Susceptibility-Weighted MRI and Microbleeds in Mild Traumatic Brain Injury: Prediction of Posttraumatic Complaints?
Background: Only in 7 –15% of patients with mild traumatic brain injury (mTBI), traumatic CT-abnormalities are found. Nevertheless, 40% of mTBI patients suffer from posttraumatic complaints not resolving after 6 months. We discuss the ability of susceptibility-weighted imaging (SWI), sensitive for microbleeds, to detec t more subtle brain abnormalities.Summary: After a search on PubMed, we selected 15 studies on SWI in adult mTBI patients; 11 studies on 3T MRI, and 4 studies on 1.5T MRI. All 1.5T studies showed that, compared to T2, gradient echo, diffusion-weighted imaging, or fluid-attenuated inversion recovery seq...
Source: European Neurology - January 17, 2022 Category: Neurology Source Type: research

The Involvement of miRNAs in Pituitary Adenomas Pathogenesis and the Clinical Implications
Pituitary adenomas (PAs) account for the top three primary intracranial tumors in terms of total incidence rate. PAs can cause severe endocrine disorders and even malignant features, such as invasion, metastasis, and recurrence. Therefore, the early diagnosis and accurate prognosis would be greatly beneficial for clinical treatment of PAs. MicroRNAs (miRNAs) are small, protein-noncoding RNAs that regulate gene expression posttranscriptionally. They regulate essential physiological processes, including proliferation, growth, and apoptosis, and also they involve in the invasion and metastasis of malignant tumors. At the tiss...
Source: European Neurology - January 14, 2022 Category: Neurology Source Type: research

Uncovering of Key Pathways and miRNAs for Intracranial Aneurysm Based on Weighted Gene Co-Expression Network Analysis
Conclusion: Hub miRNAs and key signaling pathways were identified by bioinformatics analysis. This evidence lays the foundation for understanding the underlying molecular mechanisms of IA and provided potential therapeutic targets for the treatment of this disease.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 14, 2022 Category: Neurology Source Type: research

From Discipline to Quality of Care: How Neurologists Can Learn from Decisions of Disciplinary Tribunals
Conclusion: Medical disciplinary cases in the field of neurology are usually about diagnosis- and treatment-related aspects. Recordkeeping, interpretation of neuroimaging, and involvement of several consultants frequently play a role in a complaint being upheld. It is important that specialties evaluate disciplinary decisions on a structural and continuous basis.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 11, 2022 Category: Neurology Source Type: research

Do Patient/Doctor Benefits from Telephone/Electronic Contacts Exceed Those of Face-To-Face Visits?
Eur Neurol (Source: European Neurology)
Source: European Neurology - December 30, 2021 Category: Neurology Source Type: research

Identification of Novel Biomarkers in Platelets for Diagnosing Parkinson ’s Disease
Conclusion: Our findings demonstratedWASH5P,MALAT1,EEF1A1, andCTSS may be promising biomarkers in PD, which may contribute to improving the effectiveness and accuracy of diagnosis for PD in the future.Eur Neurol (Source: European Neurology)
Source: European Neurology - December 7, 2021 Category: Neurology Source Type: research

Efficacy of Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Meta-Analysis
Conclusion: Our meta-analysis of available published data supports IAT to be an alternative treatment option for CRAO patients within 6 h from symptom onset.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 30, 2021 Category: Neurology Source Type: research

Mechanical Thrombectomy with or without Intravenous Thrombolysis in Acute Ischemic Stroke: A Meta-Analysis for Randomized Controlled Trials
Conclusion: In this meta-analysis including 7 RCTs, MT had comparable consequences to bridging treatment in efficacy and safety outcomes for patients with ischemic stroke caused by the occlusion of proximal anterior circulation, irrespective of geographical location. These findings support the adoption of dMT in acute ischemic stroke treatments and have higher cost-effectiveness in global applications.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 24, 2021 Category: Neurology Source Type: research

