Stress Sensitivity in Patients with Atopic Dermatitis in Relation to the Translocator Protein 18 kDa (TSPO).
In conclusion, the present study provides new evidence that variation in the TSPO gene affects susceptibility to AD. PMID: 24998961 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Kaga M, Nakamoto Y, Nakamura K, Ikeda K, Yoshii M, Kawana S Tags: J Nippon Med Sch Source Type: research

Treatment for crusted scabies: limitations and side effects of treatment with ivermectin.
Abstract Skin eruption with mild itching of the hands and feet developed in a man in his 90s 1 month after he was hospitalized following a traffic accident. Scabies was diagnosed in an attending nurse 3 months after the patient's hospitalization, and infection from the patient was suspected. Cornification of the patient's soles and marked hypertrophy of the nails of both feet were observed. After a large number of scabies mites were detected on microscopic examination, crusted scabies was diagnosed. The patient was given oral ivermectin, 6 mg, once per week for 3 weeks, and crotamiton topical ointment containing 3...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Fujimoto K, Kawasaki Y, Morimoto K, Kikuchi I, Kawana S Tags: J Nippon Med Sch Source Type: research

Excision of Zenker's Diverticulum to Treat Dysphagia Associated with Acute-phase Cerebral Infarction.
Abstract A 75-year-old man was admitted to our hospital with dysphagia shortly after the onset of a brainstem infarction. Videofluorography indicated the presence of a Zenker's diverticulum with a bolus at the esophageal orifice; endoscopy 5 years earlier had not shown a Zenker's diverticulum and suggests that the diverticulum had formed because of an increase in the hypopharyngeal pressure caused by the brainstem infarction. Surgical excision successfully facilitated transport of the bolus to the esophageal orifice. In the present report, we describe a case of dysphagia caused by a Zenker's diverticulum following...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Abe A, Harada-Abe M, Takayama Y, Toda Y, Ueda M, Katayama Y Tags: J Nippon Med Sch Source Type: research

Contralateral breast cancer adjacent to a fibroadenoma: report of a case.
Abstract A 64-year-old woman noticed a lump of the right breast and consulted our outpatient clinic. She had undergone multiple excisional biopsies of fibroadenomas in both breasts and mastectomy for invasive ductal carcinoma (IDC) of the left breast. After completing 5 years of treatment with adjuvant tamoxifen, she had undergone screening with annual physical examinations and occasional computed tomography. She was declared recurrence-free 13 years after breast cancer surgery, although lumps were detected in the right breast, probably due to fibroadenomas. Mammography, ultrasonography, and magnetic resonance ima...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Iwamoto M, Takei H, Iida S, Yamashita K, Yanagihara K, Kurita T, Tsuchiya S, Kanazawa Y, Uchida E Tags: J Nippon Med Sch Source Type: research

Local recurrence of lung adenocarcinoma 10 years after left upper lobectomy resembling pseudomesotheliomatous adenocarcinoma: a case report.
This report provides information that will help physicians establish an accurate diagnosis in similar cases. PMID: 24998965 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Okamoto J, Kubokura H, Motoda N, Hoshina H, Ishii H, Kitayama Y, Usuda J Tags: J Nippon Med Sch Source Type: research

A Case of Nonfunctioning Pancreatic Endocrine Tumor with Atypical Imaging Findings due to Prominent Fibrosis of the Tumor Stroma.
Abstract The patient, a 56-year-old woman, was found during routine checkup to have a disorder of hepatic function. Abdominal ultrasonography showed an ill-defined hypoechoic mass in the head and body of the pancreas; however, no blood-flow signal was observed within the tumor on Doppler ultrasonography. Abdominal computed tomography showed a low-density area in the arterial and portal venous phases. The lesion was visualized as an area of low signal intensity on both T1- and T2-weighted magnetic resonance images, whereas fluorodeoxyglucose positron emission tomography showed fluorodeoxyglucose accumulation in the...
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hoshino A, Aimoto T, Suzuki H, Mizutani S, Ishii H, Mishima K, Wada Y, Kuroda S, Yagi A, Shimizu T, Oyama R, Yamagiwa R, Satoh S, Oba H, Shibuya T, Uchida E Tags: J Nippon Med Sch Source Type: research

