A comparison of microsurgical venous anastomosis techniques.
CONCLUSIONS: The venous anastomosis technique does not affect the complication rate but does affect anastomosis time and flap ischemia time. On the basis of these results, we believe that the continuous suture and MACD techniques are easier and safer for venous anastomosis than is the traditional interrupted suture technique. PMID: 25797870 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Umezawa H, Ogawa R, Nakamizo M, Yokoshima K, Hyakusoku H Tags: J Nippon Med Sch Source Type: research

Comparison of pain and efficacy of darbepoetin alfa and epoetin Beta pegol treatment in patients receiving peritoneal dialysis.
CONCLUSION: No significant difference in pain was found between darbepoetin alfa and CERA therapies, but a significant difference in pain was noted between administration routes, just after injection, in the CERA group. The results also suggest that a change ratio of 0.8 from darbepoetin alfa to CERA is low for managing anemia. PMID: 25797871 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Otsuka T, Sakai Y, Yui S, Sukegawa M, Suzuki A, Mugishima K, Sumi Y, Otsuka Y, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Glomerular Capillary and Endothelial Cell Injury is Associated with the Formation of Necrotizing and Crescentic Lesions in Crescentic Glomerulonephritis.
CONCLUSIONS: The loss of glomerular capillaries with endothelial cell injury is commonly associated with the formation of necrotizing and cellular crescentic lesions, regardless of the pathogeneses associated with different types of crescentic GN, such as pauci-immune type ANCA-associated GN, anti-GBM GN, and immune-complex type GN. In addition, impaired capillary regeneration and a loss of endothelial cells contribute to the development of glomerular sclerosis with fibrous crescents and glomerular collapse. PMID: 25797872 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Fujita E, Nagahama K, Shimizu A, Aoki M, Higo S, Yasuda F, Mii A, Fukui M, Kaneko T, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Clinical characteristics of pregnancies with a history of recurrent miscarriage at a Japanese perinatal center.
We examined obstetric and fetal/neonatal outcomes in women with a history of recurrent miscarriage. METHODS: We reviewed the obstetric records of all 5,829 nulliparous pregnant women who delivered at #8805;14 weeks' gestation from 2008 through 2013 at our perinatal center. Of these women, 74 had a history of recurrent miscarriage (1.3%). The control population consisted of 4,176 nulliparous women without a history of miscarriage. Demographic information and characteristics of labor were extracted from patient charts. RESULTS: The rate of maternal age #8805;40 years (p
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Terada K, Nakanishi K, Suzuki S Tags: J Nippon Med Sch Source Type: research

A Case of Obesity Hypoventilation Syndrome with Respiratory Failure that Improved with Abdominoplasty.
We report on a 70-year-old man with severe respiratory failure caused by obesity hypoventilation syndrome due to abdominal adiposis. Obesity hypoventilation syndrome is a severe condition that is diagnosed when all of the following criteria are satisfied: body-mass index>30 kg/m(2); apnea hypopnea index>30; PaCO2>45 mm Hg (in the daytime); and marked daytime somnolence. Abdominoplasty, which is generally used for abdominal laxness, striae, and rectus muscle diastases and for women in the postpartum period, was performed for this patient to facilitate ventilator weaning and produced a satisfactory result. PMID...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Kuwahara H, Kubo K, Akiyama G, Takayama Y, Tosa R, Hyakusoku H Tags: J Nippon Med Sch Source Type: research

Single-incision Laparoscopic Cholecystectomy with an Additional Needle Grasper: A Novel Technique.
CONCLUSIONS: SILCAN is a safe and feasible alternative to SILC which does not compromise the qualities of CLC. It is less technically challenging, and postoperative pain and cosmesis are comparable to those of conventional SILC. PMID: 25797875 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Komine O, Suzuki H, Watanabe M, Nomura S, Mizutani S, Yoshino M, Chihara N, Mishima K, Oyama R, Uchida E Tags: J Nippon Med Sch Source Type: research