Shell Shock: The Response of UK Neurology
The neurological and psychological manifestations of trauma, confinement, and terror became apparent throughout Europe as soldiers were evacuated from the trenches of the Western Front. The response in the UK evolved as a result of the experience of medical staff embedded with the troops in base hospitals and the philosophy of those treating returned soldiers in specialist establishment. There were widely disparate approaches to the management encompassing simple supportive care, a psychanalytic approach and radical electric shock therapy. The latter was partially driven by the Queen Square experience in the UK but was als...
Source: European Neurology - November 17, 2021 Category: Neurology Source Type: research

Design and Validation of an Expanded Disability Status Scale Model in Multiple Sclerosis
Conclusions: MS disability measured through EDSS is an age-dependent magnitude that is partly conditioned by SC and GCL. Further studies assessing paraclinical disability predictors are needed.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 17, 2021 Category: Neurology Source Type: research

Contents Vol. 84, 2021
Eur Neurol 2021;84:I –VI (Source: European Neurology)
Source: European Neurology - November 16, 2021 Category: Neurology Source Type: research

Acknowledgement to Reviewers
Eur Neurol 2021;84:493 –494 (Source: European Neurology)
Source: European Neurology - November 16, 2021 Category: Neurology Source Type: research

Online Surveys Are a Useful Additional Tool in Combination with Clinical Assessments to Easily Assess Demographic and Clinical Data
Eur Neurol (Source: European Neurology)
Source: European Neurology - November 8, 2021 Category: Neurology Source Type: research

Vaccination Setting of Patients with Autoimmune Diseases in Times of Severe Acute Respiratory Syndrome Coronavirus Type 2 Pandemic Using the Example of Multiple Sclerosis Patients: A Longitudinal Multicenter Study
Conclusions: The vaccination topic was not immediately present in many patients before the pandemic. MS patients need comprehensive and understandable education meeting their concerns using evidence-based and convincing arguments on the subject of vaccination, particularly younger patients. Older patients are already more often willing to become vaccinated. Complete vaccination status is necessary to avoid multiple infections.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 5, 2021 Category: Neurology Source Type: research

Erratum
Eur Neurol (Source: European Neurology)
Source: European Neurology - October 25, 2021 Category: Neurology Source Type: research

Associations of Body Mass Index-Metabolic Phenotypes with Cognitive Decline in Parkinson ’s Disease
Conclusion: The MUNW phenotype was associated with a rapid cognitive decline in PD.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 22, 2021 Category: Neurology Source Type: research

Ten Years of Improving Acute Stroke Management in a Metropolitan Area: A Population-Based Quantification of Quality Indicators
Conclusions: Collaborative stroke care quality projects are suitable and effective to improve acute stroke care.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 14, 2021 Category: Neurology Source Type: research

Detection of Major Human Herpesviruses in Iranian Patients with Suspected Encephalitis Using Multiplex Polymerase Chain Reaction
Conclusions: This multiplex PCR assay detects simultaneously different herpesviruses in CSF samples of patients with suspected encephalitis in 2 rounds of PCR amplification; therefore, it is a reliable and cost-saving diagnostic method for evaluating patients infected with herpesvirus with neurological disorders.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 29, 2021 Category: Neurology Source Type: research

Nerve Hypertrophy and Altered Diffusion in Anti-Myelin-Associated Glycoprotein Neuropathy Detected by Brachial Plexus Magnetic Resonance Neurography
Conclusions: Nerve hypertrophy appears in the proximal portion of peripheral nerves, such as the brachial plexus, in patients with anti-MAG neuropathy. Altered diffusion in the nerve roots might be associated with the loss of myelin integrity due to the demyelination process in anti-MAG neuropathy.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 28, 2021 Category: Neurology Source Type: research

Noninvasive Brain Stimulation for Poststroke Dysphagia: A Meta-Analysis for Randomized Controlled Trials
Conclusions: The study demonstrates that rTMS and tDCS over the pharyngeal motor cortex show therapy effects on poststroke dysphagia. Many more large-scale, blinded RCTs are essential to investigate the effect of rTMS and tDCS on poststroke dysphagia.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 28, 2021 Category: Neurology Source Type: research

Lower Cranial Nerve Palsies in the COVID-19 Pandemic: A 10-Case Series of Intensive Care Unit Patients
Conclusion: The mechanical compressive hypothesis, linked to the prone-position ventilation therapy, appears to be the major factor. The direct toxicity of SARS-CoV-2 and the context of immune dysfunction induced by the virus may be involved in a multifactorial etiology.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 23, 2021 Category: Neurology Source Type: research