What Is an Adequate Esophageal Preset Temperature for Sufficient Ablation Lesion Formation While Avoiding Digestive-organ Complications during Catheter Ablation of Atrial Fibrillation?
PMID: 24998967 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Hayashi M Tags: J Nippon Med Sch Source Type: research

Relationship between Serum 1,5-anhydroglucitol, as an Indicator of Postprandial Glycemic Control, and Serum Uric Acid, Considering the Renal Threshold for Glucosuria in the Elderly.
PMID: 24998968 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 9, 2014 Category: Universities & Medical Training Authors: Ouchi M, Oba K, Ishii K, Onishi T, Saigusa T, Aoyama J, Matsumura N, Igari Y, Suzuki T, Nakano H Tags: J Nippon Med Sch Source Type: research

Simultaneous Detection of Different RNAs Using a Novel Branched DNA in situ Hybridization Method.
PMID: 24805090 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Yoshimura H, Matsuda Y, Kawamoto Y, Naito Z, Ishiwata T Tags: J Nippon Med Sch Source Type: research

An Extended Family with Familial Medullary Thyroid Carcinoma and Hirschsprung's Disease.
Abstract Familial medullary thyroid carcinoma (FMTC) is an autosomal dominant inherited disease that has highly characteristic clinical features, including medullary thyroid carcinoma (MTC). Mutation of the RET proto-oncogene is known to be responsible for development of FMTC and for multiple endocrine neoplasia types 2A and 2B. Hirschsprung's disease is the most common form of structural intestinal obstructive disease in human newborns. Hirschsprung's disease is defined by the absence of neural crest-derived enteric ganglia along a variable length of the bowel that invariably involves the rectoanal junction. Co-s...
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Igarashi T, Okamura R, Jikuzono T, Uchino S, Sugitani I, Shimizu K Tags: J Nippon Med Sch Source Type: research

A new method for differentiating benign and malignant pleomorphic clustered calcifications in mammography.
Conclusion: The DAS is a new and reliable variable for differentiating between benign and malignant pleomorphic clustered calcifications. The DAS improves diagnostic accuracy and is useful for determining whether to proceed with biopsies. PMID: 24805092 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Kikuchi M, Tsunoda H, Kaneshiro T, Takahashi O, Suzuki K, Yamauchi H, Ichikawa T, Kumita S Tags: J Nippon Med Sch Source Type: research

Amoeboid neutrophils with few granules in childhood acute precursor B cell leukemia.
Conclusion: The presence of fewer intracellular granules in amoeboid neutrophils suggests lower neutrophil activity. These results indicate that amoeboid neutrophils in patients with BCP-ALL have lower function at onset and relapse. PMID: 24805093 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Asano T, Kaizu K, Maeda M Tags: J Nippon Med Sch Source Type: research

Identification of Pathological and Normal Parathyroid Tissue by Fluorescent Labeling with 5-aminolevulinic Acid during Endocrine Neck Surgery.
Conclusions: In all but a few cases, 5-ALA clearly labeled parathyroid tissue, allowing for its clean removal or preservation according to the purpose of the surgery. This simple, benign technique is extremely useful for identifying parathyroid tissue, whether pathological or normal, during endocrine neck surgery. PMID: 24805094 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Takeuchi S, Shimizu K, Shimizu K, Akasu H, Okamura R Tags: J Nippon Med Sch Source Type: research

Association between Fibrinogen Levels and Severity of Postpartum Hemorrhage in Singleton Vaginal Deliveries at a Japanese Perinatal Center.
We examined the relationship between low fibrinogen levels (
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Shibata Y, Shigemi D, Ito M, Terada K, Nakanishi K, Kato M, Igarashi M, Suzuki S Tags: J Nippon Med Sch Source Type: research

Small cell carcinoma of the esophagus: a case report.
Abstract A case of esophageal small cell carcinoma successfully treated with combination therapy consisting of preoperative chemotherapy, radiation therapy, and surgical resection. A 76-year-old man presented with a small cell carcinoma measuring 6 cm in diameter in the middle third of the thoracic esophagus. After preoperative therapy, the gross tumor was completely resected. The patient eventually died of metastatic disease 25 months after diagosis. We discuss the treatment of esophageal small cell carcinoma. PMID: 24805096 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Akagi I, Miyashita M, Makino H, Nomura T, Shimanuki K, Satake S, Hagiwara N, Uchida E Tags: J Nippon Med Sch Source Type: research

