Trans-scaphoid Perilunate Fracture-dislocation with Concomitant Lunotriquetral Ligament Disruption: A Case Report.
We report a case of trans-scaphoid perilunate fracture-dislocation with concomitant lunotriquetral ligament disruption of the right wrist in a 44-year-old man, sustained from a 10-m fall landing on his outstretched right hand. Open reduction was performed 1 day after injury; at first the palmar dislocation of the lunate was reduced with the palmar approach. Under direct view with the dorsal approach, the scaphoid was comminuted and then treated with open reduction and internal fixation with a double threshold screw using a dorsal approach and a bone graft from the distal radius. Although the scapholunate ligament was intac...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Sonoki K, Tomori Y, Obara Y, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

A Case of Primary Malignant Lymphoma of the Prostate Gland Presenting as Right Lower Back Pain and Dysuria.
Abstract A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis and a large pelvic large mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate was palpable on digital rectal examination. A prostate tumor was suspected, and a transrectal prostate biopsy and right transurethral ureteral stent placement were performed. Histological and immunohistochemical studies revealed diffuse large B-cell lymphoma. Positron emission tomography-computed tomography showed abnormal uptake in the stomach, ...
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Yasuoka S, Kimura G, Toyama Y, Moriya K, Takahashi K, Matsuoka R, Shibayama K, Obayashi K, Inoue Y, Shindo T, Iigaya S, Endo Y, Akatsuka J, Hayashi T, Nakayama S, Hamasaki T, Inokuchi K, Kondo Y Tags: J Nippon Med Sch Source Type: research

An 8-Year-Old Girl with Autoimmune Hepatitis Following Aplastic Anemia.
Abstract We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy. PMID: 30259895 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 28, 2018 Category: Universities & Medical Training Authors: Nishigori A, Hatori T, Asano T Tags: J Nippon Med Sch Source Type: research

Plasma Adsorption Membranes Are Able to Efficiently Remove High Mobility Group Box-1 (HMGB-1).
CONCLUSIONS: Our findings showed that plasma adsorption therapy efficiently adsorbed HMGB-1 and could be safely applied for the treatment of sepsis. PMID: 30135341 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Onohara T, Sakamoto Y, Inoue S Tags: J Nippon Med Sch Source Type: research

Objective Colorimetric Evaluation of Aging-related Articular Cartilage Degeneration.
CONCLUSIONS: This study developed an original colorimetric device with high validity. Browning of articular cartilage increased with age, but this study did not detect pentosidine-caused browning. Further study is needed to clarify the factors associated with browning of cartilage. PMID: 30135342 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Satake Y, Takahashi K, Saito M, Takai S Tags: J Nippon Med Sch Source Type: research

Arthroscopic Coracoclavicular Ligament Reconstruction for Acromioclavicular Joint Dislocation.
CONCLUSION: ACCLR for acute dislocation of the ACJ is a useful surgical procedure that gives satisfactory clinical and radiologic outcomes on mid- and long-term follow-up. ACCLR can stabilize vertical instability of the ACJ. If instability in the horizontal direction remains, repair or reconstruction of the acromioclavicular ligament should be added to prevent osteoarthritic changes of the ACJ. PMID: 30135343 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Hashiguchi H, Iwashita S, Abe K, Sonoki K, Yoneda M, Takai S Tags: J Nippon Med Sch Source Type: research

Cutaneous Vasculitis in Cogan's Syndrome: A Report of Two Cases Associated with Chlamydia Infection.
Abstract Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis. Here, we report two cases of CS, one of which involved a patient who developed the typical sympto...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Kawasaki Y, Uehara T, Kawana S Tags: J Nippon Med Sch Source Type: research

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.
CONCLUSIONS: In our patients with MEN2B, prophylactic or early thyroidectomy could not be performed. The characteristic phenotype associated with MEN2B is almost always seen prior to detection of MTC or pheochromocytoma. Knowledge about the non-endocrine manifestations of MEN2B needs to be shared among pediatricians and gastroenterologists. PMID: 30135345 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Nagaoka R, Sugitani I, Sanada M, Jikuzono T, Okamura R, Igarashi T, Akasu H, Shimizu K Tags: J Nippon Med Sch Source Type: research