Technical arrangement of the williams-isu method for anterior cervical discectomy and fusion.
Abstract Anterior cervical fixation with autologous bone transplantation-without the need for harvesting bone from other sites, such as the ilium-was developed by Williams and modified by Isu et al. In recent intervertebral fusion procedures, after harvesting the cuboid bone from vertebral bodies, a hydroxyapatite block is placed between two harvested vertebral bones in the same way as in the sandwich method for intervertebral fixation. According to previous studies, this procedure has the following disadvantages: (i) as the corrective force for cervical kyphosis is insufficient, it could not be adapted for patien...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Kogure K, Isu T, Node Y, Tamaki T, Kim K, Morimoto D, Morita A Tags: J Nippon Med Sch Source Type: research

A case of maternal vitamin k deficiency associated with hyperemesis gravidarum: its potential impact on fetal blood coagulability.
We describe a pregnant woman with vitamin K deficiency possibly due to hyperemesis gravidarum. The patient was treated for the deficiency, and no fetal or neonatal hemorrhagic diseases were manifested. PMID: 25797877 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Shigemi D, Nakanishi K, Miyazaki M, Shibata Y, Suzuki S Tags: J Nippon Med Sch Source Type: research

Poststreptococcal glomerulonephritis in a patient with essential thrombocytosis.
r K Abstract In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. T...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Ulusoy S, Ozkan G, Sonmez M, Mungan S, Köseoğlu R, Cansız M, Kaynar K Tags: J Nippon Med Sch Source Type: research

Refractory leg ulcers associated with klinefelter syndrome.
We present a man with refractory leg ulcers, bilateral varicosis of the lower extremities, and Buerger disease. Autoimmune work-up was negative. However, chromosome analysis showed Klinefelter syndrome (48 XXY). Ulcerative lesions of the lower extremities are a complication of Klinefelter syndrome. To date, the pathogenesis of ulcers in Klinefelter syndrome has not been clarified, but several factors, such as abnormalities of fibrinolysis and prothrombotic states, might be involved. Our present case emphasizes the importance of considering Klinefelter syndrome in the differential diagnosis of a male patient with nonhealing...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Yabuno Y, Tosa M, Iwakiri I, Nomoto S, Kaneko M, Kuwahara K, Hyakusoku H, Murakami M Tags: J Nippon Med Sch Source Type: research

Long-term Observation of Lateral Medullary Infarction due to Vertebral Artery Dissection Assessed with Multimodal Neuroimaging.
Abstract A 33-year-old man presented with a lateral medullary infarction, vertigo, and nausea. At the time of hospital admission, he had Wallenberg syndrome. Although initial magnetic resonance imaging showed no abnormalities, subsequent diffusion-weighted magnetic resonance imaging showed a high-intensity area in the right lateral medulla oblongata. The right vertebral artery was shown to be dilated on basi-parallel anatomical scanning but to be stenosed on magnetic resonance angiography (MRA). Cerebral angiography 7 days after onset showed the "pearl and string sign" in the right vertebral artery. Foll...
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Nomura K, Mishina M, Okubo S, Suda S, Katsura K, Katayama Y Tags: J Nippon Med Sch Source Type: research

A concept of a nonneuronal cardiac cholinergic system.
PMID: 25391697 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Kakinuma Y Tags: J Nippon Med Sch Source Type: research

Catheter-retaining Balloon-occluded Retrograde Transvenous Obliteration for Gastric Varices.
CONCLUSION: These results show that catheter-retaining BRTO is a simple and highly effective procedure for difficult cases with minor complications. Furthermore, catheter-retaining BRTO does not require a large daily dose of EO and is, therefore, an effective treatment for solitary gastric varices. PMID: 25391698 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Kakutani H, Sanada J, Nakayama D, Moriyasu F Tags: J Nippon Med Sch Source Type: research

