Mid-Term Clinical Results of VerSys Hip System (Zimmer) Uncemented Total Hip Replacement Arthroplasty.
CONCLUSION: These data suggest that patients receiving VerSys Hip System uncemented THR demonstrate favorable results pertaining pain score and range of motion. However, high rate of intraoperative fracture and malalignment of implants, which may be at a risk of dislocation and/or polyethylene wear in future, suggests that this implant technique requires improvement. PMID: 27890891 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Hoshikawa N, Watanabe H, Takai S Tags: J Nippon Med Sch Source Type: research

A Survey of Actual Clinical Practice Concerning Blood Pressure Control among Patients with Hypertension in Kanagawa 2014.
Abstract We performed a cross-sectional survey to investigate actual clinical practice concerning blood-pressure control among patients with hypertension in Kanagawa. The guidelines of the Japanese Society of Hypertension (JSH) for the management of patients with hypertension were revised in 2014. From October 1 to November 30, 2014, questionnaires on the care of patients with hypertension were sent via post to members of the Kanagawa Physicians Association in Kanagawa Prefecture, Japan. -Data on 1,105 patients (mean age: 68.4±12.3 years, 537 men and 568 women) were obtained. The overall mean systolic blood...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Hatori N, Sakai H, Sato K, Miyajima M, Yuasa S, Kuboshima S, Kajiwara K, Hara Y, Minamizawa K, Miyakawa M Tags: J Nippon Med Sch Source Type: research

Successful Coil Embolization of an Aneurysm in the Arc of B ühler.
Successful Coil Embolization of an Aneurysm in the Arc of Bühler. J Nippon Med Sch. 2016;83(5):196-198 Authors: Sugihara F, Murata S, Uchiyama F, Watari J, Tajima H, Kumita SI Abstract In the present report, we describe a case of a patient with an asymptomatic aneurysm in the arc of Bühler (AOB), which was successfully treated by transcatheter arterial embolization. The patient presented with severe stenosis of the celiac trunk, which was suspected to be due to median arcuate ligament syndrome. Arteriography of the superior mesenteric artery indicated a rapid stream in an aneurysm in the AOB...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Sugihara F, Murata S, Uchiyama F, Watari J, Tajima H, Kumita SI Tags: J Nippon Med Sch Source Type: research

Clinical Complete Response from Chemotherapy in an Elderly Patient with Metastatic Gastric Cancer: A Case Report.
Abstract An 81-year-old man was admitted with upper abdominal pain and weight loss. Esophagogastroduodenoscopy revealed a large tumor located from the gastric angle to the body. Histological analysis of a biopsy revealed a moderately differentiated adenocarcinoma. Computed tomography revealed metastases in the liver and lung and the patient was subsequently diagnosed with metastatic advanced gastric cancer. He was treated with chemotherapy using S-1 (80 mg/m(2)) and cisplatin (CDDP) (60 mg/m(2)). Twenty-two months after chemotherapy, the gastric tumor, and the nodules in the liver and lung, had disappeared. We sub...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawagoe T, Maruki Y, Nagoya H, Kosugi Y, Akimoto T, Yamawaki H, Kodaka Y, Shimpuku M, Ueki N, Futagami S, Miyake K, Iwakiri K Tags: J Nippon Med Sch Source Type: research

Efficacy of Computed Tomography-Guided Catheter Drainage as the Initial Intervention and of Omentopexy as the Staged Surgery for a Prosthetic Graft Infection of Very Late Onset.
Abstract On the basis of computed tomography (CT) examination, a prosthetic graft infection of very late onset was suspected in a 72-year-old man who had undergone replacement of an bifurcated prosthetic graft 6 years earlier because of an abdominal aortic aneurysm and bilateral common iliac artery aneurysms. Emergency CT-guided needle aspiration was performed, and analysis of directly aspirated fluid confirmed the rapid diagnosis. Instead of conventional emergency surgery, CT-guided catheter drainage was the initial treatment and led to the gradual improvement of symptoms and laboratory data. Elective staged surg...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Shirakawa M, Morota T, Sakamoto SI, Miyagi Y, Ishii Y, Nitta T Tags: J Nippon Med Sch Source Type: research

