Contents Vol. 50, 2018
Neuroepidemiology 2018;50:I –IV (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 22, 2021 Category: Epidemiology Source Type: research

The Effectiveness of Stroke Riskometer ™ in Improving Stroke Risk Awareness in Malaysia: A Study Protocol of a Cluster-Randomized Controlled Trial
Conclusion: This study will evaluate the effect of Stroke Riskometer™ app on stroke awareness and stroke probability and briefly evaluate participant engagement to a pre-specified trial protocol. The findings from this will inform physicians and public health professionals of the benefit of mobile technology intervention and encourage more active mobile phone-based disease prevention apps.Trial Registration: ClinicalTrials.gov Identifier NCT04529681.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 15, 2021 Category: Epidemiology Source Type: research

Data from 235 Cases of Bell ’s Palsy during COVID-19 Pandemic: Were There Clusters of Facial Palsy?
Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - September 8, 2021 Category: Epidemiology Source Type: research

Association of Hypertension with Mild Cognitive Impairment in Population from Less-Developed Areas of Multiethnic Northwest China
Conclusion: Hypertension is in independent negative association with MCI in middle-aged and elderly population from underdeveloped regions.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 25, 2021 Category: Epidemiology Source Type: research

Comparing Vascular Brain Injury and Stroke by Cranial Magnetic Resonance Imaging, Physician-Adjudication, and Self-Report: Data from the Strong Heart Study
Conclusion: In this community-based cohort, self-report for prior stroke had good performance metrics. A majority of participants with VBI did not have overt, clinically recognized events but did have neurological or cognitive symptoms. Data collection methodology for studies in a resource-limited setting must balance practical limitations in costs, accuracy, feasibility, and research goals.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 24, 2021 Category: Epidemiology Source Type: research

Epidemiology of Parkinson ’s Disease in Chile
Conclusion: The prevalence and incidence observed in the Chilean population are consistent with studies from other countries.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 18, 2021 Category: Epidemiology Source Type: research

Pediatric Acute Ischemic Stroke by Age-Group: A Systematic Review and Meta-Analysis of Published Studies and Hospitalization Records
Conclusions: Incidence rates of pediatric AIS by age-groups followed a consistent overall pattern of a reverse J-shaped curve, with the highest rates in neonates, across predominantly European and North American countries. Further research is warranted to examine if this pattern is observed in other geographic regions and to identify AIS risk factors specific to different phases of childhood development.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - August 17, 2021 Category: Epidemiology Source Type: research

Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades
Conclusion: Over the last 2 decades, the IENT questionnaire has been continuously used in different LMICs. This result favors its promotion and updating, with the inclusion of new topics related to epilepsy (e.g., comorbidities, quality of life, and stigma), current ILAE guidelines, and digital versions.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 27, 2021 Category: Epidemiology Source Type: research

Predicting the Risk of Ischemic Stroke in Patients Treated with Novel Oral Anticoagulants: A Machine Learning Approach
Conclusions: The stroke risk in AF patients treated with NOAC could be predicted based on comorbidities like ischemic heart diseases, urinary tract infections, and dementia additionally to age and male sex. Knowing and addressing these factors may help reduce the risk of stroke in this patient population.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 21, 2021 Category: Epidemiology Source Type: research

Modeling Manifest Huntington ’s Disease Prevalence Using Diagnosed Incidence and Survival Time
Conclusion: The modeled estimates generally accord with the previously published data. This analysis contributes to better understanding of the epidemiology of HD and highlights areas of uncertainty.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 15, 2021 Category: Epidemiology Source Type: research

Estimated Prevalence and Incidence of Amyotrophic Lateral Sclerosis and SOD1 and C9orf72 Genetic Variants
Discussion: The estimated number of patients with SOD1 and C9orf72 ALS suggests that although the proportions of SOD1 and C9orf72 are higher among those with fALS, the majority of SOD1 and C9orf72 ALS cases may be found among those with sALS (about 53 and 74%, respectively). These results suggest that classification of fALS based on reported family history does not capture the full picture of ALS of genetic origin.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 9, 2021 Category: Epidemiology Source Type: research

Reduction in Acute Stroke Admissions during the COVID-19 Pandemic: Data from a National Stroke Registry
Conclusion: The marked decrease in admissions for acute stroke and TIA, occurring at a time of a relatively low burden of COVID-19, is of great concern. Public awareness campaigns are needed as patients reluctant to seek urgent stroke care are deprived of lifesaving procedures and secondary prevention treatments.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 8, 2021 Category: Epidemiology Source Type: research