Subcuticular Suturing with Closed Suction Drainage for Wound Closure Following Stoma Reversal.
Abstract Incisional surgical site infection (SSI) is a leading complication of stoma reversal procedures. This retrospective study was conducted to assess the incidence of incisional SSI and other wound complications when wound closure was achieved by subcuticular suturing and closed suction drainage following stoma reversal. We analyzed data from a total of 49 patients, all of whom had undergone insertion of a 10 Fr closed suction drainage tube in the fascia, following irrigation with approximately 300 mL of physiological saline. We then performed subcuticular suturing with 4-0 monofilament absorbable sutures. Th...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Yoshimatsu K, Sagawa M, Yokomizo H, Yano Y, Okayama S, Satake M, Yamada Y, Matsumoto A, Shiozawa S, Shimakawa T, Katsube T, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.
CONCLUSION: These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains. PMID: 30135347 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Tsuno K, Miyatake C, Nishijima H, Hotta C, Ogawa T, Asano T Tags: J Nippon Med Sch Source Type: research

Diabetes Insipidus Presenting with Oligohydramnios and Polyuria During Pregnancy.
We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3.24. A vasopressin challenge test was performed and her urine osmolality increased by>100% from baseline after the administration of desmopressin. Because central DI or transient DI of pregnancy was suspected, we prescribed her a de...
Source: Journal of Nippon Medical School - August 25, 2018 Category: Universities & Medical Training Authors: Choi HS, Kim YH, Kim CS, Ma SK, Kim SW, Bae EH Tags: J Nippon Med Sch Source Type: research

Current Practice and Outcomes of Peritoneal Dialysis in the Nippon Medical School Musashi Kosugi Hospital.
CONCLUSION: The findings of this study revealed that assessment of the nutritional status of the patient and prevention of peritonitis are important for continuation of PD. PD is a safe treatment option that can maintain the quality of life in elderly patients. In a rapidly aging society, the need for PD-based medical care is expected to increase. PMID: 29731493 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Sumi Y, Sakai Y, Mugishima K, Suzuki A, Otsuka Y, Otsuka T, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Variation in the Phenotype of Photosensitive Cells Produced from Human Fibroblast Cell Lines.
CONCLUSIONS: These results suggest that photosensitive cells produced from different cell lines by direct reprogramming might express different phenotypes. PMID: 29731494 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Ishii T, Yin C, Seko Y, Umezawa A, Kaneda M Tags: J Nippon Med Sch Source Type: research

A Case of Sj ögren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis.
A Case of Sjögren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. J Nippon Med Sch. 2018;85(2):117-123 Authors: Yamada T, Fukui M, Kashiwagi T, Arai T, Itokawa N, Atsukawa M, Shimizu A, Tsuruoka S Abstract A 61-year-old woman was admitted to our hospital because of muscle paralysis and was found to have severe hypokalemia. A gallium-67 scintigram revealed a positive accumulation in the bilateral salivary glands, and a labial minor salivary gland biopsy demonstrated a massive lymphocyte infiltrate around the salivary ducts. She was diagnosed with Sjö...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Yamada T, Fukui M, Kashiwagi T, Arai T, Itokawa N, Atsukawa M, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Aeromedical Transport Operations Using Helicopters during the 2016 Kumamoto Earthquake in Japan.
Abstract More than 6,000 people died in the Great Hanshin (Kobe) Earthquake in 1995, and it was later reported that there were around 500 preventable trauma deaths. In response, the Japanese government developed the helicopter emergency medical service in 2001, known in Japan as the "Doctor-Heli" (DH), which had 46 DHs and 2 private medical helicopters as of April 2016. DHs transport physicians and nurses to provide pre-hospital medical care at the scene of medical emergencies. Following lessons learned in the Great East Japan Earthquake in 2011, a research group in the Ministry of Health, Labour and Wel...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Motomura T, Hirabayashi A, Matsumoto H, Yamauchi N, Nakamura M, Machida H, Fujizuka K, Otsuka N, Satoh T, Anan H, Kondo H, Koido Y Tags: J Nippon Med Sch Source Type: research

