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Condition: Mitochondrial Disease

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Total 851 results found since Jan 2013.

Kaempferol Protects Cell Damage in In Vitro Ischemia Reperfusion Model in Rat Neuronal PC12 Cells.
Abstract Ischemic cerebral stroke is a severe neurodegenerative disease with high mortality. Ischemia and reperfusion injury plays a fundamental role in ischemic cerebral stroke. To date, the strategy for ischemic cerebral stroke treatment is limited. In the present study, we aimed to investigate the effect of kaempferol (KFL), a natural flavonol, on cell injury induced by oxygen and glucose deprivation (OGD) and reoxygenation (OGD-reoxygenation) in PC12 cells. We found that KFL inhibited OGD-induced decrease of cell viability and the increase of lactate dehydrogenase (LDH) release. OGD-induced activation of mitoc...
Source: Biomed Res - May 10, 2020 Category: Research Authors: Zhou YP, Li GC Tags: Biomed Res Int Source Type: research

Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease.
Abstract Creatine is of paramount importance for maintaining and managing cellular ATP stores in both physiological and pathological states. Besides these "ergogenic" actions, it has a number of additional "pleiotropic" effects, e.g., antioxidant activity, neurotransmitter-like behavior, prevention of opening of mitochondrial permeability pore and others. Creatine supplementation has been proposed for a number of conditions, including neurodegenerative diseases. However, it is likely that creatine's largest therapeutic potential is in those diseases caused by energy shortage or by increased energy demand; for exam...
Source: Amino Acids - January 21, 2016 Category: Biochemistry Authors: Balestrino M, Sarocchi M, Adriano E, Spallarossa P Tags: Amino Acids Source Type: research

Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature
Conclusions: ND3 disease due to m.10158T>C mutation was previously described only in patients with Leigh or Leigh-like syndrome. Our findings thus indicate that ND3 disease can manifest with atypical phenotype in adults. The diagnosis of mitochondrial disease caused by other than typical MELAS-associated mutations in adults with stroke-like episodes, headaches, and seizures should be considered. An analysis of tissue other than blood, which is more likely to harbor a tissue-specific mitochondrial DNA mutation at a measurable level, may be necessary for diagnosis.
Source: The Neurologist - June 29, 2016 Category: Neurology Tags: Case Report/Case Series Source Type: research

Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies Original Articles
Conclusions— We identified several novel LEA regions, in addition to previously identified genetic variations, associated with cCIMT and cardiovascular disease events among African Americans.
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Shendre, A., Wiener, H., Irvin, M. R., Zhi, D., Limdi, N. A., Overton, E. T., Wassel, C. L., Divers, J., Rotter, J. I., Post, W. S., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Genetic, Association Studies, Ultrasound, Atherosclerosis Original Articles Source Type: research

Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats RESEARCH ARTICLE
In conclusion, these results demonstrate that P4 treatment is beneficial in preserving the mitochondrial functions that are altered in cerebral ischemic injury and thus can help in defining better therapies.
Source: DMM Disease Models and Mechanisms - June 7, 2017 Category: Biomedical Science Authors: Andrabi, S. S., Parvez, S., Tabassum, H. Tags: Rat as a Disease Model RESEARCH ARTICLE Source Type: research

Theaflavic acid from black tea protects PC12 cells against ROS-mediated mitochondrial apoptosis induced by OGD/R via activating Nrf2/ARE signaling pathway
AbstractCerebral ischemic stroke is a severe disease afflicting people worldwide. Phytochemicals play a pivotal role in the discovery of novel therapeutic approaches for the prevention of ischemic stroke. In our continual search for bioactive natural products for the treatment of ischemic stroke, we have evaluated the protective effects of theaflavic acid (TFA) from black tea using PC12 cells injured by oxygen and glucose deprivation/restoration (OGD/R), and investigated the possible mechanisms. The results showed that TFA can protect PC12 cells against OGD/R through increasing cell viability and decreasing intracellular l...
Source: Journal of Natural Medicines - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Ropinirole induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in Wistar rats.
In conclusion, these results demonstrate that Ropinirole treatment is beneficial in preserving the mitochondrial functions that are altered in cerebral ischemic injury and thus can help in defining better therapies. PMID: 31816341 [PubMed - as supplied by publisher]
Source: Neurotoxicology - December 5, 2019 Category: Neurology Authors: Andrabi SS, Tabassum H, Parveen S, Parvez S Tags: Neurotoxicology Source Type: research

