Filtered By:
Condition: Mitochondrial Disease
This page shows you your search results in order of relevance. This is page number 3.
Order by Relevance | Date
Total 851 results found since Jan 2013.
Molecular mechanisms of cognitive impairment associated with stroke
AbstractStroke is the second leading cause of death after coronary heart disease in developed countries and is the greatest cause of disability and cognitive impairment. Risk factors for cognitive impairment and dementia after stroke are multifactorial including older age, family history, hypertension, arterial fibrillation, diabetes, genetic variants, low educational status, vascular comorbidities, prior transient ischaemic attack or recurrent stroke, depressive illness duration of a stroke, location, volume, intensity, and degree of neuronal degeneration, location and size of infarction after stroke, time interval after ...
Source: Metabolic Brain Disease - January 14, 2022 Category: Neurology Source Type: research
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS
AbstractMitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a disease that should be considered as a differential diagnosis to acute ischemic stroke taking into account its onset pattern and neurological symptoms, which are similar to those of an ischemic stroke. Technological advancements in neuroimaging modalities have greatly facilitated differential diagnosis between stroke and MELAS on diagnostic imaging. Stroke-like episodes in MELAS have the following features: (1) symptoms are neurolocalized according to lesion site; (2) epileptic seizures are often present; (3) lesion distri...
Source: Metabolic Brain Disease - June 12, 2021 Category: Neurology Source Type: research
Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke
Pflugers Arch. 2021 Nov 10. doi: 10.1007/s00424-021-02636-w. Online ahead of print.ABSTRACTStroke represents a main cause of death and permanent disability worldwide. In the attempt to develop targeted preventive and therapeutic strategies, several efforts were performed over the last decades to identify the specific molecular abnormalities preceding cerebral ischemia and neuronal death. In this regard, mitochondrial dysfunction, autophagy, and intracellular calcium homeostasis appear important contributors to stroke development, as underscored by recent pre-clinical evidence. Intracellular calcium (Ca2+) homeostasis is re...
Source: Pflugers Archiv : European Journal of Physiology - November 10, 2021 Category: Physiology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Speranza Rubattu Source Type: research
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS
AbstractMitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a disease that should be considered as a differential diagnosis to acute ischemic stroke taking into account its onset pattern and neurological symptoms, which are similar to those of an ischemic stroke. Technological advancements in neuroimaging modalities have greatly facilitated differential diagnosis between stroke and MELAS on diagnostic imaging. Stroke-like episodes in MELAS have the following features: (1) symptoms are neurolocalized according to lesion site; (2) epileptic seizures are often present; (3) lesion distri...
Source: Metabolic Brain Disease - November 15, 2021 Category: Neurology Source Type: research
Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria
Free Radic Biol Med. 2022 Mar 24:S0891-5849(22)00123-X. doi: 10.1016/j.freeradbiomed.2022.03.020. Online ahead of print.ABSTRACTIschemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for the progesterone receptor in exerting its potent birth control and hormone replacement therapy. Accumulating evidence implicates a new utility of Nestorone in affording neuroprotection in a variety of central nervous system diseases, including stroke. However, the mechanism o...
Source: Free Radical Biology and Medicine - March 28, 2022 Category: Biology Authors: Jea-Young Lee Vanessa Castelli Narender Kumar Regine Sitruk-Ware Cesario V Borlongan Source Type: research
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
CONCLUSIONS: Although the results from both multivariable-adjusted prospective and basis MR analyses did not show an association between low mtDNA and increased risk of ischemic stroke, in-depth MR sensitivity analyses may suggest evidence for a causal relationship.PMID:35793595 | DOI:10.1016/j.atherosclerosis.2022.06.1012
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Leon G Martens Jiao Luo Marieke J H Wermer Ko Willems van Dijk Sara H ägg Felix Grassmann Raymond Noordam Diana van Heemst Source Type: research
Regulation of the p53 ‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
Exp Ther Med. 2023 Jan 26;25(3):113. doi: 10.3892/etm.2023.11812. eCollection 2023 Mar.ABSTRACTStroke is one of the most threatening diseases worldwide, particularly in countries with larger populations; it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel ruptures) or ischemic stroke (blockage of an artery). Whilst the incidence of stroke is higher in the elderly population (≥65), it is also increasing in the younger population. Ischemic stroke accounts for ~85% of a...