Lysosomal Acid Lipase Deficiency in Japan: A Case Report of Siblings and a Literature Review of Cases in Japan.
We report on two siblings with early onset lysosomal acid lipase deficiency or Wolman disease. Their parents had a consanguineous marriage. The children showed evidence of abdominal distension and failed to thrive, despite having regular nutrition. At 3-4 months of age, their abdominal distension and jaundice progressed rapidly and they died of liver failure. Sebelipase alfa, a recombinant form of human lysosomal acid lipase has recently been used as an enzyme replacement therapy in patients with later-onset cholesteryl ester storage disease. Therefore, we investigated cases of lysosomal acid lipase deficiency in Japan and...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Ikari N, Shimizu A, Asano T Tags: J Nippon Med Sch Source Type: research

A Case of Anti-Glomerular Basement Membrane Antibody-Positive Systemic Lupus Erythematosus with Pulmonary Hemorrhage Successfully Treated at an Early Stage of the Disease.
We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum creatinine. Serological tests revealed elevated titers...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Yamada T, Mugishima K, Higo S, Yoshida Y, Itagaki F, Yui S, Kashiwagi T, Endo Y, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Mixed Cryoglobulinemic Vasculitis: A Case Report.
PMID: 29731499 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Hirama A, Mii A, Arakawa Y, Funakoshi T, Ko M, Sakai Y, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Sleep-Disordered Breathing-a Real Therapeutic Target for Hypertension, Pulmonary Hypertension, Ischemic Heart Disease, and Chronic Heart Failure?
Abstract Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Nakamoto T Tags: J Nippon Med Sch Source Type: research

SFRP1 Promoter Methylation and Renal Carcinoma Risk: A Systematic Review and Meta-Analysis.
CONCLUSION: Our results indicate that the methylation level of the SFRP1 promoter region is increased in patients with RCC compared to normal controls and might be involved in the occurrence and development of RCC. Additional well-designed studies are needed to further verify our conclusions. PMID: 29731501 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Mo S, Su Z, Heng B, Chen W, Shi L, Du X, Lai C Tags: J Nippon Med Sch Source Type: research

Idiopathic Ventricular Premature Contraction and Ventricular Tachycardia: Distribution of the Origin, Diagnostic Algorithm, and Catheter Ablation.
Abstract Idiopathic ventricular premature contractions (VPCs), defined as VPCs in the absence of obvious structural heart disease, are one of the common types of arrhythmia in clinical practice. They are sometimes complicated with non-sustained ventricular tachycardia (VT), and/or sustained VT with almost same QRS morphology in 12 leads ECG. Idiopathic VT (IVT) commonly occurs by focal mechanisms and the origins are distributed in a variety of sites in both ventricles. In this article, the clinical characteristics of IVT/IVPCs, the diagnostic algorithm, and how to ablate them will be reviewed. PMID: 29731502 ...
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Kobayashi Y Tags: J Nippon Med Sch Source Type: research

Evaluation of Teneligliptin Effects on Transcriptional Activity of PPAR γ in Cell-Based Assays.
CONCLUSION: We found that teneligliptin could increase PPARγ activity in cell-based assays irrespective of the PPARγ ligand-binding domain. PMID: 29731503 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 9, 2018 Category: Universities & Medical Training Authors: Takenaka Y, Inoue I, Nakano T, Ikeda M, Kakinuma Y, Ikegami Y, Shimada A, Noda M Tags: J Nippon Med Sch Source Type: research

Sudden Cardiac Death from the Perspective of Nonlinear Dynamics.
This study models the hemodynamics, consisting of heart rate, SNA, and blood pressure (BP), by modifying a known chaotic electrical circuit, the Chua circuit. A V-trough of the SNA appears when the resistive element between the SNA and BP in the circuit is increased, which corresponds to the impaired regulation of BP by the SNA. This finding is consistent with an acknowledged finding that a depressed baroreflex (a reflex of the BP by SNA) may trigger a lethal arrhythmia. This study indicates that a V-trough of the SNA is a possible precursor of sudden cardiac death on the basis of experimental and clinical findings as well...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Osaka M Tags: J Nippon Med Sch Source Type: research

Management of Anaplastic Thyroid Carcinoma: the Fruits from the ATC Research Consortium of Japan.
Abstract Anaplastic thyroid carcinoma (ATC) accounts for only 1 to 2% of all thyroid carcinomas, but it is one of the most lethal neoplasms in humans. To obtain further insights into this "orphan disease," we have established the ATC Research Consortium of Japan (ATCCJ) in 2009. It represents a multicenter registry for ATC that have been treated in Japan. To date, 67 institutions have taken part in the collaborative research system and over 1,200 cases have been accumulated in its database. Using this big data, several retrospective studies were carried out to evaluate 1) prognostic factors to determine ...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Sugitani I, Onoda N, Ito KI, Suzuki S Tags: J Nippon Med Sch Source Type: research

