Correlation between Pathological Findings and the Usefulness of Clinical Guidelines for the Treatment of ANCA-Positive RPGN: A Retrospective Analysis.
Abstract BACKGROUND: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments. The aim of this study was to assess the correlation between the pathological findings and...
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Yamada T, Kashiwagi T, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells.
CONCLUSION: EM900 showed an anti-inflammatory effect, such as that of CAM, due to the inhibitory effect on IL-8 production in HNEpCs. PMID: 30464143 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Ōmura S Tags: J Nippon Med Sch Source Type: research

Challenges in the Diagnosis of bone Metastasis in Patients without a History of Malignancy at Their First Clinic Visit.
CONCLUSIONS: Diagnosis of bone metastasis is challenging in patients without a history of malignancy at their first visit. For early diagnosis, it is important to recognize this challenge and to keep it in mind together with ongoing observation. PMID: 30464144 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Kitagawa Y, Ito T, Mizuno Y, Sudo Y, Kim Y, Tsunoda R, Miyamoto M, Takai S Tags: J Nippon Med Sch Source Type: research

Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids.
We report two cases of granular cell tumors (GCTs) arising on rare sites, namely, the nape and umbilicus. While GCTs have a very characteristic histology, their clinical signs and symptoms are non-specific. Therefore, it is extremely difficult to make a diagnosis of GCT on the basis of clinical findings only. The two cases reported here were clinically similar to hypertrophic scars and keloids, respectively. Skin surgeons should remember that GCTs are an important differential diagnosis from hypertrophic scars and keloids. PMID: 30464145 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Tosa M, Ansai SI, Ogawa R Tags: J Nippon Med Sch Source Type: research

Two Cases of Sclerotic Fibroma of the Skin that Mimicked Keloids Clinically.
We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Both cases were clinically similar to keloids. Skin surgeons should remember that SFSs are an important differential diagnosis from keloids. PMID: 30464146 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Tosa M, Ansai SI, Kuwahara H, Akaishi S, Ogawa R Tags: J Nippon Med Sch Source Type: research

Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
CONCLUSIONS: The risk of PCOS developing in patients with epilepsy is known to be high, and the association of VPA with PCOS is well established, so if physicians feel this is the best drug to prescribe for female patients with epilepsy, they should carefully monitor the patients' weight and menstruation, and immediately perform ovarian imaging and hormonal examinations if any abnormalities are observed. PMID: 30464147 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Kawakami Y, Fujii S, Ishikawa G, Sekiguchi A, Nakai A, Takase M Tags: J Nippon Med Sch Source Type: research

Small Cell Lung Cancer with Sarcoidosis in Spontaneous Remission: A Case Report.
Abstract A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. The pulmonary sarcoidosis did not show any deterioration despite the frequent use of amrubicin, which is known to be a cause of interstitial pneumonia. This is a case report of SCLC complicated with sarcoidosis ...
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Sasaki Y, Koga Y, Kasahara N, Hachisu Y, Murata K, Tsurumaki H, Yatomi M, Tsukagoshi Y, Sawada Y, Sakurai R, Ono A, Sunaga N, Kaira K, Hirato J, Maeno T, Dobashi K, Hisada T Tags: J Nippon Med Sch Source Type: research

Congenital Mesoblastic Nephroma Presenting with Hematuria in a Neonate.
Abstract Congenital mesoblastic nephroma (CMN) is a rare tumor of infancy. CMNs can be histologically divided into classic, cellular, and mixed subtypes. Cellular CMNs are difficult to differentiate from Wilms tumors. Herein, a neonate with cellular CMN accompanied by macroscopic hematuria, is described. The clinical, pathological, and imaging features of the disease are discussed. PMID: 30464149 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 24, 2018 Category: Universities & Medical Training Authors: Wang H, Yao Z, Liu Q Tags: J Nippon Med Sch Source Type: research