Spontaneous rupture of aneurysms of the ovarian artery at times remote from pregnancy.
We report here our experiences and consider lessons about diagnosis and management that can be drawn from this case and 5 other published cases in multiparous middle-aged women. These lessons include application of contrast-enhanced computed tomography to focus emergent care, surgical intervention, and association with systemic inflammatory response syndrome. We also consider how the cases might shed new light on the pathogenesis and evolution of this condition. PMID: 24805097 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Kodaira Y, Iwamura T, Hoshino H, Takahashi K, Kawahigashi Y, Matsumoto K Tags: J Nippon Med Sch Source Type: research

Hashimoto's Thyroiditis with Clinical Manifestations Resembling Dermatomyositis: A Case Report.
We report on a 59-year-old man with a 1-year history of forearm erythema, bilateral limb arthralgia, and muscle weakness. During the initial examination we observed infiltrative erythema of the forearm and muscle weakness and atrophy of the limbs. Blood tests revealed marked increases in myogenic enzymes. Because histopathological studies showed lymphocytic infiltration around the small blood vessels in the dermis and mucin deposition, we made a tentative diagnosis of dermatomyositis. However, the specific cutaneous manifestations of dermatomyositis, including heliotrope erythema and Gottron's sign, were absent, and the fi...
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Matayoshi T, Omi T, Mayumi N, Kawana S Tags: J Nippon Med Sch Source Type: research

Giant appendiceal mucocele: report of a case.
We report a rare case of giant appendiceal mucocele. A 48-year-old woman, with no discomfort, was admitted to our hospital after a mass was detected in the right lower quadrant of the abdomen. The patient underwent right hemicolectomy on the basis of the clinical diagnosis of a possible appendiceal tumor. The final pathologic diagnosis was mucocele of the appendix. PMID: 24805099 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Akagi I, Yokoi K, Shimanuki K, Satake S, Takeda K, Shimizu T, Kondo R, Kanazawa Y, Uchida E Tags: J Nippon Med Sch Source Type: research

The diagnostic usefulness of video capsule endoscopy in adolescent immunoglobulin a vasculitis (henoch-schönlein purpura).
In conclusion, video capsule endoscopy is a useful tool for evaluating small bowel lesions in patients with IgAV and provides valuable information for the treatment of IgAV with gastrointestinal involvement. PMID: 24805100 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - May 10, 2014 Category: Universities & Medical Training Authors: Li M, Omi T, Matano Y, Fujimori S, Kawana S Tags: J Nippon Med Sch Source Type: research

Amyloid positron emission tomography imaging for the differential diagnosis of Alzheimer's disease.
PMID: 24614388 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Tateno A, Sakayori T, Okubo Y Tags: J Nippon Med Sch Source Type: research

Evaluation of hyperbaric oxygen therapy for chronic wounds.
Conclusions: HBOT is an effective treatment for patients with chronic wounds, due to a variety of causes, when used in combination with conventional standard therapy or further interventions. However, HBOT is less effective in patients with DM than in patients with venous stasis because hemodialysis, which is more common in patients with DM, has negative effects on wound healing. PMID: 24614389 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ueno T, Omi T, Uchida E, Yokota H, Kawana S Tags: J Nippon Med Sch Source Type: research

Thoracic aortic aneurysms in octogenarians: the results of open surgical repair using hypothermic circulatory arrest with antegrade selective cerebral perfusion.
Conclusion: The early and late outcomes after thoracic aortic surgery at our hospital using HCA with ASCP in octogenarians are acceptable. The operations are performed with an acceptable operative risk, even under emergency situations, including acute aortic dissection. PMID: 24614390 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Bessho R, Ishii Y, Nishina D, Kawase Y Tags: J Nippon Med Sch Source Type: research

Low-energy Extracorporeal Shock Wave Therapy Improves Microcirculation Blood Flow of Ischemic Limbs in Patients with Peripheral Arterial Disease: Pilot Study.
Conclusion: We have demonstrated that low-energy shock wave therapy is safe and can restore blood flow in the microcirculation in patients with symptomatic PAD. PMID: 24614391 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Tara S, Miyamoto M, Takagi G, Kirinoki-Ichikawa S, Tezuka A, Hada T, Takagi I Tags: J Nippon Med Sch Source Type: research