Interventional Treatment of Severe Portal Vein Thrombosis after Living-Donor Liver Transplantation.
In conclusion, repeated and assiduous interventional radiological treatment combined with thrombolytic therapy, thrombectomy, and metallic stent replacement could be important for severe PVT. PMID: 27890896 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Kawano Y, Murata S, Taniai N, Yoshioka M, Hirakata A, Mizuguchi Y, Shimizu T, Kanda T, Ueda J, Takada H, Yoshida H, Akimaru K, Onozawa S, Kumita S, Uchida E Tags: J Nippon Med Sch Source Type: research

Pott's Puffy Tumor in an Adult: A Case Report and Review of Literature.
Abstract Pott's puffy tumor is a subperiosteal abscess of the frontal bone with osteomyelitis which has become rare because of the widespread use of antibiotics. Here, we report a case of Pott's puffy tumor in a 46-year-old man who visited the department of dermatology with painful swelling of the forehead. Despite open drainage and oral antibiotic therapy, the symptoms recurred twice in the following month. Computed tomography revealed a fistula of frontal bone. The eventual diagnosis was Pott's puffy tumor. The patient underwent endoscopic surgery at the department of otorhinolaryngology and achieved a complete ...
Source: Journal of Nippon Medical School - November 30, 2016 Category: Universities & Medical Training Authors: Tatsumi S, Ri M, Higashi N, Wakayama N, Matsune S, Tosa M Tags: J Nippon Med Sch Source Type: research

Immunofluorescence Labeling of a Mutant of Tissue Non-Specific Alkaline Phosphatase Lacking the Glysosylphosphatidylinositol Anchor.
PMID: 27680481 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Matsumura T, Saito S, Orimo H Tags: J Nippon Med Sch Source Type: research

Objective Spectrometric Measurement of Keloid Color in the East Asian Population: Pitfalls of Subjective Color Measurements.
Abstract BACKGROUND: Keloids are characterized by the formation of excessive scar tissue that extends beyond the area of the initial wound. Keloid redness is due to angiogenesis and chronic inflammation and is an important indicator of the severity of the lesion and the effectiveness of treatment. METHODS: The color of 33 untreated keloids from 30 patients was measured with a narrow-band reflectance colorimeter. The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively). The keloid color was ...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Aoki M, Akaishi S, Nakao J, Dohi T, Hyakusoku H, Ogawa R Tags: J Nippon Med Sch Source Type: research

Utility of Measurement of Serum Lactate in Diagnosis of Coagulopathy Associated with Peripheral Circulatory Insufficiency: Retrospective Evaluation Using Thromboelastometry from a Single Center in Japan.
Abstract Recently, serum lactate level rather than systolic blood pressure (sBP) has been widely used to diagnose peripheral circulatory insufficiency, which often leads to coagulopathy with systemic inflammation. However, most of the reported disorders were examined by plasma samples. The aim of this study was to evaluate the utility of serum lactate for detecting coagulopathy with circulatory failure by using thromboelastometry as well as standard coagulation test. 192 adult patients transported to our hospital between January 2013 and September 2014 were enrolled in this retrospective study. The sBP, serum lact...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Sakurai R, Ohta M, Goto A, Imahase H, Yahata M, Umeka M, Miike T, Nagashima F, Iwamura T, Chris Yamada K, Inoue S Tags: J Nippon Med Sch Source Type: research

