Filtered By:
Condition: Mitochondrial Disease

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 851 results found since Jan 2013.

Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry Clinical Sciences
Conclusions— In patients prescreened using a clinical algorithm for monogenic disorders, we identified monogenic causes of events in 7% of patients in comparison to the 1% to 5% prevalence reported in previous series.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Bersano, A., Markus, H. S., Quaglini, S., Arbustini, E., Lanfranconi, S., Micieli, G., Boncoraglio, G. B., Taroni, F., Gellera, C., Baratta, S., Penco, S., Mosca, L., Grasso, M., Carrera, P., Ferrari, M., Cereda, C., Grieco, G., Corti, S., Ronchi, D., Bas Tags: Genetics, CADASIL, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Clinical Sciences Source Type: research

Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat Session Title: Cerebrovascular Disease and Stroke
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor.The gene encoding Uncoupling Protein 2 (UCP2), a inner mitochondrial membrane protein, maps inside stroke QTL/STR1 in stroke prone spontaneously hypertensive rat (SHRSP). We explored the role of UCP2 in stroke pathogenesis of SHRSP. Male SHRSP, stroke resistant SHR (SHRSR) and reciprocal STR1/congenic rats were fed with stroke permissive Japanese style diet (JD). A group of SHRSP received JD...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Rubattu, S., Cotugno, M., Bianchi, F., Di Castro, S., Stanzione, R., Busceti, C., Marchitti, S., Nicoletti, F., Volpe, M. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease Stroke
Conclusions A significant reduction of Ndufc2 expression causes complex I dysfunction and contributes to stroke susceptibility in SHRSP. Moreover, our current evidence may suggest that Ndufc2 can contribute to an increased occurrence of early-onset ischemic stroke in humans.
Source: JAHA:Journal of the American Heart Association - February 17, 2016 Category: Cardiology Authors: Rubattu, S., Di Castro, S., Schulz, H., Geurts, A. M., Cotugno, M., Bianchi, F., Maatz, H., Hummel, O., Falak, S., Stanzione, R., Marchitti, S., Scarpino, S., Giusti, B., Kura, A., Gensini, G. F., Peyvandi, F., Mannucci, P. M., Rasura, M., Sciarretta, S., Tags: Basic Science Research, Gene Expression & Regulation, Cerebrovascular Disease/Stroke Source Type: research

MELAS Syndrome: How Stroke-like are the Stroke episodes? (P1.255)
Conclusions:Patients with MELAS syndrome may present with recurrent strokes in the arterial territory rather than SLEs. Clinicians should entertain the possibility of a mitochondrial disease in young patients with cryptogenic stroke and pursue appropriate diagnostic evaluations and treatment.Disclosure: Dr. Liaw has nothing to disclose. Dr. Lewis has nothing to disclose. Dr. Saini has nothing to disclose. Dr. Gultekin has nothing to disclose. Dr. Koch has nothing to disclose. Dr. Asdaghi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Liaw, N., Lewis, R., Saini, V., Gultekin, S. H., Koch, S., Asdaghi, N. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
This study identifies and characterizes a specific member of the miR-17 –92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged fem ales and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcome...
Source: Translational Stroke Research - April 27, 2022 Category: Neurology Source Type: research

Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke
AbstractStroke is a debilitating disease that remains the second leading cause of death and disability worldwide. Despite accumulating knowledge of the disease pathology, treatments for stroke are limited, and clinical translation of the neuroprotective agents has not been a complete success. Accumulating evidence links mitochondrial dysfunction to brain impairments after stroke. Recent studies have implicated the important roles of healthy mitochondria in neuroprotection and neural recovery following ischemic stroke. New and convincing studies have shown that mitochondrial transfer to the damaged cells can help revive cel...
Source: Translational Stroke Research - June 25, 2020 Category: Neurology Source Type: research

Ischemic Stroke Brain Sends Indirect Cell Death Signals to the Heart Basic Sciences
Conclusions— Ischemic stroke was accompanied by cardiac myocyte death, indicating a close pathological link between brain and heart. These results suggest a vigilant assessment of the heart condition in stroke patients, likely requiring the need to treat systemic cardiac symptoms after an ischemic brain episode.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Ishikawa, H., Tajiri, N., Vasconcellos, J., Kaneko, Y., Mimura, O., Dezawa, M., Borlongan, C. V. Tags: Animal models of human disease, Apoptosis Basic Sciences Source Type: research

Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice
Sirtuins, class III histone deacetylases, are involved in the regulation of tissue repair processes and brain functions after a stroke. The ability of some isoforms of sirtuins to circulate between the nucleus and cytoplasm may have various pathophysiological effects on the cells. In present work, we focused on the role of non-mitochondrial sirtuins SIRT1, SIRT2, and SIRT6 in the restoration of brain cells following ischemic stroke. Here, using a photothrombotic stroke (PTS) model in mice, we studied whether local stroke affects the level and intracellular localization of SIRT1, SIRT2, and SIRT6 in neurons and astrocytes o...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Svetlana Demyanenko, Elena Gantsgorn, Stanislav Rodkin, Svetlana Sharifulina Source Type: research

Inhibition of Mitochondrial P53 Abolishes the Detrimental Effects of Social Isolation on Ischemic Brain Injury Brief Reports
Conclusions— Poststroke SI results in increased ischemic injury in both sexes. The effect of housing on infarct was more pronounced in women. Targeting the mitochondrial P53 pathway could minimize the detrimental effects of isolation after stroke.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Venna, V. R., Verma, R., O'Keefe, L. M., Xu, Y., Crapser, J., Friedler, B., McCullough, L. D. Tags: Behavioral/psychosocial - stroke, Animal models of human disease, Apoptosis, Acute Cerebral Infarction Brief Reports Source Type: research

In reply to the letter to the editor reading: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes
We are grateful to Josef Finsterer for his comments on our recent report regarding mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) diagnosed after metformin-triggered stroke-like episodes (SLEs).1 In his letter to the editor, several limitations regarding our study were raised.
Source: Journal of Stroke and Cerebrovascular Diseases - April 19, 2023 Category: Neurology Authors: Keishu Murakami, Ken Sakamoto, Hiroshi Ishiguchi, Hidefumi Ito Tags: Letter to the Editor Source Type: research

Letter to the Editor regarding “Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes”
We read with interest the article by Murakami et al. about a 40 years-old male with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome due to the variant m.3243A>G with a heteroplasmy rate of 27%, in whom metformin was suspected to have triggered a stroke-like episode (SLE), the phenotypic hallmark of MELAS.1 Metformin was replaced by sitagliptin and the patient was discharged in a stable condition after three weeks.1 The study is excellent, but has limitations that are objectionable and should be discussed.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Clinical and radiologic reversal of stroke-like episodes in MELAS with high-dose L-arginine
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome (MT-TL1 gene) is a progressive neurologic disorder with stroke-like episodes (SLEs), which are recurrent neurologic deficits resembling vasoocclusive strokes.1 However, SLEs are not restricted to vascular territories and have a predilection for the occipital and posterior parietal and temporal cortices,2 may evolve subacutely over hours to days,3 and have greater potential for reversibility.4 Their pathophysiology is incompletely understood. Current literature suggests a combination of neuronal mitochondrial energy failure and cereb...
Source: Neurology - July 13, 2015 Category: Neurology Authors: Siddiq, I., Widjaja, E., Tein, I. Tags: MRI, Other cerebrovascular disease/ Stroke, Mitochondrial disorders; see Genetics/Mitochondrial disorders, All Pediatric CLINICAL/SCIENTIFIC NOTES Source Type: research

Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain Basic Sciences
Conclusions— RPC induces a novel extended window of ischemic tolerance in the brain that lasts for at least 14 days. Our data suggest that this tolerance may be mediated by Sirt1 through upregulation of BDNF and downregulation of uncoupling protein 2.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Koronowski, K. B., Dave, K. R., Saul, I., Camarena, V., Thompson, J. W., Neumann, J. T., Young, J. I., Perez-Pinzon, M. A. Tags: Animal models of human disease, Acute Cerebral Infarction, Embolic stroke, Neuroprotectors Basic Sciences Source Type: research

Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Inȷury Basic Sciences
Conclusions—Our results unveil a key role of mitochondrial complex I in the development of I/R brain injury and provide the mechanistic basis for the well-established mitochondrial dysfunction caused by I/R. Targeting the functional integrity of complex I in the early phase of reperfusion may provide a novel therapeutic strategy to prevent tissue injury after stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Anja Kahl, Anna Stepanova, Csaba Konrad, Corey Anderson, Giovanni Manfredi, Ping Zhou, Costantino Iadecola, Alexander Galkin Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research