Therapeutic Effects of the Long-term Use of PAN Membrane Dialyzer in Hemodialysis Patients: Efficacy in Old Dialysis Patients with Mild PAD.
CONCLUSION: The cross-over trial show the AN69 membrane eliminates less AA and Alb compared with the PS membrane. Judging from the therapeutic effects of the long-term use of the AN69 membrane, the membrane is effective for dialysis and has good biocompatibility in the treatment of elderly HD patients with mild PAD. PMID: 25186576 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nakada H, Kashiwagi T, Iino Y, Katayama Y Tags: J Nippon Med Sch Source Type: research

Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Extracts of Intestinal Epithelial Cells under Oxidative Stress.
CONCLUSION: Pattern recognition of NMR spectral data using a chemometric technique clearly visualized the differences of oxidant injury in IEC-6 cells under oxidant stress. PMID: 25186577 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nakata K, Sato N, Hirakawa K, Asakura T, Suzuki T, Zhu R, Asano T, Koike K, Ohno Y, Yokota H Tags: J Nippon Med Sch Source Type: research

Anatomical factors associated with periesophageal vagus nerve injury after catheter ablation of atrial fibrillation.
CONCLUSION: Acalculous cholecystitis, as well as gastric hypomotility, can develop as a result of periesophageal VNI in patients undergoing AF ablation. The anatomical relationships among the LA, esophagus, spine, and descending aorta may influence the occurrence of VNI. PMID: 25186578 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Tsuboi I, Hayashi M, Miyauchi Y, Iwasaki YK, Yodogawa K, Hayashi H, Uetake S, Takahashi K, Shimizu W Tags: J Nippon Med Sch Source Type: research

Changes in Blood-pressure Control among Patients with Hypertension from 2008 through 2011: Surveys of Actual Clinical Practice.
Abstract We performed cross-sectional surveys to investigate changes in clinical practices regarding blood-pressure control in patients with hypertension from 2008 through 2011. Questionnaires regarding the care of patients with hypertension were mailed to members of the Kanagawa Physicians Association in Kanagawa Prefecture, Japan. Data were obtained on 675 patients in 2008, 332 in 2009, and 1,076 in 2011. The mean systolic blood pressure (BP) was significantly lower in 2011 than in 2008 (132.2±11.9 mm Hg versus 134.6±10.6 mm Hg). The office-measured target BP, according to the 2009 guidelines of th...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Hatori N, Sakai H, Sato K, Mitani K, Miyajima M, Yuasa S, Kuboshima S, Kajiwara K, Miyakawa M Tags: J Nippon Med Sch Source Type: research

Atypical radiological and intraoperative findings of acute cerebral hemorrhage caused by ruptured cerebral aneurysm in a patient with severe chronic anemia.
Abstract Acute intracerebral hemorrhage (ICH) associated with mild anemia is commonly observed on radiological examination, and there are several reports of ruptured aneurysms occurring with ICH but without accompanying subarachnoid hemorrhage. However, the relationship among computed tomography (CT), magnetic resonance imaging (MRI), and intraoperative findings of ICH caused by ruptured cerebral aneurysm in patients with severe chronic anemia has been rarely reported and is poorly understood. Here, we report atypical radiological and intraoperative findings of acute ICH caused by ruptured cerebral aneurysm in a p...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Matano F, Murai Y, Nakagawa S, Kato T, Kitamura T, Sekine T, Takagi R, Teramoto A Tags: J Nippon Med Sch Source Type: research

Flexor pollicis longus rupture in a trigger thumb after intrasheath triamcinolone injections: a case report with literature review.
We report an unusual case of a rupture of the flexor pollicis longus tendon after two intrasheath triamcinolone injections for left trigger thumb in a 56-year-old woman. Tendon grafting from proximal to the wrist to the fingertip was carried out using the palmaris longus tendon. The clinical result was evaluated as good according to Strickland's criteria. Recently, intrasheath triamcinolone injection has been thought of as a mainstay of the treatment for trigger digits. However, flexor tendon ruptures have been reported as a serious, rare complication following the injections suspected to be the result of intratendinous in...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Nanno M, Sawaizumi T, Kodera N, Tomori Y, Takai S Tags: J Nippon Med Sch Source Type: research

