Exfoliation of alveolar rhabdomyosarcoma cells in the ascites of a 50-year-old woman: A diagnostic pitfall with a literature review.
Abstract Alveolar rhabdomyosarcoma (ARMS) is a non-epithelial tumor with skeletal muscle differentiation and typically affects adolescent and young adult patients. Cytological aspects of ARMS in the body fluid have not been well characterized in the literature, making the correct diagnosis difficult. Here, we describe cytological features of ARMS in the ascites of a 50-years-old woman. She presented with an intraabdominal mass and abundant ascites. Aspiration cytology of the ascitic fluid revealed many small-sized discohesive round cells with mild nuclear atypia and prominent nucleoli. Rhabdomyoblastic cells, char...
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Motoda N, Nakamura Y, Kuroki M, Yoneyama K, Isshiki S, Ohashi R, Naito Z Tags: J Nippon Med Sch Source Type: research

A Rare Case of Synchronous Cystic Duct Metastasis Arising from Renal Cell Carcinoma.
CONCLUSION: It was the first report in the world of such a case. PMID: 31061254 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Ueda J, Makino H, Yokoyama T, Maruyama H, Hirakata A, Takata H, Seki N, Kikuchi Y, Yoshioka M, Irie T, Yoshida H Tags: J Nippon Med Sch Source Type: research

Pancreatic Ductal Adenocarcinoma Development in the Remnant Pancreas after Pancreaticoduodenectomy for Acinar Cell Carcinoma: A Case Report.
We report the case of a pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas of a 78-year-old man after pancreaticoduodenectomy for acinar cell carcinoma. Acinar cell carcinoma is a relatively rare pancreatic neoplasm. Following the diagnosis of pancreatic carcinoma, subtotal stomach-preserving pancreaticoduodenectomy was performed. The pathological diagnosis was acinar cell carcinoma of the pancreas, disease stage IA, pT1, pN0, M0, without regional lymph node invasion. Twenty-two months after the surgery, cancer antigen 19-9 levels gradually increased, and computed tomography showed 2 solid tumors, approximatel...
Source: Journal of Nippon Medical School - April 26, 2019 Category: Universities & Medical Training Authors: Nishimura S, Utsumi M, Aoki H, Une Y, Kashima H, Kimura Y, Taniguchi F, Arata T, Katsuda K, Tanakaya K, Sato Y Tags: J Nippon Med Sch Source Type: research

Development of Cancer Immunotherapy Targeting the PD-1 Pathway.
Abstract Immune checkpoint inhibitors are causing a paradigm shift in cancer treatment. Immune checkpoint molecules such as programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) dampen T cell activation to avoid autoimmunity and the destructive effects of an excessive inflammatory response. Immune checkpoint signaling can be exploited by tumors to escape host immune surveillance, and immune checkpoint inhibitors enhance antitumor immunity by releasing the brakes on the immune system. PD-1 was identified in 1992 by Honjo and colleagues at Kyoto University. Studies in animal...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Kamimura N, Wolf AM, Iwai Y Tags: J Nippon Med Sch Source Type: research

Immunohistochemical Study of Non-Epithelial Cells in Spiradenoma.
CONCLUSIONS: In spiradenoma, CD3+ T cells were mainly seen in the parenchyma and CD8+ cells were predominant over CD4+ cells in most cases. CD20+ cells showed focal infiltration of the parenchyma and stroma, especially in VP-type lesions. S-100 protein-positive cells in spiradenoma contained not only Langerhans cells, but also cells with myoepithelial differentiation. PMID: 30918150 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Ito K, Ansai SI, Saeki H Tags: J Nippon Med Sch Source Type: research

Monoclonal Immunoglobulin Deposition Disease and Related Diseases.
Abstract Abnormal proliferation of plasma cells and some monoclonal B cells frequently cause the secretion of monoclonal immunoglobulins or immunoglobulin fragments into the serum, causing monoclonal gammopathy, which leads to various diseases including renal diseases. Therefore, monoclonal gammopathy is frequently associated with kidney diseases, including glomerular and tubulointerstitial diseases. Glomerular disease, with the deposition of monoclonal immunoglobulins or their components, includes monoclonal immunoglobulin deposition disease (MIDD), AL or AH amyloidosis, type I cryoglobulinemia, proliferative glo...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Kanzaki G, Okabayashi Y, Nagahama K, Ohashi R, Tsuboi N, Yokoo T, Shimizu A Tags: J Nippon Med Sch Source Type: research