Association between Serum Lactate Levels and Early Neurogenic Pulmonary Edema after Nontraumatic Subarachnoid Hemorrhage.
Abstract BACKGROUND AND PURPOSE: Few studies have described the risk factors associated with the development of neurological pulmonary edema (NPE) after subarachnoid hemorrhage (SAH). We have hypothesized that acute-phase increases in serum lactate levels are associated with the early development of NPE following SAH. The aim of this study was to clarify the association between lactic acidosis and NPE in patients with nontraumatic SAH. METHODS: We retrospectively evaluated 140 patients with nontraumatic SAH who were directly transported to the Nippon Medical School Hospital emergency room by the emergency med...
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Satoh E, Tagami T, Watanabe A, Matsumoto G, Suzuki G, Onda H, Fuse A, Gemma A, Yokota H Tags: J Nippon Med Sch Source Type: research

Subcutaneous angiolipoma: magnetic resonance imaging features with histological correlation.
CONCLUSION: The MR imaging features of angiolipoma are fat nodules with or without low-signal-intensity areas of various size and location on T1- and T2-weighted images. PMID: 25391700 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Kitagawa Y, Miyamoto M, Konno S, Makino A, Maruyama G, Takai S, Higashi N Tags: J Nippon Med Sch Source Type: research

Preventable trauma deaths after traffic accidents in chiba prefecture, Japan, 2011: problems and solutions.
DISCUSSION: Problems of these 20 deaths showed that appropriate triage at the scene, centralization of patients with severe trauma, and trauma centers are necessary in Japan. Under-triage before arrival at the hospital was related to clearly and possibly preventable deaths. Upgrading the triage category for victims with torso injury must be considered. Not all emergency critical care centers in Japan are able to provide severe trauma care. Preventable trauma deaths occur even in some emergency critical care centers; therefore, we need centralization of severe trauma patients from wider area to reduce the incidence of preve...
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Motomura T, Mashiko K, Matsumoto H, Motomura A, Iwase H, Oda S, Shimamura F, Shoko T, Kitamura N, Sakaida K, Fukumoto Y, Kasuya M, Koyama T, Yokota H Tags: J Nippon Med Sch Source Type: research

Effect on clinical work practice of establishing a neonatal intensive care unit at a medical school-affiliated teaching hospital.
CONCLUSION: Since the NICU was established, closer cooperation beyond the framework of a single department has come to be needed. In addition, NICUs in teaching hospitals are expected to provide opportunities for medical students and residents to observe and participate in multidisciplinary medical care. PMID: 25391702 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Shima Y, Migita M, Asakura H, Takahashi T, Yashiro K, Matsumura Y, Kurokawa A Tags: J Nippon Med Sch Source Type: research

Grade 4 epistaxis in a woman with metastatic breast cancer treated with bevacizumab: a case report.
We describe a 39-year-old woman with metastatic breast cancer who had grade 4 epistaxis induced by bevacizumab. The patient visited our outpatient clinic with complaints of a lump in her right breast, fatigue, dyspnea, abdominal distention, appetite loss, and weight loss of 10 kg over 1 year. Liver dysfunction was detected, with elevated levels of aspartate aminotransferase (271 IU/L), alanine aminotransferase (100 IU/L), alkaline phosphatase (4,205 IU/L), total bilirubin (2.7 mg/dL), and direct bilirubin (2.1 mg/dL). A secondary liver tumor that occupied most of the liver volume was found, and bone metastasis, ascites, an...
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Yanagihara K, Takei H, Iida S, Yamashita K, Kurita T, Iwamoto M, Saegusa H, Uchida E Tags: J Nippon Med Sch Source Type: research

