Weather, Weather Changes and the Risk of Bell ’s Palsy: A Multicenter Case-Crossover Study
Conclusions: Our findings support the hypothesis of an association between certain weather conditions and the risk for BP with acute changes in atmospheric pressure and ambient temperature as the main risk factors. Additionally, contrasting results for risk of BP after temperature changes in the diabetic and non-diabetic subgroups support the paradigm of a diabetic facial palsy as a distinct disease entity.Neuroepidemiology 2018;51:207 –215 (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 11, 2018 Category: Epidemiology Source Type: research

Risk of Hemorrhagic Stroke in Patients Exposed to Nonsteroidal Anti-Inflammatory Drugs: A Meta-Analysis of Observational Studies
Conclusion: Our results indicated that the use of NSAIDs is significantly associated with a higher risk of developing hemorrhagic stroke. These results should be interpreted with caution because they may be confounded owing to the observational design of the individual studies. Nevertheless, we recommend that NSAIDs should be used judiciously, and their efficacy and safety should be monitored proactively.Neuroepidemiology 2018;51:166 –176 (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Epidemiology of Transthyretin Familial Amyloid Polyneuropathy in Portugal: A Nationwide Study
Conclusions: In Portugal, TTR-FAP affects both genders and mainly young adults. TTR-FAP incidence appears to be decreasing while prevalence is increasing. In comparison to previous studies, there is an increased representativeness of late-onset patients. This epidemiological setting poses future and complex challenges for the social and healthcare system, strengthening the relevance of regular epidemiologic surveillance.Neuroepidemiology 2018;51:177 –182 (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Synergism between Female Gender and High Levels of Daily Stress Associated with Migraine Headaches in Ontario, Canada
Conclusion: We report 10.7% prevalence of migraines and synergism between female gender and stress on risk of migraine, suggesting health interventions targeting women under stress may be beneficial.Neuroepidemiology 2018;51:183 –189 (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Comprehensive Examination of Therapies for Pain in Parkinson ’s Disease: A Systematic Review and Meta-Analysis
Pain in Parkinson ’s disease (PD) is a debilitating symptom with a prevalence of 68%, yet is untreated 50% of the time. What is unclear, however, is which treatment is optimal for minimizing pain severity in PD. Thus, the objective of this systematic review and meta-analysis was to investigate the efficacy of a var iety of novel, complimentary, and conventional treatments for pain in PD and elucidate which therapy is the most effective. A systematic search was performed using MEDLINE, PsycINFO, Embase, CINAHL, and CENTRAL databases. To identify additional articles, manual searches of reference lists of include d tria...
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Multiple Sclerosis in Italy: A 40-Year Follow-Up of the Prevalence in Ferrara
Conclusion: Our study has confirmed the province of Ferrara is an area at high risk for MS, in line with epidemiological data from the regions of continental and insular Italy. The sharp increase in MS prevalence over time in this population can be imputed in part to a greater exposition to risk factors in genetically susceptible subjects but also to an increased survival and improved ascertainment. So, the results suggest that both methodologic and environmental factors are essential in determining the real distribution of MS. The need to get reliable estimates of MS prevalence must be highlighted as a public health and r...
Source: Neuroepidemiology - August 21, 2018 Category: Epidemiology Source Type: research

