Effects of 2-week food-restriction on toxicological parameters in cynomolgus monkeys
Exp Anim. 2023 Aug 29. doi: 10.1538/expanim.23-0017. Online ahead of print.ABSTRACTAnimals frequently eat less after test-article treatment in non-clinical toxicological studies, and it can be difficult to distinguish test article-derived toxicities from secondary changes related to this reduced food intake. Therefore, in this study, we restricted the food intake of cynomolgus monkeys (Cambodian, male, n=2 or 3, 4-year ± 3-month-old) to 25% of control for two weeks, and evaluated its effect on toxicological parameters (general conditions, body weight, electrocardiography, urinalysis, hematology, blood chemistry, bone marr...
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Nozomi Fujisawa Tomochika Matsushita Saori Matsuo Mayumi Hiranuma Hiroko Azabu Ryota Saito Shun-Ichiro Komatsu Atsuhiko Kato Naoto Toyota Junko Taketo Hiromi Suzuki Source Type: research
L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model
In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.PMID:37648521 | DOI:10.1538/expanim.23-0053 (Source: Experimental Animals)
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Yu Lei Yu Chen Shuhui Wang Zhuoying Lin Ping Han Dean Tian Han Wang Mei Liu Source Type: research
Effects of 2-week food-restriction on toxicological parameters in cynomolgus monkeys
Exp Anim. 2023 Aug 29. doi: 10.1538/expanim.23-0017. Online ahead of print.ABSTRACTAnimals frequently eat less after test-article treatment in non-clinical toxicological studies, and it can be difficult to distinguish test article-derived toxicities from secondary changes related to this reduced food intake. Therefore, in this study, we restricted the food intake of cynomolgus monkeys (Cambodian, male, n=2 or 3, 4-year ± 3-month-old) to 25% of control for two weeks, and evaluated its effect on toxicological parameters (general conditions, body weight, electrocardiography, urinalysis, hematology, blood chemistry, bone marr...
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Nozomi Fujisawa Tomochika Matsushita Saori Matsuo Mayumi Hiranuma Hiroko Azabu Ryota Saito Shun-Ichiro Komatsu Atsuhiko Kato Naoto Toyota Junko Taketo Hiromi Suzuki Source Type: research
L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model
In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.PMID:37648521 | DOI:10.1538/expanim.23-0053 (Source: Experimental Animals)
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Yu Lei Yu Chen Shuhui Wang Zhuoying Lin Ping Han Dean Tian Han Wang Mei Liu Source Type: research
Effects of 2-week food-restriction on toxicological parameters in cynomolgus monkeys
Exp Anim. 2023 Aug 29. doi: 10.1538/expanim.23-0017. Online ahead of print.ABSTRACTAnimals frequently eat less after test-article treatment in non-clinical toxicological studies, and it can be difficult to distinguish test article-derived toxicities from secondary changes related to this reduced food intake. Therefore, in this study, we restricted the food intake of cynomolgus monkeys (Cambodian, male, n=2 or 3, 4-year ± 3-month-old) to 25% of control for two weeks, and evaluated its effect on toxicological parameters (general conditions, body weight, electrocardiography, urinalysis, hematology, blood chemistry, bone marr...
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Nozomi Fujisawa Tomochika Matsushita Saori Matsuo Mayumi Hiranuma Hiroko Azabu Ryota Saito Shun-Ichiro Komatsu Atsuhiko Kato Naoto Toyota Junko Taketo Hiromi Suzuki Source Type: research
L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model
In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.PMID:37648521 | DOI:10.1538/expanim.23-0053 (Source: Experimental Animals)
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Yu Lei Yu Chen Shuhui Wang Zhuoying Lin Ping Han Dean Tian Han Wang Mei Liu Source Type: research
Effects of 2-week food-restriction on toxicological parameters in cynomolgus monkeys
Exp Anim. 2023 Aug 29. doi: 10.1538/expanim.23-0017. Online ahead of print.ABSTRACTAnimals frequently eat less after test-article treatment in non-clinical toxicological studies, and it can be difficult to distinguish test article-derived toxicities from secondary changes related to this reduced food intake. Therefore, in this study, we restricted the food intake of cynomolgus monkeys (Cambodian, male, n=2 or 3, 4-year ± 3-month-old) to 25% of control for two weeks, and evaluated its effect on toxicological parameters (general conditions, body weight, electrocardiography, urinalysis, hematology, blood chemistry, bone marr...
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Nozomi Fujisawa Tomochika Matsushita Saori Matsuo Mayumi Hiranuma Hiroko Azabu Ryota Saito Shun-Ichiro Komatsu Atsuhiko Kato Naoto Toyota Junko Taketo Hiromi Suzuki Source Type: research
L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model
In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.PMID:37648521 | DOI:10.1538/expanim.23-0053 (Source: Experimental Animals)
Source: Experimental Animals - August 30, 2023 Category: Research Authors: Yu Lei Yu Chen Shuhui Wang Zhuoying Lin Ping Han Dean Tian Han Wang Mei Liu Source Type: research
The compensatory increase of GLIS3 inhibited neuronal apoptosis through regulating MOB1b: a possible strategy for the functional recovery after spinal cord injury
In conclusion, our findings reveal that the compensatory increase of GLIS3 promotes functional recovery after SCI through inhibiting neuronal apoptosis by transcriptionally regulating MOB1b. Our study provides a novel target for functional recovery after SCI.PMID:37574269 | DOI:10.1538/expanim.23-0041 (Source: Experimental Animals)
Source: Experimental Animals - August 13, 2023 Category: Research Authors: Hong-Bo Yang Ying Li Xiu-Hai Li Qing-Ming Yan Xian-Zhang Han Jian Cao Hong-Peng Sang Jin-Long Li Source Type: research