Source: Experimental and Therapeutic Medicine - February 16, 2023 Category: General Medicine Authors: Shuangli Xu Xuewei Li Yanqiang Wang Source Type: research
Neuroprotective Strategies for Stroke by Natural Products: Advances and Perspectives
Curr Neuropharmacol. 2023 Jul 17. doi: 10.2174/1570159X21666230717144752. Online ahead of print.ABSTRACTCerebral ischemic stroke is a disease with high prevalence and incidence. Its management focuses on rapid reperfusion with intravenous thrombolysis and endovascular thrombectomy. Both therapeutic strategies reduce disability, but the therapy time window is short, and the risk of bleeding is high. Natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases. However, they have made little progress in clinical translation and pose challenges to the treatment of stroke. Rece...
Source: Current Neuropharmacology - July 17, 2023 Category: Drugs & Pharmacology Authors: Aifen Liu Jingyan Hu Tzu-Shao Yeh Chengniu Wang Jilong Tang Xiaohong Huang Bin Chen Liexiang Huangfu Weili Yu Lei Zhang Source Type: research
Detection of Presymptomatically Latent Lesions Developing into Stroke-Like Episodes by Arterial Spin-Labeling Perfusion MRI in MELAS Patients (P03.162)
CONCLUSIONS: These findings suggest that regional ASL hyperperfusion in the presymptomatic phase precedes the appearance of upcoming stroke-like lesions, and that presymptomatic SEs had already occurred several months before the onset of clinical symptoms. ASL imaging has great potential for detecting presymptomatic stroke-like lesions and predicting the emergence of SEs.Supported by: In part by Grants-in-Aid for the Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Young Scientists (B) from the Japan Society for the Promotion of Science, and the Re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ikawa, M., Kimura, H., Muramatsu, T., Matsunaga, A., Tsujikawa, T., Yamamoto, T., Kosaka, N., Kinoshita, K., Yamamura, O., Hamano, T., Nakamoto, Y., Yoneda, M. Tags: P03 Cerebrovascular Disease III Source Type: research
Genetic Variation within the Oxidative Phosphorylation Pathway in Stroke and Alzheimer's Disease (P6.334)
Conclusions: OXPHOS genetic variation influences clinical status and neuroimaging intermediates of AD. OXPHOS genetic variants associated with stroke are also linked to AD progression.CONCLUSIONS: OXPHOS genetic variation influences clinical status and neuroimaging intermediates of AD. OXPHOS genetic variants associated with stroke are also linked to AD progression.Disclosure: Dr. Biffi has nothing to disclose. Dr. Sabuncu has nothing to disclose. Dr. Desikan has nothing to disclose. Dr. Nick has nothing to disclose. Dr. Salat has nothing to disclose. Dr. Rosand has received personal compensation for activities with Boehri...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Biffi, A., Sabuncu, M., Desikan, R., Nick, S., Salat, D., Rosand, J., Anderson, C. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Imaging Source Type: research
Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-like Episodes (MELAS) May Respond to Adjunctive Ketogenic Diet
Conclusions: The ketogenic diet may lead to improvement of mitochondrial dysfunction in MELAS, which in turn may promote better seizure control and less frequent stroke-like episodes.
Source: Pediatric Neurology - January 9, 2014 Category: Neurology Authors: Claude Steriade, Danielle M. Andrade, Hanna Faghfoury, Mark A. Tarnopolsky, Peter Tai Tags: Clinical Observations Source Type: research