Diagnosis of Bone Metastasis in Patients Without a History of Cancer.
CONCLUSIONS: The results of this study indicate that it is difficult to diagnose bone metastasis in patients without a history of cancer. This must be considered in the early diagnosis of bone metastasis to prevent severe skeletal-related events. PMID: 30918152 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

The Effect of a Frequency-Doubled Q-Switched Nd:YAG Laser on Hairless Mice Harboring Eumelanin and Pheomelanin in the Epidermis.
CONCLUSION: The effect of the Nd:YAG laser on the cells containing different melanin subspecies was shown to be different in an in vivo irradiation system. PMID: 30918153 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Yamaguchi H, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

A 10-Year History of Anti-Smoking Campaigns and Enlightenment Activities for Chronic Obstructive Pulmonary Disease for Citizens at the Plaza in Ebina City.
We describe our activities to raise awareness of COPD through a 10-year campaign. METHODS: From 2006 to 2015, we developed activities to raise awareness of COPD, including public lectures, utilization of pulmonary function tests, and questionnaires on subjective symptoms and knowledge of COPD. RESULTS: Among 1,206 participants aged>40 years, COPD was suspected in 5.6%, as indicated by airway obstruction (i.e. forced expiratory volume in 1 second (FEV1)/forced vital capacity ratio (FVC)
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Sato Y, Taniuchi N, Kaburaki S, Aruga N, Kubota K, Seike M, Yamano Y, Gemma A Tags: J Nippon Med Sch Source Type: research

Case Report: 84-Month Disease-Free Survival after Surgery for Anaplastic Thyroid Carcinoma.
We present a rare case of a patient with anaplastic thyroid carcinoma (ATC) who survived for 87 months after surgery. The patient was a 71-year-old man who presented with a painful enlarged mass in the right side of his neck that rapidly enlarged over 2 months. He was diagnosed with T4a, stage IVA ATC with no distant metastasis and underwent total thyroidectomy with modified neck dissection. Although only radiation and radioactive iodine therapy were administered after surgery, he remained disease-free for 84 months. Bone metastasis occurred after 84 months, and he was treated with Lenvatinib, but he died from a decline in...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Kanazawa S, Kammori M Tags: J Nippon Med Sch Source Type: research

Organizing Pneumonia after Nivolumab Treatment in a Patient with Pathologically Proven Idiopathic Pulmonary Fibrosis.
We report a 72-year-old patient with lung cancer with pathologically proven idiopathic pulmonary fibrosis who was treated with nivolumab. She demonstrated pneumonitis with an organized pneumonia (OP) pattern, but no acute exacerbation of ILD featuring a diffuse alveolar damage (DAD) pattern. She was successfully treated with corticosteroid therapy, and maintained good disease control after the discontinuation of nivolumab. She also showed pseudoprogression of the primary tumor, implying infiltration of T-cells into the lung. These findings suggest that T-cell activation by nivolumab treatment might not be directly associat...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Kashiwada T, Minegishi Y, Saito Y, Kato T, Atsumi K, Seike M, Kubota K, Terasaki Y, Gemma A Tags: J Nippon Med Sch Source Type: research

An Isolated Unilateral Pontomedullary Lesion Due to An Intracranial Dural Arteriovenous Fistula Mimicking A Brain Tumor - Case and Review.
Abstract Intracranial dural arteriovenous fistula (DAVF) with perimedullary venous drainage may cause brainstem swelling and represent a diagnostic challenge. A 66-year-old man presented to the emergency room with recurrent vertigo, minimal truncal ataxia with a wide-based gait, and a slightly impaired tandem gait. Brain magnetic resonance imaging (MRI) revealed a hyperintense lesion in the left pontomedullary area on T2-weighted images (T2WIs) with partial gadolinium enhancement, but without increased signals on diffusion-weighted images. Abnormal serpentine flow void vessels surrounding the medulla and upper cer...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Chen PY, Juan YH, Lin SK Tags: J Nippon Med Sch Source Type: research

