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Familial tauopathy with P364S MAPT mutation: clinical course, neuropathology and ultrastructure of neuronal tau inclusions
ConclusionsP364S MAPT mutation is characterized clinically by a variable combination of frontotemporal dementia, parkinsonism and motor neuron disease of short duration, and neuropathologically by a widespread uniform distribution of all known neuronal tau inclusions in one family member. Two‐compartment CNTI is a unique characteristic of the P364S MAPT mutation.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 7, 2017 Category: Neurology Authors: Peter Štrafela, Jerica Pleško, Jožef Magdič, Blaž Koritnik, Andrej Zupan, Damjan Glavač, Mara Bresjanac, Mara Popović Tags: Original Article Source Type: research

Aberrant accumulation of ErbB4 in progressive supranuclear palsy
ConclusionsOur present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of PSPThis article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Aya Murakami, Masataka Nakamura, Satoshi Kaneko, Wen ‐Lang Lin, Dennis W. Dickson, Hirofumi Kusaka Tags: Original Article Source Type: research

Molecular characteristics of long ‐term epilepsy‐associated tumours (LEATs) and mechanisms for tumour‐related epilepsy (TRE)
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Thomas J Stone, Rachel Rowell, Bodiabaduge Ashan Prasanna Jayasekera, Mark O Cunningham, Thomas S Jacques Tags: Annual Review Issue ‐ Review Source Type: research

Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: X. Y Tai, B Bernhardt, M Thom, P Thompson, S Baxendale, M Koepp, N Bernasconi Tags: Annual Review Issue ‐ Review Source Type: research

Value of magnetic resonance imaging for evaluating muscle inflammation: insights from a new mouse model of myositis
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Gwladys Bourdenet, Benjamin Dubourg, Lionel Nicol, Paul Mulder, J érémie Martinet, Yves Allenbach, Christian Boitard, Olivier Boyer Tags: Scientific Correspondence Source Type: research

Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration
ConclusionsIn summary, the present study reports for the first time that age is not a major risk factor for multiple neuronal pathologies in FTLD. These findings have significant implications for the development of protein‐specific biomarkers and treatments for FTLD, and underscore the need for further research to identify the disease factors involved in driving multiple neuronal pathologies in FTLD.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Rachel H Tan, Yue Yang, Glenda M Halliday Tags: Original Article Source Type: research

Aicardi ‐Goutières‐Syndrome with muscle involvement in early infancy
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Nikolaus Deigendesch, Susanne Moralez ‐Gonzalez, Bernhard Weschke, Hans‐Hilmar Goebel, Markus Schuelke, Werner Stenzel Tags: Scientific Correspondence Source Type: research

Whole ‐exome sequencing of the BDR cohort: Evidence to support the role of the PILRA gene in Alzheimer's disease
Abstract AimLate‐onset Alzheimer's disease (LOAD) accounts for 95% of all Alzheimer's cases and is genetically complex in nature. Overlapping clinical and neuropathological features between AD, FTD and Parkinson's disease highlight the potential role of genetic pleiotropy across diseases. Recent GWAS have uncovered 20 new loci for AD risk, however these exhibit small effect sizes. Using NGS, here we perform association analyses using exome‐wide and candidate‐gene driven approaches. MethodsWhole‐exome sequencing was performed on 132 AD cases and 53 control samples. Exome‐wide single variant association and gene bu...
Source: Neuropathology and Applied Neurobiology - November 28, 2017 Category: Neurology Authors: Tulsi Patel, Keeley J. Brookes, James Turton, Sultan Chaudhury, Tamar Guetta ‐Baranes, Rita Guerreiro, Jose Bras, Dena Hernandez, Andrew Singleton, Paul T. Francis, John Hardy, Kevin Morgan Tags: Original Article Source Type: research

The past, present and future challenges in epilepsy related and sudden deaths and biobanking
This article reviews how pathologists and healthcare professionals have approached ERD, current practices, logistical problems and areas to improve and harmonize. The main neuropathology, cardiac and genetic findings in SUDEP are outlined, providing a framework for best practices, integration of clinical, pathologic and molecular genetic investigations in SUDEP, and ultimately prevention. This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 27, 2017 Category: Neurology Authors: Maria Thom, Maura Boldrini, Elizabeth Bundock, Mary N. Sheppard, Orrin Devinsky Tags: Annual Review Issue ‐ Review Source Type: research