Reproductive History and Age of Onset for Women Diagnosed with Amyotrophic Lateral Sclerosis: Data from the National ALS Registry: 2010 –2018
Conclusion: Women who reported completing menopause before age 50 were significantly more likely to be diagnosed with ALS before age 60 compared with those who reported entering menopause after age 50. More research is needed to determine the relationship between female reproductive history, especially regarding endogenous estrogen exposure and early-onset ALS.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 2, 2021 Category: Epidemiology Source Type: research

Characteristics Associated with Olfactory and Taste Disorders in COVID-19
Conclusion: This study confirms the higher frequency of OTDs in females than males and adults than children. Their high predictive value for the diagnosis of COVID-19 suggests that they should be systematically searched for in patients with respiratory symptoms, fever, or headache. The association of OTDs with headache, not previously reported, suggests that they share a common mechanism, which deserves further investigation.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 1, 2021 Category: Epidemiology Source Type: research

The Burden of Dementia due to Down Syndrome, Parkinson ’s Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019
Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson ’s disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and es...
Source: Neuroepidemiology - June 28, 2021 Category: Epidemiology Source Type: research

Characteristics, Management, and Case-Fatality of Patients Hospitalized for Stroke with a Diagnosis of COVID-19 in France
Conclusion: Patients hospitalized for stroke with a concomitant COVID-19 diagnosis had a higher inhospital and 3 months case-fatality rates compared to patients hospitalized for stroke without a COVID-19 diagnosis. Further research is needed to better understand the excess of mortality related to these cases.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 24, 2021 Category: Epidemiology Source Type: research

Current and Future Projections of Amyotrophic Lateral Sclerosis in the United States Using Administrative Claims Data
Conclusions: This study provides incidence and prevalence estimates as well as geographical distribution for what the authors believe to be the largest ALS population studied to date. By using 2 separate administrative claims data sets, confidence in our estimates is increased. Future projections based on either database demonstrate an increase in ALS cases, which has also been seen in other large-scale ALS studies. These results can be used to help improve the allocation of healthcare resources in the future.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 21, 2021 Category: Epidemiology Source Type: research

Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study
Conclusion: Markers of cSVD, specifically lacunar infarcts and microhemorrhages, appear to be associated with FHCHD, potentially representing shared mechanisms in different vascular beds, and perhaps a genetic propensity for vascular disease.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 17, 2021 Category: Epidemiology Source Type: research

Alcohol Consumption and Stroke Risk in Men: A Population-Based Cohort Study in Rural Tianjin, China
Conclusions: These findings suggest that low-dose alcohol consumption may decrease the risk of ischemic strokes among men. Even so, the adverse effects of alcohol on the liver and pancreas cannot be ignored. Additionally, the effects of alcohol consumption on stroke risk vary with age, protecting against ischemic and total strokes among males ≥55 years old. Nevertheless, recommending light drinking and its potential health benefits should not be generalized to men of all ages.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 15, 2021 Category: Epidemiology Source Type: research

Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study
Conclusion: Circulating protein C has an inverse association with incident dementia independent of established risk factors, including stroke. Our results suggest studying anticoagulants in addition to coagulants can increase our understanding on the relationship between hemostasis and dementia.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 2, 2021 Category: Epidemiology Source Type: research

Putting Fine Particulate Matter and Dementia in the Wider Context of Noncommunicable Disease: Where are We Now and What Should We Do Next: A Systematic Review
Conclusion: The evidence base for PM2.5 as a risk factor for dementia is growing. It is not yet as strong as that for other NCDs. However, varied measurement/methodology hampers clarity across the field. We propose next steps.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 1, 2021 Category: Epidemiology Source Type: research

Temporal Trends in the Incidence of Ischemic Stroke in Young Adults: Dijon Stroke Registry
Conclusions: The incidence of ischemic stroke in young adults increased during the early 2000s and remained stable thereafter. These results highlight the priority need for dedicated prevention strategies for the young to reduce the burden of stroke.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 27, 2021 Category: Epidemiology Source Type: research

Stroke and Heart Attack Symptom Recognition in Older US Adults by Cognitive Impairment Status
Conclusions: Additional work is needed to address the challenge of improving recognition levels for specific stroke and heart attack symptoms in older US adults with cognitive impairment and especially for members of this group who live alone.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 19, 2021 Category: Epidemiology Source Type: research

The Association between Substance Use Disorders and Long-Term Outcome of Stroke: Results from a Population-Based Study of Stroke among 450,229 Urban Citizens
Conclusion: SUD increased the hazard ratio of stroke mortality with no effect on the disability rate. The public should be advised about the potential harm of substance abuse.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 11, 2021 Category: Epidemiology Source Type: research