Evaluation of the Role of Balneotherapy in Rehabilitation Medicine.
Abstract Balneotherapy is a treatment with healing waters, which includes bathing and physiotherapy in thermal water, therapeutic drinks, medical massage, and water jet massage. It is based on the buoyancy, physical properties, temperature, and chemical effects of mineral water. Throughout European and Japanese medical institutions, balneology and hot spring therapy is very much a part of routine medical treatment. The mechanism of balneotherapy is not yet completely understood. Balneotherapeutic procedures are mainly performed for the prevention, treatment, and rehabilitation of musculoskeletal diseases, but they...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Matsumoto S Tags: J Nippon Med Sch Source Type: research

Early Transcatheter Arterial Embolization for the American Association for the Surgery of Trauma Grade 4 Blunt Renal Trauma in Two Institutions.
Abstract OBJECTIVES: To evaluate the efficacy of early transcatheter arterial embolization for hemodynamically stable patients with The American Association for the Surgery of Trauma (AAST) grade 4 blunt renal trauma. MATERIALS AND METHODS: The medical records of consecutive patients with grade 4 blunt renal trauma who were transported to our two critical care centers in Japan and treated with early transcatheter arterial embolization (TAE) between 2001 and 2013 were retrospectively reviewed. Treatment failure was defined as the need for further surgical intervention or re-embolization after initial embolizat...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yanagi M, Suzuki Y, Hamasaki T, Mizunuma K, Arai M, Yokota H, Murata S, Kondo Y, Nishimura T Tags: J Nippon Med Sch Source Type: research

Pulmonary Dysfunction Function and Poor Nutritional Status are Risk Factors for Remote Infections Following Surgery for Colorectal Cancer.
CONCLUSION: RI is caused by poor nutrition, immune system dysfunction and pulmonary dysfunction. PMID: 30259889 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Sagawa M, Yoshimatsu K, Yokomizo H, Yano Y, Okayama S, Yamada Y, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Kato H, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Inhibitory Effects of S-carboxymethylcystein on Goblet Cell Proliferation in Cultured Epithelium.
CONCLUSION: TNF-α promoted goblet cell proliferation in nasal polyps, suggesting its influence on nasal polyp formation. As S-CMC inhibited inflammatory stimulation-induced goblet cell proliferation in nasal polyp epithelium, it may be useful for the treatment of sinusitis. PMID: 30259890 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yamaguchi S, Matsune S, Sekine K, Wakayama N, Kitayama Y, Nakamura Y, Okubo K Tags: J Nippon Med Sch Source Type: research

Evaluation of the Impact of Preoperative Values of Hyaluronic Acid and Type IV Collagen on the Outcome of Patients with Hepatocellular Carcinoma After Hepatectomy.
CONCLUSIONS: Preoperative examinations of serum hyaluronic acid levels and type IV collagen levels are imperative for hepatic resection for HCC because these markers are significantly associated with liver function and prognosis. PMID: 30259891 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Ueda J, Yoshida H, Mamada Y, Taniai N, Yoshioka M, Hirakata A, Kawano Y, Shimizu T, Kanda T, Takata H, Uchida E Tags: J Nippon Med Sch Source Type: research

A Case of Infundibulocystic Basal Cell Carcinoma Clinically Mimicking a Melanocytic Nevus Associated with Epidermal Cysts.
This report presents a case of IFC-BCC that clinically mimicked a melanocytic nevus and was also associated with epidermal cysts. PMID: 30259892 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Kawasaki Y, Ansai SI, Fujimoto K, Saeki H, Kawana S Tags: J Nippon Med Sch Source Type: research

Trans-scaphoid Perilunate Fracture-dislocation with Concomitant Lunotriquetral Ligament Disruption: A Case Report.
We report a case of trans-scaphoid perilunate fracture-dislocation with concomitant lunotriquetral ligament disruption of the right wrist in a 44-year-old man, sustained from a 10-m fall landing on his outstretched right hand. Open reduction was performed 1 day after injury; at first the palmar dislocation of the lunate was reduced with the palmar approach. Under direct view with the dorsal approach, the scaphoid was comminuted and then treated with open reduction and internal fixation with a double threshold screw using a dorsal approach and a bone graft from the distal radius. Although the scapholunate ligament was intac...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Sonoki K, Tomori Y, Obara Y, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

