A Review of the Active Treatments for Toxic Epidermal Necrolysis.
Abstract Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with the separation of skin and mucous membranes at the dermal-epidermal junction. Although it is rare, many treatments have been trialed because of its high mortality rate. Active interventions performed to date include the use of systemic corticosteroids, intravenous immunoglobulins (IVIg), cyclosporine, plasmapheresis, anti-tumor necrosis factor drugs and N-acetylcysteine, but none has been established as the most effective therapy. IVIg and short-term high-dose corticosteroids were regarded as the most promising treatments f...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Kinoshita Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Ultrasonography-Based Classification and Reporting System for the Malignant Risk of Thyroid Nodules.
CONCLUSIONS: The TI-RADS classification used in this study is relatively simple and provides a reliable measure of the risk of malignancy of thyroid nodules. PMID: 28724845 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Xue E, Zheng M, Zhang S, Huang L, Qian Q, Huang Y Tags: J Nippon Med Sch Source Type: research

Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects.
CONCLUSION: Nine months of treatment with orlistat and sibutramine not only reduced weight but also significantly improved BMI, WC, BF, VF, FPG, adiponectin, fasting insulin, HOMA%B, HOMA%S, HOMA-IR and hs-CRP. These improvements could prove useful in the reduction of metabolic and cardiovascular risks in obese subjects. PMID: 28724846 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Al-Tahami BAM, Al-Safi Ismail AA, Sanip Z, Yusoff Z, Shihabudin TMT, Singh TSP, Rasool AHG Tags: J Nippon Med Sch Source Type: research

A Case of Primary Bacterial Pericarditis with Recurrent Cardiac Tamponade.
We present a 49-year-old man with bacterial pericarditis and recurrent cardiac tamponade, which was caused by the rupture of an upper part of the left atrium (LA). According to the autopsy findings, bacteremia from Staphylococcus aureus developed on a substrate of poorly controlled diabetes mellitus and spread to the pericardium via the blood. Subsequently, tissue necrosis developed from the pulmonary trunk and aorta to the LA, leading to recurrence of cardiac rupture and cardiac tamponade. PMID: 28724847 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Yoshizane T, Yamamoto T, Hayashi H, Kitamura M, Miyachi H, Hosokawa Y, Akutsu K, Shimizu W Tags: J Nippon Med Sch Source Type: research

Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review.
Abstract Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissu...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Matsuhashi T, Matsui R, Hasegawa C, Hatori T, Kamoi S, Takeshita T Tags: J Nippon Med Sch Source Type: research

The Ilizarov Mini-External Fixator for the Treatment of First Metatarsal Fracture: A Case Report.
Abstract Forefoot fractures are frequently accompanied by severe soft tissue damage. Therefore, treatment should focus not only on fractures but also on soft tissue damage, for which external fixation can be used as a surgical option. A 63-year-old woman presented to the emergency clinic of our hospital with forefoot pain after a motorcycle accident. Comminuted fracture of the proximal part of the metatarsal was diagnosed. Because of the swollen foot and fracture comminution, an operation using the Ilizarov mini external fixator was performed to prevent further damage to the soft tissue. Weight-bearing was permitt...
Source: Journal of Nippon Medical School - July 22, 2017 Category: Universities & Medical Training Authors: Kataoka T, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

A Complicated Case of Pregnancy Involving a Presacral Epidermoid Cyst.
Abstract Although presacral developmental cysts, including epidermoid cysts, are relatively rare diseases, an intrapelvic mass found for the first time in early pregnancy should be followed-up with the possibility of presacral developmental cysts in mind to be alert to the signs of local infection and malignancy. We treated a pregnant patient with presacral cystic disease. During pregnancy, percutaneous fenestration was performed because the cyst caused severe compression symptoms and complicated bacterial infection. Laparoscopic total cyst excision was performed after cesarean section. There is no suggested crite...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Shigemi D, Kamoi S, Matsuda A, Takeshita T Tags: J Nippon Med Sch Source Type: research