Antibiotic Use and Risk of Multiple Sclerosis: A Nested Case-Control Study in Emilia-Romagna Region, Italy
Conclusions: Our results suggest an association between the use of antibiotics and MS risk in RER population. However, further epidemiological studies should be done with information on early life and lifestyle factors.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 7, 2021 Category: Epidemiology Source Type: research

Prevalence of Medically Resistant Epilepsy in Saudi Arabia
Conclusion: The prevalence of MRE in our population (30%) is close to that in other populations (30 –36.5%). Early identification of such patients is crucial to improve their management.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 6, 2021 Category: Epidemiology Source Type: research

Epidemiology of Parkinson ’s Disease in Rural Gujarat, India
Conclusions: The present study showed the current epidemiological data of PD from Gujarat, in western India. Further studies across different regions in India need to be encouraged for better understanding of PD prevalence in the Indian population.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 5, 2021 Category: Epidemiology Source Type: research

Rural Stroke Surveillance and Establishment of Acute Stroke Care Pathway Using Frontline Health Workers in Rural Northwest India: The Ludhiana Experience
Conclusion: ASHAs were able to identify stroke patients in the villages. Despite high numbers of patients reaching health-care facilities within a window period, the hospitals were unable to provide acute stroke treatment like thrombolysis. The health-care system needs to be strengthened to improve stroke care.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 5, 2021 Category: Epidemiology Source Type: research

Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study
Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 5, 2021 Category: Epidemiology Source Type: research

The Incidence of Amyotrophic Lateral Sclerosis in Ohio 2016 –2018: The Ohio Population-Based ALS Registry
Conclusion: The estimated Ohio incidence of ALS is overall similar to that reported in other states in the USA. This study reveals a geospatial variation in incidence within the state, and areas with higher rates warrant future investigation.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 26, 2021 Category: Epidemiology Source Type: research

High-Risk Periods for Adult Traumatic Brain Injuries: A Nationwide Population-Based Study
Conclusions: TBI-related hospital admissions and mortality were more common on public holidays, weekends, and in summer months in Finland. People who sustained TBIs on these days were on average younger and healthier. The occurrence of TBIs on public holidays and weekends is increasing at an alarming rate.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 14, 2021 Category: Epidemiology Source Type: research

Cause of Death after Traumatic Brain Injury: A Population-Based Health Record Review Analysis Referenced for Nonhead Trauma
Conclusion: This population-based case-matched referent study showed that increased risk of death after TBI existed only during the first 6 months after injury, and the difference was due to external causes.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 9, 2021 Category: Epidemiology Source Type: research

Risk Factors for Olfactory and Gustatory Dysfunctions in Patients with SARS-CoV-2 Infection
Conclusion: Our study indicates that current smoking and history of allergy (particularly respiratory) significantly increase the risk for smell loss in COVID-19 patients; the latter is also significantly associated to taste loss. Hospitalization has an inverse association with the risk of olfactory and gustatory dysfunctions, suggesting that these may be symptoms characteristics of less severe SARS-CoV-2 infection.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - April 1, 2021 Category: Epidemiology Source Type: research

Increased Incidence of Stroke and Transient Ischemic Attack in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis in Germany
Conclusion: RA was significantly associated with stroke and TIA, with young patients being at a particularly increased risk. AS was tendentially associated with stroke and TIA.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 31, 2021 Category: Epidemiology Source Type: research

Development of the Madrid Stroke Programme: Milestones and Changes in Stroke Trends and Mortality from 1997 to 2017
Conclusions: Our study illustrates how measures such as the development of stroke units, implementation of a regional stroke code and treatment with intravenous thrombolysis coincide in time with a reduction in in-hospital mortality due to stroke.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 30, 2021 Category: Epidemiology Source Type: research

Morbidity, Mortality, and Conversion to Neurodegenerative Diseases in Patients with REM Sleep Behavior Disorder and REM Sleep without Atonia
Conclusions: A diagnosis of RBD is associated with increased morbidity several years before and after a diagnosis is made. Patients have a higher risk of converting to a neurodegenerative disorder than matched controls. Mortality rates are unchanged.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 29, 2021 Category: Epidemiology Source Type: research

The Prevalence of Mild Cognitive Impairment among Chinese People: A Meta-Analysis
Conclusions: The prevalence of MCI in China was 15.4%, which varied by demographics, lifestyles, morbidity, screening tools, and diagnostic criteria. In further studies, screening tools and diagnosis criteria should be considered when estimating MCI prevalence.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 23, 2021 Category: Epidemiology Source Type: research