Evaluation of Postoperative Pain Control and Quality of Recovery in Patients Using Intravenous Patient-Controlled Analgesia with Fentanyl: A Prospective Randomized Study.
Abstract AIM: Opioids are increasingly used to control postoperative pain via intravenous patient-controlled analgesia, with several advantages. The present study evaluated the effects of intravenous patient-controlled analgesia with different doses of fentanyl on postoperative pain and on the quality of physical/emotional recovery from surgery and anesthesia. METHODS: We retrospectively reviewed data from 288 patients, and evaluated whether intravenous patient-controlled analgesia with fentanyl correlated with the degree of postoperative pain. We then prospectively studied 47 patients who underwent elective ...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Onaka H, Ishikawa M, Mizuguchi Y, Uchida E, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Vigabatrin Therapy for Infantile Spasms in a Case of Cardiofaciocutaneous Syndrome with Cardiac Hypertrophy Developing during Adrenocorticotropic Hormone Treatment.
Abstract In a patient with cardiofaciocutaneous syndrome complicated by intractable infantile spasms (West syndrome), cardiac hypertrophy developed during adrenocorticotropic hormone treatment. Various types of antiepileptic drugs, intravenous immunoglobulin, thyrotropin releasing hormone, and a ketogenic diet were ineffective in this case. However, vigabatrin both decreased clinical seizures and improved electroencephalogram findings. Although vigabatrin has not been approved for use in Japan, the results in the present case suggest that this drug should be considered as an alternative therapy for cases of infant...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Hatori T, Sugiyama Y, Yamashita S, Hirakubo Y, Nonaka K, Ichihashi K Tags: J Nippon Med Sch Source Type: research

Cecal Volvulus Following Elective Laparoscopic Cholecystectomy: A Case Report.
We report on a case of cecal volvulus that developed in a 54-year-old women 1 day after elective laparoscopic cholecystectomy and was successfully treated via colonoscopic decompression. The symptoms gradually improved in conjunction with recovery from postoperative ileus. Whether the incidence of volvulus has increased with the use of laparoscopic procedures, including laparoscopic cholecystectomy, has yet to be determined. Considering the current trend toward minimally invasive surgery, cecal volvulus should be considered in patients who have postoperative abdominal pain and distention. PMID: 27680486 [PubMed - in p...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Mizuguchi Y, Mamada Y, Shimizu T, Kanda T, Furuki H, Akama Y, Taniai N, Nakamura Y, Yoshioka M, Matsushita A, Kawano Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling.
We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling. However, 5 months later, exacerbation of the swelling and nasal congestion were observed. A second biopsy of the upper eyelid revealed a diffuse dermal infiltrate composed of mononucle...
Source: Journal of Nippon Medical School - October 1, 2016 Category: Universities & Medical Training Authors: Kanzaki A, Funasaka Y, Nakamizo M, Shima A, Ryotokuji T, Dan K, Terasaki M, Sugisaki Y, Fukuda Y, Kawana S, Saeki H Tags: J Nippon Med Sch Source Type: research

Invention of Two Instruments Fitted with SECUREA ™ Useful for Laparoscopic Liver Resection.
Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection. J Nippon Med Sch. 2016;83(3):107-12 Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Abstract Laparoscopic liver resection (LLR) became common in Japan when advanced techniques and instruments for the procedure became available and the national medical insurance began covering partial resection and lateral segmentectomy. A successful LLR requires a gentle and powerful hold on the specimens, a steady operating field, and fa...
Source: Journal of Nippon Medical School - July 22, 2016 Category: Universities & Medical Training Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Tags: J Nippon Med Sch Source Type: research

Effects of Edaravone on Hippocampal Antioxidants in EL Mice.
CONCLUSION: Edaravone increases antioxidant potency and reduces seizure susceptibility in EL mice, making it a promising novel antiepileptic agent. PMID: 27430173 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Baba A, Kawakami Y, Saito K, Murashima YL, Itoh Y Tags: J Nippon Med Sch Source Type: research

Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection.
Invention of Two Instruments Fitted with SECUREA™ Useful for Laparoscopic Liver Resection. J Nippon Med Sch. 2016;83(3):107-12 Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Abstract Laparoscopic liver resection (LLR) became common in Japan when advanced techniques and instruments for the procedure became available and the national medical insurance began covering partial resection and lateral segmentectomy. A successful LLR requires a gentle and powerful hold on the specimens, a steady operating field, and fa...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Kawano Y, Taniai N, Nakamura Y, Matsumoto S, Yoshioka M, Matsushita A, Mizuguchi Y, Shimizu T, Takata H, Yoshida H, Uchida E Tags: J Nippon Med Sch Source Type: research

