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Condition: Mitochondrial Disease
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Total 851 results found since Jan 2013.
Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research
Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I
Cell Death & Disease, Published online: 21 January 2023; doi:10.1038/s41419-023-05581-xCrocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I
Source: Cell death and disease - January 21, 2023 Category: Internal Medicine Authors: Hao Wu Ying Li Qian Zhang Hanxun Wang Wenyu Xiu Pu Xu Yujie Deng Wanxu Huang Dan Ohtan Wang Source Type: research
Clinical features of epileptic seizures in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
Mitochondrial encephalomyopathy is a complex group of inherited disease with multisystem involvement that have mitochondrial respiratory chain dysfunction. Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is one of the most common well-defined mitochondrial encephalomyopathies, with a frequency of 1:6000 [1,2]. Although the most common mutation in MELAS is in the MT-TL1 gene encoding tRNALeu(UUR), known as adenine to guanine transition at nucleotide 3243 (m.3243A>G) [3,4], multiple other mutations in MELAS have been reported in mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) such as mutat...
Source: Seizure: European Journal of Epilepsy - February 18, 2023 Category: Neurology Authors: Xiaxin Yang, Anqi Sun, Kunqian Ji, Xiaotang Wang, Xue Yang, Xiuhe Zhao Source Type: research
Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research
Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions
Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future.
Ethics Statement
This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research
The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation
Conclusion: These results suggest intelectin-1 promotes angiogenesis, inhibits oxidative stress and reduces apoptosis by stimulating the Akt-eNOS signaling pathway in response to ischemia in vitro.
Introduction
Stroke is a main reason of human neurological disability, ischemic stroke (IS) accounts for almost 80–90% of all strokes. IS occurs after a cerebral blood flow disruption, leading to cellular death and tissue damage by restricting glucose and oxygen supplies (1). Ischemic vascular diseases cause substantial vascular valve and vascular endothelial cell injuries, eventually damaging the surrounding tis...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research
8-year retrospective analysis of intravenous arginine therapy for acute metabolic strokes in pediatric mitochondrial disease
Conclusions Single-center retrospective analysis suggests that IV arginine therapy yields significant therapeutic benefit with little risk in pediatric mitochondrial disease stroke subjects across a wide range of genetic etiologies beyond classical MELAS. Acute hemiplegic stroke, in particular, was highly responsive to IV arginine treatment. Prospective studies with consistent arginine dosing, and pre- and post-neuroimaging, will further inform the clinical utility of IV arginine therapy for acute metabolic stroke in pediatric mitochondrial disease.
Source: Molecular Genetics and Metabolism - April 13, 2018 Category: Genetics & Stem Cells Source Type: research
Cyclosporine A Treatment Abrogates Ischemia-Induced Neuronal Cell Death by Preserving Mitochondrial Integrity through Upregulation of the Parkinson's Disease-Associated Protein DJ-1.
CONCLUSION: These observations provided evidence that CsA maintained mitochondrial integrity likely via DJ-1 upregulation, supporting the concept that mitochondria-based treatments targeting the early phase of disease progression may prove beneficial in stroke.
PMID: 27247192 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 31, 2016 Category: Neuroscience Authors: Tajiri N, Borlongan CV, Kaneko Y Tags: CNS Neurosci Ther Source Type: research
