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Condition: Mitochondrial Disease
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Total 851 results found since Jan 2013.
Management considerations for stroke-like episodes in MELAS with concurrent COVID-19 infection
We present a challenging case of an adult patient with a known diagnosis of Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS) complicated by COVID-19 infection. She initially presented with altered mental status and vomiting and went on to develop a stroke-like episode, pancreatitis, and pneumatosis intestinalis. We review salient features of her hospitalization, including initiation of thromboprophylaxis in relation to intravenous arginine therapy, caution regarding medications such as remdesivir, and the incidence of gastrointestinal complications.
Source: Journal of Neurology - April 1, 2021 Category: Neurology Source Type: research
Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke
Aging (Albany NY). 2021 Apr 4;13. doi: 10.18632/aging.202807. Online ahead of print.ABSTRACTCerebral ischemia/reperfusion injury causes a series of intricate cascade reactions in brain tissue causing apoptosis and proinflammatory programmed cell death known as pyroptosis of nerve cells. The dysfunction of target organelle mitochondria plays a key role in the process of neuronal apoptosis and pyroptosis. Mesenchymal stem cells (MSCs) have been widely used in the experimental or clinical treatment of various ischemic diseases, but the therapeutic efficacy of MSCs on cerebral ischemia-reperfusion injury need to be improved. W...
Source: Aging - April 6, 2021 Category: Biomedical Science Authors: Yi Zhuo Wei Chen Wenshui Li Yan Huang Da Duan Lite Ge Jialin He Jianyang Liu Zhiping Hu Ming Lu Source Type: research
< em > Angelica gigas < /em > root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways
CONCLUSIONS: This study provides evidence supporting the use of A. gigas root against ischaemic stroke and suggests a novel developmental starting point for the treatment of ischaemic stroke.PMID:34062098 | DOI:10.1080/13880209.2021.1928241
Source: Pharmaceutical Biology - June 1, 2021 Category: Drugs & Pharmacology Authors: Se-Eun Lee Chiyeon Lim Suin Cho Source Type: research
Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke
Mol Med Rep. 2022 May;25(5):165. doi: 10.3892/mmr.2022.12681. Epub 2022 Mar 16.ABSTRACTIschemic stroke is a life‑threatening disease, which is closely related to neuron damage during ischemia. Mitochondrial dysfunction is essentially involved in the pathophysiological process of ischemic stroke. Mitochondrial calcium overload contributes to the development of mitochondrial dysfunction. However, the underlying mechanisms of mitochondrial calcium overload are far from being fully revealed. In the present study, middle cerebral artery obstruction (MCAO) was performed in vivo and oxygen and glucose deprivation (OGD) in vitro...
Source: Molecular Medicine - March 16, 2022 Category: Molecular Biology Authors: Bin Wen Kai Xu Rui Huang Teng Jiang Jian Wang Jiehui Chen Juan Chen Benhong He Source Type: research
circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1
Exp Neurol. 2022 May 13:114115. doi: 10.1016/j.expneurol.2022.114115. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) are aberrantly expressed in the brain and play a role in a variety of central nervous system diseases. However, the essential role and therapeutic potential of circRNAs in ischemic stroke (IS) are poorly understood. Here, using circRNA sequencing, we showed that circRNA homeodomain-interacting protein kinase 3 (circHIPK3) was abundantly expressed in ischemic brain tissues in transient middle cerebral artery occlusion (tMCAO)-evoked stroke model mice. Knockdown of circHIPK3 markedly reduced the infarc...
Source: Experimental Neurology - May 16, 2022 Category: Neurology Authors: Guozhong Chen Xiaoyun Shan Lin Li Lihua Dong Guiyuan Huang Hongmiao Tao Source Type: research
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyse
Mitochondrial dysfunction is associated with increased reactive oxygen species (ROS) that are thought to drive disease risk, including stroke. We investigated the association between mtDNA abundance, as a proxy measure of mitochondrial function, and incident stroke, using multivariable-adjusted survival and Mendelian Randomization (MR) analyses.
Source: Atherosclerosis - June 19, 2022 Category: Cardiology Authors: Leon G. Martens, Jiao Luo, Marieke J.H. Wermer, Ko Willems van Dijk, Sara H ägg, Felix Grassmann, Raymond Noordam, Diana van Heemst Source Type: research
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
In this study we investigated whether Ori exerted a protective effect against reperfusion injury-induced neuronal loss and the underlying mechanisms. Mice were subjected to transient middle cerebral artery occlusion (tMCAO), and were injected with Ori (5, 10, 20 mg/kg, i.p.) at the beginning of reperfusion. We showed that Ori treatment rescued neuronal loss in a dose-dependent manner by specifically inhibiting caspase-9-mediated neuronal apoptosis and exerted neuroprotective effects against reperfusion injury. Furthermore, we found that Ori treatment reversed neuronal mitochondrial damage and loss after reperfusion injury....
Source: Acta Pharmacologica Sinica - October 10, 2022 Category: Drugs & Pharmacology Authors: Lei Li Jing-Jing Song Meng-Xue Zhang Hui-Wen Zhang Hai-Yan Zhu Wei Guo Cai-Long Pan Xue Liu Lu Xu Zhi-Yuan Zhang Source Type: research
TMED10 inhibits mitochondrial damage and protects neurons in ischemic stroke via the JNK signaling pathway
Exp Anim. 2022 Oct 14. doi: 10.1538/expanim.22-0060. Online ahead of print.ABSTRACTStroke, a type of acute cerebrovascular disease, is a global disease with high mortality. Neuronal ischemia and hypoxia are closely related to occurrence and development of cognitive impairment. Transmembrane p24 trafficking protein 10 (TMED10) as a transmembrane protein involves in vesicle protein transport in the secretory pathways. However, the function and mechanism of TMED10 on ischemic stroke and cognitive impairments remain unclear. In current study, TMED10 was highly expressed in cerebral ischemic penumbra of middle cerebral artery o...
Source: Experimental Animals - October 16, 2022 Category: Research Authors: Qiushi Li Xuying Liu Ruixian Xing Rubo Sui Source Type: research
