Null mutation of exocyst complex component 3-like does not affect vascular development in mice
Exp Anim. 2023 Sep 1. doi: 10.1538/expanim.23-0105. Online ahead of print.ABSTRACTExocyst is an octameric protein complex implicated in exocytosis. The exocyst complex is highly conserved among mammalian species, but the physiological function of each subunit in exocyst remains unclear. Previously, we identified exocyst complex 3-like (Exoc3l) as a gene abundantly expressed in embryonic endothelial cells and implicated in the process of angiogenesis in human umbilical cord endothelial cells. Here, to reveal the physiological roles of Exoc3l during development, we generated Exoc3l knockout (KO) mice by genome editing with C...
Source: Experimental Animals - September 4, 2023 Category: Research Authors: Satsuki Takashima Eiichi Okamura Yusuke Ichiyama Kiyoto Nishi Akio Shimizu Chisato Watanabe Masanaga Muto Shoma Matsumoto Setsuko Tsukiyama-Fujii Tomoyuki Tsukiyama Hisakazu Ogita Eiichiro Nishi Masahito Ohji Fumihiro Sugiyama Satoru Takahashi Seiya Mizun Source Type: research