Hydrocephalus with Spontaneous Regression in a 14-year-old Girl.
We report on a 14-year-old girl with hydrocephalus that underwent spontaneous regression without any specific treatment, such as ventriculoperitoneal shunt surgery. A 14-year-old girl was referred to our hospital with severe headache, dizziness, nausea, and vomiting. Computed tomography and FLAIR-MRI findings on admission showed markedly dilated lateral, third and fourth ventricles with periventricular hyperintensity and downward displacement of the tonsils induced by dilatation of the fourth ventricle. We diagnosed hydrocephalus of unknown etiology. Although no specific treatment for hydrocephalus was performed, the sympt...
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Asano T, Kuwabara K, Mishina-Ikegami K, Toba-Shimizu K, Hatori T, Fujino O Tags: J Nippon Med Sch Source Type: research

Treatment of visceral malperfusion in acute type B aortic dissection by percutaneous endovascular fenestration using a stent, with additional stenting of the true lumen.
We report a case of endovascular fenestration with stenting for visceral malperfusion in ABAD. One stent was inserted across the intimal flap to keep the fenestrated site open, and another stent was placed into the narrowed true lumen. This therapeutic strategy may be feasible for ABAD with acute malperfusion. PMID: 25391705 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Miyachi H, Onozawa S, Akutsu K, Shimizu W, Kumita S, Tanaka K, Murata S Tags: J Nippon Med Sch Source Type: research

A Case of Nonfunctioning Pancreatic Endocrine Tumor with Atypical Imaging Findings due to Prominent Fibrosis of the Tumor Stroma.
Abstract The patient, a 56-year-old woman, was found during routine checkup to have a disorder of hepatic function. Abdominal ultrasonography showed an ill-defined hypoechoic mass in the head and body of the pancreas; however, no blood-flow signal was observed within the tumor on Doppler ultrasonography. Abdominal computed tomography showed a low-density area in the arterial and portal venous phases. The lesion was visualized as an area of low signal intensity on both T1- and T2-weighted magnetic resonance images, whereas fluorodeoxyglucose positron emission tomography showed fluorodeoxyglucose accumulation in the...
Source: Journal of Nippon Medical School - November 16, 2014 Category: Universities & Medical Training Authors: Hoshino A, Aimoto T, Suzuki H, Mizutani S, Nakamura Y, Ishii H, Satoh S, Oba H, Sibuya T, Uchida E Tags: J Nippon Med Sch Source Type: research

Immunohistochemical analyses of cytokeratin in breast cancers from old and new eras.
PMID: 25186572 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Takei H, Yanagihara K, Kurita T, Iwamoto M, Seki N, Hoshina H, Yokoyama T, Yamashita K, Iida S, Uchida E Tags: J Nippon Med Sch Source Type: research

Current perspectives on the unruptured cerebral aneurysms: origin, natural course, and management.
CONCLUSIONS: Unruptured intracranial aneurysms have various clinical characteristics, such as size, shape, and location and the patient's clinical condition, upon which management strategy should be stratified. In Japan, with national efforts to improve surgical and management standards, a national cohort study and individual case series have shown that the management morbidity of unruptured intracranial aneurysms is low. To improve care and to perform safer interventions, we must continue to seek better and less-invasive management methods and techniques. PMID: 25186573 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Morita A Tags: J Nippon Med Sch Source Type: research

Clinical and genetic diagnosis for inherited cardiac arrhythmias.
Abstract Molecular genetic studies in the last 2 decades have revealed a link between several inherited cardiac arrhythmias and genes encoding for ion channels or other membrane components. Two recent international expert consensus statements endorsed by 3 continental electrophysiology societies have updated the clinical and genetic diagnoses and management in patients with inherited arrhythmia syndromes, including congenital long QT syndrome (LQTS) and Brugada syndrome. Thirteen genotypes have been identified in 50% to 80% of clinically affected patients with congenital LQTS. Therefore, genotype-phenotype correla...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Shimizu W Tags: J Nippon Med Sch Source Type: research