A Case of Primary Malignant Lymphoma of the Prostate Gland Presenting as Right Lower Back Pain and Dysuria.
Abstract A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis and a large pelvic large mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate was palpable on digital rectal examination. A prostate tumor was suspected, and a transrectal prostate biopsy and right transurethral ureteral stent placement were performed. Histological and immunohistochemical studies revealed diffuse large B-cell lymphoma. Positron emission tomography-computed tomography showed abnormal uptake in the stomach, ...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yasuoka S, Kimura G, Toyama Y, Moriya K, Takahashi K, Matsuoka R, Shibayama K, Obayashi K, Inoue Y, Shindo T, Iigaya S, Endo Y, Akatsuka J, Hayashi T, Nakayama S, Hamasaki T, Inokuchi K, Kondo Y Tags: J Nippon Med Sch Source Type: research

An 8-Year-Old Girl with Autoimmune Hepatitis Following Aplastic Anemia.
Abstract We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy. PMID: 30259895 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Nishigori A, Hatori T, Asano T Tags: J Nippon Med Sch Source Type: research

Plasma Adsorption Membranes Are Able to Efficiently Remove High Mobility Group Box-1 (HMGB-1).
CONCLUSIONS: Our findings showed that plasma adsorption therapy efficiently adsorbed HMGB-1 and could be safely applied for the treatment of sepsis. PMID: 30135341 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Onohara T, Sakamoto Y, Inoue S Tags: J Nippon Med Sch Source Type: research

Objective Colorimetric Evaluation of Aging-related Articular Cartilage Degeneration.
CONCLUSIONS: This study developed an original colorimetric device with high validity. Browning of articular cartilage increased with age, but this study did not detect pentosidine-caused browning. Further study is needed to clarify the factors associated with browning of cartilage. PMID: 30135342 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Satake Y, Takahashi K, Saito M, Takai S Tags: J Nippon Med Sch Source Type: research

Arthroscopic Coracoclavicular Ligament Reconstruction for Acromioclavicular Joint Dislocation.
CONCLUSION: ACCLR for acute dislocation of the ACJ is a useful surgical procedure that gives satisfactory clinical and radiologic outcomes on mid- and long-term follow-up. ACCLR can stabilize vertical instability of the ACJ. If instability in the horizontal direction remains, repair or reconstruction of the acromioclavicular ligament should be added to prevent osteoarthritic changes of the ACJ. PMID: 30135343 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Abe K, Sonoki K, Yoneda M, Takai S Tags: J Nippon Med Sch Source Type: research

Cutaneous Vasculitis in Cogan's Syndrome: A Report of Two Cases Associated with Chlamydia Infection.
Abstract Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis. Here, we report two cases of CS, one of which involved a patient who developed the typical sympto...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Kawasaki Y, Uehara T, Kawana S Tags: J Nippon Med Sch Source Type: research

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.
CONCLUSIONS: In our patients with MEN2B, prophylactic or early thyroidectomy could not be performed. The characteristic phenotype associated with MEN2B is almost always seen prior to detection of MTC or pheochromocytoma. Knowledge about the non-endocrine manifestations of MEN2B needs to be shared among pediatricians and gastroenterologists. PMID: 30135345 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Nagaoka R, Sugitani I, Sanada M, Jikuzono T, Okamura R, Igarashi T, Akasu H, Shimizu K Tags: J Nippon Med Sch Source Type: research