Factors Associated with Stroke Misdiagnosis in the Emergency Department: A Retrospective Case-Control Study
Conclusions: Patients with stroke misdiagnosis were commonly FAST-negative with nonspecific symptoms including altered mental status, dizziness and nausea/vomiting often associated with PCS. Improved diagnostic accuracy may increase access to acute therapies.Neuroepidemiology 2018;51:123 –127 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Evidence for Seasonal Variation of Bell ’s Palsy in Germany
Neuroepidemiology 2018;51:128 –130 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Serum Vitamin D Concentrations and Cognitive Change Over 20 Years: The Atherosclerosis Risk in Communities Neurocognitive Study
Conclusions: Lower concentrations of 25(OH)D measured in midlife were not significantly associated with more rapid cognitive decline over a 20-year follow-up period. The results of this prospective study are less susceptible to reverse causation than prior studies.Neuroepidemiology 2018;51:131 –137 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Sex Differences in the Prevalence of and Risk Factors for Nonvascular Cognitive Function in Rural, Low-Income Elderly in Tianjin, China
Conclusion: These findings suggest that it is crucial to manage and control hypertension and improve educational attainment in order to reduce the prevalence and burden of nonvascular cognitive impairment among low-income residents, both men and women, in rural China.Neuroepidemiology 2018;51:138 –148 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Estimation of the Prevalence of Amyotrophic Lateral Sclerosis in the United States Using National Administrative Healthcare Data from 2002 to 2004 and Capture-Recapture Methodology
Conclusions: Federal healthcare claims databases ascertained are a very efficient method for identifying the majority of ALS-prevalent cases in the National ALS Registry, and may be enhanced by having patients self-register through the registry web portal.Neuroepidemiology 2018;51:149 –157 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Driving Your Recovery Post Stroke
Neuroepidemiology 2018;51:113 –114 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 8, 2018 Category: Epidemiology Source Type: research

Inpatient Cost of Stroke in Beijing: A Descriptive Analysis
Conclusion: Hospitalization cost of stroke was substantial. These findings provide health policymakers and healthcare professionals with evidence to help guide future spending.Neuroepidemiology 2018;51:115 –122 (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 8, 2018 Category: Epidemiology Source Type: research

Presentation, Evaluation, Management, and Outcomes of Acute Stroke in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis
Conclusions: Our review revealed the low use of evidence-based practices for acute stroke care in LMIC. The true use in hospitals that do not conduct this research is probably even lower. Strategies to evaluate and improve health system performance for acute stroke care, including implantation of stroke units and making thrombolysis more available and affordable are needed in LMIC. Registration in Prospero: CRD42017069325.Neuroepidemiology 2018;51:104 –112 (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 19, 2018 Category: Epidemiology Source Type: research

Amyotrophic Lateral Sclerosis Mortality in the United States, 2011 –2014
Conclusions: Previous reports of ALS mortality in the United States showed similar age, sex, and race distributions but with greater age-adjusted mortality rates due to the inclusion of other diseases in the case definition. When using ICD-10 data collected prior to 2017, additional review of multiple-cause of death data is required for the accurate estimation of ALS deaths.Neuroepidemiology 2018;51:96 –103 (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 10, 2018 Category: Epidemiology Source Type: research

Future Trends and the Economic Burden of Dementia in Manitoba: Comparison with the Rest of Canada and the World
Dementia is a growing public health concern in Canada. This epidemic is linked to huge human and economic costs. The number of Manitobans (65+) with dementia in 2045 (47,021), representing 2.58% of the Manitoban population, will be 2.3 times that of the year 2015 (20,235). The number of cases of dementia in Manitoba grew by 20.7% from 2015 to 2025, 68.16% from 2015 to 2035 and at an alarming rate of 125% from 2015 to 2045. Importantly, the total economic burden of dementia in Manitoba is close to one billion USD and is expected to grow more than 28 billion USD during the year 2038. The focus of this review is to compare de...
Source: Neuroepidemiology - July 3, 2018 Category: Epidemiology Source Type: research

Maternal Folate Intake and Risk of Childhood Brain and Spinal Cord Tumors: A Systematic Review and Meta-Analysis
Conclusions: Maternal consumption of folic acid is associated with a reduced risk of CBSCT. Further investigations are necessary to increase the reliability of the results and estimate the relationship between dose-response and the best outcome.Neuroepidemiology 2018;51:82 –95 (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 3, 2018 Category: Epidemiology Source Type: research

Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population
Conclusions: WMHV, especially in the anterior ­cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.Neuroepidemiology 2018;51:57 –63 (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 28, 2018 Category: Epidemiology Source Type: research