Treatment for Trochanteric Fracture of the Femur with Short Femoral Nail: A Comparison between the Asian Intramedullary Hip Screw (IMHS) and the Conventional IMHS.
CONCLUSION: Compared with the conventional IMHS, the Asian IMHS is smaller, has increased variations in the shaft/neck angle of the lag screw, and has a titanium-alloy construction, allowing magnetic resonance imaging. The intraoperative fracture may have occurred because of the configuration of the distal interlocking screw in the Asian IMHS. Breakage of the implant likely occurred because the nail was too small in diameter, and too short in length for the unstable AO 31-A3 fracture. If careful attention is paid to the configuration of its distal interlocking screw intraoperatively and a nail of appropriate size is select...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Oba R, Satake Y, Hoshikawa N, Takai S Tags: J Nippon Med Sch Source Type: research

Neutrophil/Lymphocyte Ratio in Patients with Rheumatoid Arthritis Treated with Biological Agents.
CONCLUSION: The N/L ratio is a marker of disease activity in RA. The ΔN/L ratio reflects the efficacy of biological agents but does not predict the response to biological agents. PMID: 27430176 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Koiwa M, Goto S, Takahashi K, Kamada T, Takai S, Nakamura H Tags: J Nippon Med Sch Source Type: research

Use of an Inverted and Segmented Galea-Calvarial Flap for the Simultaneous Reconstruction of the Frontal Sinus and Forehead: A New Supplementary Method of Reconstructive Cranial Surgery.
We report on a new technical method of using an inverted and segmented galea-calvarial flap for simultaneous reconstruction of the frontal sinus and forehead. A 73-year-old man presented with the production of pus at the forehead, in which the frontal sinus had been involved 6 years postoperatively. The patient underwent surgery with our new simultaneous technique. During the 7 years of follow-up after this reconstructive surgery, no recurrence of surgical wound problems was noted. PMID: 27430177 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Takumi I, Akimoto M, Morita A Tags: J Nippon Med Sch Source Type: research

Prenatal Detection of Peters' Plus Syndrome in a Patient with No Known Family History.
We present a case of this uncommon syndrome that we diagnosed during a fetal ultrasonographical examination. Because the patient exhibited microcephaly and anterior staphyloma of the right eye and because impending rupture was feared, we performed ophthalmectomy during the neonatal period. Fetal ophthalmological anomalies are often detected during ultrasonographic examination targeting other systemic abnormalities, with positive family histories providing important diagnostic clues. This case is, to our knowledge, the first to be reported of prenatally diagnosed Peters' plus syndrome in a patient with no known family histo...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Shima Y, Migita M Tags: J Nippon Med Sch Source Type: research

Pancreatic Metastasis from Gastrointestinal Stromal Tumor of the Stomach: A Case Report.
We report the first documented case of pancreatic metastasis from a gastrointestinal stromal tumor of the stomach. A 42-year-old Japanese man presented with severe abdominal discomfort. Computed tomography of the abdomen showed a huge heterogeneous mass consisting of cystic and solid components in the left upper abdomen. (18)F-Fluorodeoxyglucose positron-emission tomography revealed high tracer uptake in the abdominal mass. After total gastrectomy with lymphnodectomy was performed, a hard mass was palpated in the pancreatic tail. The pancreatic tumor was also resected under the therapeutic strategy. Histological examinatio...
Source: Journal of Nippon Medical School - July 21, 2016 Category: Universities & Medical Training Authors: Hagiwara N, Matsutani T, Nomura T, Fujita I, Kanazawa Y, Ueda J, Arai H, Kakinuma D, Kanno H, Naito Z, Uchida E Tags: J Nippon Med Sch Source Type: research

Metronidazole-Induced Encephalopathy: A Case Report.
PMID: 27180788 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Bae EH, Ma SK, Kim SK, Kim SW Tags: J Nippon Med Sch Source Type: research

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy.
Abstract Keloids and hypertrophic scars are fibroproliferative disorders of the skin that are caused by abnormal healing of injured or irritated skin. It is possible that they are both manifestations of the same fibroproliferative skin disorder and just differ in terms of the intensity and duration of inflammation. These features may in turn be influenced by genetic, systemic, and local risk factors. Genetic factors may include single nucleotide polymorphisms, while systemic factors may include hypertension, pregnancy, hormones, and cytokines. The most important local factor is tension on the scar. Over the past 1...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ogawa R, Akaishi S, Kuribayashi S, Miyashita T Tags: J Nippon Med Sch Source Type: research