Subcuticular Suturing with Closed Suction Drainage for Wound Closure Following Stoma Reversal.
Abstract Incisional surgical site infection (SSI) is a leading complication of stoma reversal procedures. This retrospective study was conducted to assess the incidence of incisional SSI and other wound complications when wound closure was achieved by subcuticular suturing and closed suction drainage following stoma reversal. We analyzed data from a total of 49 patients, all of whom had undergone insertion of a 10 Fr closed suction drainage tube in the fascia, following irrigation with approximately 300 mL of physiological saline. We then performed subcuticular suturing with 4-0 monofilament absorbable sutures. Th...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Yoshimatsu K, Sagawa M, Yokomizo H, Yano Y, Okayama S, Satake M, Yamada Y, Matsumoto A, Shiozawa S, Shimakawa T, Katsube T, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.
CONCLUSION: These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains. PMID: 30135347 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Tsuno K, Miyatake C, Nishijima H, Hotta C, Ogawa T, Asano T Tags: J Nippon Med Sch Source Type: research

Diabetes Insipidus Presenting with Oligohydramnios and Polyuria During Pregnancy.
We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3.24. A vasopressin challenge test was performed and her urine osmolality increased by>100% from baseline after the administration of desmopressin. Because central DI or transient DI of pregnancy was suspected, we prescribed her a de...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Choi HS, Kim YH, Kim CS, Ma SK, Kim SW, Bae EH Tags: J Nippon Med Sch Source Type: research

Current Practice and Outcomes of Peritoneal Dialysis in the Nippon Medical School Musashi Kosugi Hospital.
CONCLUSION: The findings of this study revealed that assessment of the nutritional status of the patient and prevention of peritonitis are important for continuation of PD. PD is a safe treatment option that can maintain the quality of life in elderly patients. In a rapidly aging society, the need for PD-based medical care is expected to increase. PMID: 29731493 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Sumi Y, Sakai Y, Mugishima K, Suzuki A, Otsuka Y, Otsuka T, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Variation in the Phenotype of Photosensitive Cells Produced from Human Fibroblast Cell Lines.
CONCLUSIONS: These results suggest that photosensitive cells produced from different cell lines by direct reprogramming might express different phenotypes. PMID: 29731494 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Ishii T, Yin C, Seko Y, Umezawa A, Kaneda M Tags: J Nippon Med Sch Source Type: research

A Case of Sj ögren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis.
A Case of Sjögren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. J Nippon Med Sch. 2018;85(2):117-123 Authors: Yamada T, Fukui M, Kashiwagi T, Arai T, Itokawa N, Atsukawa M, Shimizu A, Tsuruoka S Abstract A 61-year-old woman was admitted to our hospital because of muscle paralysis and was found to have severe hypokalemia. A gallium-67 scintigram revealed a positive accumulation in the bilateral salivary glands, and a labial minor salivary gland biopsy demonstrated a massive lymphocyte infiltrate around the salivary ducts. She was diagnosed with Sjö...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Yamada T, Fukui M, Kashiwagi T, Arai T, Itokawa N, Atsukawa M, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Aeromedical Transport Operations Using Helicopters during the 2016 Kumamoto Earthquake in Japan.
Abstract More than 6,000 people died in the Great Hanshin (Kobe) Earthquake in 1995, and it was later reported that there were around 500 preventable trauma deaths. In response, the Japanese government developed the helicopter emergency medical service in 2001, known in Japan as the "Doctor-Heli" (DH), which had 46 DHs and 2 private medical helicopters as of April 2016. DHs transport physicians and nurses to provide pre-hospital medical care at the scene of medical emergencies. Following lessons learned in the Great East Japan Earthquake in 2011, a research group in the Ministry of Health, Labour and Wel...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Motomura T, Hirabayashi A, Matsumoto H, Yamauchi N, Nakamura M, Machida H, Fujizuka K, Otsuka N, Satoh T, Anan H, Kondo H, Koido Y Tags: J Nippon Med Sch Source Type: research