Caffeine Consumption in First-Degree Relatives of Essential Tremor Cases: Evidence of Dietary Modification Before Disease Onset
Conclusion: The balance of caffeinated to decaffeinated beverages is different in FD-ET than Co. These data raise several intriguing questions. Among these is whether relatives of ET cases modify their caffeine consumption before disease onset.Neuroepidemiology 2018;51:64 –70 (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 28, 2018 Category: Epidemiology Source Type: research

Prevalence of Multiple Sclerosis in Iceland
Conclusion: MS prevalence was high in Iceland compared to the prevalence mentioned in reports from most of the world, and was similar to prevalence rates in other Nordic countries.Neuroepidemiology 2018;51:50 –56 (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 25, 2018 Category: Epidemiology Source Type: research

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study
Conclusion: Our results indicate that some environmental factors, in particular those associated with exposure to pesticides and air pollutants as a result of urban traffic, could be associated with the occurrence of ALS.Neuroepidemiology 2018;51:33 –49 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 31, 2018 Category: Epidemiology Source Type: research

Obesity and Migraine: Effect Modification by Gender and Perceived Stress
Conclusions: We found support for gender- and stress-dependent associations between obesity and migraine using a large, heterogeneous adult sample. This underscores the need for evidence-based strategies for weight loss and stress reduction for female migraineurs.Neuroepidemiology 2018;51:25 –32 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 29, 2018 Category: Epidemiology Source Type: research

Comorbidities Are Associated with Altered Health Services Use in Multiple Sclerosis: A Prospective Cohort Study
Discussion: The presence of fatigue and higher physical comorbidity burden were associated with higher rates of health services use. Findings have implications for those examining healthcare burden or organizing health services for persons with MS.Neuroepidemiology 2018;51:1 –10 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 16, 2018 Category: Epidemiology Source Type: research

Relevance of Dementia in Atrial Fibrillation Patients within a Specific European Health Care Area
Conclusions: Patients with dementia presented a more adverse risk profile, with significant differences in all-cause mortality.Neuroepidemiology 2018;51:11 –18 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 16, 2018 Category: Epidemiology Source Type: research

Epidemiology of Traumatic Spinal Cord Injury in Ireland, 2010 –2015
Conclusions: The epidemiological trends identified are similar to those prevalent elsewhere in the developed world. More incomplete tetraplegia among an older patient population necessitates a review of how acute care and rehabilitation services are delivered.Neuroepidemiology 2018;51:19 –24 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 16, 2018 Category: Epidemiology Source Type: research

Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer
Conclusions: We found that persons with MCI tended to have an increased risk of cancer, whereas those with dementia have a decreased risk. These findings call into question a biological explanation for the inverse link between dementia and cancer, thereby suggesting the presence of methodological bias.Neuroepidemiology 2018;50:207 –215 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 14, 2018 Category: Epidemiology Source Type: research

Estimating the Marginal Causal Effect of Fish Consumption during Adolescence on Multiple Sclerosis: A Population-Based Incident Case-Control Study
Discussion: Subject to limitation of case-control studies in interpreting associations causally, this study suggests that both fresh and canned fish consumptions in adolescence can decrease the risk of MS.Neuroepidemiology 2018;50:111 –118 (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 7, 2018 Category: Epidemiology Source Type: research

Differences in Race and Ethnicity in Muscular Dystrophy Mortality Rates for Males under 40 Years of Age, 2006 –2015
Conclusion: Since DMD is the primary cause of deaths in young males with MD, mortality rates are a reasonable proxy for the relative difference in racial prevalence. It appears that DMD is significantly more common in white males than in males of other races.Neuroepidemiology 2018;50:201 –206 (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 26, 2018 Category: Epidemiology Source Type: research

Premature Mortality Due to Malignancies of the Central Nervous System in Canada, 1980 –2010
Conclusion: Our study shows that ­Canadian people with CNS cancers have had their lives prolonged at the end of the study period.Neuroepidemiology 2018;50:195 –200 (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 25, 2018 Category: Epidemiology Source Type: research