Micrococcus aloeverae - A Rare Cause of Peritoneal Dialysis-Related Peritonitis Confirmed by 16S rRNA Gene Sequencing.
Abstract The number of patients receiving peritoneal dialysis has increased worldwide. Herein, we report the first case to our knowledge of continuous ambulatory peritoneal dialysis (CAPD) peritonitis caused by Micrococcus aloeverae, which was initially reported to be caused by Micrococcus luteus in the dialysate culture report but later identified by 16S ribosomal ribonucleic acid (rRNA) gene sequencing as M. aloeverae. A 59-year-old woman visited the emergency room due to abdominal pain. She was hospitalized with CAPD peritonitis. The patient initially responded to empirical antibiotic treatment comprising intra...
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Song SH, Choi HS, Ma SK, Kim SW, Shin JH, Bae EH Tags: J Nippon Med Sch Source Type: research

The Effect of Alcohol Dehydrogenase Isozymes on Alcoholic Liver Disease and Alcoholic Osteoporosis.
PMID: 30918159 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 29, 2019 Category: Universities & Medical Training Authors: Okuda T Tags: J Nippon Med Sch Source Type: research

Evaluation of Resistance by Clinically Pathogenic Bacteria to Antimicrobials and Common Disinfectants in Beijing, China.
CONCLUSIONS: Based on the pathogen spectrum for bacterial infective pathogens evaluated in this study, as well as the status quo of their resistance to antimicrobial agents and common clinical disinfectants, it is essential for healthcare professionals to pay attention not only to the standardized use of antimicrobial agents but also to the rational application of disinfectants. PMID: 30568055 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Shan K, Li J, Yao W, Li J, He X, Li F, Wen W, Liu Q, Guo W Tags: J Nippon Med Sch Source Type: research

Effects of Endoprosthesis Head Material on Acetabular Cartilage Metabolism: An Animal Study Using Crossbred Pigs.
CONCLUSIONS: The present study showed that ceramic bipolar produces smaller adverse effects on cartilage cells compared to Co-Cr bipolar. These results could have significant implications for implant usage not only in hip joints, but also in other joints, including the shoulder, talus and radial head. PMID: 30568056 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Matsui S, Majima T, Mominoki K, Hirayama H, Oshima Y, Takahashi K, Takai S Tags: J Nippon Med Sch Source Type: research

Diagnostic Value of Plain Radiography for Symptomatic Bone Metastasis at the First Visit.
CONCLUSIONS: Plain radiography around the time of the first visit has a definitive role in the early diagnosis of symptomatic bone metastasis. PMID: 30568057 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Kitagawa Y, Yamaoka T, Yokouchi M, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Takai S Tags: J Nippon Med Sch Source Type: research

The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice.
CONCLUSIONS: The Adh3-/- control mice exhibited a high turnover of osteoporosis since osteoclastogenesis dominated osteoblastogenesis; however, bone resorption was not enhanced after CAC. In comparison, CAC lead to alcoholic osteoporosis in WT mice, accompanied by increased mRNA levels of ADH3. Hence, ADH3 can prevent osteoporosis development in normal ADH genotypes with no alcohol ingestion. However, ADH3 contributes to the development of alcoholic osteoporosis under CAC by participating in alcohol metabolism, increasing metabolic toxicity, and lowering GSNO reducing activity. PMID: 30568058 [PubMed - in process] (So...
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Okuda T, Naruo M, Iijima O, Igarashi T, Katsuyama M, Maruyama M, Akimoto T, Ohno Y, Haseba T Tags: J Nippon Med Sch Source Type: research

Efficacy of Mirtazapine on Irritable Bowel Syndrome with Anxiety and Depression: A Case Study.
Abstract Irritable bowel syndrome (IBS) is a disease in which gastrointestinal symptoms-primarily abdominal pain or discomfort and abnormal bowel movements persist chronically. For patients with IBS, mental illness, especially depression and/or anxiety, leads to a further lower quality of life. The purpose of this case study was to investigate the effects of mirtazapine (MIR) on mental health and IBS symptoms in a case of IBS accompanied by anxiety and a depressive state. This case report suggests that MIR is efficacious for the treatment of IBS with predominant diarrhea accompanied by depression and anxiety. ...
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Akama F, Mikami K, Watanabe N, Kimoto K, Yamamoto K, Matsumoto H Tags: J Nippon Med Sch Source Type: research

