Time course of histopathology of bleomycin-induced pulmonary fibrosis using an intratracheal sprayer in mice
In conclusion, we have observed a detailed time course of histological changes in bleomycin-induced pulmonary fibrosis in ICR mice using the aerosolization technique. We found that our protocol can induce a highly homogeneous lesion in the lung and that the most suitable time point to assess anti-fibrotic agents is 14 days after treatment in this model.PMID:37518267 | DOI:10.1538/expanim.23-0048 (Source: Experimental Animals)
Source: Experimental Animals - July 30, 2023 Category: Research Authors: Hideyuki Kobayashi Ayami Tachi Sumihiko Hagita Source Type: research
Renal transcriptome analysis of uninephrectomized db/db mice identified a mechanism for the transition to severe diabetic nephropathy
In this study, transcriptome analysis of kidneys from 26-week-old and 35-week-old uninephrectomized (UNX) db/db mice was used to identify the pathways that affect the deterioration of renal function in db/db mice. Differentially expressed genes suggested that there was increased interferon (IFN)-γ signaling during the 26 to 35-week period. Modules that changed between 26 and 35 weeks of age extracted by weighted gene co-expression network analysis (WGCNA) suggested increased the tumor necrosis factor (TNF)-α and nuclear factor-kappa B (NF-κB) signaling pathway in component cells of glomeruli. The protein-protein interac...
Source: Experimental Animals - July 23, 2023 Category: Research Authors: Mariko Maekawa Tatsuya Maekawa Tomohiko Sasase Takeshi Wakashima Atsuhiro Uemura Kinuko Uno Takeshi Ohta Takahisa Yamada Source Type: research
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake
Exp Anim. 2023 Jul 18. doi: 10.1538/expanim.23-0071. Online ahead of print.ABSTRACTThe interconnection of heart performance and kidney function plays an important role for maintaining homeostasis through a variety of physiological crosstalk between these organs. It has been suggested that acute or chronic dysfunction in one organ causes dysregulation in another one, like patients with cardiorenal syndrome. Despite its growing recognition as global health issues, still little is known on pathophysiological evaluation between the two organs. Previously, we established a preclinical murine model with cardiac hypertrophy and f...
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Naoto Muromachi Junji Ishida Kazuyuki Noguchi Tomoki Akiyama Syunsuke Maruhashi Kaori Motomura Joichi Usui Kunihiro Yamagata Akiyoshi Fukamizu Source Type: research
Comparison of retinal parameters between rhesus and cynomolgus macaques
This study provides normative retinal parameters for nonhuman primate research on basic and clinical ophthalmology, as well as a reference for researchers in the appropriate selection of rhesus or cynomolgus macaques as models for ophthalmology studies.PMID:37460311 | DOI:10.1538/expanim.22-0022 (Source: Experimental Animals)
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Chengjie He Jingyi Peng Jiayi Jin Wanwen Shao Yongxin Zheng Liuxueying Zhong Source Type: research
Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake
Exp Anim. 2023 Jul 18. doi: 10.1538/expanim.23-0071. Online ahead of print.ABSTRACTThe interconnection of heart performance and kidney function plays an important role for maintaining homeostasis through a variety of physiological crosstalk between these organs. It has been suggested that acute or chronic dysfunction in one organ causes dysregulation in another one, like patients with cardiorenal syndrome. Despite its growing recognition as global health issues, still little is known on pathophysiological evaluation between the two organs. Previously, we established a preclinical murine model with cardiac hypertrophy and f...
Source: Experimental Animals - July 17, 2023 Category: Research Authors: Naoto Muromachi Junji Ishida Kazuyuki Noguchi Tomoki Akiyama Syunsuke Maruhashi Kaori Motomura Joichi Usui Kunihiro Yamagata Akiyoshi Fukamizu Source Type: research