Paclitaxel Enhances Antibody-dependent Cell-mediated Cytotoxicity of Trastuzumab by Rapid Recruitment of Natural Killer Cells in HER2-positive Breast Cancer.
Abstract INTRODUCTION: An important mechanism by which trastuzumab inhibits the growth of human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells is the activation of a host tumor response via antibody-dependent cell-mediated cytotoxicity (ADCC). Although paclitaxel has a synergistic effect in combination with trastuzumab, whether ADCC is enhanced by paclitaxel is not known. In the present study we examined whether adding paclitaxel to trastuzumab enhances ADCC and also investigated the kinetics of effector cells in ADCC. MATERIALS AND METHODS: The subjects were 20 patients with HER2-posi...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Miura D, Yoneyama K, Furuhata Y, Shimizu K Tags: J Nippon Med Sch Source Type: research

Therapeutic Effects of the Long-term Use of PAN Membrane Dialyzer in Hemodialysis Patients: Efficacy in Old Dialysis Patients with Mild PAD.
CONCLUSION: The cross-over trial show the AN69 membrane eliminates less AA and Alb compared with the PS membrane. Judging from the therapeutic effects of the long-term use of the AN69 membrane, the membrane is effective for dialysis and has good biocompatibility in the treatment of elderly HD patients with mild PAD. PMID: 25186576 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nakada H, Kashiwagi T, Iino Y, Katayama Y Tags: J Nippon Med Sch Source Type: research

Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Extracts of Intestinal Epithelial Cells under Oxidative Stress.
CONCLUSION: Pattern recognition of NMR spectral data using a chemometric technique clearly visualized the differences of oxidant injury in IEC-6 cells under oxidant stress. PMID: 25186577 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nakata K, Sato N, Hirakawa K, Asakura T, Suzuki T, Zhu R, Asano T, Koike K, Ohno Y, Yokota H Tags: J Nippon Med Sch Source Type: research

Anatomical factors associated with periesophageal vagus nerve injury after catheter ablation of atrial fibrillation.
CONCLUSION: Acalculous cholecystitis, as well as gastric hypomotility, can develop as a result of periesophageal VNI in patients undergoing AF ablation. The anatomical relationships among the LA, esophagus, spine, and descending aorta may influence the occurrence of VNI. PMID: 25186578 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Tsuboi I, Hayashi M, Miyauchi Y, Iwasaki YK, Yodogawa K, Hayashi H, Uetake S, Takahashi K, Shimizu W Tags: J Nippon Med Sch Source Type: research

Changes in Blood-pressure Control among Patients with Hypertension from 2008 through 2011: Surveys of Actual Clinical Practice.
Abstract We performed cross-sectional surveys to investigate changes in clinical practices regarding blood-pressure control in patients with hypertension from 2008 through 2011. Questionnaires regarding the care of patients with hypertension were mailed to members of the Kanagawa Physicians Association in Kanagawa Prefecture, Japan. Data were obtained on 675 patients in 2008, 332 in 2009, and 1,076 in 2011. The mean systolic blood pressure (BP) was significantly lower in 2011 than in 2008 (132.2±11.9 mm Hg versus 134.6±10.6 mm Hg). The office-measured target BP, according to the 2009 guidelines of th...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Hatori N, Sakai H, Sato K, Mitani K, Miyajima M, Yuasa S, Kuboshima S, Kajiwara K, Miyakawa M Tags: J Nippon Med Sch Source Type: research

Atypical radiological and intraoperative findings of acute cerebral hemorrhage caused by ruptured cerebral aneurysm in a patient with severe chronic anemia.
Abstract Acute intracerebral hemorrhage (ICH) associated with mild anemia is commonly observed on radiological examination, and there are several reports of ruptured aneurysms occurring with ICH but without accompanying subarachnoid hemorrhage. However, the relationship among computed tomography (CT), magnetic resonance imaging (MRI), and intraoperative findings of ICH caused by ruptured cerebral aneurysm in patients with severe chronic anemia has been rarely reported and is poorly understood. Here, we report atypical radiological and intraoperative findings of acute ICH caused by ruptured cerebral aneurysm in a p...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Matano F, Murai Y, Nakagawa S, Kato T, Kitamura T, Sekine T, Takagi R, Teramoto A Tags: J Nippon Med Sch Source Type: research