A Case with Unique Dermoscopic Findings: Collision of an Apocrine Gland Cyst and a Trichoblastoma.
We report a case of a blue-black nodule on the left upper eyelid of a 77-year-old woman. Dermoscopic examination of the lesion revealed a purple or purple-red homogenous opaque area like that often observed in apocrine gland cysts and a yellow-whitish homogenous structure with arborizing vessels. After resection of the tumor, a final diagnosis of collision of an apocrine gland cyst and a trichoblastoma was made. We should note the possibility that trichoblastoma may exhibit a yellow-whitish homogenous structure in dermoscopy. PMID: 30568060 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Ito K, Ansai SI, Ogita A, Matsuda H, Saeki H Tags: J Nippon Med Sch Source Type: research

The Relationship Between Premature Ventricular Contractions and Lifestyle-Related Habits among the Japanese Working Population (FUJITSU Cardiovascular and Respiratory Observational Study-1; FACT-1).
CONCLUSION: The frequency of PVCs recorded at regular medical checkups in Japanese office workers without heart disease was 1.7%. Within our group of participants, the factors related to the onset of PVCs were a history of regularly drinking alcohol and sleep disorders. PMID: 30568061 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Sekizuka H, Miyake H Tags: J Nippon Med Sch Source Type: research

Epidermoid Cyst Arising on the Body of the Tongue: Case Report and Literature Review.
DISCUSSION: Epidermoid cysts of the body of the tongue are congenital or acquired. The congenital type can arise due to a failure of surface ectoderm separation or invagination of the surface ectoderm along the embryologic fusion sites. The acquired type is caused by trauma, with implanting of an epithelial element into the deeper tissue. In the present case, it was difficult to determine whether the pathogenesis was congenital or acquired because there are no clinical or histopathological differences between the two types. PMID: 30568062 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Ueno T, Takayama R, Osada SI, Saeki H Tags: J Nippon Med Sch Source Type: research

Expectations for the Next Generation of Simulated Patients Born from Thoughtful Anticipation of Artificial Intelligence-Equipped Robot.
Abstract It is predicted that in the near future robot simulated patients (SPs) will come into use. Through the impressions of five SPs about robot SPs, we explored their vision of the future of medical education as an indicator of what ordinary citizens think. The opinions of SPs were collected using a semi-structured focus group interview, after which the perspectives provided were explored using a qualitative research method called Steps for Coding and Theorization (SCAT). Although SPs accepted the introduction of robot SPs, they regard them as potential substitutes. The use of robot SPs raised concerns about t...
Source: Journal of Nippon Medical School - December 21, 2018 Category: Universities & Medical Training Authors: Hayasaka Y, Fujikura T, Kashimura M Tags: J Nippon Med Sch Source Type: research

Nonsyndromic Congenital Absence of the Pectoralis Muscles.
Abstract The congenital absence of the pectoralis muscle is usually a manifestation of Poland syndrome. However, a nonsyndromic congenital absence of this muscle is rare, and such absences are usually partial and unilateral. A complete or bilateral absence is even rarer. Two young men presented to our outpatient clinic with incidentally noted unilateral flat chest walls. By chest computed tomography, they were diagnosed with a congenital unilateral absence of the pectoralis muscles. They did not show any functional disability of the arms. As the congenital absence of the pectoralis muscles is often associated with...
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Yuan SM Tags: J Nippon Med Sch Source Type: research

Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis.
CONCLUSION: Certain cytokine clusters are strongly correlated with a positive therapeutic outcome, suggesting they have a role in the MOA of immunotherapy. PMID: 30464141 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O, Nakaya A Tags: J Nippon Med Sch Source Type: research

Correlation between Pathological Findings and the Usefulness of Clinical Guidelines for the Treatment of ANCA-Positive RPGN: A Retrospective Analysis.
Abstract BACKGROUND: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments. The aim of this study was to assess the correlation between the pathological findings and...
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Yamada T, Kashiwagi T, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells.
CONCLUSION: EM900 showed an anti-inflammatory effect, such as that of CAM, due to the inhibitory effect on IL-8 production in HNEpCs. PMID: 30464143 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Ōmura S Tags: J Nippon Med Sch Source Type: research