Lysosomal Acid Lipase Deficiency in Japan: A Case Report of Siblings and a Literature Review of Cases in Japan.
We report on two siblings with early onset lysosomal acid lipase deficiency or Wolman disease. Their parents had a consanguineous marriage. The children showed evidence of abdominal distension and failed to thrive, despite having regular nutrition. At 3-4 months of age, their abdominal distension and jaundice progressed rapidly and they died of liver failure. Sebelipase alfa, a recombinant form of human lysosomal acid lipase has recently been used as an enzyme replacement therapy in patients with later-onset cholesteryl ester storage disease. Therefore, we investigated cases of lysosomal acid lipase deficiency in Japan and...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Ikari N, Shimizu A, Asano T Tags: J Nippon Med Sch Source Type: research

A Case of Anti-Glomerular Basement Membrane Antibody-Positive Systemic Lupus Erythematosus with Pulmonary Hemorrhage Successfully Treated at an Early Stage of the Disease.
We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum creatinine. Serological tests revealed elevated titers...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Yamada T, Mugishima K, Higo S, Yoshida Y, Itagaki F, Yui S, Kashiwagi T, Endo Y, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Mixed Cryoglobulinemic Vasculitis: A Case Report.
PMID: 29731499 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Hirama A, Mii A, Arakawa Y, Funakoshi T, Ko M, Sakai Y, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Sleep-Disordered Breathing-a Real Therapeutic Target for Hypertension, Pulmonary Hypertension, Ischemic Heart Disease, and Chronic Heart Failure?
Abstract Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Nakamoto T Tags: J Nippon Med Sch Source Type: research

SFRP1 Promoter Methylation and Renal Carcinoma Risk: A Systematic Review and Meta-Analysis.
CONCLUSION: Our results indicate that the methylation level of the SFRP1 promoter region is increased in patients with RCC compared to normal controls and might be involved in the occurrence and development of RCC. Additional well-designed studies are needed to further verify our conclusions. PMID: 29731501 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Mo S, Su Z, Heng B, Chen W, Shi L, Du X, Lai C Tags: J Nippon Med Sch Source Type: research

Idiopathic Ventricular Premature Contraction and Ventricular Tachycardia: Distribution of the Origin, Diagnostic Algorithm, and Catheter Ablation.
Abstract Idiopathic ventricular premature contractions (VPCs), defined as VPCs in the absence of obvious structural heart disease, are one of the common types of arrhythmia in clinical practice. They are sometimes complicated with non-sustained ventricular tachycardia (VT), and/or sustained VT with almost same QRS morphology in 12 leads ECG. Idiopathic VT (IVT) commonly occurs by focal mechanisms and the origins are distributed in a variety of sites in both ventricles. In this article, the clinical characteristics of IVT/IVPCs, the diagnostic algorithm, and how to ablate them will be reviewed. PMID: 29731502 ...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Kobayashi Y Tags: J Nippon Med Sch Source Type: research

Evaluation of Teneligliptin Effects on Transcriptional Activity of PPAR γ in Cell-Based Assays.
CONCLUSION: We found that teneligliptin could increase PPARγ activity in cell-based assays irrespective of the PPARγ ligand-binding domain. PMID: 29731503 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Takenaka Y, Inoue I, Nakano T, Ikeda M, Kakinuma Y, Ikegami Y, Shimada A, Noda M Tags: J Nippon Med Sch Source Type: research

Sudden Cardiac Death from the Perspective of Nonlinear Dynamics.
This study models the hemodynamics, consisting of heart rate, SNA, and blood pressure (BP), by modifying a known chaotic electrical circuit, the Chua circuit. A V-trough of the SNA appears when the resistive element between the SNA and BP in the circuit is increased, which corresponds to the impaired regulation of BP by the SNA. This finding is consistent with an acknowledged finding that a depressed baroreflex (a reflex of the BP by SNA) may trigger a lethal arrhythmia. This study indicates that a V-trough of the SNA is a possible precursor of sudden cardiac death on the basis of experimental and clinical findings as well...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Osaka M Tags: J Nippon Med Sch Source Type: research

