 Levels Predict Postoperative Complications after Colorectal Cancer Surgery.
CONCLUSIONS: These results indicate that increased perioperative blood galectin-3 levels may be associated with POC after CRC surgery. PMID: 31292325 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Matsuda A, Yamada M, Matsumoto S, Sakurazawa N, Kawano Y, Sekiguchi K, Yamada T, Matsutani T, Miyashita M, Yoshida H Tags: J Nippon Med Sch Source Type: research

Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.
CONCLUSIONS: The rs11045879 minor allele in the SLCO1B1 gene is a potential predictor of non-responders to MTX treatment among Japanese RA patients. In future collaborative research, we will investigate whether the association with SLCO1B1 polymorphism is significant by performing statistical analysis with a larger study population. PMID: 31292326 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Takahashi K, Nakamura H, Watanabe A, Majima T, Koiwa M, Kamada T, Takai S Tags: J Nippon Med Sch Source Type: research

Symptoms Related to Moderate Skeletal-Related Events as Clues for the Diagnosis of Bone Metastasis.
CONCLUSION: The results of the present study suggest that symptoms related to SREs can be used to diagnose bone metastasis in the absence of a screening test. Bone metastasis should be diagnosed as often as possible based on symptoms related to moderate SREs and should be treated as soon as possible before patients develop severe SREs. PMID: 31292327 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

Multicenter Observational Study of Fulvestrant 500 mg in Postmenopausal Japanese Women with Estrogen Receptor-Positive Advanced or Recurrent Breast Cancer after Prior Endocrine Treatment (SBCCSG29 Study).
CONCLUSION: Fulvestrant 500 mg is an effective and safe treatment for patients with advanced or recurrent breast cancer after prior endocrine treatment. PMID: 31292328 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Kimizuka K, Inoue K, E Nagai S, Saito T, Nakano S, Futsuhara K, Yamada H, Kaneko S, Sakurai T, Hata S, Kurosumi M Tags: J Nippon Med Sch Source Type: research

Long-Term Outcomes of Endovascular Stenting for Blunt Renal Artery Injuries with Stenosis: A Report of Five Consecutive Cases.
CONCLUSIONS: Renal artery stenting for hemodynamically stable blunt renal artery injuries with stenosis is suggested to be safe and helps in avoiding long-term hemodialysis and renovascular hypertension. PMID: 31292329 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Okada I, Inoue J, Kato H, Koido Y, Kiriu N, Hattori T, Morimoto K, Ichinose Y, Yokota H Tags: J Nippon Med Sch Source Type: research

Huge Littoral Cell Angioma of the Spleen: A Case Report.
Abstract Littoral cell angioma (LCA), a rare vascular neoplasm that occurs in the spleen, is difficult to definitively diagnose preoperatively because histological examination is the only accurate means of diagnosing this condition. Thus, the preoperative diagnosis is often incorrect. Splenectomy is the appropriate treatment and can be performed laparoscopically or by open surgery depending on the size of the tumor. Here we present a case of a 38-year-old man who presented with a history of slight non-specific abdominal distension for 2 months. An abdominal CT scan showed a huge spleen measuring 35×18 cm and...
Source: Journal of Nippon Medical School - July 13, 2019 Category: Universities & Medical Training Authors: Lyu S, He Q Tags: J Nippon Med Sch Source Type: research