A Phase II Study of Paclitaxel and Carboplatin with a Biweekly Schedule in Patients with Epithelial Ovarian Cancer: Gynecologic Cancer Network Trial.
Conclusion: Paclitaxel combined with carboplatin using a biweekly schedule is a safe and effective chemotherapy regimen for patients with epithelial ovarian cancer. Our results suggest that a biweekly schedule is well tolerated and is less toxic than a triweekly schedule. PMID: 24614392 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Yoneyama K, Konishi H, Yahata T, Fujita K, Aoki Y, Doi D, Matsushima T, Kodama S, Honma S, Kato H, Nakayama H, Kamoi S, Asakura H, Takeshita T, Tanaka K Tags: J Nippon Med Sch Source Type: research

Intracranial Extra-axial Chondroma: A Case Report.
Abstract Intracranial chondroma is a rare benign neoplasm that occurs most often at the skull base. In extremely rare instances, it arises from the dura mater of the convexity or from the falx cerebri. The tumor cells are thought to originate from meningeal fibroblasts, perivascular mesenchymal tissue, or ectopic chondrocytes. Because the clinical presentation of such cases is nonspecific and because neuroimaging findings are not pathognomonic, intracranial chondromas mimic other intracranial tumors. Herein, we report a chondroma originating from the dura mater in the frontal region. The patient had been followed-...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Oz Atalay F, Ozgun G, Tolunay S, Bekar A Tags: J Nippon Med Sch Source Type: research

Cholelithiasis in a patient with type 2 Gaucher disease.
We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement. PMID: 24614394 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Migita M, Kumasaka S, Matsumoto T, Tajima H, Ueda T, Yamataka A Tags: J Nippon Med Sch Source Type: research

Hemothorax after the intravenous administration of tissue plasminogen activator in a patient with acute ischemic stroke and rib fractures.
Abstract A 79-year-old man experienced sudden-onset left hemiparesis and disturbance of consciousness. Diffusion-weighted magnetic resonance imaging showed an acute ischemic stroke in the territory of the right middle cerebral artery. He underwent systemic thrombolysis via the intravenous administration of tissue plasminogen activator (t-PA). Chest radiography and computed tomography performed the following day showed severe hemothorax with atelectasis of the left lung and multiple rib fractures; the initial chest radiogram had revealed rib fractures but we did not recognize them at the time. Conservative treatmen...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Shirokane K, Umeoka K, Mishina M, Mizunari T, Kobayashi S, Teramoto A Tags: J Nippon Med Sch Source Type: research

IgA vasculitis complicated by cytomegalovirus enteritis: a case report.
Abstract A 61-year-old man was admitted to our department with purpura and hemorrhagic bullae on his lower limbs, dull pain affecting the entire abdomen, and hematochezia. Histopathological examination and immunostaining revealed leukocytoclastic vasculitis of the small blood vessels of the dermis and IgA deposition; multiple ulcers were observed in the ileum during lower gastrointestinal (GI) endoscopy, so we made a diagnosis of IgA vasculitis (Henoch-Schönlein). Treatment with oral prednisolone (PSL) at a dose of 80 mg/day (1 mg/kg/day) for one week resolved the symptoms almost completely. However, when the...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ninomiya R, Omi T, Kato T, Mayumi N, Kawarasaki M, Kawana S Tags: J Nippon Med Sch Source Type: research

Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice.
This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced...
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Ise Y, Mori T, Katayama S, Suzuki T, Wang TC Tags: J Nippon Med Sch Source Type: research

Novel biomarkers for the prevention of cardiovascular diseases.
PMID: 24614398 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Otsuka T Tags: J Nippon Med Sch Source Type: research

Gene therapy using neuroprotective factors in glaucoma.
PMID: 24614399 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 15, 2014 Category: Universities & Medical Training Authors: Igarashi T Tags: J Nippon Med Sch Source Type: research

Establishment of MLL/AF4 Transgenic Mice with the Phenotype of Lymphoblastic Leukemia or Lymphoma.
PMID: 24189350 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Tamai H, Inokuchi K Tags: J Nippon Med Sch Source Type: research