Myoblots: dystrophin quantification by in ‐cell western assay for a streamlined development of Duchenne muscular dystrophy (DMD) treatments
ConclusionsWe expect that this new tool to quantify muscle proteins in DMD and other muscle disorders will aid in their diagnosis and in the development of new therapies. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 27, 2017 Category: Neurology Authors: E. Ruiz ‐Del‐Yerro, I. Garcia‐Jimenez, K. Mamchaoui, V. Arechavala‐Gomeza Tags: Original Article Source Type: research

Low FoxG1 and high Olig ‐2 labelling indices define a prognostically favourable subset in isocitrate dehydrogenase (IDH)‐mutant gliomas
AimsPrevious data suggest that expression of transcription factors FoxG1 and Olig‐2 can separate hotspot histone H3 family member 3A (H3F3A)‐mutant tumours in paediatric glioma. We evaluated their prognostic potential and feasibility for identifying H3F3A‐mutant tumours among IDH‐mutant/wild‐type gliomas. MethodsImmunohistochemistry of FoxG1/Olig‐2 and α‐thalassaemia/mental‐retardation‐syndrome‐X‐linked gene (ATRX) in 471 cases of diffuse gliomas and molecular determination of IDH, H3F3A, MGMT and 1p/19 codeletion status. ResultsMean percentage of FoxG1‐positive tumour cells increased from 17%...
Source: Neuropathology and Applied Neurobiology - November 23, 2017 Category: Neurology Authors: S. Sch äfer, F. Behling, M. Skardelly, M. Koch, I. Ott, F. Paulsen, G. Tabatabai, J. Schittenhelm Tags: Original Article Source Type: research

Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 12, 2017 Category: Neurology Authors: Albert J. Becker Tags: Invited Review Source Type: research

Concomitant IDH ‐wildtype glioblastoma and IDH1‐mutant anaplastic astrocytoma in a patient with constitutional mismatch repair deficiency syndrome
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 12, 2017 Category: Neurology Authors: Francesca Galuppini, Enrico Opocher, Uri Tabori, Isabella Mammi, Melissa Edwards, Britany Campbell, Jacalyn Kelly, Alessandra Viel, Michele Quaia, Francesca Rivieri, Domenico D'Avella, Antonella Arcella, Felice Giangaspero, Matteo Fassan, Marina Paola Gar Tags: Scientific Correspondence Source Type: research

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful treatment in humans. The use of transgenic mouse models has helped to develop our understanding of AD, not only in terms of disease pathology, but also with the associated cognitive impairments typical of AD. Plaques and neurofibrillary tangles are often among the last pathological changes in AD mouse models, after neuronal loss and gliosis. There is a general consensus that successful treatments need to be applied before the onset of these pathologies and associated cog...
Source: Neuropathology and Applied Neurobiology - November 9, 2017 Category: Neurology Authors: K. E. Ameen ‐Ali, S. B. Wharton, J. E. Simpson, P. R. Heath, P. Sharp, J. Berwick Tags: Review Source Type: research

In This Issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 9, 2017 Category: Neurology Tags: In This Issue Source Type: research

Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 9, 2017 Category: Neurology Tags: Issue Information Source Type: research

Myoblots: dystrophin quantification by in ‐cell western assay for a streamlined development of DMD treatments
ConclusionsWe expect that this new tool to quantify muscle proteins in DMD and other muscle disorders will aid in their diagnosis and in the development of new therapies.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - October 1, 2017 Category: Neurology Authors: Est íbaliz Ruiz‐Del‐Yerro, Iker Garcia‐Jimenez, Kamel Mamchaoui, Virginia Arechavala‐Gomeza Tags: Original Article Source Type: research