Different Patterns of Acetylation and Dimethylation of Histone H3 between Young and Aged Cases with Chronic Tonsillitis: Influences of Inflammation and Aging.
CONCLUSION: Our results suggest that epigenetic changes participate in chronic inflammation and aging in the palatine tonsils. Although the results do not lead to a direct treatment, the epigenetic pathogenesis of chronic inflammation, such as immunoglobulin A nephropathy, by focal infections will be described in greater detail in future studies, which will lead to new treatments being developed. PMID: 27180790 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Saito A, Watanabe K, Egawa S, Okubo K Tags: J Nippon Med Sch Source Type: research

Urgent Catheter Ablation in Octogenarians with Serious Tachyarrhythmias.
This study included consecutive octogenarians who underwent urgent radiofrequency catheter ablation (RFCA) for various serious tachyarrhythmias (urgent group, n=28) that were life-threatening, hemodynamically deleterious, or provoking ischemia, and consecutive octogenarians who underwent elective RFCA (control group, n=36). The rate of a successful RFCA, complications, later arrhythmia recurrences, and mortality were compared between the groups. RESULTS: There was no significant difference in the breakdown of the targeted arrhythmias between the groups, and common-type atrial flutter was most often targeted in both th...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Takahashi K, Hayashi M, Iwasaki YK, Miyauchi Y, Yodogawa K, Tsuboi I, Hayashi H, Oka E, Hagiwara K, Fujimoto YH, Shimizu W Tags: J Nippon Med Sch Source Type: research

Usefulness of Single Photon Emission Computed Tomography/Computed Tomography Fusion-Hybrid Imaging to Evaluate Coronary Artery Disorders in Patients with a History of Kawasaki Disease.
CONCLUSION: Fusion imaging was capable of accurately evaluating myocardial ischemia/infarction as cardiovascular sequelae of Kawasaki disease and confirming the culprit coronary arteries. In addition, analysis of fusion images confirmed that small-range infarct lesions were concomitantly present directly under giant coronary artery aneurysms in the anterior descending coronary artery. PMID: 27180792 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Abe M, Fukazawa R, Ogawa S, Watanabe M, Fukushima Y, Kiriyama T, Hayashi H, Itoh Y Tags: J Nippon Med Sch Source Type: research

Combining Fulvestrant with Low-Dose Capecitabine is Effective and Tolerable in Woman with Metastatic Breast Cancer.
Abstract Although the use of endocrine therapy in combination with intravenous chemotherapy has not been standardized, the combination of fulvestrant and chemotherapy may be promising. A 62-year-old woman came to our hospital's outpatient clinic with extensive ascites. Approximately 10 years earlier, she had undergone mastectomy and sentinel lymph node biopsy. Pathologically invasive lobular carcinoma, with a maximum diameter of 28 mm, had been diagnosed in the left breast. The cancer had a histological grade of 2, was positive for estrogen receptor (95% or more positive cells), and was negative for both progester...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Nakai M, Takei H, Yanagihara K, Yamashita K, Uchida E Tags: J Nippon Med Sch Source Type: research

Homonymous Hemianopsia Associated with Probable Alzheimer's Disease.
We describe a case of PCA in which a combination of imaging methods, in conjunction with symptoms and neurological and neuropsychological examinations, led to its being diagnosed and to AD being identified as its probable cause. Treatment with donepezil for 6 months mildly improved alexia symptoms, but other symptoms remained unchanged. A 59-year-old Japanese woman with progressive alexia, visual deficit, and mild memory loss was referred to our neurologic clinic for the evaluation of right homonymous hemianopsia. Our neurological examination showed alexia, constructional apraxia, mild disorientation, short-term memory los...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ishiwata A, Kimura K Tags: J Nippon Med Sch Source Type: research

