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Condition: Mitochondrial Disease

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Total 851 results found since Jan 2013.

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)
Int J Mol Med. 2022 Jun;49(6):74. doi: 10.3892/ijmm.2022.5130. Epub 2022 Apr 8.ABSTRACTPost‑ischemic neuroinflammation induced by the innate local immune response is a major pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of mortality and disability worldwide. NLR family pyrin domain containing (NLRP)3 inflammasome crucially mediates post‑ischemic inflammatory responses via its priming, activation and interleukin‑1β release during hypoxic‑ischemic brain damage. Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. In th...
Source: Molecular Medicine - April 14, 2022 Category: Molecular Biology Authors: Xiaolu Zhang Wenyun Zeng Yue Zhang Qun Yu Miao Zeng Jiali Gan Wenlan Zhang Xijuan Jiang Huhu Li Source Type: research

MiR-182 Inhibition Protects Against Experimental Stroke in vivo and Mitigates Astrocyte Injury and Inflammation in vitro via Modulation of Cortactin Activity
Neurochem Res. 2022 Aug 11. doi: 10.1007/s11064-022-03718-6. Online ahead of print.ABSTRACTIschemic stroke remains a devastating cerebrovascular disease that accounts for a high proportion of mortality and disability worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that are responsible for regulation of post-transcriptional gene expression, and growing evidence supports a role for miRNAs in stroke injury and recovery. The current study examined the role of miR-182 in experimental stroke using both in vitro and in vivo models of ischemic injury. Brain levels of miR-182 significantly increased after transie...
Source: Neurochemical Research - August 11, 2022 Category: Neuroscience Authors: Qasim M Alhadidi Lijun Xu Xiaoyun Sun Yusuf S Althobaiti Atiah Almalki Hashem O Alsaab Creed M Stary Source Type: research

Delay in diagnosing a patient with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes  (MELAS) syndrome who presented with status epilepticus and lactic acidosis: a case report
ConclusionThis case report emphasizes the importance of considering mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episode syndrome as a potential cause of status epilepticus with lactic acidosis in a young female patient with a past history of stroke-like episodes. It also stresses the most important workup to rule out every possible life-threatening complication to improve patients ’ lives.
Source: Journal of Medical Case Reports - October 10, 2022 Category: General Medicine Source Type: research

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke.
CONCLUSIONS: NIX primarily regulates basal level of mitophagy in physiological conditions, whereas BNIP3 exclusively activates excessive mitophagy leading to cell death. PMID: 25230377 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - September 17, 2014 Category: Neuroscience Authors: Shi R, Zhu S, Li V, Gibson SB, Xu X, Kong J Tags: CNS Neurosci Ther Source Type: research

Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke
AbstractStroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential ofIndian Ginseng, also known asWithania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system;...
Source: Metabolic Brain Disease - April 18, 2018 Category: Neurology Source Type: research

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
ConclusionsThe NVU on-a-chip model presented here can be used for fundamental studies of NVU function in stroke and other neurological diseases and for investigation of potential restorative therapies to fight neurological disorders. Due to the platform ’s relatively high throughput and compatibility with automation, the model holds potential for drug compound screening.
Source: Fluids and Barriers of the CNS - December 14, 2021 Category: Neuroscience Source Type: research

Advances in Management of the Stroke Etiology One-Percenters
AbstractPurpose of ReviewUncommon causes of stroke merit specific attention; when clinicians have less common etiologies of stoke in mind, the diagnosis may come more easily. This is key, as optimal management will in many cases differs significantly from “standard” care.Recent FindingsRandomized controlled trials (RCT) on the best medical therapy in the treatment of cervical artery dissection (CeAD) have demonstrated low rates of ischemia with both antiplatelet and vitamin K antagonism. RCT evidence supports the use of anticoagulation with vitamin K antagonism in “high-risk” patients with antiphospholipid antibody...
Source: Current Neurology and Neuroscience Reports - May 29, 2023 Category: Neuroscience Source Type: research