Future perspective of cardioplegic protection in cardiac surgery.
Abstract "Depolarized arrest", induced by hyperkalemic (moderately increased extracellular potassium) cardioplegia is the gold standard to achieve elective temporary cardiac arrest in cardiac surgery. Hyperkalemic cardioplegic solutions provide good myocardial protection, which is relatively safe and easily and rapidly reversible. However, this technique has detrimental effects associated with ionic imbalance involving sodium and calcium overload of the cardiac cell induced by depolarization of the cell membrane. Hence, the development of an improved cardioplegic solution that enhances myocardial protect...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Maruyama Y, Chambers DJ, Ochi M Tags: J Nippon Med Sch Source Type: research

Gastric Emptying of a Carbohydrate-electrolyte Solution in Healthy Volunteers Depends on Osmotically Active Particles.
Abstract Background: Preoperative ingestion of only clear fluids until 2 hours before induction of anesthesia is a common preoperative fasting regimen. Gastric emptying times, however, vary among clear fluids. We therefore investigated the gastric emptying of 2 clear glucose-electrolyte drinks. Method: A 2-way crossover study was performed in 10 healthy volunteers. After fasting, the volunteers drank 500 mL of either OS-1(®), an oral rehydration solution, or Pocari Sweat(®), a popular sports drink, over 3 minutes in a standing position. Magnetic resonance imaging was performed before, immediately after, an...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Kim C, Okabe T, Sakurai M, Kanaya K, Ishihara K, Inoue T, Kumita S, Sakamoto A Tags: J Nippon Med Sch Source Type: research

Antagonistic Effects of Tetrodotoxin on Aconitine-induced Cardiac Toxicity.
Abstract Aconitine, well-known for its high cardiotoxicity, causes severe arrhythmias, such as ventricular tachycardia and ventricular fibrillation, by opening membrane sodium channels. Tetrodotoxin, a membrane sodium-channel blocker, is thought to antagonize aconitine activity. Tetrodotoxin is a potent blocker of the skeletal muscle sodium-channel isoform Nav1.4 (IC50 10 nM), but micromolar concentrations of tetrodotoxin are required to inhibit the primary cardiac isoform Nav1.5. This suggests that substantial concentrations of tetrodotoxin are required to alleviate the cardiac toxicity caused by aconitine. To el...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Ono T, Hayashida M, Tezuka A, Hayakawa H, Ohno Y Tags: J Nippon Med Sch Source Type: research

Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia.
Abstract Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail. Methods: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the (13)C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) ...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Futagami S, Yamawaki H, Shimpuku M, Izumi N, Wakabayashi T, Kodaka Y, Nagoya H, Shindo T, Kawagoe T, Sakamoto C Tags: J Nippon Med Sch Source Type: research

Significance of aggressive surgery for an invasive carcinoma derived from an intraductal papillary mucinous neoplasm diagnosed preoperatively as borderline resectable.
Abstract Purpose: We investigated the clinicopathological features of borderline resectable invasive carcinomas (BRICs) derived from intraductal papillary mucinous neoplasms (IPMNs) and examined the significance of the aggressive "surgery first" approach compared with the treatment of conventional borderline resectable pancreatic ductal adenocarcinomas (BRPDAs). Patients and Methods: We retrospectively studied 7 patients with BRICs derived from IPMNs and 14 patients with conventional BRPDAs. Several factors were reviewed: initial symptoms, preoperative imaging, serum level of CA19-9, perioperative factor...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Aimoto T, Mizutani S, Kawano Y, Suzuki H, Uchida E Tags: J Nippon Med Sch Source Type: research

Adjuvant Chemotherapy with S-1 Followed by Docetaxel for Gastric Cancer and CY1P0 Peritoneal Metastasis after Relatively Curative Surgery.
Abstract Objective: The aim of this study was to assess the feasibility and safety of adjuvant chemotherapy with S-1 followed by docetaxel. Patients and Method: Twenty-eight patients with advanced gastric cancer underwent gastrectomy without preoperative chemotherapy. These patients were divided into 3 groups on the basis of cytologic results of peritoneal lavage (CY) and the presence of local peritoneal metastatic nodules (P): CY1-P0, CY0-P1, and CY1-P1. Oral S-1 (80 mg/m(2)/day) was administered for 3 consecutive weeks, followed by intravenous docetaxel (35 mg/m(2)) on days 29 and 43 (1 cycle). This cycle was re...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Kanazawa Y, Kato S, Fujita I, Onodera H, Uchida E Tags: J Nippon Med Sch Source Type: research

