Transient receptor potential vanilloid 1 interacts with TLR4/CD14 signaling pathway in lipopolysaccharide-mediated inflammation in macrophages
In conclusion, the TRPV1 receptor may positively regulate the LPS-mediated inflammatory responses in macrophages by increasing the interaction with the TLR4-CD14 complex and activating the downstream signaling cascade.PMID:38508727 | DOI:10.1538/expanim.23-0148 (Source: Experimental Animals)
Source: Experimental Animals - March 20, 2024 Category: Research Authors: Julia Chu-Ning Hsu Hsu-Wen Tseng Chia-Hui Chen Tzong-Shyuan Lee Source Type: research
Dehydroepiandrosterone modulates the PTEN/PI3K/AKT signaling pathway to alleviate 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency in rats
In conclusion, it has been determined that DHEA may exert beneficial effects on ovarian stimulation response by enhancing the initiation of primordial follicles and supporting antral follicle populations.PMID:38494723 | DOI:10.1538/expanim.23-0179 (Source: Experimental Animals)
Source: Experimental Animals - March 18, 2024 Category: Research Authors: Cihan Cakir Goktan Kuspinar Kiper Aslan Cengiz Bozyigit Isil Kasapoglu Melahat Dirican Gurkan Uncu Berrin Avci Source Type: research
Autologous transplantation of green tea epigallocatechin-3-gallate pretreated adipose-derived stem cells increases cardiac regenerative capability through C-X-C motif chemokine receptor 4 expression in the treatment of rats with diabetic cardiomyopathy
This study investigates whether adipose-derived stem cells (ADSC) pretreated with EGCG show better protective effect on diabetic cardiomyopathy than ADSC without EGCG pretreatment. A cell model indicated that ADSC pretreated with EGCG increased cell functions including colony formation, migration and survival markers. All of these functions are blocked by small interfering C-X-C motif chemokine receptor 4 (siCXCR4) administration. These findings suggest that ADSC pretreatment with EGCG increases cell functions through CXCR4 expression. A diabetic animal model was designed to verify the above findings, including Sham, DM (d...
Source: Experimental Animals - March 6, 2024 Category: Research Authors: Tung-Sheng Chen Wei-Wen Kuo Chih-Yang Huang Source Type: research
Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression
Exp Anim. 2024 Mar 6. doi: 10.1538/expanim.24-0002. Online ahead of print.ABSTRACTAllele-specific monoallelic gene expression is a unique phenomenon and a great resource for analyzing gene regulation. To study this phenomenon, we established new embryonic stem (ES) cell lines derived from F1 hybrid blastocysts from crosses between four mouse subspecies (Mus musculus domesticus, C57BL/6; M. musculus molossinus, MSM/Ms; M. musculus, PWK; M. musculuscastaneus, HMI/Ms) and analyzed the expression levels of undifferentiated pluripotent stem cell markers and karyotypes of each line. To demonstrate the utility of our cell lines, ...
Source: Experimental Animals - March 6, 2024 Category: Research Authors: Ayaka Saito Ryosuke Tahara Michiko Hirose Masayo Kadota Ayumi Hasegawa Shinji Kondo Hidemasa Kato Takanori Amano Atsushi Yoshiki Atsuo Ogura Hidenori Kiyosawa Source Type: research