Squamous Cell Carcinomas on Bilateral Feet Arising in Long-Standing Eczematous Lesions.
We present a woman with squamous cell carcinomas on both feet in long-standing eczematous lesions. Histopathological examination of biopsies from the both feet revealed highly atypical cells invading the reticular layer of the dermis in the hyperkeratotic lesion and they were associated with surrounding dermatitis with spongiosis. Although the cause and etiology of eczema in our case is unclear, we speculate that the exceptionally long-lasting dermatitis might have induced double SCCs on bilateral feet with an unusual constitution. To the best of our knowledge, this is a first case of SCC on bilateral feet arising in long-...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Yamase A, Funasaka Y, Ueno T, Ito M, Otsuka Y, Kawana S, Saeki H Tags: J Nippon Med Sch Source Type: research

Circulating Anti-Nuclear Antibodies in Systemic Sclerosis: Utility in Diagnosis and Disease Subsetting.
Abstract The presence of circulating anti-nuclear antibodies (ANAs) is a hallmark of immune dysregulation in patients with systemic sclerosis (SSc). Currently, a variety of SSc-specific ANAs, including anticentromere, anti-topoisomerase I, and anti-RNA polymerase III antibodies, have been well characterized, and their commercial kits are available worldwide. Since these autoantibodies are specifically detected in SSc patients and are associated with unique sets of disease manifestations, they are widely used in routine clinical practice for diagnosis, clinical subgrouping, and prediction of future organ involvemen...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Kuwana M Tags: J Nippon Med Sch Source Type: research

Haptoglobin Reduces Inflammatory Cytokine INF- γ and Facilitates Clot Formation in Acute Severe Burn Rat Model.
Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model. J Nippon Med Sch. 2017;84(2):64-72 Authors: Koami H, Sakamoto Y, Miyasho T, Noguchi R, Sato N, Kai K, Chris Yamada K, Inoue S Abstract Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Miyasho T, Noguchi R, Sato N, Kai K, Chris Yamada K, Inoue S Tags: J Nippon Med Sch Source Type: research

Treatment Results of Transurethral Resection of the Prostate by Non-Japanese Board-Certified Urologists for Benign Prostate Hyperplasia: Analysis by Resection Volume.
CONCLUSIONS: In this study, TURP performed by non-Japanese board-certified urologists was relatively safe and achieved sufficient efficacy. Cases with resection volume less than 20 g appear the most appropriate for non-Japanese board-certified urologists. PMID: 28502962 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Suzuki Y, Toyama Y, Nakayama S, Nomura S, Minowa T, Tanabe K, Kondo Y Tags: J Nippon Med Sch Source Type: research

A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest.
We report a case of syringocystadenoma papilliferum (SCAP) combined with tubular papillary adenoma (TPA) arising on the chest of a 45-year-old Japanese woman. Histopathological examination revealed the characteristic findings of SCAP in the superficial part of the lesion and those of TPA in the deeper part. We reviewed the English literature about this combination. SCAP and TPA have the same cellular components, but show differences of the general structure. The combination of these two neoplasms is more frequent than expected by most dermatopathologists or pathologists. This combination is frequently seen in patients with...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Ito K, Ansai SI, Saeki H Tags: J Nippon Med Sch Source Type: research

Primary Volvulus of the Small Intestine Exhibiting Chylous Ascites: A Case Report.
Abstract BACKGROUND: Primary volvulus of the small intestine associated with chylous ascites is very rare, with only four reported cases. In this paper, we report a new case of primary volvulus associated with chylous ascites. CASE PRESENTATION: The patient was a 70-year-old man. After experiencing bloating and abdominal pain for several hours, he called an ambulance and underwent an emergency examination at our hospital. Abdominal distension, pressure pain, and rebound tenderness were observed throughout his entire abdomen. The patient had a history of hypertension for which he was receiving oral treatment. ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Hayama T, Shioya T, Hankyo M, Shimizu T, Shibuya H, Komine O, Watanabe Y, Nanbu K, Yamada T Tags: J Nippon Med Sch Source Type: research

Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma with a Nodular Opacity: Report of a Case.
Abstract Herein, we describe our experience in treating a case of primary pulmonary mucosa-associated lymphoid tissue lymphoma detected as a nodular opacity. A 79-year-old man was referred to our hospital. Computed tomography showed a nodular opacity measuring 20 mm in diameter with regular margins in segment 5 of the right middle lobe of the lung. Although the bronchoscopic brush cytology result was class III, the patient was tentatively diagnosed with suspected mucosa-associated lymphoid tissue lymphoma. A thoracoscopic right middle lobectomy was performed. The pathological findings showed nodular proliferation ...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Yoshino N, Hirata T, Takeuchi C, Usuda J, Hosone M Tags: J Nippon Med Sch Source Type: research

Laparoscopic Repair of Vaginal Evisceration after Abdominal Hysterectomy for Uterine Corpus Cancer: A Case Report and Literature Review.
Abstract Vaginal cuff dehiscence is a rare but serious complication that can develop after hysterectomy. Emergent surgical intervention is required for vaginal cuff dehiscence due to the potential subsequent vaginal evisceration, which may lead to necrosis of the small bowel. A 62-year-old nulliparous woman with a 30-year history of smoking, diabetes mellitus, and rheumatoid arthritis (treated with oral steroids) presented with a vaginal cuff dehiscence. Thirty-eight days before the admission, she had undergone a radical operation including total abdominal hysterectomy for uterine corpus cancer at another hospital...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Matsuhashi T, Nakanishi K, Hamano E, Kamoi S, Takeshita T Tags: J Nippon Med Sch Source Type: research

Neck and Occipital Pain Caused by Deep Cervical Intramuscular Lipoma: A Surgical Case.
We describe here a patient with a large intramuscular lipoma in the deep cervical tissue. The patient experienced troublesome pain in the neck and occipital area, and surgical treatment was therefore suggested. Particularly in the cervical area, intramuscular lipomas sometimes invade the surrounding muscles and tissue layers and develop into an irregular mass, despite being benign. In addition, the cervical area has one of the most complex muscle structures. Nevertheless, surgical management of intramuscular lipoma in the cervical and cranial area is sometimes indicated, for example, in patients with clinical symptoms or m...
Source: Journal of Nippon Medical School - May 17, 2017 Category: Universities & Medical Training Authors: Kogure K, Yamazaki M, Tamaki T, Node Y, Morita A Tags: J Nippon Med Sch Source Type: research

Delayed Expression of Circulating TGF- β1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing.
CONCLUSION: The expression levels of TGF-β1 and BMP-2 appeared to be delayed in nonunion patients which could play an important role in developing an early marker of fracture union condition and facilitate improved patient's management. PMID: 28331138 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Hara Y, Ghazizadeh M, Shimizu H, Matsumoto H, Saito N, Yagi T, Mashiko K, Mashiko K, Kawai M, Yokota H Tags: J Nippon Med Sch Source Type: research

Arthroscopic Removal and Tendon Repair for Refractory Rotator Cuff Calcific Tendinitis of the Shoulder.
CONCLUSION: When treating calcific tendinitis of the shoulder, it is important to accurately determine the size and location of calcific deposit by radiographs and 3-dimensional computed tomography. Satisfactory clinical and radiological outcomes can be expected after reliable removal of calcific deposit through a single longitudinal incision and side-to-side repair with strong sutures, in association with an appropriate rehabilitation program. PMID: 28331139 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Okubo A, Takai S Tags: J Nippon Med Sch Source Type: research

Management of Atopic Dermatitis in Japan.
Abstract The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and...
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Saeki H Tags: J Nippon Med Sch Source Type: research

Characteristics and Outcomes of Laparoscopic Surgery in Patients with Gastroesophageal Reflux and Related Disease: A Single Center Experience.
CONCLUSIONS: The characteristics of the patients who underwent LARS at our hospital differed according to pathophysiology and from those in western countries. Satisfactory outcomes depended on the pathophysiology of individual patients. PMID: 28331141 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Nomura T, Iwakiri K, Matsutani T, Hagiwara N, Fujita I, Nakamura Y, Kanazawa Y, Makino H, Kawami N, Miyashita M, Uchida E Tags: J Nippon Med Sch Source Type: research