Efficacy of tracheostomy for central alveolar hypoventilation syndrome caused by lateral medullary infarction.
We describe 2 patients with CAHS-LMI and review the case reports for 17 previously described patients. Patient 1 was a 78-year-old man who was referred to our hospital because of dizziness. After admission, Wallenberg syndrome developed. Magnetic resonance imaging showed left LMI. He had hypercapnia and respiratory acidosis the next afternoon and temporarily received mechanical ventilation. A tracheotomy was performed on the 12th hospital day, and the patient was weaned from the ventilator on the 18th hospital day. Patient 2 was 72-year-old man who was referred to our hospital because of dizziness and gait disturbance. Wal...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Mishina M, Ohkubo S, Kamiya N, Abe A, Suda S, Sakamaki M, Kominami S, Mizunari T, Kobayashi S, Katayama Y Tags: J Nippon Med Sch Source Type: research

Timing of elective cesarean singleton delivery and neonatal respiratory outcomes at a Japanese perinatal center.
Abstract The present study examined the relation between the timing of elective cesarean delivery at term and neonatal respiratory outcomes at our institution. From 2005 through 2013, 1,951 elective cesarean singleton deliveries were performed at term. Of the neonates, 141 (7%) had respiratory disorders requiring oxygen supplementation. In comparison to the incidence of respiratory disorders in neonates delivered at full term (39-40 weeks), the incidences in neonates delivered at ≤38+1/7 weeks' and at 41 weeks' gestation were significantly higher. Uncomplicated elective cesarean singleton delivery should be avo...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Terada K, Ito M, Kumasaka S, Suzuki S Tags: J Nippon Med Sch Source Type: research

Obstetrician gender and delivery mode at a Japanese perinatal center.
We examined differences in delivery modes between deliveries managed by female obstetricians and gynecologists (OB/GYNs) and those managed by male OB/GYNs at our hospital. The rate of vacuum extraction/forceps delivery was significantly lower when deliveries were managed by female OB/GYNs. Logistic regression analysis showed that the lower rate of vacuum extraction/forceps delivery was associated with a lower rate of diagnosis of nonreassuring fetal status during the second stage of labor by female OB/GYNs. The rate of cesarean delivery and obstetric outcomes did not differ with the gender of the managing OB/GYN. The incre...
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Ito M, Terada K, Hayashi Z, Suzuki S Tags: J Nippon Med Sch Source Type: research

Molecular targeted therapy of lung cancer and the development of a molecular predictive model.
PMID: 25186585 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 5, 2014 Category: Universities & Medical Training Authors: Miyanaga A Tags: J Nippon Med Sch Source Type: research

Dense deposit disease in an elderly patient: report of a case.
PMID: 24998957 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Ohno D, Sakai Y, Suzuki A, Mugishima K, Sumi Y, Otsuka Y, Otsuka T, Shimizu A, Tsuruoka S Tags: J Nippon Med Sch Source Type: research

Differential Expression of ADAM (a Disintegrin and Metalloproteinase) Genes between Human First Trimester Villous and Extravillous Trophoblast Cells.
Abstract A disintegrin and metalloproteinases (ADAMs) are members of the metzincin family of zinc-dependent metalloproteinases that play pivotal roles in the proteolytic degradation of the extracellular matrix for cell invasion. Few studies have investigated the ADAM subtypes that are expressed in first trimester trophoblast cells. The purpose of this study was to elucidate the differential expression profiles of ADAMs between first trimester villous trophoblast cells (VTs) and extravillous trophoblast cells (EVTs). We isolated EVTs from explanted human first trimester chorionic villi and investigated the mRNA exp...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Takahashi H, Yuge K, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Suzuki M, Takizawa T Tags: J Nippon Med Sch Source Type: research