Dual Factors May Be Necessary for Development of Atopic March in Early Infancy.
Abstract The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging. Development of these diseases is strongly influenced by the fol...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Taniuchi S, Soejima K, Hatano Y, Takahashi M, Minami H Tags: J Nippon Med Sch Source Type: research

Contrast-Enhanced High-Resolution MRI for Evaluating Time Course Changes in Middle Cerebral Artery Plaques.
CONCLUSION: Gadolinium contrast enhancement was found to be useful for effective evaluation of time course changes in the stability of symptomatic MCA stenotic plaques. PMID: 29540643 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Abe A, Sekine T, Sakamoto Y, Harada-Abe M, Takagi R, Suda S, Suzuki K, Aoki J, Yoneyama M, Kimura K Tags: J Nippon Med Sch Source Type: research

The Incidence of Pediatric Invasive Bacterial Diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the Introduction of Conjugate Vaccines.
Abstract The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Sano T, Suzuki T, Nishigori A, Miyatake C, Koizumi S, Kaizu K, Fujita A, Kamisago M, Chang B, Ishiwada N, Asano T Tags: J Nippon Med Sch Source Type: research

Sphingosine-1-Phosphate (S1P) Is a Feasible Biomarker in Predicting the Efficacy of Polymyxin B-Immobilized Fiber Direct Hemoperfusion (PMX-DHP) in Patients with Septic Shock.
CONCLUSION: S1P levels prior to PMX-DHP can be used to predict its efficacy. In addition, continuous monitoring of S1P levels can indicate the effectiveness of PMX-DHP in patients with septic shock. PMID: 29540645 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Inoue S, Sakamoto Y, Koami H, Yamada C K, Nagashima F, Miike T, Iwamura T, Obata T Tags: J Nippon Med Sch Source Type: research

Two Cases of Verrucous Carcinoma: Revisiting the Definition.
Abstract Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin. Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Histopathologically, epithelial tumor cells grew pushing the stroma, while the basement membrane was intact. No prominent cellular atypia or hyperchromatin was found. Case 2, a male patient, aged 53 years, had a verrucous plaque at the border between his scrotum and inner aspect of his thigh. A pathological diagno...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Shimizu A, Hoashi T, Kataoka K, Shirakawa N, Mayumi N, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report.
Abstract Carcinosarcoma (CS) is a rare tumor, consisting of both carcinomatous and sarcomatous components. In this paper, we present a case of CS arising from a pleomorphic adenoma (PA) of the submandibular gland. A 64-year-old Japanese man presented with a left submandibular mass that had developed for 20 years with complaints of pain for the last 3 months. Magnetic resonance imaging showed a lesion involving the left submandibular gland. The patient underwent total dissection of the left submandibular gland and left cervical lymph nodes. Upon gross examination, the mass appeared completely covered by fibroadipos...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Endo Y, Ohashi R, Inai S, Yokoshima K, Nakamizo M, Shimizu A, Okubo K, Naito Z Tags: J Nippon Med Sch Source Type: research

Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency.
We describe an adult case of purpura fulminans developing in association with AT 3 deficiency without infection following a surgical procedure, and acute kidney injury (AKI) developing secondary to rhabdomyolysis and disseminated intravascular coagulation (DIC). To the best of our knowledge there have been no previous cases of purpura fulminans and AKI developing in association with acquired AT 3 deficiency without infection after surgery. PMID: 29540648 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Özkan G, Kübra Emeksiz G, Volkan Atar R, Sedef S, Sonat Kara P, Öznur M, Turgut B Tags: J Nippon Med Sch Source Type: research