Usefulness of Color Coding Resected Samples from a Pancreaticoduodenectomy with Tissue Marking Dyes for a Detailed Examination of Surgical Margin Surrounding the Uncinate Process of the Pancreas.
CONCLUSION: By subclassifying the MUP with tissue marking dyes of different colors, we could confirm regional characteristics of MUP (+). As a result, circumferential superior mesenteric arterial nerve plexus-preserving pancreticoduodenectomy was able to be performed in R0 operations in selected patients while a better postoperative quality of life was maintained. Furthermore, Area D (+) represents an extension beyond the limit of the local disease and may indicate the need for early aggressive adjuvant chemotherapy. PMID: 28331142 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Mizutani S, Suzuki H, Aimoto T, Yamagishi S, Mishima K, Watanabe M, Kitayama Y, Motoda N, Isshiki S, Uchida E Tags: J Nippon Med Sch Source Type: research

Chopstick Injury: Successful Stent-Graft Therapy for Traumatic Left Subclavian Artery Aneurysm.
We present an unusual case of a 19-year-old man who presented at the emergency department after being stabbed with a chopstick by his elder brother. Computed tomography revealed a left subclavian artery pseudoaneurysm, which increased from 4 mm to 7 mm in diameter within 47 days. We successfully deployed a Niti-S stent graft for the increasing aneurysm, thereby avoiding a surgical operation. Balloon angioplasty was added for re-stenosis 8 months after the first intervention. PMID: 28331143 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Ueda T, Tajima H, Murata S, Takagi R, Yokota H, Kumita SI Tags: J Nippon Med Sch Source Type: research

Totally Extraperitoneal (TEP) Removal of an Infected Mesh by Laparoscopy after Open Preperitoneal Repair: Initial Case Report.
Abstract Prosthetic mesh infection after open or laparoscopic hernia repair is a rare complication. Superficial wound infection can be resolved by treatment with a combination of antibiotics and wound drainage, whereas deep-seated mesh infection, which can lead to chronic groin sepsis, usually requires removal of the mesh. A 56-year-old Japanese man was admitted to our hospital for the treatment of deep-seated mesh infection. The patient had undergone inguinal hernia repair at another hospital 18 months earlier. The operation was prosthetic mesh repair via an anterior approach. The patient developed deep-seated me...
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Chihara N, Mishima K, Suzuki H, Watanabe M, Toyoda T, Uchida E Tags: J Nippon Med Sch Source Type: research

Modified Marionette Technique for Laparoscopic Colorectal Surgery.
CONCLUSION: The "modified marionette technique" using IOR introduced here is an easy, economical, effective and safe traction technique for colorectal surgeries. This technique will be a useful tool for performing both reduced port and multiport laparoscopic colorectal surgeries. PMID: 28331145 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 25, 2017 Category: Universities & Medical Training Authors: Shinji S, Kan H, Yamada T, Koizumi M, Yamagishi A, Yokoyama Y, Takahashi G, Iwai T, Hara K, Takeda K, Ohta K, Uchida E Tags: J Nippon Med Sch Source Type: research

Perivascular Hematoma along Pulmonary Artery Complicating Aortic Dissection.
PMID: 27890890 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Wakakuri H, Hyodo H, Ohara T, Yasutake M Tags: J Nippon Med Sch Source Type: research

Mid-Term Clinical Results of VerSys Hip System (Zimmer) Uncemented Total Hip Replacement Arthroplasty.
CONCLUSION: These data suggest that patients receiving VerSys Hip System uncemented THR demonstrate favorable results pertaining pain score and range of motion. However, high rate of intraoperative fracture and malalignment of implants, which may be at a risk of dislocation and/or polyethylene wear in future, suggests that this implant technique requires improvement. PMID: 27890891 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Hoshikawa N, Watanabe H, Takai S Tags: J Nippon Med Sch Source Type: research