Management of Anaplastic Thyroid Carcinoma: the Fruits from the ATC Research Consortium of Japan.
Abstract Anaplastic thyroid carcinoma (ATC) accounts for only 1 to 2% of all thyroid carcinomas, but it is one of the most lethal neoplasms in humans. To obtain further insights into this "orphan disease," we have established the ATC Research Consortium of Japan (ATCCJ) in 2009. It represents a multicenter registry for ATC that have been treated in Japan. To date, 67 institutions have taken part in the collaborative research system and over 1,200 cases have been accumulated in its database. Using this big data, several retrospective studies were carried out to evaluate 1) prognostic factors to determine ...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Sugitani I, Onoda N, Ito KI, Suzuki S Tags: J Nippon Med Sch Source Type: research

Dual Factors May Be Necessary for Development of Atopic March in Early Infancy.
Abstract The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging. Development of these diseases is strongly influenced by the fol...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Taniuchi S, Soejima K, Hatano Y, Takahashi M, Minami H Tags: J Nippon Med Sch Source Type: research

Contrast-Enhanced High-Resolution MRI for Evaluating Time Course Changes in Middle Cerebral Artery Plaques.
CONCLUSION: Gadolinium contrast enhancement was found to be useful for effective evaluation of time course changes in the stability of symptomatic MCA stenotic plaques. PMID: 29540643 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Abe A, Sekine T, Sakamoto Y, Harada-Abe M, Takagi R, Suda S, Suzuki K, Aoki J, Yoneyama M, Kimura K Tags: J Nippon Med Sch Source Type: research

The Incidence of Pediatric Invasive Bacterial Diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the Introduction of Conjugate Vaccines.
Abstract The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Sano T, Suzuki T, Nishigori A, Miyatake C, Koizumi S, Kaizu K, Fujita A, Kamisago M, Chang B, Ishiwada N, Asano T Tags: J Nippon Med Sch Source Type: research

Sphingosine-1-Phosphate (S1P) Is a Feasible Biomarker in Predicting the Efficacy of Polymyxin B-Immobilized Fiber Direct Hemoperfusion (PMX-DHP) in Patients with Septic Shock.
CONCLUSION: S1P levels prior to PMX-DHP can be used to predict its efficacy. In addition, continuous monitoring of S1P levels can indicate the effectiveness of PMX-DHP in patients with septic shock. PMID: 29540645 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Inoue S, Sakamoto Y, Koami H, Yamada C K, Nagashima F, Miike T, Iwamura T, Obata T Tags: J Nippon Med Sch Source Type: research

Two Cases of Verrucous Carcinoma: Revisiting the Definition.
Abstract Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin. Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Histopathologically, epithelial tumor cells grew pushing the stroma, while the basement membrane was intact. No prominent cellular atypia or hyperchromatin was found. Case 2, a male patient, aged 53 years, had a verrucous plaque at the border between his scrotum and inner aspect of his thigh. A pathological diagno...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Shimizu A, Hoashi T, Kataoka K, Shirakawa N, Mayumi N, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report.
Abstract Carcinosarcoma (CS) is a rare tumor, consisting of both carcinomatous and sarcomatous components. In this paper, we present a case of CS arising from a pleomorphic adenoma (PA) of the submandibular gland. A 64-year-old Japanese man presented with a left submandibular mass that had developed for 20 years with complaints of pain for the last 3 months. Magnetic resonance imaging showed a lesion involving the left submandibular gland. The patient underwent total dissection of the left submandibular gland and left cervical lymph nodes. Upon gross examination, the mass appeared completely covered by fibroadipos...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Endo Y, Ohashi R, Inai S, Yokoshima K, Nakamizo M, Shimizu A, Okubo K, Naito Z Tags: J Nippon Med Sch Source Type: research

Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency.
We describe an adult case of purpura fulminans developing in association with AT 3 deficiency without infection following a surgical procedure, and acute kidney injury (AKI) developing secondary to rhabdomyolysis and disseminated intravascular coagulation (DIC). To the best of our knowledge there have been no previous cases of purpura fulminans and AKI developing in association with acquired AT 3 deficiency without infection after surgery. PMID: 29540648 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Özkan G, Kübra Emeksiz G, Volkan Atar R, Sedef S, Sonat Kara P, Öznur M, Turgut B Tags: J Nippon Med Sch Source Type: research

Irreducible Elbow Fracture and Dislocation due to Incarceration of the Medial Epicondyle of the Humerus in a Child.
We report a case of an irreducible elbow fracture and dislocation due to incarceration of the medial epicondyle fragment of the humerus, classified as a Watson-Jones type 3 fracture of the medial epicondyle, and present the mechanism of the intra-articular incarceration of the medial epicondyle fragment. The patient was a 9-year-old boy who injured his right elbow in a fall, and was diagnosed with a Watson-Jones type 3 fracture of the medial epicondyle. As we could not achieve a good reduction under fluoroscopic imaging, surgery was immediately performed using a medial approach. We discovered that the incarcerated fracture...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Satake Y, Tomori Y, Sawaizumi T, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

Pharmacotherapy for Neuropathic Pain in Japan.
Abstract Neuropathic pain (NeP) results from injury to, or disease of, the peripheral or central components of the neural systems involved in pain. In contrast to inflammatory pain, NeP can persist after healing from the initial injury has resolved. Antipyretic agents, such as non-steroidal anti-inflammatory drugs, steroids, and acetaminophen are ineffective, while specific agents such as gabapentinoids, antidepressants, antiepileptics, and opioids are effective in treating NeP. In this review, we address the definition of NeP, pharmacotherapy for NeP in Japan, pain classification, setting goals for successful NeP...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Masuda R, Ajimi J, Murata T Tags: J Nippon Med Sch Source Type: research

Lymphangiography Was Useful in Postoperative Intractable Chylothorax after Surgery for Esophageal Cancer: A Case Report.
This report describes a 72-year-old man with Stage III esophageal squamous cell carcinoma. Subtotal esophagectomy, through a right thoracoabdominal approach with two-field lymphadenectomy, and cervical esophagogastric anastomosis via the retrosternal route, were performed. On the 12th postoperative day, a diagnosis of chylothorax was made. Conservative treatment was initiated, but it proved to be ineffective. Therefore, ligation of the thoracic duct via a thoracotomy was performed, but this was not effective, either. Lymphangiography undertaken to identify the site of the leak in the thoracic duct enabled a diagnosis of an...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Shimakawa T, Naritaka Y, Miyazawa M, Asaka S, Shimazaki A, Yamaguchi K, Yokomizo H, Yoshimatsu K, Shiozawa S, Katsube T Tags: J Nippon Med Sch Source Type: research

Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility.
CONCLUSIONS: The measurement of genetic polymorphisms in metabolizing enzymes of tacrolimus, within one medical facility, is applicable for the selection of immunosuppressants and individual dosing for the treatment of autoimmune disease. PMID: 29279557 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kaneko T, Arai M, Watanabe A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case Report.
We report a case of concurrent bilateral hip arthroscopy for symptomatic bilateral femoroacetabular impingement (FAI) performed under the single anesthesia on an elite rugby player. A 27-year-old rugby player who played for a top league had bilateral hip joint pain. Physical examination revealed bilateral tenderness in the anterior area of the hips, with positive impingement signs. Based on the findings of hip radiography and magnetic resonance imaging, the patient's symptoms were diagnosed as bilateral FAI with hip labral tears. Bilateral hip arthroscopy under the single anesthesia was performed due to refractory symptoms...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Chinzei N, Hashimoto S, Hayashi S, Kanzaki N, Araki D, Kuroda R, Kurosaka M Tags: J Nippon Med Sch Source Type: research