The Effects of Polymyxin B-immobilized Fiber Hemoperfusion on Respiratory Impairment in Endotoxemic Pigs.
Conclusion: PMX-DHP is effective for treating respiratory impairment and contributes to the decreased mortality rate in the endotoxemic pigs. PMID: 24998959 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Koami H, Sakamoto Y, Miyasho T, Itami T, Tamura J, Ishizuka T, Kawamura Y, Nakamura K, Miyoshi K, Yamashita K Tags: J Nippon Med Sch Source Type: research

Comparison of Outcomes between Women with De novo Stage IV and Relapsed Breast Cancer.
Conclusion: No differences in outcome were found between de novo stage IV disease and relapsed disease. However, their prognostic factors differed substantially and suggest that different treatment strategies may be warranted for metastatic disease in each type of breast cancer. PMID: 24998960 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Kitagawa D, Horiguchi S, Yamashita T, Kuroi K, Shimizu K Tags: J Nippon Med Sch Source Type: research

Stress Sensitivity in Patients with Atopic Dermatitis in Relation to the Translocator Protein 18 kDa (TSPO).
In conclusion, the present study provides new evidence that variation in the TSPO gene affects susceptibility to AD. PMID: 24998961 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Kaga M, Nakamoto Y, Nakamura K, Ikeda K, Yoshii M, Kawana S Tags: J Nippon Med Sch Source Type: research

Treatment for crusted scabies: limitations and side effects of treatment with ivermectin.
Abstract Skin eruption with mild itching of the hands and feet developed in a man in his 90s 1 month after he was hospitalized following a traffic accident. Scabies was diagnosed in an attending nurse 3 months after the patient's hospitalization, and infection from the patient was suspected. Cornification of the patient's soles and marked hypertrophy of the nails of both feet were observed. After a large number of scabies mites were detected on microscopic examination, crusted scabies was diagnosed. The patient was given oral ivermectin, 6 mg, once per week for 3 weeks, and crotamiton topical ointment containing 3...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Fujimoto K, Kawasaki Y, Morimoto K, Kikuchi I, Kawana S Tags: J Nippon Med Sch Source Type: research

Excision of Zenker's Diverticulum to Treat Dysphagia Associated with Acute-phase Cerebral Infarction.
Abstract A 75-year-old man was admitted to our hospital with dysphagia shortly after the onset of a brainstem infarction. Videofluorography indicated the presence of a Zenker's diverticulum with a bolus at the esophageal orifice; endoscopy 5 years earlier had not shown a Zenker's diverticulum and suggests that the diverticulum had formed because of an increase in the hypopharyngeal pressure caused by the brainstem infarction. Surgical excision successfully facilitated transport of the bolus to the esophageal orifice. In the present report, we describe a case of dysphagia caused by a Zenker's diverticulum following...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Abe A, Harada-Abe M, Takayama Y, Toda Y, Ueda M, Katayama Y Tags: J Nippon Med Sch Source Type: research

Contralateral breast cancer adjacent to a fibroadenoma: report of a case.
Abstract A 64-year-old woman noticed a lump of the right breast and consulted our outpatient clinic. She had undergone multiple excisional biopsies of fibroadenomas in both breasts and mastectomy for invasive ductal carcinoma (IDC) of the left breast. After completing 5 years of treatment with adjuvant tamoxifen, she had undergone screening with annual physical examinations and occasional computed tomography. She was declared recurrence-free 13 years after breast cancer surgery, although lumps were detected in the right breast, probably due to fibroadenomas. Mammography, ultrasonography, and magnetic resonance ima...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Iwamoto M, Takei H, Iida S, Yamashita K, Yanagihara K, Kurita T, Tsuchiya S, Kanazawa Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Local recurrence of lung adenocarcinoma 10 years after left upper lobectomy resembling pseudomesotheliomatous adenocarcinoma: a case report.
This report provides information that will help physicians establish an accurate diagnosis in similar cases. PMID: 24998965 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Okamoto J, Kubokura H, Motoda N, Hoshina H, Ishii H, Kitayama Y, Usuda J Tags: J Nippon Med Sch Source Type: research