Molecular and neurological features of MELAS syndrome in paediatric patients: A case series and review of the literature
ConclusionThe threshold for investigating MELAS syndrome in children with suspicious neurological symptoms should be low. If blood m.3243A>G analysis is negative, yet clinical suspicion remains high, invasive testing or further interrogation of the mitochondrial genome should be considered.
Source: Molecular Genetics & Genomic Medicine - April 27, 2022 Category: Genetics & Stem Cells Authors: Lydia M. Seed, Andrew Dean, Deepa Krishnakumar, Poe Phyu, Rita Horvath, Pooja Devi Harijan Tags: ORIGINAL ARTICLE Source Type: research

Elderly onset of MELAS in a male: A case report
ConclusionElderly onset of MELAS is rare and easily misdiagnosed as an ischemic stroke. MELAS with the onset of stroke-like episodes should be considered in adult or elderly patients with imaging findings that are atypical for cerebral infarction. The use of multimodal MRI in the clinical diagnosis of MELAS could be extremely beneficial.
Source: Frontiers in Neurology - December 1, 2022 Category: Neurology Source Type: research

Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis
Free Radic Biol Med. 2023 Jan 18:S0891-5849(23)00009-6. doi: 10.1016/j.freeradbiomed.2023.01.008. Online ahead of print.ABSTRACTFerroptosis is a form of non-apoptotic cell death caused by iron-dependent peroxidation of lipids. It contributes to ischemic stroke-induced neuronal damage. Elabela (ELA), a novel endogenous ligand for Apelin receptor (APJ), regulates oxidative stress and exerts a protective role in cardiovascular disease. However, the effect of ELA-APJ axis on cellular ferroptosis in cerebral ischemia/reperfusion (I/R) remains elusive. The present study showed that ELA and APJ were expressed on neurons and incre...
Source: Free Radical Biology and Medicine - January 21, 2023 Category: Biology Authors: Pengfei Xu Lingqi Kong Chunrong Tao Yuyou Zhu Juan Cheng Wenyu Li Nan Shen Rui Li Chao Zhang Li Wang Yan Zhang Guoping Wang Xinfeng Liu Wen Sun Wei Hu Source Type: research

The Parkinson's disease‐associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1
This study demonstrates that PINK1 prevents ischemic damage in neurons by attenuating mitochondrial translocation of Drp1, which maintains mitochondrial function and inhibits ischemia‐induced mitochondrial fission. These novel findings implicate a pivotal role of PINK1 regulated mitochondrial dynamics in the pathology of ischemic stroke. This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - June 16, 2013 Category: Neurology Authors: Yanxin Zhao, Fangzhe Chen, Shufen Chen, Xueyuan Liu, Mei Cui, Qiang Dong Tags: Original Article Source Type: research

The Applications of Pharmacogenomics to Neurological Disorders.
Abstract The most common neurological disorders, including neurodegenerative diseases and psychiatric disorders, have received recent attention with regards to pharmacogenomics and personalized medicine. Here, we will focus on a neglected neurodegenerative disorder, cerebral ischemic stroke (CIS), and highlight recent advances in two disorders, Parkinson's disease (PD) and Alzheimer's diseases (AD), that possess both similar and distinct mechanisms in regards to therapeutic targets. Current attempts to link symptoms from other disorders to candidate genes have been effective in identifying candidate genes for stro...
Source: Current Molecular Medicine - August 11, 2014 Category: Molecular Biology Authors: Gilman C, McSweeney C, Mao Y Tags: Curr Mol Med Source Type: research