Neonatal Case of Late-onset Sepsis Involving Group B Streptococcus Type Ib.
We report a case of late-onset infection by type Ib GBS. A female neonate weighing 574 g was delivered at 27 weeks' gestation. An endotracheal tube was inserted shortly after birth because of respiratory distress syndrome, and ampicillin was administered by the age of 3 days. At the age of 54 days after cardiopulmonary adaptation had been achieved, the patient presented with tachycardia following refractory apnea and bradycardia, and her skin became pale. She was suspected of having sepsis, and intensive treatment, including intubation and administration of catecholamines, was started. Despite these measures, the patient d...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Kumasaka S, Shima Y, Mine M, Nakajima M, Migita M Tags: J Nippon Med Sch Source Type: research

Seroconversion of Hepatitis B Envelope Antigen by Entecavir in a Child with Hepatitis B Virus-related Membranous Nephropathy.
Abstract Membranous nephropathy (MN) is caused by subepithelial deposition of immune complexes in the glomerular basement membrane, with secondary MN arising in association with infection. In secondary MN caused by hepatitis B virus (HBV), seroconversion has been known to occur after the onset of MN, particularly in children. In patients with high serum concentrations of HBV DNA, treatment with interferon-α2b or a nucleoside analog has been reported to induce seroconversion and suppress HBV-DNA levels. We treated a 7-year-old boy who presented with proteinuria and liver dysfunction. He had a history of HBV i...
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Igarashi T, Shimizu A, Igarashi T, Hanaoka K, Yoshizaki K, Shigemori T, Shimizu S, Komeichi H, Itoh Y Tags: J Nippon Med Sch Source Type: research

Intravenous cyclophosphamide pulse therapy in Japanese children with systemic lupus erythematosus.
Conclusions: IVCY pulse therapy for SLE in children achieved good long-term outcomes with no serious adverse effects, such as digestive symptoms, bone marrow suppression, infection, and hemorrhagic cystitis. IVCY pulse therapy for children with SLE has recently been approved by the Ministry of Health, Labour and Welfare. Accordingly, this paper might become a guideline for this treatment. PMID: 24189359 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - November 8, 2013 Category: Universities & Medical Training Authors: Igarashi T, Igarashi T, Shimizu A, Itoh Y Tags: J Nippon Med Sch Source Type: research

Preoperative diagnosis of abdominal diseases with endoscopic ultrasonography.
PMID: 23995566 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Mizuguchi Y, Mamada Y, Nakamura Y, Matsushita A, Yoshioka M, Kawano Y, Shimizu T, Kanda T, Fujita I, Uchida E Tags: J Nippon Med Sch Source Type: research

Risk factors for bleeding esophagogastric varices.
Abstract Bleeding from gastric varices (GVs) is generally considered more severe than that from esophageal varices (EVs) but occurs less frequently. We review the risk factors for bleeding EVs and GVs. GVs were divided into 2 groups: cardiac varices (CVs, Lg-c) and fundal varices (FVs), i.e., varices involving the fundus alone (Lg-f) or varices involving both the cardia and fundus (Lg-cf). Elevated pressure in the portal vein is a risk factor for bleeding EVs. The portal pressure in patients with GVs and a gastrorenal shunt is lower than that in patients with EVs. The large size of varices is a risk factor for ble...
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Yoshida H, Mamada Y, Taniai N, Yoshioka M, Hirakata A, Kawano Y, Mizuguchi Y, Shimizu T, Ueda J, Uchida E Tags: J Nippon Med Sch Source Type: research

Developmental changes in left and right ventricular function evaluated with color tissue Doppler imaging and strain echocardiography.
Conclusions: Systolic and diastolic variables change markedly from birth to 1 year of age and show only small changes thereafter. PMID: 23995568 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Akao M, Katsube Y, Kamisago M, Watanabe M, Abe M, Fukazawa R, Ogawa S, Itoh Y Tags: J Nippon Med Sch Source Type: research