A Case of Nonfunctioning Pancreatic Endocrine Tumor with Atypical Imaging Findings due to Prominent Fibrosis of the Tumor Stroma.
Abstract The patient, a 56-year-old woman, was found during routine checkup to have a disorder of hepatic function. Abdominal ultrasonography showed an ill-defined hypoechoic mass in the head and body of the pancreas; however, no blood-flow signal was observed within the tumor on Doppler ultrasonography. Abdominal computed tomography showed a low-density area in the arterial and portal venous phases. The lesion was visualized as an area of low signal intensity on both T1- and T2-weighted magnetic resonance images, whereas fluorodeoxyglucose positron emission tomography showed fluorodeoxyglucose accumulation in the...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hoshino A, Aimoto T, Suzuki H, Mizutani S, Ishii H, Mishima K, Wada Y, Kuroda S, Yagi A, Shimizu T, Oyama R, Yamagiwa R, Satoh S, Oba H, Shibuya T, Uchida E Tags: J Nippon Med Sch Source Type: research

What Is an Adequate Esophageal Preset Temperature for Sufficient Ablation Lesion Formation While Avoiding Digestive-organ Complications during Catheter Ablation of Atrial Fibrillation?
PMID: 24998967 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hayashi M Tags: J Nippon Med Sch Source Type: research

Relationship between Serum 1,5-anhydroglucitol, as an Indicator of Postprandial Glycemic Control, and Serum Uric Acid, Considering the Renal Threshold for Glucosuria in the Elderly.
PMID: 24998968 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Ouchi M, Oba K, Ishii K, Onishi T, Saigusa T, Aoyama J, Matsumura N, Igari Y, Suzuki T, Nakano H Tags: J Nippon Med Sch Source Type: research

Simultaneous Detection of Different RNAs Using a Novel Branched DNA in situ Hybridization Method.
PMID: 24805090 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Yoshimura H, Matsuda Y, Kawamoto Y, Naito Z, Ishiwata T Tags: J Nippon Med Sch Source Type: research

An Extended Family with Familial Medullary Thyroid Carcinoma and Hirschsprung's Disease.
Abstract Familial medullary thyroid carcinoma (FMTC) is an autosomal dominant inherited disease that has highly characteristic clinical features, including medullary thyroid carcinoma (MTC). Mutation of the RET proto-oncogene is known to be responsible for development of FMTC and for multiple endocrine neoplasia types 2A and 2B. Hirschsprung's disease is the most common form of structural intestinal obstructive disease in human newborns. Hirschsprung's disease is defined by the absence of neural crest-derived enteric ganglia along a variable length of the bowel that invariably involves the rectoanal junction. Co-s...
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Igarashi T, Okamura R, Jikuzono T, Uchino S, Sugitani I, Shimizu K Tags: J Nippon Med Sch Source Type: research

A new method for differentiating benign and malignant pleomorphic clustered calcifications in mammography.
Conclusion: The DAS is a new and reliable variable for differentiating between benign and malignant pleomorphic clustered calcifications. The DAS improves diagnostic accuracy and is useful for determining whether to proceed with biopsies. PMID: 24805092 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Kikuchi M, Tsunoda H, Kaneshiro T, Takahashi O, Suzuki K, Yamauchi H, Ichikawa T, Kumita S Tags: J Nippon Med Sch Source Type: research

Amoeboid neutrophils with few granules in childhood acute precursor B cell leukemia.
Conclusion: The presence of fewer intracellular granules in amoeboid neutrophils suggests lower neutrophil activity. These results indicate that amoeboid neutrophils in patients with BCP-ALL have lower function at onset and relapse. PMID: 24805093 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Asano T, Kaizu K, Maeda M Tags: J Nippon Med Sch Source Type: research

Identification of Pathological and Normal Parathyroid Tissue by Fluorescent Labeling with 5-aminolevulinic Acid during Endocrine Neck Surgery.
Conclusions: In all but a few cases, 5-ALA clearly labeled parathyroid tissue, allowing for its clean removal or preservation according to the purpose of the surgery. This simple, benign technique is extremely useful for identifying parathyroid tissue, whether pathological or normal, during endocrine neck surgery. PMID: 24805094 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Takeuchi S, Shimizu K, Shimizu K, Akasu H, Okamura R Tags: J Nippon Med Sch Source Type: research

