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Condition: Mitochondrial Disease
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Total 851 results found since Jan 2013.
Mitochondrial Implications in Cardiovascular Aging and Diseases: The Specific Role of Mitochondrial Dynamics and Shifts
Int J Mol Sci. 2022 Mar 9;23(6):2951. doi: 10.3390/ijms23062951.ABSTRACTCardiovascular disease has been, and remains, one of the leading causes of death in the modern world. The elderly are a particularly vulnerable group. The aging of the body is inevitably accompanied by the aging of all its systems, and the cardiovascular system is no exception. The aging of the cardiovascular system is a significant risk factor for the development of various diseases and pathologies, from atherosclerosis to ischemic stroke. Mitochondria, being the main supplier of energy necessary for the normal functioning of cells, play an important ...
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Anastasia V Poznyak Tatiana V Kirichenko Evgeny E Borisov Nikolay K Shakhpazyan Andrey G Kartuesov Alexander N Orekhov Source Type: research
Diagnosis of adult-onset MELAS with suspected recurrent strokes: A case report
Exp Ther Med. 2022 May 25;24(1):466. doi: 10.3892/etm.2022.11393. eCollection 2022 Jul.ABSTRACTMitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is caused by mutations in mitochondrial DNA and is one of the most common syndromes among the mitochondrial diseases. Clinical manifestations typically occur before the age of 40 years. The present study reports a case of MELAS with a mutation in the adenine to guanine conversion at mitochondrial genome 3243 in a 48-year-old woman who was suspected of suffering from recurrent strokes. Finally, the genomic analysis confirmed the diagnosis of MELAS. T...
Source: Experimental and Therapeutic Medicine - June 24, 2022 Category: General Medicine Authors: Fei Yang Shan Peng Qiaojun Peng Source Type: research
Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research
Age-related vascular changes exemplified by the carotid artery
Gefasschirurgie. 2022 Jun 24;27(4):1-7. doi: 10.1007/s00772-022-00901-5. Online ahead of print.ABSTRACTOne of the main risk factors for the presence of carotid stenosis and carotid-related stroke is age. The aim of this review article is to present the current state of knowledge on age-related vascular changes using carotid stenosis as an example.Vascular aging (vascular senescence) is a decrease of structural and functional properties of the vessel wall that takes place on different levels. At the multicellular level an increase in vessel volume and diameter as well as intima media thickness occurs with age mainly due to ...
Source: Atherosclerosis - July 5, 2022 Category: Cardiology Authors: Benedikt Reutersberg Philip D üppers Anna-Leonie Menges Claudia Schrimpf Alexander Zimmermann Jaroslav Pelisek Source Type: research
Irisin, An Exercise-induced Bioactive Peptide Beneficial for Health Promotion During Aging Process
This study is expected to improve the understanding of irisin, which may be beneficial to identify novel and effective targets for the screening, diagnosis, or therapy of these chronic diseases, or develop promising interventional strategies, effective drug candidates, functional foods, or exercise mimetics.PMID:35793739 | DOI:10.1016/j.arr.2022.101680
Source: Ageing Research Reviews - July 6, 2022 Category: Genetics & Stem Cells Authors: Hu Zhang Xiaowen Wu Jiling Liang Michael Kirberger Ning Chen Source Type: research
Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research
Irisin, An Exercise-induced Bioactive Peptide Beneficial for Health Promotion During Aging Process
This study is expected to improve the understanding of irisin, which may be beneficial to identify novel and effective targets for the screening, diagnosis, or therapy of these chronic diseases, or develop promising interventional strategies, effective drug candidates, functional foods, or exercise mimetics.PMID:35793739 | DOI:10.1016/j.arr.2022.101680
Source: Ageing Research Reviews - July 6, 2022 Category: Genetics & Stem Cells Authors: Hu Zhang Xiaowen Wu Jiling Liang Michael Kirberger Ning Chen Source Type: research
Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research
Vitexin Improves Cerebral ischemia ‑reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling
In this study, we established the oxygen-glucose deprivation and reoxygenation (OGD/R) neuron cell and middle cerebral artery occlusion/reperfusion (MCAO/R) rat model. The cell viability, cell apoptosis and reactive oxygen species (ROS) levels were tested by CCK-8 assay and Flow cytometry, respectively. Hematoxylin-eosin staining, TTC, TEM, immunofluorescence analysis and western blot were used to investigate the effects of Vitexin. The results demonstrated that Vitexin could enhanced the cell viability and decreased the cell apoptosis in OGD/R cell model. Meanwhile, incubation with Vitexin maintained the neuroprotective e...
Source: Neurochemical Research - November 26, 2022 Category: Neuroscience Authors: Lei Guo Lei Shi Source Type: research