Clinical Significance of Blood Coagulation Factor XIII Activity in Adult Henoch-Schönlein Purpura.
Conclusion: Measurement of plasma factor XIII activity in adult HSP is clinically useful because it indicates disease severity and the severity of digestive tract and joint disorders. Factor XIII substitution therapy is effective for joint and abdominal symptoms but not for renal symptoms. Further investigation of the effect of this treatment on renal symptoms is necessary. PMID: 23995569 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Matayoshi T, Omi T, Sakai N, Kawana S Tags: J Nippon Med Sch Source Type: research

Efficacy of steroid pulse therapy in combination with mizoribine following tonsillectomy for immunoglobulin a nephropathy in renally impaired patients.
Abstract Background: The long-term prognosis of immunoglobulin A nephropathy is poor. Treatment is intended to achieve complete remission in the early stage or to preserve renal function in the advanced stages. In Japan, aggressive steroid pulse therapy following tonsillectomy (tonsillectomy-pulse therapy) has recently been used to treat early IgA nephropathy and has achieved favorable outcomes. However, steroid doses are sometimes limited because of adverse reactions s and the efficacy of tonsillectomy-steroid pulse therapy has not been established in patients with renal dysfunction. In our current treatment prot...
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Kaneko T, Shimizu A, Tsuruoka S, Iino Y, Katayama Y Tags: J Nippon Med Sch Source Type: research

Efficacy of therapeutic hypothermia for neurological salvage in patients with cardiogenic sudden cardiac arrest: the importance of prehospital return of spontaneous circulation.
Conclusion: MTH is associated with favorable neurological outcomes after sudden cardiac arrest, including those with non-shockable rhythms, especially in patients with prehospital ROSC. PMID: 23995571 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Shinada T, Hata N, Kobayashi N, Tomita K, Shirakabe A, Tsurumi M, Matsushita M, Okazaki H, Yamamoto Y, Yokoyama S Tags: J Nippon Med Sch Source Type: research

Cysts of the round ligament simulating inguinal hernia: report of a case.
We report on a 49-year-old woman with cysts of the round ligament causing a nonreducible mass of the groin. Cysts of the round ligament are rare. Physical findings were similar to those of an inguinal hernia. Such cysts are usually not considered in the differential diagnosis of groin hernias and might be identified only at the time of herniorraphy. PMID: 23995572 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Saylam B, Gülseren MO, Han O, Comçalı B, Vural V, Coşkun F Tags: J Nippon Med Sch Source Type: research

Solitary Nasal Schwannoma: Usefulness of CD34 and Calretinin Staining for Distinction from Histological Mimics.
Abstract A solitary nasal schwannoma in a 31-year-old woman is described. The patient had a 10-year history of left nasal obstruction and presented with worsening symptoms. Computed tomography revealed a mass in the left nasal cavity extending into the ethmoidal and sphenoidal sinuses. A large, white polypoidal mass with a smooth surface was removed endoscopically piece by piece. Microscopic examination showed the tumor to be a benign spindle-cell neoplasm with predominantly mixed cellular pattern and with an indistinct focal mixture of hypercellular and hypocellular areas, likely representing Antoni A and B areas...
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Ohashi R, Wakayama N, Kawamoto M, Tsuchiya S, Okubo K Tags: J Nippon Med Sch Source Type: research

Gastric Lavage Guided by Ultrathin Transnasal Esophagogastroduodenoscopy in a Life-threatening Case of Tobacco Extract Poisoning: A Case Report.
Abstract Nicotine, which is found in tobacco, is one of the most toxic of all known poisons. A 31-year-old woman was brought to our emergency department 2 hours after ingesting a usually fatal dose of a tobacco extract. Although gastric lavage was once commonly used to treat poisoning cases of this type, lavage can lead to such complications as aspiration, hypoxia, oropharyngeal and gastric trauma, and electrolyte disturbances. Recent guidelines have suggested less-aggressive gastric-emptying procedures as initial treatments. Currently, there are no absolute indications for gastric lavage use. The present patient ...
Source: Journal of Nippon Medical School - September 4, 2013 Category: Universities & Medical Training Authors: Miyauchi M, Hayashida M, Hirata K, Hirata K, Yokota H Tags: J Nippon Med Sch Source Type: research