Detection of Presymptomatically Latent Lesions Developing into Stroke-Like Episodes by Arterial Spin-Labeling Perfusion MRI in MELAS Patients (P03.162)

CONCLUSIONS: These findings suggest that regional ASL hyperperfusion in the presymptomatic phase precedes the appearance of upcoming stroke-like lesions, and that presymptomatic SEs had already occurred several months before the onset of clinical symptoms. ASL imaging has great potential for detecting presymptomatic stroke-like lesions and predicting the emergence of SEs.Supported by: In part by Grants-in-Aid for the Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Young Scientists (B) from the Japan Society for the Promotion of Science, and the Research on Intractable Diseases (Mitochondrial Disorder) from the Ministry of Health, Labour and Welfare of Japan.Disclosure: Dr. Ikawa has nothing to disclose. Dr. Kimura has nothing to disclose. Dr. Muramatsu has nothing to disclose. Dr. Matsunaga has nothing to disclose. Dr. Tsujikawa has nothing to disclose. Dr. Yamamoto has nothing to disclose. Dr. Kosaka has nothing to disclose. Dr. Kinoshita has nothing to disclose. Dr. Yamamura has nothing to disclose. Dr. Hamano has nothing to disclose. Dr. Nakamoto has nothing to disclose. Dr. Yoneda has nothing to disclose.

Source: Neurology - February 14, 2013 Category: Neurology Authors: Ikawa, M., Kimura, H., Muramatsu, T., Matsunaga, A., Tsujikawa, T., Yamamoto, T., Kosaka, N., Kinoshita, K., Yamamura, O., Hamano, T., Nakamoto, Y., Yoneda, M. Tags: P03 Cerebrovascular Disease III Source Type: research