Flexor pollicis longus rupture in a trigger thumb after intrasheath triamcinolone injections: a case report with literature review.
We report an unusual case of a rupture of the flexor pollicis longus tendon after two intrasheath triamcinolone injections for left trigger thumb in a 56-year-old woman. Tendon grafting from proximal to the wrist to the fingertip was carried out using the palmaris longus tendon. The clinical result was evaluated as good according to Strickland's criteria. Recently, intrasheath triamcinolone injection has been thought of as a mainstay of the treatment for trigger digits. However, flexor tendon ruptures have been reported as a serious, rare complication following the injections suspected to be the result of intratendinous in...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Efficacy of tracheostomy for central alveolar hypoventilation syndrome caused by lateral medullary infarction.
We describe 2 patients with CAHS-LMI and review the case reports for 17 previously described patients. Patient 1 was a 78-year-old man who was referred to our hospital because of dizziness. After admission, Wallenberg syndrome developed. Magnetic resonance imaging showed left LMI. He had hypercapnia and respiratory acidosis the next afternoon and temporarily received mechanical ventilation. A tracheotomy was performed on the 12th hospital day, and the patient was weaned from the ventilator on the 18th hospital day. Patient 2 was 72-year-old man who was referred to our hospital because of dizziness and gait disturbance. Wal...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Mishina M, Ohkubo S, Kamiya N, Abe A, Suda S, Sakamaki M, Kominami S, Mizunari T, Kobayashi S, Katayama Y Tags: J Nippon Med Sch Source Type: research

Timing of elective cesarean singleton delivery and neonatal respiratory outcomes at a Japanese perinatal center.
Abstract The present study examined the relation between the timing of elective cesarean delivery at term and neonatal respiratory outcomes at our institution. From 2005 through 2013, 1,951 elective cesarean singleton deliveries were performed at term. Of the neonates, 141 (7%) had respiratory disorders requiring oxygen supplementation. In comparison to the incidence of respiratory disorders in neonates delivered at full term (39-40 weeks), the incidences in neonates delivered at ≤38+1/7 weeks' and at 41 weeks' gestation were significantly higher. Uncomplicated elective cesarean singleton delivery should be avo...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Terada K, Ito M, Kumasaka S, Suzuki S Tags: J Nippon Med Sch Source Type: research

Obstetrician gender and delivery mode at a Japanese perinatal center.
We examined differences in delivery modes between deliveries managed by female obstetricians and gynecologists (OB/GYNs) and those managed by male OB/GYNs at our hospital. The rate of vacuum extraction/forceps delivery was significantly lower when deliveries were managed by female OB/GYNs. Logistic regression analysis showed that the lower rate of vacuum extraction/forceps delivery was associated with a lower rate of diagnosis of nonreassuring fetal status during the second stage of labor by female OB/GYNs. The rate of cesarean delivery and obstetric outcomes did not differ with the gender of the managing OB/GYN. The incre...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Ito M, Terada K, Hayashi Z, Suzuki S Tags: J Nippon Med Sch Source Type: research

Molecular targeted therapy of lung cancer and the development of a molecular predictive model.
PMID: 25186585 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Miyanaga A Tags: J Nippon Med Sch Source Type: research

Dense deposit disease in an elderly patient: report of a case.
PMID: 24998957 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Ohno D, Sakai Y, Suzuki A, Mugishima K, Sumi Y, Otsuka Y, Otsuka T, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Differential Expression of ADAM (a Disintegrin and Metalloproteinase) Genes between Human First Trimester Villous and Extravillous Trophoblast Cells.
Abstract A disintegrin and metalloproteinases (ADAMs) are members of the metzincin family of zinc-dependent metalloproteinases that play pivotal roles in the proteolytic degradation of the extracellular matrix for cell invasion. Few studies have investigated the ADAM subtypes that are expressed in first trimester trophoblast cells. The purpose of this study was to elucidate the differential expression profiles of ADAMs between first trimester villous trophoblast cells (VTs) and extravillous trophoblast cells (EVTs). We isolated EVTs from explanted human first trimester chorionic villi and investigated the mRNA exp...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Takahashi H, Yuge K, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Suzuki M, Takizawa T Tags: J Nippon Med Sch Source Type: research