Ginsenoside Rd and ischemic stroke; a short review of literatures
Publication date: Available online 23 February 2015 Source:Journal of Ginseng Research Author(s): Seyed Fazel Nabavi , Antoni Sureda , Solomon Habtemariam , Seyed Mohammad Nabavi Panax ginseng is a well-known economic medical plant which is broadly used in Chinese traditional medicine. This species contains unique class of natural products, namely ginsenosides. Recent clinical and experimental studies lined a plethora of evidences up for the promising role of ginsenosides on different diseases including neurodegenerative, cardiovascular, certain types of cancer, etc. Nowadays, much attention has been paid to ginsenoside ...
Source: Journal of Ginseng Research - February 24, 2015 Category: Complementary Medicine Source Type: research

Evaluation of Clinico-radiological, Molecular and Histological Diagnosis of m.3243A>G-related MELAS Syndrome (P2.259)
CONCLUSIONS: Our data suggest that SLE phenomenology is much more uniform than purported in the literature. These findings highlights the importance of a comprehensive clinical examination including detailed visual field evaluation and consideration of m.3243A>G in all cases of stroke and encephalopathy irrespective of age, gender or family pedigree with an unrecognised high recurrence rate within first year of initial presentation. Aggressive mangement of seizure is advocated to prevent ensuing SLE. Study Supported by:Disclosure: Dr. Ng has nothing to disclose. Dr. Gorman has nothing to disclose. Dr. Schaefer has nothi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ng, Y. S., Gorman, G., Schaefer, A., Taylor, R., McFarland, R., Turnbull, D. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Mitochondrial Encephalopathy with Lactic Acidosis and Stroke (MELAS) presenting as an apparent neoplastic process (P5.015)
CONCLUSION: MELAS can mimic more common disorders. The slow onset of her symptoms and the MRI's appearance led to suspicion for neoplasm. This is the first report to our knowledge where MELAS has presented as such. Documentation of this and other unusual presentations of mitochondrial disease is crucial to appropriate diagnosis of the condition.Disclosure: Dr. Rothstein has nothing to disclose. Dr. Haq has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rothstein, A., Haq, I. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology ePosters Source Type: research

Frequency of MELAS main mutation in a phenotype-targeted young ischemic stroke patient population
Abstract Mitochondrial diseases, predominantly mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), may occasionally underlie or coincide with ischemic stroke (IS) in young and middle-aged individuals. We searched for undiagnosed patients with MELAS in a target subpopulation of unselected young IS patients enrolled in the Stroke in Young Fabry Patients study (sifap1). Among the 3291 IS patients aged 18–55 years recruited to the sifap1 study at 47 centers across 14 European countries, we identified potential MELAS patients with the following phenotypic features: (a) diagnosed cardi...
Source: Journal of Neurology - November 14, 2015 Category: Neurology Source Type: research

Naringenin prevents ischemic stroke damage via anti-apoptotic and anti-oxidant effects.
This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signaling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) ...
Source: Pharmacological Reports - April 28, 2017 Category: Drugs & Pharmacology Authors: Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W Tags: Clin Exp Pharmacol Physiol Source Type: research

Importance of Distinguishing Between Mitochondrial Encephalomyopathy With Elderly Onset of Stroke-Like Episodes and Cerebral Infarction.
Abstract The most common disease-causing mitochondrial DNA (mtDNA) mutation in mitochondrial encephalomyopathy (ME) with lactic acidosis and stroke-like episodes (MELAS) is m.3243A>G. In the future, the incidence of patients with cerebral infarction and diabetes mellitus is expected to increase tremendously. Additionally, the A3243G mutation typical of diabetes is estimated to be present in approximately 2% of all diabetes patients, which suggests that the potential disease population with a mitochondrial disorder is greater than previously thought, and there may have been many cases among the elderly that were...
Source: Clin Med Res - August 18, 2017 Category: Research Authors: Tetsuka S, Tagawa A, Ogawa T, Otsuka M, Hashimoto R, Kato H Tags: J Clin Med Res Source Type: research

Correlation of serum biomarkers and magnetic resonance spectroscopy (MRS) in monitoring disease progression in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) due to mtDNA A3243G mutation
Analysis of serum biomarkers, including lactate and the lactate-to-pyruvate (Lac/Pyr) ratio, and magnetic resonance spectroscopy (MRS) are useful for monitoring disease progression in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). We aim to evaluate the correlation of serum biomarkers and MRS parameters during changes associated with stroke-like episodes. Thirteen symptomatic MELAS patients carrying the A3243G mutation were recruited and a total of 207 voxels from 41 MRS studies were divided into 3 groups according to the temporal association with stroke-like episodes.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: H. Lee, Y. Lee Source Type: research