Association between Fibrinogen Levels and Severity of Postpartum Hemorrhage in Singleton Vaginal Deliveries at a Japanese Perinatal Center.
We examined the relationship between low fibrinogen levels (
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Shibata Y, Shigemi D, Ito M, Terada K, Nakanishi K, Kato M, Igarashi M, Suzuki S Tags: J Nippon Med Sch Source Type: research

Small cell carcinoma of the esophagus: a case report.
Abstract A case of esophageal small cell carcinoma successfully treated with combination therapy consisting of preoperative chemotherapy, radiation therapy, and surgical resection. A 76-year-old man presented with a small cell carcinoma measuring 6 cm in diameter in the middle third of the thoracic esophagus. After preoperative therapy, the gross tumor was completely resected. The patient eventually died of metastatic disease 25 months after diagosis. We discuss the treatment of esophageal small cell carcinoma. PMID: 24805096 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Akagi I, Miyashita M, Makino H, Nomura T, Shimanuki K, Satake S, Hagiwara N, Uchida E Tags: J Nippon Med Sch Source Type: research

Spontaneous rupture of aneurysms of the ovarian artery at times remote from pregnancy.
We report here our experiences and consider lessons about diagnosis and management that can be drawn from this case and 5 other published cases in multiparous middle-aged women. These lessons include application of contrast-enhanced computed tomography to focus emergent care, surgical intervention, and association with systemic inflammatory response syndrome. We also consider how the cases might shed new light on the pathogenesis and evolution of this condition. PMID: 24805097 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Kodaira Y, Iwamura T, Hoshino H, Takahashi K, Kawahigashi Y, Matsumoto K Tags: J Nippon Med Sch Source Type: research

Hashimoto's Thyroiditis with Clinical Manifestations Resembling Dermatomyositis: A Case Report.
We report on a 59-year-old man with a 1-year history of forearm erythema, bilateral limb arthralgia, and muscle weakness. During the initial examination we observed infiltrative erythema of the forearm and muscle weakness and atrophy of the limbs. Blood tests revealed marked increases in myogenic enzymes. Because histopathological studies showed lymphocytic infiltration around the small blood vessels in the dermis and mucin deposition, we made a tentative diagnosis of dermatomyositis. However, the specific cutaneous manifestations of dermatomyositis, including heliotrope erythema and Gottron's sign, were absent, and the fi...
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Matayoshi T, Omi T, Mayumi N, Kawana S Tags: J Nippon Med Sch Source Type: research

Giant appendiceal mucocele: report of a case.
We report a rare case of giant appendiceal mucocele. A 48-year-old woman, with no discomfort, was admitted to our hospital after a mass was detected in the right lower quadrant of the abdomen. The patient underwent right hemicolectomy on the basis of the clinical diagnosis of a possible appendiceal tumor. The final pathologic diagnosis was mucocele of the appendix. PMID: 24805099 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Akagi I, Yokoi K, Shimanuki K, Satake S, Takeda K, Shimizu T, Kondo R, Kanazawa Y, Uchida E Tags: J Nippon Med Sch Source Type: research

The diagnostic usefulness of video capsule endoscopy in adolescent immunoglobulin a vasculitis (henoch-schönlein purpura).
In conclusion, video capsule endoscopy is a useful tool for evaluating small bowel lesions in patients with IgAV and provides valuable information for the treatment of IgAV with gastrointestinal involvement. PMID: 24805100 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Li M, Omi T, Matano Y, Fujimori S, Kawana S Tags: J Nippon Med Sch Source Type: research

Amyloid positron emission tomography imaging for the differential diagnosis of Alzheimer's disease.
PMID: 24614388 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Tateno A, Sakayori T, Okubo Y Tags: J Nippon Med Sch Source Type: research

