Nucleic acid sensing Toll-like receptors 3 and 9 play complementary roles in the development of bacteremia after nasal colonization associated with influenza co-infection
Exp Anim. 2023 Aug 3. doi: 10.1538/expanim.23-0001. Online ahead of print.ABSTRACTStreptococcus pneumoniae can cause mortality in infant, elderly, and immunocompromised individuals owing to invasion of bacteria to the lungs, the brain, and the blood. In building strategies against invasive infections, it is important to achieve greater understanding of how the pneumococci are able to survive in the host. Toll-like receptors (TLRs), critically important components in the innate immune system, have roles in various stages of the development of infectious diseases. Endosomal TLRs recognize nucleic acids of the pathogen, but t...
Source: Experimental Animals - August 2, 2023 Category: Research Authors: Denisa Nanushaj Masamitsu Kono Hideki Sakatani Daichi Murakami Muneki Hotomi Source Type: research