Challenges in the Diagnosis of bone Metastasis in Patients without a History of Malignancy at Their First Clinic Visit.
CONCLUSIONS: Diagnosis of bone metastasis is challenging in patients without a history of malignancy at their first visit. For early diagnosis, it is important to recognize this challenge and to keep it in mind together with ongoing observation. PMID: 30464144 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Miyamoto M, Takai S Tags: J Nippon Med Sch Source Type: research

Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids.
We report two cases of granular cell tumors (GCTs) arising on rare sites, namely, the nape and umbilicus. While GCTs have a very characteristic histology, their clinical signs and symptoms are non-specific. Therefore, it is extremely difficult to make a diagnosis of GCT on the basis of clinical findings only. The two cases reported here were clinically similar to hypertrophic scars and keloids, respectively. Skin surgeons should remember that GCTs are an important differential diagnosis from hypertrophic scars and keloids. PMID: 30464145 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Tosa M, Ansai SI, Ogawa R Tags: J Nippon Med Sch Source Type: research

Two Cases of Sclerotic Fibroma of the Skin that Mimicked Keloids Clinically.
We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Both cases were clinically similar to keloids. Skin surgeons should remember that SFSs are an important differential diagnosis from keloids. PMID: 30464146 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Tosa M, Ansai SI, Kuwahara H, Akaishi S, Ogawa R Tags: J Nippon Med Sch Source Type: research

Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
CONCLUSIONS: The risk of PCOS developing in patients with epilepsy is known to be high, and the association of VPA with PCOS is well established, so if physicians feel this is the best drug to prescribe for female patients with epilepsy, they should carefully monitor the patients' weight and menstruation, and immediately perform ovarian imaging and hormonal examinations if any abnormalities are observed. PMID: 30464147 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Kawakami Y, Fujii S, Ishikawa G, Sekiguchi A, Nakai A, Takase M Tags: J Nippon Med Sch Source Type: research

Small Cell Lung Cancer with Sarcoidosis in Spontaneous Remission: A Case Report.
Abstract A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. The pulmonary sarcoidosis did not show any deterioration despite the frequent use of amrubicin, which is known to be a cause of interstitial pneumonia. This is a case report of SCLC complicated with sarcoidosis ...
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Sasaki Y, Koga Y, Kasahara N, Hachisu Y, Murata K, Tsurumaki H, Yatomi M, Tsukagoshi Y, Sawada Y, Sakurai R, Ono A, Sunaga N, Kaira K, Hirato J, Maeno T, Dobashi K, Hisada T Tags: J Nippon Med Sch Source Type: research

Congenital Mesoblastic Nephroma Presenting with Hematuria in a Neonate.
Abstract Congenital mesoblastic nephroma (CMN) is a rare tumor of infancy. CMNs can be histologically divided into classic, cellular, and mixed subtypes. Cellular CMNs are difficult to differentiate from Wilms tumors. Herein, a neonate with cellular CMN accompanied by macroscopic hematuria, is described. The clinical, pathological, and imaging features of the disease are discussed. PMID: 30464149 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Wang H, Yao Z, Liu Q Tags: J Nippon Med Sch Source Type: research

Evaluation of the Role of Balneotherapy in Rehabilitation Medicine.
Abstract Balneotherapy is a treatment with healing waters, which includes bathing and physiotherapy in thermal water, therapeutic drinks, medical massage, and water jet massage. It is based on the buoyancy, physical properties, temperature, and chemical effects of mineral water. Throughout European and Japanese medical institutions, balneology and hot spring therapy is very much a part of routine medical treatment. The mechanism of balneotherapy is not yet completely understood. Balneotherapeutic procedures are mainly performed for the prevention, treatment, and rehabilitation of musculoskeletal diseases, but they...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Matsumoto S Tags: J Nippon Med Sch Source Type: research

