Filtered By:
Condition: Mitochondrial Disease

This page shows you your search results in order of relevance. This is page number 15.

Order by Relevance | Date

Total 851 results found since Jan 2013.

Wernicke Encephalopathy Mimicking MELAS
CONCLUSIONS: the case suggests that thiamine deficiency presumably causes mitochondrial dysfunction with cerebrospinal fluid lactic acidosis and a stroke-like lesion mimicking MELAS syndrome. It should be further studied whether nutritional deficits, such as thiamine deficiency, could give rise to secondary stroke-like lesions.PMID:35630076 | PMC:PMC9144475 | DOI:10.3390/medicina58050660
Source: Medicina (Kaunas) - May 28, 2022 Category: Universities & Medical Training Authors: Josef Finsterer Source Type: research

Phagocytosis in the Brain: Homeostasis and Disease
Conclusions and Perspectives In this review we have summarized the critical role phagocytosis plays in both CNS homeostasis and disease. While much progress has been made in recent years, many unanswered questions remain. How phagocytosis in the CNS is influenced by numerous factors, such as microenvironment or phagocytic target, have yet to be fully resolved. Additionally, the utilization of novel technologies, including in vivo imaging techniques (217), iPSC-derived microglia (213) and high-throughput screens (66), will likely contribute to further identification of phagocytic pathways and consequences of phagocytosis w...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Neuromuscular and Muscle Metabolic Functions in MELAS Before and After Resistance Training: A Case Study
Conclusion To conclude, this study suggests a preserved plasticity in the skeletal muscle of a patient with MELAS. More importantly, Resistance Training appears to be a safe and effective method to increase skeletal muscle function in this patient population, and this effect is mediated by both neuromuscular and mitochondrial adaptations. However, particular attention and caution is needed in the interpretation of the data of this single case study and further studies are warranted including larger sample of patients. Ethics Statement For this case study the participant caregiver provided written informed consent. Auth...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject.Graphical abstract
Source: Biomedicine and Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization.
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. PMID: 32028240 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 2, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Xiao G, He S, Liu X, Zhu L, Yang X, Zhang Y, Orgah J, Feng Y, Wang X, Zhang B, Zhu Y Tags: Biomed Pharmacother Source Type: research

Genes, Vol. 12, Pages 1855: Monogenic Causes of Strokes
icz Strokes are the main cause of death and long-term disability worldwide. A stroke is a heterogeneous multi-factorial condition, caused by a combination of environmental and genetic factors. Monogenic disorders account for about 1% to 5% of all stroke cases. The most common single-gene diseases connected with strokes are cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Fabry disease, mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS) and a lot of single-gene diseases associated particularly with cerebral small-vessel disease, such as COL4A1 syn...
Source: Genes - November 23, 2021 Category: Genetics & Stem Cells Authors: Justyna Chojdak- Łukasiewicz Edyta Dziadkowiak S ławomir Budrewicz Tags: Review Source Type: research

The Yin and Yang of Inflammation.
Abstract Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach. PMID: 2532399...
Source: Current Molecular Medicine - October 15, 2014 Category: Molecular Biology Authors: Blackman MA, Yates JL, Spencer CM, Vomhof-DeKrey EE, Cooper AM, Leadbetter EA Tags: Curr Mol Med Source Type: research

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options
Publication date: Available online 15 June 2015 Source:Molecular Genetics and Metabolism Author(s): Ayman W. El-Hattab , Adekunle M. Adesina , Jeremy Jones , Fernando Scaglia Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS syndrome is a multi-organ disease with broad manifestations including stroke-like episodes, dementia, epilepsy, lactic acidemia, myopathy, recurrent headaches, hearing impairment, diabetes, and short stature. The most common mutation associated with MELAS syndrome is the m.3243A&a...
Source: Molecular Genetics and Metabolism - June 27, 2015 Category: Genetics & Stem Cells Source Type: research

Short bursts of intense exercise 'as good' as endurance training
Conclusion The idea that a 10-minute workout could have the same benefits as spending 45 minutes in the gym is tempting. The researchers found it may improve specific markers of health, in one group of young men. However, this is a small study in a specific population, and we don't know whether it would have comparable effects in older people or women. Also, we don't know the long-term effects of this type of training programme on people's health. Studies that look at the effects of an intervention, whether it's exercise, diet or medicine, on health measures such as insulin resistance and oxygen uptake, can only give us a...
Source: NHS News Feed - April 28, 2016 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Diabetes Source Type: news

Molecules, Vol. 23, Pages 2401: Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways
Xiaobo Sun Ischemic stroke is a clinically common cerebrovascular disease whose main risks include necrosis, apoptosis and cerebral infarction, all caused by cerebral ischemia and reperfusion (I/R). Ischemia and reperfusion-induced injury of or apoptosis inhibition in human brain tissue may exert an irreplaceable protective effect on ischemic nerves. This process has particular significance for the treatment of stroke patients. However, the development of neuroprotective drugs remains challenging. Radix Scrophulariae, traditionally considered a valuable medicine, has been discovered to have neuroprotective effects. ...
Source: Molecules - September 19, 2018 Category: Chemistry Authors: Xiaobo Meng Weijie Xie Quanfu Xu Tian Liang Xudong Xu Guibo Sun Xiaobo Sun Tags: Article Source Type: research

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T > C Mutation in the Mitochondrial MTND3 Gene
Conclusion The m.10191T>C mutation in the mtDNA of the complex I (CI) subunit of MTND3 results in the substitution of a highly conserved amino acid (p.Ser45Pro) within the ND3 protein, leading to CI dysfunction through impaired enzyme catalysis rather than impaired stability or assembly, causing a broad clinical spectrum of disorders (26). Patients with the m.10191T>C mutation are rare. In the present study, we report on a family of patients with the extremely rare adult-onset Leigh-like syndrome with the m.10191T>C mutation. Including the two patients from our reported family, the m.10191T...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia
Conclusion: Using three different strategies to either prevent formation or enhance elimination of O2⋅_ during the post-asphyxial period, we saw both reduced leukocyte adherence and preserved BBB function with treatment. These findings suggest that agents which lower O2⋅_ in brain may be attractive new therapeutic interventions for the protection of the neonatal brain following asphyxia. Introduction Asphyxia is a relatively common source of neonatal brain damage (1), affecting ~2 in every 1,000 births (2). The hypoxic ischemia resulting from this oxygen deprivation can produ...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research