Low FoxG1 and high Olig ‐2 labelling indices define a prognostically favorable subset in IDH‐mutant gliomas
Abstract AimsPrevious data suggest that expression of transcription factors FoxG1 and Olig‐2 can separate hotspot H3F3A‐mutant tumors in pediatric glioma. We evaluated their prognostic potential and feasibility for identifying H3F3A‐mutant tumors among IDH‐mutant/wildtype gliomas. MethodsImmunohistochemistry of FoxG1/Olig‐2 and ATRX in 471 cases of diffuse gliomas and molecular determination of IDH, H3F3A, MGMT and 1p/19 codeletion status. ResultsMean percentage of FoxG1 positive tumor cells increased from 17% in WHO grade II to over 21% in grade III to 37% in grade IV tumors, while mean Olig‐2 indices decrease...
Source: Neuropathology and Applied Neurobiology - October 1, 2017 Category: Neurology Authors: Sarah Sch äfer, Felix Behling, Marco Skardelly, Marilin Koch, Ines Ott, Frank Paulsen, Ghazaleh Tabatabai, Jens Schittenhelm Tags: Original Article Source Type: research

Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post ‐mortem study
ConclusionsOverall, we found that the neuroinflammatory pathological markers in late stage AD human tissue to have a similar pattern in both EOAD and LOAD, though the severity of the pathological markers in the younger group was higher. Understanding the age effect in AD will be important when testing modifying agents that act on the neuroinflammation.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - October 1, 2017 Category: Neurology Authors: Ricardo Taipa, Vitor Ferreira, Paulo Brochado, Andrew Robinson, In ês Reis, Fernanda Marques, David M Mann, Manuel Melo Pires, Nuno Sousa Tags: Original Article Source Type: research

Neuroinflammatory pathways as treatment targets and biomarker candidates in  epilepsy: emerging evidence from preclinical and clinical studies
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - October 1, 2017 Category: Neurology Authors: Erwin A. van Vliet, Eleonora Aronica, Annamaria Vezzani, Teresa Ravizza Tags: Annual Review Issue ‐Review Source Type: research

CNS embryonal tumours: WHO 2016 and beyond
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 26, 2017 Category: Neurology Authors: Jessica C Pickles, Cynthia Hawkins, Torsten Pietsch, Thomas S Jacques Tags: Short Review Source Type: research

Taxonomy of CNS Tumours; A Series of Three Short Reviews on the WHO 2016 Classification and Beyond
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 25, 2017 Category: Neurology Authors: Pieter Wesseling, Thomas S Jacques Tags: Editorial Source Type: research

Prevalence of transactive response DNA ‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults: systematic review and meta‐analysis
ObjectiveTo perform a systematic review and meta‐analysis on the prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults. MethodsWe systematically reviewed and performed a meta‐analysis on the prevalence of TDP‐43 proteinopathy in older adults with normal cognition, evaluated by the Mini‐Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP‐43 using random‐effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP‐43 aggregates, analysed brain regions, Braak st...
Source: Neuropathology and Applied Neurobiology - September 20, 2017 Category: Neurology Authors: C. Nascimento, A. T. Di Lorenzo Alho, C. Bazan Concei ção Amaral, R. E. P. Leite, R. Nitrini, W. Jacob‐Filho, C. A. Pasqualucci, S. R. K. Hokkanen, S. Hunter, H. Keage, G. G. Kovacs, L. T. Grinberg, C. K. Suemoto Tags: Original Article Source Type: research

Thomas A. Woolsey, Joseph Hanaway, Mokhtar H. Gado The Brain Atlas: A Visual Guide to the Human Central Nervous System (4th edition) Wiley Blackwell, 2017. 258 Pages. ( £45 with a digital companion). ISBN 9781118438770
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 12, 2017 Category: Neurology Authors: Abel Devadass Tags: Book Review Source Type: research

Fausto J. Rodriguez, Charles G. Eberhart Review of The Johns Hopkins Atlas of Surgical Neuropathology. By Johns Hopkins Mobile medicine. Volume 3 in the series: The Johns Hopkins Atlases of Pathology Johns Hopkins University, 2016. ( £4.99 iPAD App available in the iTunes store)
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 12, 2017 Category: Neurology Authors: Abel Devadass Tags: Book Review Source Type: research

In this issue October 2017
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 12, 2017 Category: Neurology Tags: In This Issue Source Type: research

Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 12, 2017 Category: Neurology Tags: Issue Information Source Type: research

Incidental neuronal intermediate filament inclusion pathology: unexpected biopsy findings in a 37 ‐year old woman with epilepsy
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 7, 2017 Category: Neurology Authors: Ellen Gelpi, Cristina Carrato, Laia Grau ‐López, Juan Luis Becerra, Roser Garcia‐Armengol, Anna Massuet, Laura Cervera, Jordi Clarimon, Katrin Beyer, Ramiro Álvarez Tags: Scientific Correspondence Source Type: research

Tumour ‐associated microglia/macrophages predict poor prognosis in high‐grade gliomas and correlate with an aggressive tumour subtype
ConclusionsThis is the first study to use automated quantitative immunofluorescence to determine the prognostic impact of TAMs. Our results suggest that M2‐like TAMs hold an unfavourable prognostic value in high‐grade gliomas and may contribute to a pro‐tumourigenic microenvironment. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - September 5, 2017 Category: Neurology Authors: M. D. S ørensen, R. H. Dahlrot, H. B. Boldt, S. Hansen, B. W. Kristensen Tags: Original Article Source Type: research

Connexin ‐43 and aquaporin‐4 are markers of ageing‐related tau astrogliopathy (ARTAG)‐related astroglial response
AimsAgeing‐related tau astrogliopathy (ARTAG) appears in subependymal, subpial, perivascular, white matter (WM) and grey matter (GM) locations. Physical effects, blood–brain barrier dysfunction and blood‐ or vessel‐related factors have been considered as aetiology. As connexin‐43 (Cx43) and aquaporin‐4 (AQP4) are related to these, we hypothesized that their immunoreactivity (IR) varies with ARTAG in a location‐specific manner. MethodsWe performed a morphometric immunohistochemical study measuring the densities of IR of Cx43, AQP4, AT8 (phospho‐tau) and glial fibrillar acidic protein (GFAP). We analysed ...
Source: Neuropathology and Applied Neurobiology - August 25, 2017 Category: Neurology Authors: G. G. Kovacs, A. Yousef, S. Kaindl, V. M. Lee, J. Q. Trojanowski Tags: Original Article Source Type: research

Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: Kamar E. Ameen ‐Ali, Stephen B. Wharton, Julie E. Simpson, Paul R. Heath, Paul Sharp, Jason Berwick Tags: Invited Review Source Type: research

WHO 2016 Classification of Gliomas
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: Pieter Wesseling, David Capper Tags: Short Review Source Type: research

Evidence of er stress and upr activation in patients with brody disease and brody syndrome
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: V. Guglielmi, N. C. Voermans, A. Oosterhof, D. Nowis, B. G. van Engelen, G. Tomelleri, G. Vattemi Tags: Scientific Correspondence Source Type: research

Prevalence of TDP ‐43 proteinopathy in cognitively normal older adults: systematic review and meta‐analysis
Abstract ObjectiveTo perform a systematic review and meta‐analysis on the prevalence of TDP‐43 proteinopathy in cognitively normal older adults. MethodsWe systematically reviewed and performed a meta‐analysis on the prevalence of TDP‐43 proteinopathy in older adults with normal cognition, evaluated by the Mini‐Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP‐43 using random‐effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP‐43 aggregates, analyzed brain regions, Braak stage, CERAD score, hippocampal sclerosis...
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: Camila Nascimento, Ana Tereza Di Lorenzo Alho, Caroline Bazan Concei ção Amaral, Renata Elane Paraizo Leite, Ricardo Nitrini, Wilson Jacob‐Filho, Carlos Augusto Pasqualucci, Suvi Rosa Kastehelmi Hokkanen, Sally Hunter, Hannah Keage, Gabor G Kovacs, Le Tags: Original Article Source Type: research

Distinctive cerebral neuropathology in an adult case of SANDO syndrome
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: Daniel Kirschenbaum, Carola Hedberg ‐Oldfors, Anders Oldfors, Eduard Scherer, Herbert Budka Tags: Scientific Correspondence Source Type: research