Early Transcatheter Arterial Embolization for the American Association for the Surgery of Trauma Grade 4 Blunt Renal Trauma in Two Institutions.
Abstract OBJECTIVES: To evaluate the efficacy of early transcatheter arterial embolization for hemodynamically stable patients with The American Association for the Surgery of Trauma (AAST) grade 4 blunt renal trauma. MATERIALS AND METHODS: The medical records of consecutive patients with grade 4 blunt renal trauma who were transported to our two critical care centers in Japan and treated with early transcatheter arterial embolization (TAE) between 2001 and 2013 were retrospectively reviewed. Treatment failure was defined as the need for further surgical intervention or re-embolization after initial embolizat...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yanagi M, Suzuki Y, Hamasaki T, Mizunuma K, Arai M, Yokota H, Murata S, Kondo Y, Nishimura T Tags: J Nippon Med Sch Source Type: research

Pulmonary Dysfunction Function and Poor Nutritional Status are Risk Factors for Remote Infections Following Surgery for Colorectal Cancer.
CONCLUSION: RI is caused by poor nutrition, immune system dysfunction and pulmonary dysfunction. PMID: 30259889 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Sagawa M, Yoshimatsu K, Yokomizo H, Yano Y, Okayama S, Yamada Y, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Kato H, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Inhibitory Effects of S-carboxymethylcystein on Goblet Cell Proliferation in Cultured Epithelium.
CONCLUSION: TNF-α promoted goblet cell proliferation in nasal polyps, suggesting its influence on nasal polyp formation. As S-CMC inhibited inflammatory stimulation-induced goblet cell proliferation in nasal polyp epithelium, it may be useful for the treatment of sinusitis. PMID: 30259890 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yamaguchi S, Matsune S, Sekine K, Wakayama N, Kitayama Y, Nakamura Y, Okubo K Tags: J Nippon Med Sch Source Type: research

Evaluation of the Impact of Preoperative Values of Hyaluronic Acid and Type IV Collagen on the Outcome of Patients with Hepatocellular Carcinoma After Hepatectomy.
CONCLUSIONS: Preoperative examinations of serum hyaluronic acid levels and type IV collagen levels are imperative for hepatic resection for HCC because these markers are significantly associated with liver function and prognosis. PMID: 30259891 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Ueda J, Yoshida H, Mamada Y, Taniai N, Yoshioka M, Hirakata A, Kawano Y, Shimizu T, Kanda T, Takata H, Uchida E Tags: J Nippon Med Sch Source Type: research

A Case of Infundibulocystic Basal Cell Carcinoma Clinically Mimicking a Melanocytic Nevus Associated with Epidermal Cysts.
This report presents a case of IFC-BCC that clinically mimicked a melanocytic nevus and was also associated with epidermal cysts. PMID: 30259892 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Kawasaki Y, Ansai SI, Fujimoto K, Saeki H, Kawana S Tags: J Nippon Med Sch Source Type: research

Trans-scaphoid Perilunate Fracture-dislocation with Concomitant Lunotriquetral Ligament Disruption: A Case Report.
We report a case of trans-scaphoid perilunate fracture-dislocation with concomitant lunotriquetral ligament disruption of the right wrist in a 44-year-old man, sustained from a 10-m fall landing on his outstretched right hand. Open reduction was performed 1 day after injury; at first the palmar dislocation of the lunate was reduced with the palmar approach. Under direct view with the dorsal approach, the scaphoid was comminuted and then treated with open reduction and internal fixation with a double threshold screw using a dorsal approach and a bone graft from the distal radius. Although the scapholunate ligament was intac...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Sonoki K, Tomori Y, Obara Y, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

A Case of Primary Malignant Lymphoma of the Prostate Gland Presenting as Right Lower Back Pain and Dysuria.
Abstract A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis and a large pelvic large mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate was palpable on digital rectal examination. A prostate tumor was suspected, and a transrectal prostate biopsy and right transurethral ureteral stent placement were performed. Histological and immunohistochemical studies revealed diffuse large B-cell lymphoma. Positron emission tomography-computed tomography showed abnormal uptake in the stomach, ...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yasuoka S, Kimura G, Toyama Y, Moriya K, Takahashi K, Matsuoka R, Shibayama K, Obayashi K, Inoue Y, Shindo T, Iigaya S, Endo Y, Akatsuka J, Hayashi T, Nakayama S, Hamasaki T, Inokuchi K, Kondo Y Tags: J Nippon Med Sch Source Type: research