Irreducible Elbow Fracture and Dislocation due to Incarceration of the Medial Epicondyle of the Humerus in a Child.
We report a case of an irreducible elbow fracture and dislocation due to incarceration of the medial epicondyle fragment of the humerus, classified as a Watson-Jones type 3 fracture of the medial epicondyle, and present the mechanism of the intra-articular incarceration of the medial epicondyle fragment. The patient was a 9-year-old boy who injured his right elbow in a fall, and was diagnosed with a Watson-Jones type 3 fracture of the medial epicondyle. As we could not achieve a good reduction under fluoroscopic imaging, surgery was immediately performed using a medial approach. We discovered that the incarcerated fracture...
Source: Journal of Nippon Medical School - March 17, 2018 Category: Universities & Medical Training Authors: Satake Y, Tomori Y, Sawaizumi T, Nanno M, Kodera N, Takai S Tags: J Nippon Med Sch Source Type: research

Pharmacotherapy for Neuropathic Pain in Japan.
Abstract Neuropathic pain (NeP) results from injury to, or disease of, the peripheral or central components of the neural systems involved in pain. In contrast to inflammatory pain, NeP can persist after healing from the initial injury has resolved. Antipyretic agents, such as non-steroidal anti-inflammatory drugs, steroids, and acetaminophen are ineffective, while specific agents such as gabapentinoids, antidepressants, antiepileptics, and opioids are effective in treating NeP. In this review, we address the definition of NeP, pharmacotherapy for NeP in Japan, pain classification, setting goals for successful NeP...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Masuda R, Ajimi J, Murata T Tags: J Nippon Med Sch Source Type: research

Lymphangiography Was Useful in Postoperative Intractable Chylothorax after Surgery for Esophageal Cancer: A Case Report.
This report describes a 72-year-old man with Stage III esophageal squamous cell carcinoma. Subtotal esophagectomy, through a right thoracoabdominal approach with two-field lymphadenectomy, and cervical esophagogastric anastomosis via the retrosternal route, were performed. On the 12th postoperative day, a diagnosis of chylothorax was made. Conservative treatment was initiated, but it proved to be ineffective. Therefore, ligation of the thoracic duct via a thoracotomy was performed, but this was not effective, either. Lymphangiography undertaken to identify the site of the leak in the thoracic duct enabled a diagnosis of an...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Shimakawa T, Naritaka Y, Miyazawa M, Asaka S, Shimazaki A, Yamaguchi K, Yokomizo H, Yoshimatsu K, Shiozawa S, Katsube T Tags: J Nippon Med Sch Source Type: research

Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility.
CONCLUSIONS: The measurement of genetic polymorphisms in metabolizing enzymes of tacrolimus, within one medical facility, is applicable for the selection of immunosuppressants and individual dosing for the treatment of autoimmune disease. PMID: 29279557 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kaneko T, Arai M, Watanabe A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case Report.
We report a case of concurrent bilateral hip arthroscopy for symptomatic bilateral femoroacetabular impingement (FAI) performed under the single anesthesia on an elite rugby player. A 27-year-old rugby player who played for a top league had bilateral hip joint pain. Physical examination revealed bilateral tenderness in the anterior area of the hips, with positive impingement signs. Based on the findings of hip radiography and magnetic resonance imaging, the patient's symptoms were diagnosed as bilateral FAI with hip labral tears. Bilateral hip arthroscopy under the single anesthesia was performed due to refractory symptoms...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Chinzei N, Hashimoto S, Hayashi S, Kanzaki N, Araki D, Kuroda R, Kurosaka M Tags: J Nippon Med Sch Source Type: research

A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
Abstract A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy showed a nodular and morpheic basal cell carcinoma (BCC). A chest computed tomography (CT) scan showed multiple lung tumors. CT-guided biopsy of the lung and the cervical lymph node revealed metastatic basal cell carcinoma (MBCC). The primary skin tumor was resected and a total of 10 courses of cisplatin (25 mg/m2/day×...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kanzaki A, Ansai SI, Ueno T, Kawana S, Shimizu A, Naito Z, Saeki H Tags: J Nippon Med Sch Source Type: research

A Drug Interaction between Crizotinib and Warfarin in Non-Small-Cell Lung Cancer: A Case Report.
We report a case of increased prothrombin time-international normalized ratio (PT-INR) when crizotinib and warfarin were co-administered. A 74-year-old Japanese woman presented to the hospital with dyspnea, and was diagnosed with anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Three years after surgical resection of the tumor, the patient started crizotinib because of the recurrence of NSCLC. She received 2 mg/day warfarin due to a medical history of cerebral infarction and chronic atrial fibrillation. Before crizotinib initiation, the patient's PT-INR was 2.60. After 7 days of daily doses of ...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Kubomura Y, Ise Y, Wako T, Katayama S, Noro R, Kubota K Tags: J Nippon Med Sch Source Type: research