Evaluation of hyperbaric oxygen therapy for chronic wounds.
Conclusions: HBOT is an effective treatment for patients with chronic wounds, due to a variety of causes, when used in combination with conventional standard therapy or further interventions. However, HBOT is less effective in patients with DM than in patients with venous stasis because hemodialysis, which is more common in patients with DM, has negative effects on wound healing. PMID: 24614389 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ueno T, Omi T, Uchida E, Yokota H, Kawana S Tags: J Nippon Med Sch Source Type: research

Thoracic aortic aneurysms in octogenarians: the results of open surgical repair using hypothermic circulatory arrest with antegrade selective cerebral perfusion.
Conclusion: The early and late outcomes after thoracic aortic surgery at our hospital using HCA with ASCP in octogenarians are acceptable. The operations are performed with an acceptable operative risk, even under emergency situations, including acute aortic dissection. PMID: 24614390 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Bessho R, Ishii Y, Nishina D, Kawase Y Tags: J Nippon Med Sch Source Type: research

Low-energy Extracorporeal Shock Wave Therapy Improves Microcirculation Blood Flow of Ischemic Limbs in Patients with Peripheral Arterial Disease: Pilot Study.
Conclusion: We have demonstrated that low-energy shock wave therapy is safe and can restore blood flow in the microcirculation in patients with symptomatic PAD. PMID: 24614391 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Tara S, Miyamoto M, Takagi G, Kirinoki-Ichikawa S, Tezuka A, Hada T, Takagi I Tags: J Nippon Med Sch Source Type: research

A Phase II Study of Paclitaxel and Carboplatin with a Biweekly Schedule in Patients with Epithelial Ovarian Cancer: Gynecologic Cancer Network Trial.
Conclusion: Paclitaxel combined with carboplatin using a biweekly schedule is a safe and effective chemotherapy regimen for patients with epithelial ovarian cancer. Our results suggest that a biweekly schedule is well tolerated and is less toxic than a triweekly schedule. PMID: 24614392 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Yoneyama K, Konishi H, Yahata T, Fujita K, Aoki Y, Doi D, Matsushima T, Kodama S, Honma S, Kato H, Nakayama H, Kamoi S, Asakura H, Takeshita T, Tanaka K Tags: J Nippon Med Sch Source Type: research

Intracranial Extra-axial Chondroma: A Case Report.
Abstract Intracranial chondroma is a rare benign neoplasm that occurs most often at the skull base. In extremely rare instances, it arises from the dura mater of the convexity or from the falx cerebri. The tumor cells are thought to originate from meningeal fibroblasts, perivascular mesenchymal tissue, or ectopic chondrocytes. Because the clinical presentation of such cases is nonspecific and because neuroimaging findings are not pathognomonic, intracranial chondromas mimic other intracranial tumors. Herein, we report a chondroma originating from the dura mater in the frontal region. The patient had been followed-...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Oz Atalay F, Ozgun G, Tolunay S, Bekar A Tags: J Nippon Med Sch Source Type: research

Cholelithiasis in a patient with type 2 Gaucher disease.
We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement. PMID: 24614394 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Migita M, Kumasaka S, Matsumoto T, Tajima H, Ueda T, Yamataka A Tags: J Nippon Med Sch Source Type: research

Hemothorax after the intravenous administration of tissue plasminogen activator in a patient with acute ischemic stroke and rib fractures.
Abstract A 79-year-old man experienced sudden-onset left hemiparesis and disturbance of consciousness. Diffusion-weighted magnetic resonance imaging showed an acute ischemic stroke in the territory of the right middle cerebral artery. He underwent systemic thrombolysis via the intravenous administration of tissue plasminogen activator (t-PA). Chest radiography and computed tomography performed the following day showed severe hemothorax with atelectasis of the left lung and multiple rib fractures; the initial chest radiogram had revealed rib fractures but we did not recognize them at the time. Conservative treatmen...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Shirokane K, Umeoka K, Mishina M, Mizunari T, Kobayashi S, Teramoto A Tags: J Nippon Med Sch Source Type: research