Establishing Stroke Services in the Republic of Georgia
Conclusion: The Georgian example might be useful for doctors in other post-Soviet countries or other parts of the world.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 20, 2021 Category: Neurology Source Type: research

Comprehensive Analysis of Potential miRNA-Target mRNA-Immunocyte Subtype Network in Cerebral Infarction
Conclusions: The network including miRNA, target mRNA, and immunocyte subtype may be novel regulators and diagnostic and therapeutic targets in CI.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 20, 2021 Category: Neurology Source Type: research

D ésiré Bourneville: A Socialist in Charcot’s Inner Circle
D ésiré Bourneville was one of Jean-Martin Charcot’s most important disciples. His previous works as an alienist allowed him to influence his master’s interest in hysteria, which led to the creation of a service regarded as a neurological mecca. During his time under Charcot, Bourneville, a pass ionate left-wing radical, had to coexist with characters representative of the conservative,bourgeois Parisian society. The aim of this study is to describe Bourneville ’s life and work, as well as the ambiguity of a progressive man such as him, immersed within the economic and cultural elites.Eur Ne...
Source: European Neurology - September 17, 2021 Category: Neurology Source Type: research

A 3-Gene-Based Diagnostic Signature in Alzheimer ’s Disease
Conclusion: The comprehensive bioinformatic analysis of gene expression in AD patients and the effective logistic regression model built in our study may provide promising research value for diagnostic methods of AD.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 14, 2021 Category: Neurology Source Type: research

Early Experiences in Switching between Monoclonal Antibodies in Patients with Nonresponsive Migraine in Spain: A Case Series
Monoclonal antibodies targeting the calcitonin gene-related peptide have been introduced into the therapeutic arsenal of migraine prophylaxis. Clinical trials report similar efficacy between them, and there is no evidence of switching to another one after failure. We aim to describe our experience in switching from erenumab to galcanezumab after therapeutic failure. We retrospectively reviewed 30 migraine patients who received monoclonal antibodies, with 15 of them switched after failure to achieve reduction in migraine days per month ≥30%. A ≥30% reduction in migraine days per month compared to baseline was observed...
Source: European Neurology - September 10, 2021 Category: Neurology Source Type: research

Investigating the Association between Wake-Up Stroke and Obstructive Sleep Apnea: A Meta-Analysis
Conclusion: WUS patients have severer SDB problems compared to NWUS patients suggesting that respiratory events during sleep might be underlying the induction of WUS. Besides, the induction of WUS was significantly associated with men rather than women. Therefore, early diagnosis and management of potential WUS patients should benefit from the detection of SDB status and respiratory effects.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 9, 2021 Category: Neurology Source Type: research

In Memoriam of Prof. Henri M. Duvernoy (1931 –2021)
Eur Neurol (Source: European Neurology)
Source: European Neurology - August 31, 2021 Category: Neurology Source Type: research

Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine
Conclusions: Retinal neural and vascular structures might be affected in migraine sufferers, including those in subgroups. Rebound vasodilation may cause alterations in CL thickness during a migraine attack. Factors other than hypoperfusion may contribute to the pathophysiology responsible for the formation of WMH.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 30, 2021 Category: Neurology Source Type: research

A pilot study of the ticagrelor role in ischemic stroke secondary prevention
Conclusion: Ticagrelor was noninferior to aspirin regarding safety profile. Compared with aspirin, ticagrelor had a better clinical outcome based on NIHSS and mRS in first-ever acute ischemic stroke patients who received it within 9 h from symptom onset, leading to a shorter hospital stay.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 30, 2021 Category: Neurology Source Type: research

Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke
Background: Astrocytes are the most numerous cell types within the central nervous system, and many efforts have been put into determining the exact role of astrocytes in neuroprotection and repair after ischemic stroke. Although numerous studies have been done in recent years, there is still no thorough understanding of the exact function of astrocytes in the whole course of the stroke.Summary: According to the recent literature, there are many structures and factors that play important roles in the process of ischemic stroke, among which blood-brain barrier, various growth factors, gap junctions, AQP4, and glial scars ha...
Source: European Neurology - August 27, 2021 Category: Neurology Source Type: research

