Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat
Exp Anim. 2023 Nov 1. doi: 10.1538/expanim.23-0087. Online ahead of print.ABSTRACTDuchenne muscular dystrophy (DMD) is an X-linked recessive myopathy caused by dystrophin mutations. Inevitable progressive cardiomyopathy is a current leading cause of premature death although respiratory management has improved the prognosis of patients with DMD. Recent evidence shows that reducing the heart rate is expected as one of the promising strategies for heart failure treatment, but administering a sufficient dose of β-blocker for patients with DMD with tachycardia is difficult because of their low blood pressure (BP). Thus, this s...
Source: Experimental Animals - November 1, 2023 Category: Research Authors: Ryota Tochinai Koichi Kimura Takeru Saika Wataru Fujii Hiroyuki Morita Koki Nakanishi Yoshiharu Tsuru Shin-Ichi Sekizawa Keitaro Yamanouchi Masayoshi Kuwahara Source Type: research
Eriocalyxin B alleviated ischemic cerebral injury via limiting microglia-mediated excessive neuroinflammation in mice
In conclusions, EriB exerted anti-inflammatory effects in ischemia stroke through regulating NF-κB signaling pathway, which may provide insights into the neuroprotective effect of EriB on the treatment of ischemic stroke.PMID:37839867 | DOI:10.1538/expanim.23-0070 (Source: Experimental Animals)
Source: Experimental Animals - October 15, 2023 Category: Research Authors: Yanqiang Chen Cong Zhang Liming Zhao Rong Chen Peipei Zhang Junxia Li Xueping Zhang Xiangjian Zhang Source Type: research
