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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Brain Research Bulletin - March 19, 2022 Category: Neurology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research

Early Identification Of Cognitive Decline Via Brain-Imaging And Stroke Risk Test
UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia. The connection between stroke risk and cognitive decline has been well established by previous research. Individuals with higher stroke risk, as measured by factors like high blood pressure, have traditionally performed worse on tests of memory, attention and abstract reasoning...
Source: Health News from Medical News Today - April 5, 2013 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

Morphometry of the hippocampal microvasculature in post‐stroke and age‐related dementias
ConclusionsAn increase in microvascular Lv in AD and PSD suggests either an increase in angiogenesis or the formation of newer microvessel loops in response to cerebral hypoperfusion. The decreased vessel diameters found in AD and VaD suggests increased vasoconstriction in dementia.
Source: Neuropathology and Applied Neurobiology - August 1, 2013 Category: Neurology Authors: Matthew CJ Burke, Lucy Nelson, Janet Y Slade, Arthur E Oakley, Ahmad A Khundakar, Raj N Kalaria Tags: Original Article Source Type: research

Correspondence Global burden of stroke: an underestimate
The global burden of stroke outlined by Valery Feigin and colleagues' Article (Jan 18, p 245) is likely to be a substantial underestimation in view of the consequences of stroke disease on conditions other than acute stroke, which substantially affect health and wellbeing. Overt and occult cerebrovascular disease, both large and small vessel, have been recognised to contribute to Alzheimer's disease and vascular dementia.
Source: LANCET - April 4, 2014 Category: Journals (General) Authors: Desmond O'Neill Tags: Correspondence Source Type: research

rtPA in acute stroke patients with history of cognitive impairment: Do not hesitate to treat
A solid body of evidence has accumulated over the past 20 years confirming the critical role of cerebrovascular disease in Alzheimer disease (AD) and other dementias of the aged.1–6 Most recently, data from the National Alzheimer's Coordinating Center7 demonstrated the presence of vascular pathology in 79.9% of 4,629 brains from patients with neuropathologically confirmed AD. Lesions included atherosclerosis in the circle of Willis, arteriosclerotic leukoencephalopathy, arteriolosclerosis, large infarcts, lacunes, multiple microinfarcts, and hemorrhages. Notably, cerebral amyloid angiopathy was present in less than h...
Source: Neurology - June 9, 2014 Category: Neurology Authors: Roman, G. C., Hakim, A. M. Tags: EDITORIALS Source Type: research

Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms.
Abstract Continuous increases in the incidence of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and brain stroke demand the urgent development of therapeutics. Marine organisms are well-known producers of natural products with diverse structures and pharmacological activities. Therefore, researchers have endeavored to identify marine natural products with neuroprotective effects. In this regard, this review summarizes therapeutic targets for AD, PD, and ischemic brain stroke and marine natural products with pharmacological activities on the targets according to taxonomies ...
Source: Archives of Pharmacal Research - October 28, 2014 Category: Drugs & Pharmacology Authors: Choi DY, Choi H Tags: Arch Pharm Res Source Type: research

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Discussion: These results suggest that telmisartan comprehensively protected the NVU components by reducing inflammatory reactions relative to AD in hypertensive rats, which could also preclude the risk of AD under hypertension. PMID: 25591419 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Diabetes, hypertension and stroke - does Alzheimer protect you?
CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of Alzheimer's disease. PMID: 25702297 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes
This article evaluated the interaction between stroke risk and AD biomarkers on hippocampal volume and cognitive performance. We first evaluated the interaction between stroke risk factors and AD biomarkers using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 1202).
Source: Neurobiology of Aging - June 5, 2015 Category: Neuroscience Authors: Timothy J. Hohman, Lauren R. Samuels, Dandan Liu, Katherine A. Gifford, Shubhabrata Mukherjee, Elleena M. Benson, Ty Abel, Frederick L. Ruberg, Angela L. Jefferson, Alzheimer's Neuroimaging Initiative Source Type: research

Protective features of peripheral monocytes/macrophages in stroke.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26584587 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 12, 2015 Category: Biochemistry Authors: Gliem M, Schwaninger M, Jander S Tags: Biochim Biophys Acta Source Type: research

Imaging of Neuroinflammation in Alzheimer's Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26643549 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 28, 2015 Category: Biochemistry Authors: Janssen B, Vugts DJ, Funke U, Molenaar GT, Kruijer PS, van Berckel BN, Lammertsma AA, Windhorst AD Tags: Biochim Biophys Acta Source Type: research