Cerebrovascular Accident and SARS-CoV-19 (COVID-19): A Systematic Review
Discussion: The data suggest SARS-CoV-2 is a risk factor for developing stroke, particularly in patients with hypertension and diabetes. Furthermore, the younger average age of stroke in patients with SARS-CoV-2, particularly those patients with zero identifiable preexisting conditions, creates high suspicion that SARS-CoV-2 is an independent risk factor for development of stroke; however, this cannot yet be proven without comparable control population. The data suggest the risk of developing CVA in the setting of COVID-19 infection is not dependent upon severity of illness. Continued studies must be done to understand the...
Source: European Neurology - August 5, 2021 Category: Neurology Source Type: research

The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study
Conclusions: The results of the COVQoL-CND study showed that lockdown causes posttraumatic stress and deterioration in the QoL in CND.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 3, 2021 Category: Neurology Source Type: research

The Role of Apolipoprotein E ε4 in Early and Late Mild Cognitive Impairment
Conclusions: AnAPOEε4 allele is associated with increased CSF tau and worse cognition in both EMCI and LMCI, and this association may be mediated by Aβ. We conclude thatAPOEε4 may be an important mediator of tau pathology and cognition in the early stages of AD.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 2, 2021 Category: Neurology Source Type: research

CXCL13 Levels Indicate Treatment Responsiveness to Fingolimod in MS Patients
Eur Neurol (Source: European Neurology)
Source: European Neurology - August 2, 2021 Category: Neurology Source Type: research

Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis
Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 29, 2021 Category: Neurology Source Type: research

Total Cerebral Small Vessel Disease Score and Anthropometric Indices: A Population-Based Study in Older Adults of Amerindian Ancestry
A total of 590 older adults of Amerindian ancestry living in rural Ecuador received anthropometric measurements and a brain magnetic resonance imaging to estimate the total cerebral small vessel disease (cSVD) score. A fully adjusted ordinal logistic regression model, with categories of the total cSVD score as the dependent variable, disclosed significant associations between the waist circumference, the waist-to-hip, and the waist-to-height ratios – but not the body mass index (BMI) – and the cSVD burden. Indices of abdominal obesity may better correlate with severity of cSVD than the BMI in Amerindians. Pheno...
Source: European Neurology - July 27, 2021 Category: Neurology Source Type: research

Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Analysis of Microvascular Permeability in Peritumor Brain Edema of Fibrous Meningiomas
Conclusion: DCE-magnetic resonance imaging ·Meningioma·Blood vessel MRI can be used to quantify the microvascular permeability of PTBE in patients with meningioma.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 27, 2021 Category: Neurology Source Type: research

Reallocation of Carotid Surgery Activity with the Support of Telemedicine in a COVID-Free Clinic during COVID-19 Pandemic
The aim of this study is to report the reallocation of carotid surgery activity with the support of telemedicine in a COVID-free clinic during COVID-19 pandemic. Patients with symptomatic carotid stenosis or asymptomatic vulnerable plaques were reallocated to a COVID-free private clinic which began to cooperate with the National Health System during the emergency. Quick training of staff nurses was performed. Surgeons moved to the COVID-19 free clinic. Remote cerebral monitoring was performed with the support of telemedicine. Twenty-four patients underwent standard carotid endarterectomy with eversion technique. Five patie...
Source: European Neurology - July 23, 2021 Category: Neurology Source Type: research

Cognitive Impairment in Multiple System Atrophy Is Related to White Matter Damage Detected by the T1-Weighted/T2-Weighted Ratio
Conclusion: The sT1w/T2w ratio is sensitive to degenerative changes in the white matter that is associated with cognitive ability in MSA patients.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 20, 2021 Category: Neurology Source Type: research