Right Inguinal Hernia Encompassing the Uterus, Right Ovary and Fallopian Tube in an Elderly Female: Case Report.
We report on an operation to treat just such a rare condition for a right inguinal hernia. An 87-year-old Japanese woman was admitted with swelling in the right inguinal region and a purulent discharge from the vagina. Vital signs were stable, but the mobile mass was irreducible. Computed tomography of the abdomen indicated uterine tissue in a right inguinal hernia. We diagnosed an inguinal hernia with an incarcerated uterus and performed surgery on that basis. An incision approximately 6 cm long was made in the skin above the swollen area to open the inguinal sac, disclosing a tumor enveloped by a hernial sac. Opening the...
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Authors: Ueda J, Yoshida H, Makino H, Maruyama H, Yokoyama T, Hirakata A, Akagi I, Watanabe M, Uchida E, Uchida E Tags: J Nippon Med Sch Source Type: research

Errata.
Authors: PMID: 27180796 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 19, 2016 Category: Universities & Medical Training Tags: J Nippon Med Sch Source Type: research

Conservative Treatment for Fracture of the Proximal Femur with Complications.
CONCLUSION: This study showed that in patients with hip fractures, severe complications, and poor general conditions, early prognosis after conservative treatment aiming for early transfer to wheelchair is no worse than that following surgical treatment. Thus, conservative treatment should be considered for patients with poor ability for activities of daily living. PMID: 26960582 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Kawaji H, Uematsu T, Oba R, Takai S Tags: J Nippon Med Sch Source Type: research

Pregnancy-associated Deaths: 31-year Experience.
CONCLUSIONS: Amniotic fluid embolism was the leading cause of maternal deaths and was followed by obstetric hemorrhage. To prevent and reduce the number of maternal deaths in Japan, further basic and clinical research on amniotic fluid embolism is required. PMID: 26960583 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Yoneyama K, Sekiguchi A, Matsushima T, Kawase R, Nakai A, Asakura H, Takeshita T Tags: J Nippon Med Sch Source Type: research

Effect of Dual Therapy with Botulinum Toxin A Injection and Electromyography-controlled Functional Electrical Stimulation on Active Function in the Spastic Paretic Hand.
Abstract BACKGROUND: Many previous studies have demonstrated that botulinum toxin A (BTX-A) injections satisfactorily reduce spasticity. Nevertheless, BTX-A, with or without an adjuvant therapy, effectively improves the direct functional movement in few patients with spastic upper extremity paralysis. Therefore the present study aimed to determine the effectiveness of task-orientated therapy on spasticity and functional movement by using electromyography-triggered functional electrical stimulation (EMG-FES) after BTX-A injections. DESIGN: Open-label, prospective clinical trial Method: The subjects were 15 pat...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Tsuchiya M, Morita A, Hara Y Tags: J Nippon Med Sch Source Type: research

Superior Dislocation of the Patella in a Young Woman without Osteophytes: A Case Report.
Abstract Superior dislocation of the patella without patellar ligament injury is an extremely rare condition. A review of the English-language literature found only 23 reported cases. In addition, the primary factor for dislocation in most of these cases was considered to be osteophytes in the inferior pole of the patella and the anterior surface of the femoral condyle; only 1 case had no osteophytes. We treated a 19-year-old woman who sustained a painful locking of the left knee after colliding with a friend. Plain radiography and computed tomography showed superior-lateral dislocation of the patella and an inter...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Kataoka T, Iizawa N, Takai S Tags: J Nippon Med Sch Source Type: research

Glue Embolization of a Blunt Traumatic Hepatic Arteriovenous Fistula under Inflow and Outflow Control.
We report on a rare case of blunt traumatic hepatic arteriovenous fistula arising from a pseudoaneurysm in a 35-year-old woman. Transarterial embolization was performed with n-butyl-2-cyanoacrylate, under inflow control with loose coil packing within the pseudoaneurysm and outflow control by balloon occlusion of the hepatic vein. A promising therapeutic outcome was achieved without any serious adverse events. Thus, the combination of these techniques to control inflow and outflow was successfully used to treat this rare hepatic vascular injury. PMID: 26960586 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Mine T, Murata S, Yasui D, Yokota H, Tajima H, Kumita S Tags: J Nippon Med Sch Source Type: research

Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine.
CONCLUSION: Our findings indicate that topical tacrolimus should be considered for treating refractory interstitial keratitis in children. PMID: 26960587 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Joko T, Shiraishi A, Ogata M, Ohashi Y Tags: J Nippon Med Sch Source Type: research

Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia.
We report a case of the extremely rare condition Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (LPD) which occurred after umbilical cord blood transplantation. A 25-year-old Japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. Bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. Chronic symptoms of graft-versus-host disease appeared only on the skin and were successfully treated with cyclosporine alone. Three years later, however, the patien...
Source: Journal of Nippon Medical School - March 12, 2016 Category: Universities & Medical Training Authors: Yui S, Yamaguchi H, Imadome K, Arai A, Takahashi M, Ohashi R, Tamai H, Moriya K, Nakayama K, Shimizu A, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Rhabdomyosarcoma of the Uterus: A Case Report.
PMID: 26568387 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Kuroki M, Yoneyama K, Watanabe A, Fukami T, Matsushima T, Katsumata N, Takeshita T Tags: J Nippon Med Sch Source Type: research

Ultrasound Evaluation of the Transverse Movement of the Flexor Pollicis Longus Tendon on the Distal Radius during Wrist and Finger Motion in Healthy Volunteers.
CONCLUSIONS: There is a significant relationship between the transverse movement of the FPL at the distal radius and wrist and finger motions. Our findings indicated that the irritation of the FPL caused by the movement of both the FPL itself and of the flexor digitorum superficialis and profundus is most induced with the wrist in dorsal flexion with all 5 fingers at full flexion compared to other wrist positions during finger motion. This wrist position might be the optimum one at which to evaluate the irritation of the FPL from volar locking plates in patients with distal radius fracture. We believe that our transverse u...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Improvements in Signs and Symptoms of Dry Eye after Instillation of 2% Rebamipide.
CONCLUSIONS: The administration of 2% rebamipide 4 times daily for 4 weeks improves the signs and symptoms of dry eye and improves patients' quality of life. PMID: 26568389 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Igarashi T, Fujita M, Yamada Y, Kobayashi M, Fujimoto C, Takahashi H, Igarashi T, Nakano Y, Suzuki H, Takahashi H Tags: J Nippon Med Sch Source Type: research

Ethanol Dose- and Time-dependently Increases α and β Subunits of Mitochondrial ATP Synthase of Cultured Neonatal Rat Cardiomyocytes.
In this study, the effects of ethanol on protein composition was examined with 2-dimensional electrophoresis of protein extracts from cultured neonatal rat cardiomyocytes exposed to 100 mM ethanol for 24 hours. A putative β subunit of mitochondrial ATP synthase was increased, which was confirmed by Western blot. The cellular protein abundances in the α and β subunits of ATP synthase increased in dose (0, 10, 50, and 100 mM) - and time (0.5 hour and 24 hours) -dependent manners. The DNA microarray analysis of total RNA extract demonstrated that gene expression of the corresponding messenger RNAs of these sub...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Mashimo K, Arthur PG, Ohno Y Tags: J Nippon Med Sch Source Type: research

Intraperitoneal Migration of a Mesh Plug from a Hernioplasty Forming a Colocutaneous Fistula with the Cecum: Report of a Case.
This report describes the case of a 57-year-old man who had undergone a right inguinal hernioplasty 13 years previously. Recovery was uneventful until he experienced inflammation of the groin, and required open drainage three times for a refractory abscess in his right groin. Additional colonoscopy and x-ray examinations with contrast medium clearly demonstrated a mesh plug that had migrated and penetrated the cecum, forming a colocutaneous fistula. The mesh was successfully removed under general anesthesia, and the inflammation in the groin resolved. PMID: 26568391 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Sekiguchi K, Mizuguchi Y, Mamada Y, Koizumi M, Uchida E Tags: J Nippon Med Sch Source Type: research