Temporal Trends of Stroke Epidemiology in Southern Sweden: A Population-Based Study on Stroke Incidence and Early Case-Fatality
Conclusion: First-ever stroke incidence in southern Sweden has decreased to 33% since the beginning of this millennium. Incidence rates have decreased among the elderly but remain unchanged among younger age groups. Our findings warrant further studies on trends in risk factor profiles and effects of prevention strategies, and heightened focus on stroke in the young.Neuroepidemiology 2018;50:174 –182 (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 5, 2018 Category: Epidemiology Source Type: research

Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006 –2015: The Silesian Stroke Registry
Conclusions: In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.Neuroepidemiology 2018;50:183 –194 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 27, 2018 Category: Epidemiology Source Type: research

Distance from Home to Research Center: A Barrier to In-Person Visits but Not Treatment Adherence in a Stroke Trial
Conclusions: Distance between patient and study center was an independent predictor of missed in-person visits but not with adherence to study treatment or preventive care.Neuroepidemiology 2018;50:137 –143 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 23, 2018 Category: Epidemiology Source Type: research

Resting Heart Rate Is Not Associated with Cognitive Function
Conclusion: While elevated RHR has been shown to be associated with adverse health events and poor fitness level, RHR has no relation to cognitive function in the general population.Neuroepidemiology 2018;50:160 –167 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 22, 2018 Category: Epidemiology Source Type: research

Parkinson ’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study
Conclusions: We report a positive relationship between PD and risk of BCC. These results should stimulate greater awareness on the part of healthcare providers to the increased risk of BCC in PD patients.Neuroepidemiology 2018;50:168 –173 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 22, 2018 Category: Epidemiology Source Type: research

Epidemiology of Myasthenia Gravis in Slovakia in the Years 1977 –2015
Conclusion: The age at onset and incidence increased significantly over the study period due to marked increase of MG incidence in elderly, particularly over 70 years. Possible reasons for this trend are discussed.Neuroepidemiology 2018;50:153 –159 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 21, 2018 Category: Epidemiology Source Type: research

Incidence and Risk Profile of Dementia in the Regions of Middle East and North Africa
Conclusions: MENA is youthful and dementia here is neither likely to be an epidemic nor looming over. The only possible exception might be Arab pocket in Israel. To us, previous attributions on dementia do not seem to be based on the realities of this region and, therefore, may prevent pragmatic addressal of dementia. Lastly, values-based collaborations are invited to jointly fill the awareness deficit in a unique low-cost manner.Neuroepidemiology 2018;50:144 –152 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 14, 2018 Category: Epidemiology Source Type: research

Risk Factors and Clinical Impact of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Analysis from the China National Stroke Registry
Conclusions: Female sex, a history of diabetes mellitus, and poor clinical grade are independent early risk factors for the development of DCI and can contribute to a better identification of patients at a high risk for DCI. DCI was associated with severe clinical course, poor outcome, and mortality both in the short- and long-term in patients with aSAH in China.Neuroepidemiology 2018;50:128 –136 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 12, 2018 Category: Epidemiology Source Type: research

Place of Residence and Cognitive Function among the Adult Population in India
Conclusion: Cognition among adults in India differed significantly according to their current and past place of residence. Socioeconomic factors played an important role in the cognitive function of adults in urban areas.Neuroepidemiology 2018;50:119 –127 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 7, 2018 Category: Epidemiology Source Type: research

The Prevalence of Multiple Sclerosis in the Metropolitan Area of Rome: A Capture-Recapture Analysis
Conclusion: The results confirm that the metropolitan area of Rome is a high-risk area for MS.Neuroepidemiology 2018;50:105 –110 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 2, 2018 Category: Epidemiology Source Type: research

Abstracts of the 15th Italian Congress of Neuroepidemiology
Neuroepidemiology 2018;50:74 –103 (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 22, 2018 Category: Epidemiology Source Type: research

Analysis of Hospital Charges of Inpatients with Acute Ischemic Stroke in Beijing, China, 2012 –2015
Conclusions: The proportion of medicine fees for the ischemic stroke inpatients showed a downward trend during the period from 2012 to 2015, but medicine fees still accounted for the largest percentage of hospital charges in China. LOHS emerged to be the main determinant of the cost. Decreasing medicine fees and LOHS might be strategies to decrease hospital charges and reduce economic burden of stroke in China.Neuroepidemiology 2018;50:63 –73 (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 8, 2018 Category: Epidemiology Source Type: research

