Inhibition of Mitochondrial P53 Abolishes the Detrimental Effects of Social Isolation on Ischemic Brain Injury [Brief Reports]

Conclusions— Poststroke SI results in increased ischemic injury in both sexes. The effect of housing on infarct was more pronounced in women. Targeting the mitochondrial P53 pathway could minimize the detrimental effects of isolation after stroke.

http://stroke.ahajournals.org/cgi/content/short/45/10/3101?rss=1

Source: Stroke - September 22, 2014 Category: Neurology Authors: Venna, V. R., Verma, R., O'Keefe, L. M., Xu, Y., Crapser, J., Friedler, B., McCullough, L. D. Tags: Behavioral/psychosocial - stroke, Animal models of human disease, Apoptosis, Acute Cerebral Infarction Brief Reports Source Type: research