7th International Conference on Neurology and Epidemiology
Neuroepidemiology 2021;55(suppl 1):I –II (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 16, 2021 Category: Epidemiology Source Type: research

7th International Conference on Neurology and Epidemiology (ICNE), Virtual Conference, March 19-20, 2021
Neuroepidemiology 2021;55:1 –106 (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 16, 2021 Category: Epidemiology Source Type: research

7th International Conference on Neurology and Epidemiology
Neuroepidemiology 2021;55(suppl 1):III (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 16, 2021 Category: Epidemiology Source Type: research

Validation of an Algorithm to Detect Multiple Sclerosis Cases in Administrative Health Databases in Piedmont (Italy): An Application to the Estimate of Prevalence by Age and Urbanization Level
Conclusion: We validated an algorithm based on EHAs to identify cases of MS for epidemiological use. The prevalence of MS, adjusted for undercount, was among the highest in Italy. We also found that the prevalence was higher in highly urbanized areas.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 10, 2021 Category: Epidemiology Source Type: research

Multiple Sclerosis and Incidence of Urinary and Fecal Incontinence in Almost 9,000 Patients Followed Up for up to 10 Years in Germany
Conclusions: UI and FI are frequent complications of MS, and the presence of these complications should be regularly assessed in primary care practices.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 4, 2021 Category: Epidemiology Source Type: research

Incidence of Cognitive Impairment during Aging in Rural South Africa: Evidence from HAALSI, 2014 to 2019
Conclusions: This study presents some of the first incidence rate estimates for aging-related cognitive impairment in rural South Africa. Social disparities in incident cognitive impairment rates were apparent in patterns similar to those observed in many high-income countries.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - March 3, 2021 Category: Epidemiology Source Type: research

Surveillance Study of Acute Neurological Manifestations among 439 Egyptian Patients with COVID-19 in Assiut and Aswan University Hospitals
Conclusion: In COVID-19, both the CNS and PNS are affected. Stroke was the most common complication for CNS, and anosmia and/or ageusia were common for PNS diseases. However, there were 6 cases of encephalitis, 2 cases of spinal cord myelopathy, 2 cases of MG, and 2 cases of myositis.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 25, 2021 Category: Epidemiology Source Type: research

The Association of Cognitive and Visual Function in a Nationally Representative Study of Older Adults in India
Conclusion: This study illustrates that VI is cross-sectionally associated with lower cognitive performance, largely in a dose-response pattern, across various cognitive domains in the Indian population. These findings are important for informing future longitudinal and interventional studies.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 24, 2021 Category: Epidemiology Source Type: research

Head Injury and Amyotrophic Lateral Sclerosis: A Meta-Analysis
Conclusion: This meta-analysis indicates that head injury, especially severe head injury, could increase ALS risk. Although a strong association is found between head injury #x3c;1 year and ALS risk in the current study, this result suggests a possibility of reverse causation.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 23, 2021 Category: Epidemiology Source Type: research

Myasthenia Gravis in Poland: National Healthcare Database Epidemiological Study
Conclusions: Our findings provide information on epidemiology of MG in Poland and can serve as a tool to evaluate healthcare resources needed for MG patients.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 19, 2021 Category: Epidemiology Source Type: research

Interrelationships between Survival, Sex, and Blood Pressure in Patients with Multiple System Atrophy
Conclusions: The findings of a sex-based difference in the effect of BP on death risk may be important for adjusting the therapeutic approach to MSA patients.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 18, 2021 Category: Epidemiology Source Type: research

Stroke Epidemiology in Oceania: A Review
Conclusions: Stroke is a major healthcare problem in Oceania. Variations in stroke epidemiology are found between countries in Oceania. Data are lacking in some; more research into the burden of stroke in Oceania is needed. With the expected increase in life expectancy and vascular risk factors, the burden of stroke in Oceania will likely rise. Some of the disparities in stroke burden may be addressed by great investment in healthcare.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 18, 2021 Category: Epidemiology Source Type: research

Characterization of Traumatic Brain Injury Research in the Middle East and North Africa Region: A Systematic Review
Conclusions: Despite its clinical, social, and economic burden, the evidence of TBI research in the MENA region is scarce. Further research and high-quality epidemiological studies are urgently needed to gain a deep understanding of the TBI burden in the region, facilitate the allocation of adequate resources, implement effective preventive and intervention strategies and advise on the TBI patient management as reflective on the TBI patterns and modes.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - February 10, 2021 Category: Epidemiology Source Type: research