The Effects of Polymyxin B-immobilized Fiber Hemoperfusion on Respiratory Impairment in Endotoxemic Pigs.
Conclusion: PMX-DHP is effective for treating respiratory impairment and contributes to the decreased mortality rate in the endotoxemic pigs. PMID: 24998959 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Miyasho T, Itami T, Tamura J, Ishizuka T, Kawamura Y, Nakamura K, Miyoshi K, Yamashita K Tags: J Nippon Med Sch Source Type: research

Comparison of Outcomes between Women with De novo Stage IV and Relapsed Breast Cancer.
Conclusion: No differences in outcome were found between de novo stage IV disease and relapsed disease. However, their prognostic factors differed substantially and suggest that different treatment strategies may be warranted for metastatic disease in each type of breast cancer. PMID: 24998960 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Kitagawa D, Horiguchi S, Yamashita T, Kuroi K, Shimizu K Tags: J Nippon Med Sch Source Type: research

Stress Sensitivity in Patients with Atopic Dermatitis in Relation to the Translocator Protein 18 kDa (TSPO).
In conclusion, the present study provides new evidence that variation in the TSPO gene affects susceptibility to AD. PMID: 24998961 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Kaga M, Nakamoto Y, Nakamura K, Ikeda K, Yoshii M, Kawana S Tags: J Nippon Med Sch Source Type: research

Treatment for crusted scabies: limitations and side effects of treatment with ivermectin.
Abstract Skin eruption with mild itching of the hands and feet developed in a man in his 90s 1 month after he was hospitalized following a traffic accident. Scabies was diagnosed in an attending nurse 3 months after the patient's hospitalization, and infection from the patient was suspected. Cornification of the patient's soles and marked hypertrophy of the nails of both feet were observed. After a large number of scabies mites were detected on microscopic examination, crusted scabies was diagnosed. The patient was given oral ivermectin, 6 mg, once per week for 3 weeks, and crotamiton topical ointment containing 3...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Fujimoto K, Kawasaki Y, Morimoto K, Kikuchi I, Kawana S Tags: J Nippon Med Sch Source Type: research

Excision of Zenker's Diverticulum to Treat Dysphagia Associated with Acute-phase Cerebral Infarction.
Abstract A 75-year-old man was admitted to our hospital with dysphagia shortly after the onset of a brainstem infarction. Videofluorography indicated the presence of a Zenker's diverticulum with a bolus at the esophageal orifice; endoscopy 5 years earlier had not shown a Zenker's diverticulum and suggests that the diverticulum had formed because of an increase in the hypopharyngeal pressure caused by the brainstem infarction. Surgical excision successfully facilitated transport of the bolus to the esophageal orifice. In the present report, we describe a case of dysphagia caused by a Zenker's diverticulum following...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Abe A, Harada-Abe M, Takayama Y, Toda Y, Ueda M, Katayama Y Tags: J Nippon Med Sch Source Type: research