A Survey of Actual Clinical Practice Concerning Blood Pressure Control among Patients with Hypertension in Kanagawa 2014.
Abstract We performed a cross-sectional survey to investigate actual clinical practice concerning blood-pressure control among patients with hypertension in Kanagawa. The guidelines of the Japanese Society of Hypertension (JSH) for the management of patients with hypertension were revised in 2014. From October 1 to November 30, 2014, questionnaires on the care of patients with hypertension were sent via post to members of the Kanagawa Physicians Association in Kanagawa Prefecture, Japan. -Data on 1,105 patients (mean age: 68.4±12.3 years, 537 men and 568 women) were obtained. The overall mean systolic blood...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Hatori N, Sakai H, Sato K, Miyajima M, Yuasa S, Kuboshima S, Kajiwara K, Hara Y, Minamizawa K, Miyakawa M Tags: J Nippon Med Sch Source Type: research

Successful Coil Embolization of an Aneurysm in the Arc of B ühler.
Successful Coil Embolization of an Aneurysm in the Arc of Bühler. J Nippon Med Sch. 2016;83(5):196-198 Authors: Sugihara F, Murata S, Uchiyama F, Watari J, Tajima H, Kumita SI Abstract In the present report, we describe a case of a patient with an asymptomatic aneurysm in the arc of Bühler (AOB), which was successfully treated by transcatheter arterial embolization. The patient presented with severe stenosis of the celiac trunk, which was suspected to be due to median arcuate ligament syndrome. Arteriography of the superior mesenteric artery indicated a rapid stream in an aneurysm in the AOB...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Sugihara F, Murata S, Uchiyama F, Watari J, Tajima H, Kumita SI Tags: J Nippon Med Sch Source Type: research

Clinical Complete Response from Chemotherapy in an Elderly Patient with Metastatic Gastric Cancer: A Case Report.
Abstract An 81-year-old man was admitted with upper abdominal pain and weight loss. Esophagogastroduodenoscopy revealed a large tumor located from the gastric angle to the body. Histological analysis of a biopsy revealed a moderately differentiated adenocarcinoma. Computed tomography revealed metastases in the liver and lung and the patient was subsequently diagnosed with metastatic advanced gastric cancer. He was treated with chemotherapy using S-1 (80 mg/m(2)) and cisplatin (CDDP) (60 mg/m(2)). Twenty-two months after chemotherapy, the gastric tumor, and the nodules in the liver and lung, had disappeared. We sub...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawagoe T, Maruki Y, Nagoya H, Kosugi Y, Akimoto T, Yamawaki H, Kodaka Y, Shimpuku M, Ueki N, Futagami S, Miyake K, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Efficacy of Computed Tomography-Guided Catheter Drainage as the Initial Intervention and of Omentopexy as the Staged Surgery for a Prosthetic Graft Infection of Very Late Onset.
Abstract On the basis of computed tomography (CT) examination, a prosthetic graft infection of very late onset was suspected in a 72-year-old man who had undergone replacement of an bifurcated prosthetic graft 6 years earlier because of an abdominal aortic aneurysm and bilateral common iliac artery aneurysms. Emergency CT-guided needle aspiration was performed, and analysis of directly aspirated fluid confirmed the rapid diagnosis. Instead of conventional emergency surgery, CT-guided catheter drainage was the initial treatment and led to the gradual improvement of symptoms and laboratory data. Elective staged surg...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Shirakawa M, Morota T, Sakamoto SI, Miyagi Y, Ishii Y, Nitta T Tags: J Nippon Med Sch Source Type: research

Interventional Treatment of Severe Portal Vein Thrombosis after Living-Donor Liver Transplantation.
In conclusion, repeated and assiduous interventional radiological treatment combined with thrombolytic therapy, thrombectomy, and metallic stent replacement could be important for severe PVT. PMID: 27890896 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawano Y, Murata S, Taniai N, Yoshioka M, Hirakata A, Mizuguchi Y, Shimizu T, Kanda T, Ueda J, Takada H, Yoshida H, Akimaru K, Onozawa S, Kumita S, Uchida E Tags: J Nippon Med Sch Source Type: research