IgA vasculitis complicated by cytomegalovirus enteritis: a case report.
Abstract A 61-year-old man was admitted to our department with purpura and hemorrhagic bullae on his lower limbs, dull pain affecting the entire abdomen, and hematochezia. Histopathological examination and immunostaining revealed leukocytoclastic vasculitis of the small blood vessels of the dermis and IgA deposition; multiple ulcers were observed in the ileum during lower gastrointestinal (GI) endoscopy, so we made a diagnosis of IgA vasculitis (Henoch-Schönlein). Treatment with oral prednisolone (PSL) at a dose of 80 mg/day (1 mg/kg/day) for one week resolved the symptoms almost completely. However, when the...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ninomiya R, Omi T, Kato T, Mayumi N, Kawarasaki M, Kawana S Tags: J Nippon Med Sch Source Type: research

Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice.
This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ise Y, Mori T, Katayama S, Suzuki T, Wang TC Tags: J Nippon Med Sch Source Type: research

Novel biomarkers for the prevention of cardiovascular diseases.
PMID: 24614398 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Otsuka T Tags: J Nippon Med Sch Source Type: research

Gene therapy using neuroprotective factors in glaucoma.
PMID: 24614399 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Igarashi T Tags: J Nippon Med Sch Source Type: research

Establishment of MLL/AF4 Transgenic Mice with the Phenotype of Lymphoblastic Leukemia or Lymphoma.
PMID: 24189350 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Tamai H, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Future perspective of cardioplegic protection in cardiac surgery.
Abstract "Depolarized arrest", induced by hyperkalemic (moderately increased extracellular potassium) cardioplegia is the gold standard to achieve elective temporary cardiac arrest in cardiac surgery. Hyperkalemic cardioplegic solutions provide good myocardial protection, which is relatively safe and easily and rapidly reversible. However, this technique has detrimental effects associated with ionic imbalance involving sodium and calcium overload of the cardiac cell induced by depolarization of the cell membrane. Hence, the development of an improved cardioplegic solution that enhances myocardial protect...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Maruyama Y, Chambers DJ, Ochi M Tags: J Nippon Med Sch Source Type: research

Gastric Emptying of a Carbohydrate-electrolyte Solution in Healthy Volunteers Depends on Osmotically Active Particles.
Abstract Background: Preoperative ingestion of only clear fluids until 2 hours before induction of anesthesia is a common preoperative fasting regimen. Gastric emptying times, however, vary among clear fluids. We therefore investigated the gastric emptying of 2 clear glucose-electrolyte drinks. Method: A 2-way crossover study was performed in 10 healthy volunteers. After fasting, the volunteers drank 500 mL of either OS-1(®), an oral rehydration solution, or Pocari Sweat(®), a popular sports drink, over 3 minutes in a standing position. Magnetic resonance imaging was performed before, immediately after, an...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Kim C, Okabe T, Sakurai M, Kanaya K, Ishihara K, Inoue T, Kumita S, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Antagonistic Effects of Tetrodotoxin on Aconitine-induced Cardiac Toxicity.
Abstract Aconitine, well-known for its high cardiotoxicity, causes severe arrhythmias, such as ventricular tachycardia and ventricular fibrillation, by opening membrane sodium channels. Tetrodotoxin, a membrane sodium-channel blocker, is thought to antagonize aconitine activity. Tetrodotoxin is a potent blocker of the skeletal muscle sodium-channel isoform Nav1.4 (IC50 10 nM), but micromolar concentrations of tetrodotoxin are required to inhibit the primary cardiac isoform Nav1.5. This suggests that substantial concentrations of tetrodotoxin are required to alleviate the cardiac toxicity caused by aconitine. To el...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Ono T, Hayashida M, Tezuka A, Hayakawa H, Ohno Y Tags: J Nippon Med Sch Source Type: research

Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia.
Abstract Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail. Methods: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the (13)C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) ...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Futagami S, Yamawaki H, Shimpuku M, Izumi N, Wakabayashi T, Kodaka Y, Nagoya H, Shindo T, Kawagoe T, Sakamoto C Tags: J Nippon Med Sch Source Type: research