Contralateral breast cancer adjacent to a fibroadenoma: report of a case.
Abstract A 64-year-old woman noticed a lump of the right breast and consulted our outpatient clinic. She had undergone multiple excisional biopsies of fibroadenomas in both breasts and mastectomy for invasive ductal carcinoma (IDC) of the left breast. After completing 5 years of treatment with adjuvant tamoxifen, she had undergone screening with annual physical examinations and occasional computed tomography. She was declared recurrence-free 13 years after breast cancer surgery, although lumps were detected in the right breast, probably due to fibroadenomas. Mammography, ultrasonography, and magnetic resonance ima...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Iwamoto M, Takei H, Iida S, Yamashita K, Yanagihara K, Kurita T, Tsuchiya S, Kanazawa Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Local recurrence of lung adenocarcinoma 10 years after left upper lobectomy resembling pseudomesotheliomatous adenocarcinoma: a case report.
This report provides information that will help physicians establish an accurate diagnosis in similar cases. PMID: 24998965 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Okamoto J, Kubokura H, Motoda N, Hoshina H, Ishii H, Kitayama Y, Usuda J Tags: J Nippon Med Sch Source Type: research

A Case of Nonfunctioning Pancreatic Endocrine Tumor with Atypical Imaging Findings due to Prominent Fibrosis of the Tumor Stroma.
Abstract The patient, a 56-year-old woman, was found during routine checkup to have a disorder of hepatic function. Abdominal ultrasonography showed an ill-defined hypoechoic mass in the head and body of the pancreas; however, no blood-flow signal was observed within the tumor on Doppler ultrasonography. Abdominal computed tomography showed a low-density area in the arterial and portal venous phases. The lesion was visualized as an area of low signal intensity on both T1- and T2-weighted magnetic resonance images, whereas fluorodeoxyglucose positron emission tomography showed fluorodeoxyglucose accumulation in the...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hoshino A, Aimoto T, Suzuki H, Mizutani S, Ishii H, Mishima K, Wada Y, Kuroda S, Yagi A, Shimizu T, Oyama R, Yamagiwa R, Satoh S, Oba H, Shibuya T, Uchida E Tags: J Nippon Med Sch Source Type: research

What Is an Adequate Esophageal Preset Temperature for Sufficient Ablation Lesion Formation While Avoiding Digestive-organ Complications during Catheter Ablation of Atrial Fibrillation?
PMID: 24998967 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hayashi M Tags: J Nippon Med Sch Source Type: research

Relationship between Serum 1,5-anhydroglucitol, as an Indicator of Postprandial Glycemic Control, and Serum Uric Acid, Considering the Renal Threshold for Glucosuria in the Elderly.
PMID: 24998968 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Ouchi M, Oba K, Ishii K, Onishi T, Saigusa T, Aoyama J, Matsumura N, Igari Y, Suzuki T, Nakano H Tags: J Nippon Med Sch Source Type: research

Simultaneous Detection of Different RNAs Using a Novel Branched DNA in situ Hybridization Method.
PMID: 24805090 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Yoshimura H, Matsuda Y, Kawamoto Y, Naito Z, Ishiwata T Tags: J Nippon Med Sch Source Type: research

An Extended Family with Familial Medullary Thyroid Carcinoma and Hirschsprung's Disease.
Abstract Familial medullary thyroid carcinoma (FMTC) is an autosomal dominant inherited disease that has highly characteristic clinical features, including medullary thyroid carcinoma (MTC). Mutation of the RET proto-oncogene is known to be responsible for development of FMTC and for multiple endocrine neoplasia types 2A and 2B. Hirschsprung's disease is the most common form of structural intestinal obstructive disease in human newborns. Hirschsprung's disease is defined by the absence of neural crest-derived enteric ganglia along a variable length of the bowel that invariably involves the rectoanal junction. Co-s...
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Igarashi T, Okamura R, Jikuzono T, Uchino S, Sugitani I, Shimizu K Tags: J Nippon Med Sch Source Type: research

A new method for differentiating benign and malignant pleomorphic clustered calcifications in mammography.
Conclusion: The DAS is a new and reliable variable for differentiating between benign and malignant pleomorphic clustered calcifications. The DAS improves diagnostic accuracy and is useful for determining whether to proceed with biopsies. PMID: 24805092 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Kikuchi M, Tsunoda H, Kaneshiro T, Takahashi O, Suzuki K, Yamauchi H, Ichikawa T, Kumita S Tags: J Nippon Med Sch Source Type: research