Pott's Puffy Tumor in an Adult: A Case Report and Review of Literature.
Abstract Pott's puffy tumor is a subperiosteal abscess of the frontal bone with osteomyelitis which has become rare because of the widespread use of antibiotics. Here, we report a case of Pott's puffy tumor in a 46-year-old man who visited the department of dermatology with painful swelling of the forehead. Despite open drainage and oral antibiotic therapy, the symptoms recurred twice in the following month. Computed tomography revealed a fistula of frontal bone. The eventual diagnosis was Pott's puffy tumor. The patient underwent endoscopic surgery at the department of otorhinolaryngology and achieved a complete ...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Tatsumi S, Ri M, Higashi N, Wakayama N, Matsune S, Tosa M Tags: J Nippon Med Sch Source Type: research

Immunofluorescence Labeling of a Mutant of Tissue Non-Specific Alkaline Phosphatase Lacking the Glysosylphosphatidylinositol Anchor.
PMID: 27680481 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Matsumura T, Saito S, Orimo H Tags: J Nippon Med Sch Source Type: research

Objective Spectrometric Measurement of Keloid Color in the East Asian Population: Pitfalls of Subjective Color Measurements.
Abstract BACKGROUND: Keloids are characterized by the formation of excessive scar tissue that extends beyond the area of the initial wound. Keloid redness is due to angiogenesis and chronic inflammation and is an important indicator of the severity of the lesion and the effectiveness of treatment. METHODS: The color of 33 untreated keloids from 30 patients was measured with a narrow-band reflectance colorimeter. The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively). The keloid color was ...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Aoki M, Akaishi S, Nakao J, Dohi T, Hyakusoku H, Ogawa R Tags: J Nippon Med Sch Source Type: research

Utility of Measurement of Serum Lactate in Diagnosis of Coagulopathy Associated with Peripheral Circulatory Insufficiency: Retrospective Evaluation Using Thromboelastometry from a Single Center in Japan.
Abstract Recently, serum lactate level rather than systolic blood pressure (sBP) has been widely used to diagnose peripheral circulatory insufficiency, which often leads to coagulopathy with systemic inflammation. However, most of the reported disorders were examined by plasma samples. The aim of this study was to evaluate the utility of serum lactate for detecting coagulopathy with circulatory failure by using thromboelastometry as well as standard coagulation test. 192 adult patients transported to our hospital between January 2013 and September 2014 were enrolled in this retrospective study. The sBP, serum lact...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Sakurai R, Ohta M, Goto A, Imahase H, Yahata M, Umeka M, Miike T, Nagashima F, Iwamura T, Chris Yamada K, Inoue S Tags: J Nippon Med Sch Source Type: research

Evaluation of Postoperative Pain Control and Quality of Recovery in Patients Using Intravenous Patient-Controlled Analgesia with Fentanyl: A Prospective Randomized Study.
Abstract AIM: Opioids are increasingly used to control postoperative pain via intravenous patient-controlled analgesia, with several advantages. The present study evaluated the effects of intravenous patient-controlled analgesia with different doses of fentanyl on postoperative pain and on the quality of physical/emotional recovery from surgery and anesthesia. METHODS: We retrospectively reviewed data from 288 patients, and evaluated whether intravenous patient-controlled analgesia with fentanyl correlated with the degree of postoperative pain. We then prospectively studied 47 patients who underwent elective ...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Onaka H, Ishikawa M, Mizuguchi Y, Uchida E, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Vigabatrin Therapy for Infantile Spasms in a Case of Cardiofaciocutaneous Syndrome with Cardiac Hypertrophy Developing during Adrenocorticotropic Hormone Treatment.
Abstract In a patient with cardiofaciocutaneous syndrome complicated by intractable infantile spasms (West syndrome), cardiac hypertrophy developed during adrenocorticotropic hormone treatment. Various types of antiepileptic drugs, intravenous immunoglobulin, thyrotropin releasing hormone, and a ketogenic diet were ineffective in this case. However, vigabatrin both decreased clinical seizures and improved electroencephalogram findings. Although vigabatrin has not been approved for use in Japan, the results in the present case suggest that this drug should be considered as an alternative therapy for cases of infant...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Hatori T, Sugiyama Y, Yamashita S, Hirakubo Y, Nonaka K, Ichihashi K Tags: J Nippon Med Sch Source Type: research

