Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia

Conclusion: Using three different strategies to either prevent formation or enhance elimination of O2⋅_ during the post-asphyxial period, we saw both reduced leukocyte adherence and preserved BBB function with treatment. These findings suggest that agents which lower O2⋅_ in brain may be attractive new therapeutic interventions for the protection of the neonatal brain following asphyxia. Introduction Asphyxia is a relatively common source of neonatal brain damage (1), affecting ~2 in every 1,000 births (2). The hypoxic ischemia resulting from this oxygen deprivation can produce long-term sequelae, including intellectual disability and neurologic deficits, and nearly a quarter of neonatal deaths worldwide are attributable to birth asphyxia (2). A dominant response to ischemia is inflammation (2, 3), resulting from the accumulation of circulating leukocytes in the cerebral microvasculature and their subsequent extravasation into brain parenchyma (4–7). The mechanisms promoting the early increase in leukocyte-endothelial interactions in the cerebral circulation await further elucidation, but probable causes include the elaboration of cytokines and chemokines (8, 9), and other proinflammatory mediators (10). There is also consensus that reactive oxygen species (ROS), formed during reperfusion following transient ischemia, including in the neonatal brain, also modulate inflammation (11–13). ROS are generated in multiple compartments within a cell and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

ConclusionCollectively our data suggest that the bioactive chemical pool which is responsible for the therapeutic effects of EW can be extracted in petroleum ether, and fractionated to a relatively small multiple components. Such components include known anti-inflammatory chemicals, which may contribute to the possible microglia polarization in brain lesion during the recovery of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsYGY has obvious reversal effects on the abnormal symptoms of adenine-induced CKD and the abnormal symptoms of rats with hypothyroidism and male reproductive hypotension. Its mechanism is related to its ability to regulate the HIF1α-STAT5 pathway.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe present method did not only preliminarily reveal the active substances and mechanism of NAC in treatment of IS from the perspective of network pharmacology, but show its potential application for research and development of other TCM prescriptions.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionUsing NMA, this study will offer new and informative evaluations of current TCPMs for ACI. The results will inform clinicians, provide optimal clinical treatment strategies, bridge the evidence gaps, and identify promising TCPMs for evaluation in future trials.The protocol has been registered on PROSPERO (International Prospective Register of Systematic Reviews) (CRD42018110307).
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionActual body weight and bone marrow involvement may be utilized as potential predictive indicators of R-IRRs. Further study is needed to validate these indicators and determine appropriate utilization in practice.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
ConclusionStrict monitoring and control of hemodynamic parameters as well as meticulous fluid therapy is the cornerstone in improving outcome in patients with dilated cardiomyopathy undergoing renal transplant surgery.ResumoJustificativa e objetivosA cardiomiopatia dilatada é um estado de aumento progressivo das câmaras cardíacas, principalmente do ventrículo esquerdo, que leva à diminuição do débito cardíaco e, por fim, à insuficiência cardíaca. Embora tenha etiologia multifatorial, é bastante comum em pacientes com doença rena...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Conclusion: Specific contexts appeared to be associated with problematic drinking for both sexes. Among both men and women, "social drinking" was associated with problematic drinking. Both "home drinking" (men) and "daytime drinking" (women) contexts, were associated with problematic drinking and depressive symptoms. Targeted alcohol-focused interventions need to address co-occurring mental health issues. PMID: 31519127 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions/Importance: The findings contribute to future strategies to curb the consumption of areca nut, and also help to explain unsuccessful control in China of other substances such as tobacco which overlooked social context. It is imperative that health professionals and researchers engage with the culture, health beliefs, and society of specific populations to formulate culturally appropriate and innovative oral health strategies. PMID: 31519115 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions: The incidence of omental metastasis is not low in patients with USC. Visual assessment and omental biopsy may be insufficient for recognizing occult metastases. Omentectomy should be part of the staging surgery in USC patients because it provides additional information about survival. Prospective studies are needed to confirm these results. PMID: 31517308 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Conclusions: Reduced expression of ER stress markers in trophoblast cells against increased VEGF highlighted a new window to explore prospective drugs that can be designed to modulate the activities of various ER stress sensors in order to alleviate ER stress in pregnant women with preeclampsia. PMID: 31517301 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
More News: Academia | Allopurinol | Alzheimer's | Anesthesia | Anesthesiology | Biology | Brain | Canada Health | Chemistry | Child Development | Children | China Health | Cytology | Disability | Education | Geriatrics | Hypothermia | International Medicine & Public Health | Ischemic Stroke | Medical Ethics | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Opthalmology | Perinatology & Neonatology | Physiology | Pregnancy | Profits and Losses | Reproduction Medicine | Respiratory Medicine | Science | Sodium | Statistics | Stroke | Study | Toxicology | Universities & Medical Training | USA Health | Vitamin A | Washington University | Women