Tumor ‐associated microglia/macrophages predict poor prognosis in high‐grade gliomas and correlate with an aggressive tumor subtype
ConclusionsThis is the first study to use automated quantitative immunofluorescence to determine the prognostic impact of TAMs. Our results suggest that M2‐like TAMs hold an unfavorable prognostic value in high‐grade gliomas and may contribute to a protumorigenic microenvironment.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - August 1, 2017 Category: Neurology Authors: Mia D. S ørensen, Rikke H. Dahlrot, Henning B. Boldt, Steinbjørn Hansen, Bjarne W. Kristensen Tags: Original Article Source Type: research

Connexin ‐43 and Aquaporin‐4 are markers of ARTAG‐related astroglial response
Abstract AimsAgeing‐related tau astrogliopathy (ARTAG) appears in subependymal, subpial, perivascular, white matter (WM) and grey matter (GM) locations. Physical effects, blood‐brain barrier dysfunction, blood‐ or vessel‐related factors have been considered as aetiology. Since Connexin‐43 (Cx43) and Aquaporin‐4 (AQP4) are related to these, we hypothesized that their immunoreactivity varies with ARTAG in a location‐specific manner. MethodsWe performed a morphometric immunohistochemical study measuring the densities of immunoreactivity (IR) of Cx43, AQP4, AT8 (phospho‐tau), and glial fibrillar acidic protein ...
Source: Neuropathology and Applied Neurobiology - July 29, 2017 Category: Neurology Authors: Gabor G. Kovacs, Ahmed Yousef, Sabine Kaindl, Virginia M. Lee, John Q. Trojanowski Tags: Original Article Source Type: research

Super ‐Resolution Imaging of Subcortical White Matter using Stochastic Optical Reconstruction Microscopy (STORM) and Super‐Resolution Optical Fluctuation Imaging (SOFI)
ConclusionsSuper resolution imaging of intact cryo‐cut human brain tissue is feasible. For quantitation, STORM can under‐estimate diameters of thin fluorescent objects. SOFI is more robust. The greatest limitation for super‐resolution imaging in brain sections is imposed by sample preparation. We anticipate that improved strategies to reduce autofluorescence and to enhance fluorophore performance will enable rapid expansion of this approach. [232 words]This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 11, 2017 Category: Neurology Authors: Atticus H Hainsworth, Sarah Lee, Peter Foot, Anita Patel, Wayne W Poon, Alex E Knight Tags: Original Article Source Type: research

Response to: Comment on ‘Human adult neurogenesis across the ages: An immunohistochemical study’
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 11, 2017 Category: Neurology Authors: C. V. Dennis, L. S. Suh, M. L. Rodriguez, J. J. Kril, G. T. Sutherland Tags: Letter to the Editor Source Type: research

In This Issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 11, 2017 Category: Neurology Tags: In This Issue Source Type: research

Issue Information
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - July 11, 2017 Category: Neurology Tags: Issue Information Source Type: research

Prognostic value of O ‐6‐methylguanine–DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis
ConclusionOur data indicate that MGMT protein expression in tumour cells has an independent prognostic significance. Exclusion of nontumour cells contributed to a more exact analysis of tumour‐specific MGMT protein expression. This should be incorporated in future studies evaluating MGMT status before potential integration into clinical practice. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 28, 2017 Category: Neurology Authors: R. H. Dahlrot, J. Dowsett, S. Fosmark, A. Malmstr öm, R. Henriksson, H. Boldt, K. Stricker, M. D. Sørensen, H. S. Poulsen, M. Lysiak, P. Söderkvist, J. Rosell, S. Hansen, B. W. Kristensen Tags: Original Article Source Type: research

Astrogliosis and impaired aquaporin ‐4 and dystrophin systems in idiopathic normal pressure hydrocephalus
ConclusionsiNPH patients responding to CSF diversion present with abnormal pulsatile ICP, indicative of impaired intracranial compliance. A main histopathological finding was astrogliosis and reduction of AQP4 and of Dp71 in astrocytic perivascular endfeet. We propose that the altered AQP4 and Dp71 complex contributes to the sub‐ischemia prevalent in the brain tissue of iNPH.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 19, 2017 Category: Neurology Authors: Per Kristian Eide, Hans ‐Arne Hansson Tags: Original Article Source Type: research