Cecal Volvulus Following Elective Laparoscopic Cholecystectomy: A Case Report.
We report on a case of cecal volvulus that developed in a 54-year-old women 1 day after elective laparoscopic cholecystectomy and was successfully treated via colonoscopic decompression. The symptoms gradually improved in conjunction with recovery from postoperative ileus. Whether the incidence of volvulus has increased with the use of laparoscopic procedures, including laparoscopic cholecystectomy, has yet to be determined. Considering the current trend toward minimally invasive surgery, cecal volvulus should be considered in patients who have postoperative abdominal pain and distention. PMID: 27680486 [PubMed - in p...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Mizuguchi Y, Mamada Y, Shimizu T, Kanda T, Furuki H, Akama Y, Taniai N, Nakamura Y, Yoshioka M, Matsushita A, Kawano Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling.
We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling. However, 5 months later, exacerbation of the swelling and nasal congestion were observed. A second biopsy of the upper eyelid revealed a diffuse dermal infiltrate composed of mononucle...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Kanzaki A, Funasaka Y, Nakamizo M, Shima A, Ryotokuji T, Dan K, Terasaki M, Sugisaki Y, Fukuda Y, Kawana S, Saeki H Tags: J Nippon Med Sch Source Type: research

Invention of Two Instruments Fitted with SECUREA ™ Useful for Laparoscopic Liver Resection.
Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection. J Nippon Med Sch. 2016;83(3):107-12 Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Abstract Laparoscopic liver resection (LLR) became common in Japan when advanced techniques and instruments for the procedure became available and the national medical insurance began covering partial resection and lateral segmentectomy. A successful LLR requires a gentle and powerful hold on the specimens, a steady operating field, and fa...
Source: Journal of Nippon Medical School - July 22, 2016 Category: Universities & Medical Training Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Tags: J Nippon Med Sch Source Type: research

Effects of Edaravone on Hippocampal Antioxidants in EL Mice.
CONCLUSION: Edaravone increases antioxidant potency and reduces seizure susceptibility in EL mice, making it a promising novel antiepileptic agent. PMID: 27430173 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Baba A, Kawakami Y, Saito K, Murashima YL, Itoh Y Tags: J Nippon Med Sch Source Type: research

Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection.
Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection. J Nippon Med Sch. 2016;83(3):107-12 Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Abstract Laparoscopic liver resection (LLR) became common in Japan when advanced techniques and instruments for the procedure became available and the national medical insurance began covering partial resection and lateral segmentectomy. A successful LLR requires a gentle and powerful hold on the specimens, a steady operating field, and fa...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Tags: J Nippon Med Sch Source Type: research

Treatment for Trochanteric Fracture of the Femur with Short Femoral Nail: A Comparison between the Asian Intramedullary Hip Screw (IMHS) and the Conventional IMHS.
CONCLUSION: Compared with the conventional IMHS, the Asian IMHS is smaller, has increased variations in the shaft/neck angle of the lag screw, and has a titanium-alloy construction, allowing magnetic resonance imaging. The intraoperative fracture may have occurred because of the configuration of the distal interlocking screw in the Asian IMHS. Breakage of the implant likely occurred because the nail was too small in diameter, and too short in length for the unstable AO 31-A3 fracture. If careful attention is paid to the configuration of its distal interlocking screw intraoperatively and a nail of appropriate size is select...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Oba R, Satake Y, Hoshikawa N, Takai S Tags: J Nippon Med Sch Source Type: research

