Ando-Tajima Award.
Authors: PMID: 32759505 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Understanding Animal Research Lecture 2.
Authors: PMID: 32759506 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Autopsy, Histology and Pathology.
Authors: PMID: 32759507 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Breeding and lineage development.
Authors: PMID: 32759508 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Developmental Engineering (Including Regenerative Medicine), etc.
Authors: PMID: 32759509 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 1.
Authors: PMID: 32759510 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Genetics, Selective Breeding and Gere Function.
Authors: PMID: 32759511 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Pharmacology and Safety, etc.
Authors: PMID: 32759512 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Microorganisms, Infection and Immunity.
Authors: PMID: 32759513 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 2.
Authors: PMID: 32759514 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Disease models.
Authors: PMID: 32759515 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Encouragement Award.
Authors: PMID: 32759516 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 3.
Authors: PMID: 32759517 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Bioresources, etc.
Authors: PMID: 32759518 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Other Classification, etc.
Authors: PMID: 32759519 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 4.
Authors: PMID: 32759520 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 6.
Authors: PMID: 32759521 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 7.
Authors: PMID: 32759522 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Symposium 8.
Authors: PMID: 32759523 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Plenary Lecture.
Authors: PMID: 32759524 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

LAS Seminar 1.
Authors: PMID: 32759525 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

LAS Seminar 2.
Authors: PMID: 32759526 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

LAS Seminar 3.
Authors: PMID: 32759527 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Educationnal Forum.
Authors: PMID: 32759528 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Educationnal Seminar 1.
Authors: PMID: 32759529 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Educationnal Seminar 2.
Authors: PMID: 32759530 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Family Day.
Authors: PMID: 32759531 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Best Presentation Award.
Authors: PMID: 32759532 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Outstanding Presentation Award.
Authors: PMID: 32759533 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Management, Facilities, Ethics and Welfare.
Authors: PMID: 32759534 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Understanding Animal Research Lecture 1.
Authors: PMID: 32759535 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Experimental Technique, Substitution, Anesthesia and Analgesia, etc.
Authors: PMID: 32759536 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Nutrition, Physiology and Biochemistry.
Authors: PMID: 32759537 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Aging.
Authors: PMID: 32759538 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Brain, Neurology and Behavior.
Authors: PMID: 32759539 [PubMed - in process] (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.
Authors: Hasan ASH, Dinh TTH, LE HT, Mizuno-Iijima S, Daitoku Y, Ishida M, Tanimoto Y, Kato K, Yoshiki A, Murata K, Mizuno S, Sugiyama F Abstract Two members of the CDK5 and ABL enzyme substrate (CABLES) family, CABLES1 and CABLES2, share a highly homologous C-terminus. They interact and associate with cyclin-dependent kinase 3 (CDK3), CDK5, and c-ABL. CABLES1 mediates tumor suppression, regulates cell proliferation, and prevents protein degradation. Although Cables2 is ubiquitously expressed in adult mouse tissues at RNA level, the role of CABLES2 in vivo remains unknown. Here, we generated bicistronic Cables2 kno...
Source: Experimental Animals - August 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Low maternal licking/grooming stimulation increases pain sensitivity in male mouse offspring.
Authors: Sakamoto T, Ishio Y, Ishida Y, Mogi K, Kikusui T Abstract Deprivation of maternal care has been associated with higher pain sensitivity in offspring. In the present study, we hypothesized that the maternal licking/grooming behavior was an important factor for the development of the pain regulatory system. To test this hypothesis, we used male F2 offspring of early-weaned (EW) F1 mother mice that exhibit lower frequency of licking/grooming behavior. The formalin test revealed that F2 offspring of EW F1 dams showed significantly higher pain behavior than F2 offspring of normally-weaned (NW) F1 dams. We found...
Source: Experimental Animals - August 4, 2020 Category: Research Tags: Exp Anim Source Type: research

Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides.
In conclusion, EA stimulation at CV-12, RN-7, ST-36, and LR-3 effectively alleviates the NMS of PD partly through regulating the levels of brain-gut peptides. PMID: 32669479 [PubMed - as supplied by publisher] (Source: Experimental Animals)
Source: Experimental Animals - July 18, 2020 Category: Research Tags: Exp Anim Source Type: research