Increasing Burden of Stroke: The Dijon Stroke Registry (1987 –2012)
Conclusions: Increasing attack rates and decreasing mortality have led to a rise in the number of stroke survivors in the population, thus indicating a growing need for the implementation of dedicated services.Neuroepidemiology 2018;50:47 –56 (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 1, 2018 Category: Epidemiology Source Type: research

Population-Based Cohort Study on Dementia Risk in Patients with Type 1 Diabetes Mellitus
Conclusions: The relative risk of developing dementia (118 –314%) in patients with type 1 DM was much higher than the ­previously reported relative risk (15–28%) associated with type 2 DM.Neuroepidemiology 2018;50:57 –62 (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 1, 2018 Category: Epidemiology Source Type: research

Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor
Conclusion: The burden of ET extends beyond the boundaries of the clinically defined disease, and partially expressed forms of ET are abundant in ET families. This fact greatly complicates gene-finding studies and epidemiological studies whose goal is to detect disease-linked associations.Neuroepidemiology 2018;50:41 –46 (Source: Neuroepidemiology)
Source: Neuroepidemiology - January 16, 2018 Category: Epidemiology Source Type: research

Multiple Sclerosis Mortality by Race/Ethnicity, Age, Sex, and Time Period in the United States, 1999 –2015
Conclusion: MS-specific mortality trends demonstrate distinctive differences by race/ethnicity and age. The observations that whites and females are more likely to die from MS is in line with the overall understanding that these groups are affected more by MS. However, the findings of blacks dying at an earlier age and having more substantially increasing mortality trends than whites suggest that MS burden weighs unequally by race. Further investigation into these trends may provide additional evidence into risk or protective factors within each group.Neuroepidemiology 2018;50:35 –40 (Source: Neuroepidemiology)
Source: Neuroepidemiology - January 16, 2018 Category: Epidemiology Source Type: research

Adjudication of Transient Ischemic Attack and Stroke in the Multi-Ethnic Study of Atherosclerosis
Conclusions: We hope that this work will motivate and facilitate investigators to use MESA data to investigate issues concerning TIA and stroke and will inform investigators seeking to adjudicate TIA and stroke in other studies.Neuroepidemiology 2018;50:23 –28 (Source: Neuroepidemiology)
Source: Neuroepidemiology - January 11, 2018 Category: Epidemiology Source Type: research

Using the Capture-Recapture Method to Estimate the Incidence of Amyotrophic Lateral Sclerosis in Beijing, China
Conclusions: The total incidence of ALS in Beijing is similar to international reports. The onset of ALS is not merely the result of ageing.Neuroepidemiology 2018;50:29 –34 (Source: Neuroepidemiology)
Source: Neuroepidemiology - January 11, 2018 Category: Epidemiology Source Type: research

Five-Year Recurrence Rate and the Predictors Following Stroke in the Mashhad Stroke Incidence Study: A Population-Based Cohort Study of Stroke in the Middle East
Conclusion: A substantial number of our patients either died or had stroke recurrences during the study period. Advanced age and the severity of the index stroke significantly increased the risk of recurrence. This is an important finding for health policy makers and for designing preventive strategies in people surviving their stroke.Neuroepidemiology 2018;50:18 –22 (Source: Neuroepidemiology)
Source: Neuroepidemiology - January 10, 2018 Category: Epidemiology Source Type: research

Comorbid Conditions in Parkinson ’s Disease: A Population-Based Study of Statewide Parkinson’s Disease Registry
Conclusions: The findings highlight PD as a multisystem neurodegenerative disorder, and this information is crucial for creating strategies to better prevent and manage PD complications.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - December 22, 2017 Category: Epidemiology Source Type: research

Acknowledgments to Referees
Neuroepidemiology 2017;49:198-199 (Source: Neuroepidemiology)
Source: Neuroepidemiology - December 21, 2017 Category: Epidemiology Source Type: research