Neutrophil/Lymphocyte Ratio in Patients with Rheumatoid Arthritis Treated with Biological Agents.
CONCLUSION: The N/L ratio is a marker of disease activity in RA. The ΔN/L ratio reflects the efficacy of biological agents but does not predict the response to biological agents. PMID: 27430176 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Koiwa M, Goto S, Takahashi K, Kamada T, Takai S, Nakamura H Tags: J Nippon Med Sch Source Type: research

Use of an Inverted and Segmented Galea-Calvarial Flap for the Simultaneous Reconstruction of the Frontal Sinus and Forehead: A New Supplementary Method of Reconstructive Cranial Surgery.
We report on a new technical method of using an inverted and segmented galea-calvarial flap for simultaneous reconstruction of the frontal sinus and forehead. A 73-year-old man presented with the production of pus at the forehead, in which the frontal sinus had been involved 6 years postoperatively. The patient underwent surgery with our new simultaneous technique. During the 7 years of follow-up after this reconstructive surgery, no recurrence of surgical wound problems was noted. PMID: 27430177 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Takumi I, Akimoto M, Morita A Tags: J Nippon Med Sch Source Type: research

Prenatal Detection of Peters' Plus Syndrome in a Patient with No Known Family History.
We present a case of this uncommon syndrome that we diagnosed during a fetal ultrasonographical examination. Because the patient exhibited microcephaly and anterior staphyloma of the right eye and because impending rupture was feared, we performed ophthalmectomy during the neonatal period. Fetal ophthalmological anomalies are often detected during ultrasonographic examination targeting other systemic abnormalities, with positive family histories providing important diagnostic clues. This case is, to our knowledge, the first to be reported of prenatally diagnosed Peters' plus syndrome in a patient with no known family histo...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Shima Y, Migita M Tags: J Nippon Med Sch Source Type: research

Pancreatic Metastasis from Gastrointestinal Stromal Tumor of the Stomach: A Case Report.
We report the first documented case of pancreatic metastasis from a gastrointestinal stromal tumor of the stomach. A 42-year-old Japanese man presented with severe abdominal discomfort. Computed tomography of the abdomen showed a huge heterogeneous mass consisting of cystic and solid components in the left upper abdomen. (18)F-Fluorodeoxyglucose positron-emission tomography revealed high tracer uptake in the abdominal mass. After total gastrectomy with lymphnodectomy was performed, a hard mass was palpated in the pancreatic tail. The pancreatic tumor was also resected under the therapeutic strategy. Histological examinatio...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Hagiwara N, Matsutani T, Nomura T, Fujita I, Kanazawa Y, Ueda J, Arai H, Kakinuma D, Kanno H, Naito Z, Uchida E Tags: J Nippon Med Sch Source Type: research

Metronidazole-Induced Encephalopathy: A Case Report.
PMID: 27180788 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Bae EH, Ma SK, Kim SK, Kim SW Tags: J Nippon Med Sch Source Type: research

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy.
Abstract Keloids and hypertrophic scars are fibroproliferative disorders of the skin that are caused by abnormal healing of injured or irritated skin. It is possible that they are both manifestations of the same fibroproliferative skin disorder and just differ in terms of the intensity and duration of inflammation. These features may in turn be influenced by genetic, systemic, and local risk factors. Genetic factors may include single nucleotide polymorphisms, while systemic factors may include hypertension, pregnancy, hormones, and cytokines. The most important local factor is tension on the scar. Over the past 1...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ogawa R, Akaishi S, Kuribayashi S, Miyashita T Tags: J Nippon Med Sch Source Type: research

Different Patterns of Acetylation and Dimethylation of Histone H3 between Young and Aged Cases with Chronic Tonsillitis: Influences of Inflammation and Aging.
CONCLUSION: Our results suggest that epigenetic changes participate in chronic inflammation and aging in the palatine tonsils. Although the results do not lead to a direct treatment, the epigenetic pathogenesis of chronic inflammation, such as immunoglobulin A nephropathy, by focal infections will be described in greater detail in future studies, which will lead to new treatments being developed. PMID: 27180790 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Saito A, Watanabe K, Egawa S, Okubo K Tags: J Nippon Med Sch Source Type: research