Prompt Procedures Have a Great Impact on the Consequences of Asiatic Black Bear Mauling.
CONCLUSIONS: Although the severity and mortality rate following bear-inflicted injuries are not high, these encounters usually take place in remote rural areas, so a delay in rescue and proper care can lead to the incident becoming fatal. Hence, early decisions and arrangements for patient transportation to a tertiary care center and prompt measures to save lives will have a positive impact on the consequences of such incidents. PMID: 29279561 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Akiyama G, Kuwahara H, Asahi R, Tosa R, Yokota H Tags: J Nippon Med Sch Source Type: research

Midterm Result of Arthroscopic Bicruciate Ligament Sutures for Multiligament Knee Injury in an Adolescent Patient.
We present a case report on performing bicruciate ligament sutures arthroscopically in an adolescent patient. PATIENT AND METHODS: The patient was a 14-year-old boy, who was diagnosed with injuries to the anterior cruciate ligament, posterior cruciate ligament, and medial collateral ligament. Single-stage arthroscopic primary suturing of the anterior and posterior cruciate ligaments and open medial collateral ligament suturing were performed 7 days after the injury. RESULTS AND DISCUSSION: The patient returned to routine activities, including high-level competitive sports, at 8 months post-surgery, and currently,...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Oshima Y, Iizawa N, Takai S Tags: J Nippon Med Sch Source Type: research

A Case of Anomalous Congenital Band that Was Difficult to Differentiate from Omphalomesenteric Duct Anomaly.
Abstract Anomalous congenital band (ACB) is rare and difficult to identify preoperatively. Here we report a pediatric ACB case that was preoperatively suspected using computed tomography and was difficult to differentiate from omphalomesenteric duct anomaly. ACB should be considered in the differential diagnosis of acute abdomen. PMID: 29279563 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Miyao M, Takahashi T, Uchida E Tags: J Nippon Med Sch Source Type: research

A Case of a Giant Cell Tumor of the Tendon Sheath of the Middle Phalanx of the Fourth Toe.
Abstract Giant cell tumors of the tendon sheath (GCT-TS) are one of the most common tumors of the hand, along with ganglions. However, occurrence in the toes is far less common. Here we present a rare case of GCT-TS at the middle phalanx level of the flexor digitorum longus tendon sheath. Magnetic resonance imaging showed low intensity both on T1 and T2 weighted images. To the best of our knowledge, our case is the first report of a GCT-TS arising at the middle phalanx level of the flexor digitorum longus tendon sheath of the fourth toe. Although GCT-TS are rare in the toe, they must be included in the differentia...
Source: Journal of Nippon Medical School - December 28, 2017 Category: Universities & Medical Training Authors: Okabe K, Hoashi T, Asahara M, Esaki E, Ito M, Otsuka R, Funasaka Y, Saeki H Tags: J Nippon Med Sch Source Type: research

Review on Recent Topics in Hypophysitis.
Abstract The number of cases of lymphocytic hypophysitis is small, although the condition is not rare. For optimal therapy, the correct diagnosis from imaging, immunological studies, and pathological findings from a pituitary biopsy is important. Recently, anti-Rabphilin antibody has been proposed to be a biomarker for lymphocytic infundibulo-neurohypophysitis. Immunological disorders such as anti-Pit-1 antibody syndrome are similar to the pathogenesis of lymphocytic hypophysitis. Moreover, recent immune checkpoint blockade such ipilimumab has been shown to induce anti-CTLA-4-related hypophysitis. In the future, e...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Sugihara H Tags: J Nippon Med Sch Source Type: research

Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis.
Abstract Reflux esophagitis is characterized by excessive esophageal acid exposure. To treat reflux esophagitis, it is necessary to reduce excessive esophageal acid exposure to within the normal range. The first-line drug for the treatment of reflux esophagitis is a standard-dose proton-pump inhibitor (PPI), which is also recommended by the Evidence-based Clinical Practice Guidelines 2015 for gastroesophageal disease of the Japanese Society of Gastroenterology. It has been reported that the response to a standard dose of PPI in patients with mild reflux esophagitis is 90-100%, and that in patients with severe refl...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Iwakiri K Tags: J Nippon Med Sch Source Type: research