A Girl with Idiopathic Epilepsy Showing Forced Normalization after Levetiracetam Administration.
CONCLUSIONS: To the best of our knowledge, this is the first report of a patient with idiopathic epilepsy but without disabilities in everyday life showing forced normalization associated with LEV administration. PMID: 26568392 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Kawakami Y, Okazaki T, Takase M, Fujino O, Itoh Y Tags: J Nippon Med Sch Source Type: research

Neurosyphilis Mimicking Ramsay Hunt Syndrome.
Abstract A 36-year-old man presented with facial nerve palsy, hearing loss, vertigo and headache. He was initially diagnosed with Ramsay Hunt syndrome and treated with a systemic steroid and valaciclovir; however, his symptoms deteriorated. Serum rapid plasma reagin (RPR) and treponema pallidum hemagglutination tests were positive. Cerebrospinal fluid analysis revealed an elevated white blood cell count and positive RPR, confirming the diagnosis of neurosyphilis. Penicillin G (PCG) was administered, and his facial nerve function and headache improved. However, left-side hearing loss worsened temporarily, which was...
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Maeda T, Yoshizawa S, Hirayama T, Saga T, Tateda K, Urita Y Tags: J Nippon Med Sch Source Type: research

Successful Rescue of a Patient with Acute Aconitine Poisoning Complicated by Polycystic Renal Hemorrhage.
CONCLUSIONS: This case significantly advances our understanding of hemoperfusion with reduced heparin for the treatment of ventricular arrhythmia caused by aconitine poisoning. PMID: 26568394 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 17, 2015 Category: Universities & Medical Training Authors: Chen X, Wu R, Jin H, Gao R, Yang B, Wang Q Tags: J Nippon Med Sch Source Type: research

Idiopathic Intracranial Hypertension: The "Moth-eaten" Skull Base and Encephaloceles.
Idiopathic Intracranial Hypertension: The "Moth-eaten" Skull Base and Encephaloceles. J Nippon Med Sch. 2015;82(4):168-9 Authors: Isshiki S, Tajima H, Wakayama N, Tateyama K PMID: 26328792 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Isshiki S, Tajima H, Wakayama N, Tateyama K Tags: J Nippon Med Sch Source Type: research

Transverse Ultrasound Assessment of the Displacement of the Median Nerve in the Carpal Tunnel during Wrist and Finger Motion in Healthy Volunteers.
Abstract PURPOSE: The purpose of this study was to investigate the displacement of the median nerve in the carpal tunnel during finger motion at varied wrist positions using transverse ultrasound in healthy volunteers, in order to clarify the appropriate position of a wrist splint in treating carpal tunnel syndrome. METHODS: Fifty wrists of 25 asymptomatic volunteers were evaluated by transverse ultrasound. The location of the median nerve in the carpal tunnel was examined at 5 wrist positions (neutral, 60° dorsiflexion, 60° palmar flexion, 40° ulnar flexion, 10° radial flexion) with all 5 fin...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Normative Data and Predictive Equation of Interrupter Airway Resistance in Preschool Children in Japan.
Abstract Measurement of interrupter airway resistance (Rint) is a convenient alternative to standard spirometry for assessing respiratory function in uncooperative young children. The aim of the present prospective study was to establish the normative data and predictive equation of Rint in Japanese preschool children. A total of 214 children were enrolled from a single kindergarten; however, 129 were excluded because they met at least 1 of the exclusion criteria, such as wheezing history or recent common cold. Expiratory Rint values were assessed in 85 of the children, but technically unsatisfactory measurements ...
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Imai T, Takase M Tags: J Nippon Med Sch Source Type: research

Too Early Initiation of Enteral Nutrition is Not Nutritionally Advantageous for Comatose Acute Stroke Patients.
CONCLUSION: It is nutritionally disadvantageous not to start nutritional support within 3 days after admission in comatose acute stroke patients. However, starting EN too early is not nutritionally beneficial, and TPN with 20% glucose fed through a tube is recommended as adequate nutrition for these patients. However, TPN should not be employed for longer than 10 days, because switching to EN after this period contributes to better nutritional recovery than continuing TPN. PMID: 26328795 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2015 Category: Universities & Medical Training Authors: Yamada SM Tags: J Nippon Med Sch Source Type: research