Comparison of retinal parameters between rhesus and cynomolgus macaques
This study provides normative retinal parameters for nonhuman primate research on basic and clinical ophthalmology, as well as a reference for researchers in the appropriate selection of rhesus or cynomolgus macaques as models for ophthalmology studies.PMID:37460311 | DOI:10.1538/expanim.22-0022 (Source: Experimental Animals)
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Chengjie He Jingyi Peng Jiayi Jin Wanwen Shao Yongxin Zheng Liuxueying Zhong Source Type: research
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake
Exp Anim. 2023 Jul 18. doi: 10.1538/expanim.23-0071. Online ahead of print.ABSTRACTThe interconnection of heart performance and kidney function plays an important role for maintaining homeostasis through a variety of physiological crosstalk between these organs. It has been suggested that acute or chronic dysfunction in one organ causes dysregulation in another one, like patients with cardiorenal syndrome. Despite its growing recognition as global health issues, still little is known on pathophysiological evaluation between the two organs. Previously, we established a preclinical murine model with cardiac hypertrophy and f...
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Naoto Muromachi Junji Ishida Kazuyuki Noguchi Tomoki Akiyama Syunsuke Maruhashi Kaori Motomura Joichi Usui Kunihiro Yamagata Akiyoshi Fukamizu Source Type: research
Comparison of retinal parameters between rhesus and cynomolgus macaques
This study provides normative retinal parameters for nonhuman primate research on basic and clinical ophthalmology, as well as a reference for researchers in the appropriate selection of rhesus or cynomolgus macaques as models for ophthalmology studies.PMID:37460311 | DOI:10.1538/expanim.22-0022 (Source: Experimental Animals)
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Chengjie He Jingyi Peng Jiayi Jin Wanwen Shao Yongxin Zheng Liuxueying Zhong Source Type: research
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake
Exp Anim. 2023 Jul 18. doi: 10.1538/expanim.23-0071. Online ahead of print.ABSTRACTThe interconnection of heart performance and kidney function plays an important role for maintaining homeostasis through a variety of physiological crosstalk between these organs. It has been suggested that acute or chronic dysfunction in one organ causes dysregulation in another one, like patients with cardiorenal syndrome. Despite its growing recognition as global health issues, still little is known on pathophysiological evaluation between the two organs. Previously, we established a preclinical murine model with cardiac hypertrophy and f...
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Naoto Muromachi Junji Ishida Kazuyuki Noguchi Tomoki Akiyama Syunsuke Maruhashi Kaori Motomura Joichi Usui Kunihiro Yamagata Akiyoshi Fukamizu Source Type: research
Comparison of retinal parameters between rhesus and cynomolgus macaques
This study provides normative retinal parameters for nonhuman primate research on basic and clinical ophthalmology, as well as a reference for researchers in the appropriate selection of rhesus or cynomolgus macaques as models for ophthalmology studies.PMID:37460311 | DOI:10.1538/expanim.22-0022 (Source: Experimental Animals)
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Chengjie He Jingyi Peng Jiayi Jin Wanwen Shao Yongxin Zheng Liuxueying Zhong Source Type: research
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake
Exp Anim. 2023 Jul 18. doi: 10.1538/expanim.23-0071. Online ahead of print.ABSTRACTThe interconnection of heart performance and kidney function plays an important role for maintaining homeostasis through a variety of physiological crosstalk between these organs. It has been suggested that acute or chronic dysfunction in one organ causes dysregulation in another one, like patients with cardiorenal syndrome. Despite its growing recognition as global health issues, still little is known on pathophysiological evaluation between the two organs. Previously, we established a preclinical murine model with cardiac hypertrophy and f...
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Naoto Muromachi Junji Ishida Kazuyuki Noguchi Tomoki Akiyama Syunsuke Maruhashi Kaori Motomura Joichi Usui Kunihiro Yamagata Akiyoshi Fukamizu Source Type: research
Comparison of retinal parameters between rhesus and cynomolgus macaques
This study provides normative retinal parameters for nonhuman primate research on basic and clinical ophthalmology, as well as a reference for researchers in the appropriate selection of rhesus or cynomolgus macaques as models for ophthalmology studies.PMID:37460311 | DOI:10.1538/expanim.22-0022 (Source: Experimental Animals)
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Chengjie He Jingyi Peng Jiayi Jin Wanwen Shao Yongxin Zheng Liuxueying Zhong Source Type: research
Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility
We examined their fertility and sperm mitochondrial function to determine the significance of testis-enriched COX subunits in male fertility. The mating test revealed that disrupting COX6B2 induces male subfertility, while disrupting COX8C does not affect male fertility. Cox6b2 KO spermatozoa showed low sperm motility, but mitochondrial function was normal according to oxygen consumption rates. Therefore, low sperm motility seems to cause subfertility in Cox6b2 KO male mice. These results also indicate that testis-enriched COX, COX6B2 and COX8C, are not essential for OXPHOS in mouse spermatozoa.PMID:37423748 | DOI:10.1538/...
Source: Experimental Animals - July 9, 2023 Category: Research Authors: Keisuke Shimada Yonggang Lu Masahito Ikawa Source Type: research
Humanized CD36 mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36
In this study, we have successfully generated a novel CD36 humanized mouse strain where the sequences encoding the extracellular domains of the mouse Cd36 gene were replaced with the corresponding human sequences. The results showed that CD36 humanized mice only expressed human CD36, and the proportion of each lymphocyte was not significantly changed compared with wild-type mice. Furthermore, CD36 monoclonal antibody could significantly inhibit tumor growth after treatment. Therefore, the CD36 humanized mice represent a validated preclinical mouse model for the evaluation of tumor immunotherapy targeting CD36.PMID:37407484...
Source: Experimental Animals - July 5, 2023 Category: Research Authors: Xiulong Xie Zhenlan Niu Linlin Wang Xiaofei Zhou Xingyan Yu Hongyan Jing Yi Yang Source Type: research