KLF5 regulates chicken skeletal muscle atrophy  via the canonical Wnt/β-catenin signaling pathway.
KLF5 regulates chicken skeletal muscle atrophy via the canonical Wnt/β-catenin signaling pathway. Exp Anim. 2020 Jul 07;: Authors: Zhang DH, Yin HD, Li JJ, Wang Y, Yang CW, Jiang XS, DU HR, Liu YP Abstract Recent studies in mice suggested that KLF5 (Kruppel like factor 5), a zinc-finger transcription factor, plays an important role in skeletal muscle development and regeneration. As an important factor in the process of muscle development, KLF5 participates in the regulation of the cell cycle, cell survival, and cell dryness under different environmental conditions, but it is not clear whethe...
Source: Experimental Animals - July 11, 2020 Category: Research Tags: Exp Anim Source Type: research

Blunt olfaction in sexually sluggish male rats.
This study investigated whether sexually sluggish (SS) males show behavioral differences from normal copulatory (NC) males, other than those concerning sexual behavior. The olfactory preference of males was measured through the time spent displaying nose-poking behavior directed at sexually active males and estrous females for odor exploration in a three-chamber apparatus. Both the NC and SS males showed a significant preference for the odor of estrous females compared with that of male odors. However, SS males spent significantly less time nose-poking estrous females than NC males. The food-finding test was performed afte...
Source: Experimental Animals - July 4, 2020 Category: Research Tags: Exp Anim Source Type: research

Effect of PIERCE1 on colorectal cancer.
Authors: Park BM, Kim HJ, Oh JH, Roh JI, Lee HW Abstract Colorectal cancer is the second most lethal cancer type across all ages and sexes, the many mechanisms of which are still currently being further elucidated. PIERCE1 has been known to be involved in the cell cycle and proliferation, the expression of which is regulated by stress conditions in a p53-dependent manner. Through a database search, we found that PIERCE1 was significantly augmented in patients with colorectal carcinoma compared to normal samples, suggesting its possible role in tumor regulation. Recently, PIERCE1 has also been reported to increase p...
Source: Experimental Animals - June 27, 2020 Category: Research Tags: Exp Anim Source Type: research

Analysis of the sperm flagellar axoneme using gene-modified mice.
Authors: Miyata H, Morohoshi A, Ikawa M Abstract Infertility is a global health issue that affects 1 in 6 couples, with male factors contributing to 50% of cases. The flagellar axoneme is a motility apparatus of spermatozoa, and disruption of its structure or function could lead to male infertility. The axoneme consists of a "9+2" structure that contains a central pair of two singlet microtubules surrounded by nine doublet microtubules, in addition to several macromolecular complexes such as dynein arms, radial spokes, and nexin-dynein regulatory complexes. Molecular components of the flagellar axoneme ar...
Source: Experimental Animals - June 21, 2020 Category: Research Tags: Exp Anim Source Type: research

Simple transport and cryopreservation of cold-stored mouse embryos.
Authors: Mukunoki A, Takeo T, Nakao S, Tamura K, Horikoshi Y, Nakagata N Abstract The cold storage of two-cell embryos is a useful technique for transporting genetically engineered mice without the shipment of live animals. However, the developmental ability of cold-stored embryos decreases with prolonged storage periods. Therefore, the transported embryos must be readily transferred to recipient mice upon arrival. The cryopreservation of cold-transported embryos may improve the flexibility of the schedule of embryo transfer. In this paper, we examined the viability and developmental ability of vitrified-warmed mou...
Source: Experimental Animals - June 21, 2020 Category: Research Tags: Exp Anim Source Type: research

Backcrossing to an appropriate genetic background improves the birth rate of carbohydrate sulfotransferase 14 gene-deleted mice.
Authors: Shimada S, Yoshizawa T, Takahashi Y, Nitahara-Kasahara Y, Okada T, Nomura Y, Yamanaka H, Kosho T, Matsumoto K Abstract Ehlers-Danlos syndromes (EDSs) are heterogeneous group of heritable connective tissue disorders characterized by joint and skin hyperextensibility as well as fragility of various organs. Recently, we described a new type of EDS, musculocontractual EDS (mcEDS-CHST14), caused by pathogenic variants of the carbohydrate sulfotransferase 14 (CHST14) gene mutation. B6;129S5-Chst14tm1Lex/Mmucd (B6;129-Chst14 KO) mice are expected to be an animal model of mcEDS-CHST14. However,>90% of B6;129-Ch...
Source: Experimental Animals - June 13, 2020 Category: Research Tags: Exp Anim Source Type: research

Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.
Authors: Nishitani A, Nagayoshi H, Takenaka S, Asano M, Shimizu S, Ohno Y, Kuramoto T Abstract We recently demonstrated that aspartoacylase (Aspa) and hyperpolarized-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) genes were causative of essential tremor (ET) in rats. This finding was obtained using Aspaem34Kyo/Hcn1A354V double-mutant rats, but they were bred on a heterogeneous genetic background of two strains, F344 and WTC. Here, we developed an Aspaem34Kyo/Hcn1em1Kyo double-knockout rat strain with a homogenous F344 genetic background and studied the ability of glutamate receptor antagonists to supp...
Source: Experimental Animals - June 10, 2020 Category: Research Tags: Exp Anim Source Type: research

Gender difference in development of steatohepatitis in p62/Sqstm1 and Nrf2 double-knockout mice.
Authors: Watahiki T, Okada K, Warabi E, Nagaoka T, Suzuki H, Ishige K, Yanagawa T, Takahashi S, Mizokami Y, Tokushige K, Ariizumi SI, Yamamoto M, Shoda J Abstract Gender and menopause influence the severity and development manner of nonalcoholic steatohepatitis (NASH). Male p62/Sqstm1 and nuclear factor E2-related factor-2 (p62 and Nrf2) double-knockout (DKO) mice exhibit severe steatohepatitis caused by hyperphagia-induced obesity, overload of lipopolysaccharide (LPS) into the liver, and potentiation of the inflammatory response in Kupffer cells. However, the pathogenetic phenotype of steatohepatitis in female DKO...
Source: Experimental Animals - June 5, 2020 Category: Research Tags: Exp Anim Source Type: research

Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an in vivo microdialysis study of male rats.
In this study, we investigated DAergic transmission in both these brain regions. The extracellular levels of amygdalar DA in adulthood were two times higher in rats weaned at 16 days compared to those weaned at 30 days in both the home cage and the open-field. This difference in extracellular DA levels was not apparent in the prefrontal cortex. The concurrently measured locomotor and rearing behaviors did not vary according to the weaning period and the probe-implanted region, respectively. These results suggest that the effects of early weaning on DA tone appear to be specific to the amygdala and do not represent ubiquito...
Source: Experimental Animals - May 2, 2020 Category: Research Tags: Exp Anim Source Type: research

Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in STZ-induced Alzheimer's disease rats.
In conclusion, schisandrin ameliorated STZ-induced cognitive dysfunction, ER stress and neuroinflammation which may be associated with up-regulation of SIRT1. Our study provides novel mechanisms for the neuroprotective effect of schisandrin in AD treatment. PMID: 32336744 [PubMed - as supplied by publisher] (Source: Experimental Animals)
Source: Experimental Animals - April 29, 2020 Category: Research Tags: Exp Anim Source Type: research

Therapeutic effects of Co-Venenum Bufonis Oral Liquid on radiation-induced esophagitis in rats.
Authors: Li Y, Lin J, Xiao J, Li Z, Chen JS, Wei L, Wang X Abstract To investigate the effects of Co-Venenum Bufonis Oral Liquid (cVBOL) on radiation-induced esophagitis in rats. Irradiation (30 Gy) with X-RAD 225 x-ray was applied to induce esophagitis in 64 Wistar rats and treated by different methods. The body weight of rats either in radiation treatment (RT) group, cVBOL+RT, or esophagus mixture (EM)+RT group was significantly decreased when compared with that in normal group (P
Source: Experimental Animals - April 15, 2020 Category: Research Tags: Exp Anim Source Type: research

Various biological functions of carbohydrate chains learned from glycosyltransferase-deficient mice.
Authors: Asano M Abstract Carbohydrate chains are attached to various proteins and lipids and modify their functions. The complex structures of carbohydrate chains, which have various biological functions, are involved not only in regulating protein conformation, transport, and stability but also in cell-cell and cell-matrix interactions. These functional carbohydrate structures are designated as "glyco-codes." Carbohydrate chains are constructed through complex reactions of glycosyltransferases, glycosidases, nucleotide-sugar donors, and protein and lipid substrates in a cell. To elucidate the functions ...
Source: Experimental Animals - April 15, 2020 Category: Research Tags: Exp Anim Source Type: research