An 8-Year-Old Girl with Autoimmune Hepatitis Following Aplastic Anemia.
Abstract We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy. PMID: 30259895 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Nishigori A, Hatori T, Asano T Tags: J Nippon Med Sch Source Type: research

Plasma Adsorption Membranes Are Able to Efficiently Remove High Mobility Group Box-1 (HMGB-1).
CONCLUSIONS: Our findings showed that plasma adsorption therapy efficiently adsorbed HMGB-1 and could be safely applied for the treatment of sepsis. PMID: 30135341 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Onohara T, Sakamoto Y, Inoue S Tags: J Nippon Med Sch Source Type: research

Objective Colorimetric Evaluation of Aging-related Articular Cartilage Degeneration.
CONCLUSIONS: This study developed an original colorimetric device with high validity. Browning of articular cartilage increased with age, but this study did not detect pentosidine-caused browning. Further study is needed to clarify the factors associated with browning of cartilage. PMID: 30135342 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Satake Y, Takahashi K, Saito M, Takai S Tags: J Nippon Med Sch Source Type: research

Arthroscopic Coracoclavicular Ligament Reconstruction for Acromioclavicular Joint Dislocation.
CONCLUSION: ACCLR for acute dislocation of the ACJ is a useful surgical procedure that gives satisfactory clinical and radiologic outcomes on mid- and long-term follow-up. ACCLR can stabilize vertical instability of the ACJ. If instability in the horizontal direction remains, repair or reconstruction of the acromioclavicular ligament should be added to prevent osteoarthritic changes of the ACJ. PMID: 30135343 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Abe K, Sonoki K, Yoneda M, Takai S Tags: J Nippon Med Sch Source Type: research

Cutaneous Vasculitis in Cogan's Syndrome: A Report of Two Cases Associated with Chlamydia Infection.
Abstract Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis. Here, we report two cases of CS, one of which involved a patient who developed the typical sympto...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Kawasaki Y, Uehara T, Kawana S Tags: J Nippon Med Sch Source Type: research

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.
CONCLUSIONS: In our patients with MEN2B, prophylactic or early thyroidectomy could not be performed. The characteristic phenotype associated with MEN2B is almost always seen prior to detection of MTC or pheochromocytoma. Knowledge about the non-endocrine manifestations of MEN2B needs to be shared among pediatricians and gastroenterologists. PMID: 30135345 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Nagaoka R, Sugitani I, Sanada M, Jikuzono T, Okamura R, Igarashi T, Akasu H, Shimizu K Tags: J Nippon Med Sch Source Type: research

Subcuticular Suturing with Closed Suction Drainage for Wound Closure Following Stoma Reversal.
Abstract Incisional surgical site infection (SSI) is a leading complication of stoma reversal procedures. This retrospective study was conducted to assess the incidence of incisional SSI and other wound complications when wound closure was achieved by subcuticular suturing and closed suction drainage following stoma reversal. We analyzed data from a total of 49 patients, all of whom had undergone insertion of a 10 Fr closed suction drainage tube in the fascia, following irrigation with approximately 300 mL of physiological saline. We then performed subcuticular suturing with 4-0 monofilament absorbable sutures. Th...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Yoshimatsu K, Sagawa M, Yokomizo H, Yano Y, Okayama S, Satake M, Yamada Y, Matsumoto A, Shiozawa S, Shimakawa T, Katsube T, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.
CONCLUSION: These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains. PMID: 30135347 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Tsuno K, Miyatake C, Nishijima H, Hotta C, Ogawa T, Asano T Tags: J Nippon Med Sch Source Type: research

Diabetes Insipidus Presenting with Oligohydramnios and Polyuria During Pregnancy.
We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3.24. A vasopressin challenge test was performed and her urine osmolality increased by>100% from baseline after the administration of desmopressin. Because central DI or transient DI of pregnancy was suspected, we prescribed her a de...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Choi HS, Kim YH, Kim CS, Ma SK, Kim SW, Bae EH Tags: J Nippon Med Sch Source Type: research