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Condition: Mitochondrial Disease

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Total 851 results found since Jan 2013.

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.
Source: AGE - September 9, 2023 Category: Geriatrics Source Type: research

Parkinson ’ s Patients Get More Mobility And Better Balance With Whole Body Vibration Therapy
I’ve always believed that with a little coaxing, your body can self-heal – and the same is true for your brain. Conventional doctors will never tell you this. For them, being a physician means managing symptoms with Big Pharma meds. But for years, I’ve been helping patients recover using dietary changes, lasers, stem cells, and hyperbaric oxygen (HBOT). These therapies help your body heal itself. No Big Pharma drug can do this. But I recently began researching another natural therapy – called Whole Body Vibration, or WBV – that can help Parkinson’s patients regain their mobility and balance. WBV isn’t new. It...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Natural Cures Source Type: news

A patient with MELAS syndrome combined with autoimmune abnormalities: a case report
ConclusionMitochondrial encephalomyopathy is a rare clinical condition; however, the association with autoimmune diseases is not yet clear and still needs further research and analysis.
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research

Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research

Sestrin2 as a Potential Target in Hypertension
Diagnostics (Basel). 2023 Jul 14;13(14):2374. doi: 10.3390/diagnostics13142374.ABSTRACTHypertension is a highly complex, intricate condition affecting millions of individuals across the globe. Nearly half of adults in the United States are diagnosed with hypertension, with incident rates projected to rise over the next decade. Hypertension is a precursor to many cardiovascular diseases including atherosclerosis, stroke, myocardial infarction, heart failure, and peripheral artery disease. This review describes the major processes contributing to the development of hypertension and how Sestrin2 (Sesn2), an antioxidative prot...
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Steven Didik Hao Wang Adewale Segun James Lily Slotabec Ji Li Source Type: research

Neuroprotective Strategies for Stroke by Natural Products: Advances and Perspectives
Curr Neuropharmacol. 2023 Jul 17. doi: 10.2174/1570159X21666230717144752. Online ahead of print.ABSTRACTCerebral ischemic stroke is a disease with high prevalence and incidence. Its management focuses on rapid reperfusion with intravenous thrombolysis and endovascular thrombectomy. Both therapeutic strategies reduce disability, but the therapy time window is short, and the risk of bleeding is high. Natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases. However, they have made little progress in clinical translation and pose challenges to the treatment of stroke. Rece...
Source: Current Neuropharmacology - July 17, 2023 Category: Drugs & Pharmacology Authors: Aifen Liu Jingyan Hu Tzu-Shao Yeh Chengniu Wang Jilong Tang Xiaohong Huang Bin Chen Liexiang Huangfu Weili Yu Lei Zhang Source Type: research

Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research

Melatonin mitigates type 1 diabetes ‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects
ConclusionsT1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
Source: Brain and Behavior - June 16, 2023 Category: Neurology Authors: Qian Xu, Raymond Tak Fai Cheung Tags: ORIGINAL ARTICLE Source Type: research

New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery
Neurobiol Dis. 2023 Jun 13:106200. doi: 10.1016/j.nbd.2023.106200. Online ahead of print.ABSTRACTOligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to axonal dystrophy, neuronal dysfunction, and neurological impairments. OLs damage can result in demyelination and myelination disorders, severely impacting axonal function, structure, metabolism, and survival. Adult-onset stroke, per...
Source: Neurobiology of Disease - June 15, 2023 Category: Neurology Authors: Shuangfeng Huang Changhong Ren Yumin Luo Yuchuan Ding Xunming Ji Sijie Li Source Type: research