Effects of short ‐to‐long term Enzyme Replacement Therapy (ERT) on skeletal muscle tissue in Late Onset Pompe disease (LOPD)
We examined muscle biopsies from 18 LOPD patients at both histopathological and biochemical level. All patients underwent two muscle biopsies, before and after ERT administration respectively. The study is partially retrospective because the first biopsies were taken before the study was designed whereas the second biopsy was always performed after at least six months of ERT administration. ResultsAfter ERT, 15 out of 18 patients showed improved 6MWT (p=0.0007) and most of them achieved respiratory stabilization. Pre‐treatment muscle biopsies disclosed marked histopathological variability, ranging from an almost normal p...
Source: Neuropathology and Applied Neurobiology - June 2, 2017 Category: Neurology Authors: Michela Ripolone, Raffaella Violano, Dario Ronchi, Stefania Mondello, Annachiara Nascimbeni, Irene Colombo, Gigliola Fagiolari, Andreina Bordoni, Francesco Fortunato, Valeria Lucchini, Simona Saredi, Massimiliano Filosto, Olimpia Musumeci, Paola Tonin, Ti Tags: Original Article Source Type: research

Evolving concepts of chronic traumatic encephalopathy as a neuropathological entity
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Helen Ling, James W Neal, Tamas Revesz Tags: Invited Review Source Type: research

Cholinesterases in Normal and Alzheimer's Disease Primary Olfactory Gyrus
ConclusionsAChE and BChE activities in normal POG recapitulated their distributions in other cortical regions. Greater abundance of BChE‐associated, in comparison to AChE‐associated, AD pathology in the POG suggests preferential involvement of BChE in olfactory dysfunction in AD.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Hayam Hamodat, Meghan K. Cash, John D. Fisk, Sultan Darvesh Tags: Original Article Source Type: research

Aggregation and phosphorylation of α‐synuclein with proteinase K‐resistance in focal α‐synucleinopathy predominantly localized to the cardiac sympathetic nervous system
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Nei Fukasawa, Takahiro Fukuda, Masato Nagaoka, Tohru Harada, Hiroyuki Takahashi, Masahiro Ikegami Tags: Scientific Correspondence Source Type: research

Marinesco Bodies and Substantia Nigra Neuron Density in Parkinson's Disease
Abstract AimMarinesco bodies (MB) are intranuclear inclusions in pigmented neurons of the substantia nigra (SN). While rare in children, frequency increases with normal aging and is high in Alzheimer's disease, dementia with Lewy bodies, and other neurodegenerative disorders. Coinciding with the age‐related rise in MB frequency is initiation of cell death among SN neurons. Whether MB have a role in this process is unknown. Our aim is to examine the association of MB with SN neuron density in Parkinson's disease (PD) in the Honolulu‐Asia Aging Study. MethodsData on MB and neuron density were measured in SN transverse se...
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Robert D. Abbott, James S. Nelson, G. Webster Ross, Jane H. Uyehara ‐Lock, Caroline M. Tanner, Kamal H. Masaki, Lenore J. Launer, Lon R. White, Helen Petrovitch Tags: Original Article Source Type: research

Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Andrew King, Claire Troakes, Miren Aizpurua, Ambreen Mirza, Angela Hodges, Safa Al ‐Sarraj, Christopher Exley Tags: Scientific Correspondence Source Type: research

Prognostic value of MGMT protein expression in glioblastoma excluding non ‐tumour cells from the analysis
ConclusionOur data indicate that MGMT protein expression in tumour cells has an independent prognostic significance. Exclusion of non‐tumour cells contributed to a more exact analysis of tumour‐specific MGMT protein expression. This should be incorporated in future studies evaluating MGMT status before potential integration into clinical practice.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Rikke H. Dahlrot, Joseph Dowsett, Sigurd Fosmark, Annika Malmstr öm, Roger Henriksson, Henning Boldt, Karin Stricker, Mia D. Sørensen, Hans S. Poulsen, Malgorzata Lysiak, Peter Söderkvist, Johan Rosell, Steinbjørn Hansen, Bjarne W. Kristensen Tags: Original Article Source Type: research