A Real-World Retrospective Cohort Study of Combined Therapy with Bevacizumab and Paclitaxel in Japanese Patients with Metastatic Breast Cancer.
CONCLUSIONS: The BP regimen was active and well tolerated in the real-world clinical settings. As many as 28.9% of patients who received the initial dose of 90 mg/m(2) required a dose reduction of paclitaxel by 20 mg/m(2). Therefore, there is a need to find a therapeutic regimen that is less likely to result in dose reductions for patients with MBC who undergo a BP regimen using the initial paclitaxel dose of 90 mg/m(2). PMID: 29142182 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Yamada H, Inoue K, Nagai SE, Nakai M, Arisawa F, Ueda H, Saito T, Ninomiya J, Kuroda T, Sakurai T, Kodama H, Kimizuka K, Hata S, Kai T, Kurosumi M, SBCCSG investigators Tags: J Nippon Med Sch Source Type: research

Worse Preoperative Status Based on Inflammation and Host Immunity Is a Risk Factor for Surgical Site Infections in Colorectal Cancer Surgery.
CONCLUSION: mGPS is an independent risk factor for SSIs. Our results suggest that cachexia before surgery in patients with colorectal cancer might predict the incidence of SSIs. PMID: 29142183 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Sagawa M, Yoshimatsu K, Yokomizo H, Yano Y, Okayama S, Usui T, Yamaguchi K, Shiozawa S, Shimakawa T, Katsube T, Kato H, Naritaka Y Tags: J Nippon Med Sch Source Type: research

Efficacy of Cell-Free and Concentrated Ascites Reinfusion Therapy for Palliative Care in a Patient with Malignant Pleural Mesothelioma: A Case Report.
We report the case of malignant ascites in a patient with malignant pleural mesothelioma (MPM) whose symptoms were relieved by CART. A 59-year-old Japanese male with MPM who had undergone pleural decortication had pleural and peritoneal recurrence. His general status deteriorated as he developed massive ascites due to peritoneal metastases. With the initiation of CART, he recovered well enough to receive cisplatin-based systemic chemotherapy. Repeated use of CART contributed to the maintenance of his good general condition and enabled him to undergo successive systemic chemotherapy, which might have lengthened his life. Th...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Hisakane K, Ohmatsu H, Umemura S, Kirita K, Matsumoto S, Yoh K, Niho S, Goto K Tags: J Nippon Med Sch Source Type: research

Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case.
In conclusion, despite the absence of pain sensitivity in CIPA syndrome cases, there is an absolute need for the administration of anesthesia in surgical procedures because of tactile hyperesthesia. PMID: 29142185 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Urfalioglu A, Arslan M, Duman Y, Gisi G, Oksuz G, Yildiz H, Oksuz H, Balaban A Tags: J Nippon Med Sch Source Type: research

Endoscopic Treatment of Boerhaave Syndrome Using Polyglycolic Acid Sheets and Fibrin Glue: A Report of Two Cases.
We report the cases of two patients with Boerhaave syndrome who were successfully treated using PGA sheets. The present clinical outcomes suggest that the use of PGA sheets is feasible and safe for treating patients with Boerhaave syndrome, and that they may be another treatment option. PMID: 29142186 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Ishikawa Y, Tagami T, Hirashima H, Fukuda R, Moroe Y, Unemoto K Tags: J Nippon Med Sch Source Type: research

An ATP2A2 Missense Mutation in a Japanese Family with Darier Disease: A Case Report and Review of the Japanese Darier Disease Patients with ATP2A2 Mutations.
Abstract Darier disease (DD) is a rare autosomal dominant skin disorder due to mutations in the ATP2A2 gene, which encodes sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2). The clinical manifestations of DD are characterized by warty papules and plaques in seborrheic areas, and association with neuropsychiatric abnormalities has also been reported in a few families with DD. We herein report a classic Japanese DD case with a previously described mutation (p.C560R) in ATP2A2. In Japan, 26 mutations in the ATP2A2 gene in 7 pedigrees and 19 sporadic cases with DD have been reported, among which one pedigre...
Source: Journal of Nippon Medical School - November 18, 2017 Category: Universities & Medical Training Authors: Li M, Higashi N, Nakano H, Saeki H Tags: J Nippon Med Sch Source Type: research