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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
' Probable Misconduct ' in Fracture Risk Trials in Stroke, PD ' Probable Misconduct ' in Fracture Risk Trials in Stroke, PD
A systematic review of 33 trials from one research group found inconsistencies, errors, and misleading text regarding incidence of hip fractures in patients with stroke, Alzheimer ’ s, or Parkinson ' s.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - November 18, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Benzodiazepines, related drugs increase stroke risk among persons with Alzheimer ' s disease
The use of benzodiazepines and benzodiazepine-like drugs was associated with a 20 per cent increased risk of stroke among persons with Alzheimer ’s disease, shows a recent study. Benzodiazepines were associated with a similar risk of stroke as benzodiazepine-like drugs.
Source: ScienceDaily Headlines - January 16, 2017 Category: Science Source Type: news
PCSK9 Variants, LDL-Cholesterol, and Neurocognitive Impairment: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
Conclusions -These results suggest life-long exposure to low PCSK9 levels and cumulative exposure to lower LDL-C are not associated with neurocognitive effects in African Americans.
PMID: 29146683 [PubMed - as supplied by publisher]
Source: Circulation - November 16, 2017 Category: Cardiology Authors: Mefford MT, Rosenson RS, Cushman M, Farkouh ME, McClure LA, Wadley VG, Irvin MR, Bittner VA, Safford MM, Somaratne R, Monda KL, Muntner P, Levitan EB Tags: Circulation Source Type: research
Different Associations of Plasma Biomarkers in Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, and Ischemic Stroke.
CONCLUSIONS: This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases.
PMID: 29629537 [PubMed]
Source: Journal of Clinical Neurology - April 10, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research
The role of NLRP3 inflammasome in stroke and central poststroke pain
Conclusions:
These possible mechanisms will help become knowledgeable about the occurrence CPSP and provide potential therapy for CPSP.
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-analysis Source Type: research
Blood –brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals
AbstractTo test whether genetic variants inPICALM,BIN1,CD2AP, andRIN3—suggested to be involved in blood–brain barrier amyloid-β transcytosis pathways—associate with Alzheimer’s disease, all dementia, suggested vascular dementia, and stroke, and whether such associations are independent of the strong ε4APOE risk allele. In a prospective cohort study of 74,754 individuals from the general population we genotypedPICALM (rs10792832),BIN1 (rs6733839),CD2AP (rs10948363), andRIN3 (rs10498633), and generated a weighted and a simple allele score. Multifactorially adjusted hazard ratios for the fourth quartile versus the f...
Source: European Journal of Epidemiology - March 3, 2019 Category: Epidemiology Source Type: research
Shared genes between Alzheimer's disease and ischemic stroke.
CONCLUSIONS: The observation that AD and IS had shared disease-associated genes offered mechanistic insights into their common pathogenesis, predominantly involving the immune system. More importantly, our findings have important implications for future research directions, which are encouraged to verify the involvement of these candidates in AD and IS and interpret the exact molecular mechanisms of action.
PMID: 30859738 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - March 10, 2019 Category: Neuroscience Authors: Wei CJ, Cui P, Li H, Lang WJ, Liu GY, Ma XF Tags: CNS Neurosci Ther Source Type: research
Strictly Lobar Cerebral Microbleeds Are Associated with Increased White Matter Volume
AbstractCerebral small vessel diseases (CSVD), such as white matter hyperintensities (WMH), have been acknowledged as a cause of brain atrophy. However, the relationship between brain volumes and cerebral microbleeds (CMBs) has not yet been determined. We aimed to evaluate whether the presence and topography of CMBs are associated with altered volumes of gray matter (GMV) and white matter (WMV). Non-stroke and non-demented subjects were prospectively recruited from the I-Lan Longitudinal Aging Study. High-resolution 3-T MRI was performed to quantify total and regional WMV and GMV, including Alzheimer ’s disease-susceptib...
Source: Translational Stroke Research - April 28, 2019 Category: Neurology Source Type: research
COVID-19 neuro findings marked by mental status, stroke
Neuroimaging features of hospitalized COVID-19 patients can vary, but they...Read more on AuntMinnie.comRelated Reading:
CT angio images show stroke in COVID-19 patient
MRI illuminates neurologic manifestations of COVID-19
AI predicts Alzheimer's disease using MRI, patient info
Stroke scans drop by 40% during COVID-19 outbreak
Brain images may show 'cytokine storm' from COVID-19
Source: AuntMinnie.com Headlines - May 26, 2020 Category: Radiology Source Type: news
The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review
Conclusions: Changes in retinal microvasculature identified using OCTA are associated with monogenic SVD and different stages of AD, but data are limited and partly confounded by methodological differences. Larger studies with risk factors adjustment and more consistent OCTA methods are needed to fully exploit this technology.PROSPERO registration number: CRD42020166929.
Source: Frontiers in Neurology - September 9, 2020 Category: Neurology Source Type: research
Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.
This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social d...
Source: The Journal of Alzheimers Association - October 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Reminiscence therapy serves as an optional nursing care strategy in attenuating cognitive impairment, anxiety, and depression in acute ischemic stroke patients
ConclusionReminiscence therapy cripples cognitive impairment, anxiety, and depression, but does not affect RFS in AIS patients, indicating its potential for post-stroke management.
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research
Direct AT2R Stimulation Slows Post-stroke Cognitive Decline in the 5XFAD Alzheimer ’s Disease Mice
AbstractAlzheimer ’s disease (AD), currently the single leading cause of death still on the rise, almost always coexists alongside vascular cognitive impairment (VCI). In fact, the ischemic disease affects up to 90% of AD patients, with strokes and major infarctions representing over a third of vascular lesions. St udies also confirmed that amyloid plaques, typical of AD, are much more likely to cause dementia if strokes or cerebrovascular damage also exist, leading to the term “mixed pathology” cognitive impairment. Although its incidence is expected to grow, there are no satisfactory treatments. There is hence an u...
Source: Molecular Neurobiology - June 5, 2022 Category: Neurology Source Type: research
The therapeutic benefits of intravenously administrated nanoparticles in stroke and age-related neurodegenerative diseases
Curr Pharm Des. 2022 Jun 8. doi: 10.2174/1381612828666220608093639. Online ahead of print.ABSTRACTThe mean global lifetime risk of neurological disorders such as stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) has shown a large effect on economy and society.Researchersare stillstruggling to find effective drugs to treatneurological disordersand drug delivery through the blood-brain barrier (BBB) is a major challenge to be overcome. The BBB is a specialized multicellular barrier between the peripheral blood circulation and the neural tissue. Unique and selective features of the BBB allow it to tightly control...
Source: Current Pharmaceutical Design - June 9, 2022 Category: Drugs & Pharmacology Authors: Mehdi Farhoudi Saeed Sadigh-Eteghad Javad Mahmoudi Afsaneh Farjami Afsaneh Farjami Mohammad Mahmoudian Sara Salatin Source Type: research