“You Are Older, although You Do Not Know That”: Time, Consciousness, and Memory in “A Kind of Alaska” by Harold Pinter (1930–2008)
This article analyzes how Pinter’s drama investigated the mysterious and fascinating relationship between time, memory, and consciousness. The term “awakenings,” chosen by Sacks himself, clearly refers to the restoration of voluntary motor function in patients with postencephalitic parkinsonism who responded to levodopa. However, it also suggests that these patients had an impairment of awareness. Actually, beyond the acute phase, subjects with postencephal itic parkinsonism were not sleeping but severely akinetic and therefore probably aware of the passage of time. Oliver Sacks probably did not entirely ...
Source: European Neurology - July 20, 2021 Category: Neurology Source Type: research

The Effect of Water-Based Therapy Compared to Land-Based Therapy on Balance and Gait Parameters of Patients with Stroke: A Systematic Review
Conclusion: Findings from meta-analysis support the effectiveness of land-based therapy in the improvement of balance and gait parameters of patients with stroke. However, the evidence for water-based therapy continues to be limited, and higher quality studies are required to determine the effectiveness of water-based therapy on patients with stroke, particularly on balance and gait.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 16, 2021 Category: Neurology Source Type: research

Validation of the Finnish Version of the Unified Dyskinesia Rating Scale
Conclusion: The overall factor structure of the Finnish version was consistent with that of the reference standard, and it can be designated as the official version of the UDysRS for Finnish speaking populations.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 14, 2021 Category: Neurology Source Type: research

Clinical Course of Migraine during Strict Quarantine due to SARS-CoV-2: Effect of Psychiatric Comorbidities in a Clinical Cohort
Conclusion: During the SARS-CoV-2 pandemic, depression, anxiety, and the deterioration of sleep quality influenced the probability of progression from episodic migraine to chronic migraine.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 9, 2021 Category: Neurology Source Type: research

Do Not Replace Personal Patient/Doctor Interactions by Electronic Visits in Myotonic Dystrophy Patients
Eur Neurol (Source: European Neurology)
Source: European Neurology - July 1, 2021 Category: Neurology Source Type: research

Secondary Trigeminal Neuralgia: Do Not Forget the Pontine Ischemic Infarction
Eur Neurol (Source: European Neurology)
Source: European Neurology - July 1, 2021 Category: Neurology Source Type: research

On the Threshold of Scientific Medicine: Gerard van Swieten and His Perception of the Pathophysiology in Traumatic Brain Injury
Gerard van Swieten (1700 –1772), famous pupil of Professor Herman Boerhaave (1668–1738) of Leiden University and personal physician of Austrian Habsburg Empress Maria Theresa (1717–1780). Herman Boerhaave was a renowned Dutch physician inside and outside Europe in the 18th century. He was not only appointed professor in medicine, chemistry, and botany but also a chancellor of the Leiden University in 1714 and published his well-knownAphorismi de cognoscendis et curandis morbis in 1709. Gerard van Swieten commented upon Boerhaave ’s aphorisms and demonstrated actual knowledge, less well-known among t...
Source: European Neurology - July 1, 2021 Category: Neurology Source Type: research

Volatile Organic Compounds to Identify Infectious (Bacteria/Viruses) Diseases of the Central Nervous System: A Pilot Study
Conclusions: Ethylene oxide and phenol may be potential biomarkers to distinguish bacterial ME and viral ME. VOC analysis of CSF may be used as a supporting tool for clinical diagnosis.Eur Neurol (Source: European Neurology)
Source: European Neurology - June 28, 2021 Category: Neurology Source Type: research

Association of Anxiety and Depressive Symptoms with Memory Function following Traumatic Brain Injury
Conclusion: More depressive symptoms rather than anxiety symptoms and less years of education are significant predictors for posttraumatic memory dysfunction.Eur Neurol (Source: European Neurology)
Source: European Neurology - June 28, 2021 Category: Neurology Source Type: research

Diagnostic Validity of the Sleep Condition Indicator to Screen for Diagnostic and Statistical Manual-5 Insomnia Disorder in Patients with Parkinson ’s Disease
Conclusion: The SCI can be used as a valid and reliable screener for DSM-5 insomnia disorder in PD patients. Due to its short length, it is useful in both clinical practice and scientific research.Eur Neurol (Source: European Neurology)
Source: European Neurology - June 28, 2021 Category: Neurology Source Type: research