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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

Brain Imaging and Cognitive Predictors of Stroke and Alzheimer Disease in the Framingham Heart Study Clinical Sciences
Conclusions— Specific patterns of cognitive and brain structural measures observed even in early aging predict stroke risk and may serve as biomarkers for risk prediction.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Weinstein, G., Beiser, A. S., DeCarli, C., Au, R., Wolf, P. A., Seshadri, S. Tags: Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Positron Emission Tomographic Imaging in Stroke: Cross-Sectional and Follow-Up Assessment of Amyloid in Ischemic Stroke Clinical Sciences
Conclusions— There was no significant increase in 11C-PiB accumulation in or around the infarct. There was no increase in ipsilesional hemispheric 11C-PiB accumulation over time. We found no evidence that infarction leads to sustained or increased β-amyloid deposition ≤18 months after stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Sahathevan, R., Linden, T., Villemagne, V. L., Churilov, L., Ly, J. V., Rowe, C., Donnan, G., Brodtmann, A. Tags: Nuclear Cardiology and PET, Cognitive Impairment, Ischemic Stroke Clinical Sciences Source Type: research

Memantine Enhances Recovery From Stroke Basic Sciences
Conclusions— Our results suggest that memantine improves stroke outcomes in an apparently non-neuroprotective manner involving increased brain-derived neurotrophic factor signaling, reduced reactive astrogliosis, and improved vascularization, associated with improved recovery of sensory and motor cortical function. The clinical availability and tolerability of memantine make it an attractive candidate for clinical translation.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Lopez-Valdes, H. E., Clarkson, A. N., Ao, Y., Charles, A. C., Carmichael, S. T., Sofroniew, M. V., Brennan, K. C. Tags: Animal models of human disease, Imaging, Other imaging, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Multidomain Lifestyle Interventions for the Prevention of Cognitive Decline After Ischemic Stroke: Randomized Trial Clinical Sciences
Conclusions— This trial found no benefit of 24-month multidomain intervention with focus on improvement in lifestyle and vascular risk factors on the incidence of poststroke cognitive decline in comparison with standard stroke care. Studies with a larger sample size are needed. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT01109836.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Matz, K., Teuschl, Y., Firlinger, B., Dachenhausen, A., Keindl, M., Seyfang, L., Tuomilehto, J., Brainin, M., on behalf of the ASPIS Study Group, Participants in the ASPIS Study Group in addition to the authors named, Schnider, Bancher, Pinter, Kepplinger Tags: Embolic stroke Clinical Sciences Source Type: research

Influence of Amyloid-{beta} on Cognitive Decline After Stroke/Transient Ischemic Attack: Three-Year Longitudinal Study Clinical Sciences
Conclusions— Compared with subjects without Alzheimer’s disease–like Aβ deposition, those with Aβ deposition experienced a more severe and rapid cognitive decline over 3 years after stroke/transient ischemic attack. Aβ was associated with changes in multiple cognitive domains.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Liu, W., Wong, A., Au, L., Yang, J., Wang, Z., Leung, E. Y. L., Chen, S., Ho, C. L., Mok, V. C. T. Tags: Behavioral Changes and Stroke, PET and SPECT Clinical Sciences Source Type: research

Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke Basic Sciences
Conclusions— These results support the idea that lipid raft integrity, ensured by seladin-1/DHCR24, plays a crucial protective role in the ischemic brain by guaranteeing EAAT2-mediated uptake of glutamate excess.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Hernandez-Jimenez, M., Martinez-Lopez, D., Gabande-Rodriguez, E., Martin-Segura, A., Lizasoain, I., Ledesma, M. D., Dotti, C. G., Moro, M. A. Tags: Cerebrovascular Disease/Stroke, Neuroprotectants Basic Sciences Source Type: research

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia Clinical Sciences
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Associations between Parkinson Disease and Stroke (S51.006)
Conclusions:Among Medicare beneficiaries, the relationships between stroke and PD were similar to those between stroke and AD. As in AD, a link may exist between cerebrovascular disease and PD.Study Supported by: Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund. Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke.Disclosure: Dr. Kummer has nothing to disclose. Dr. Aaroe has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel h...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kummer, B., Aaroe, A., Kamel, H., Iadecola, C., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Does the Influence of Stroke on Dementia Vary by Different Levels of Prestroke Cognitive Functioning?: A Cohort Study Clinical Sciences
Conclusions— Stroke and prestroke cognition were independently associated with increased probability of poststroke dementia. Stroke results in disproportionate increase in the risk of dementia when premorbid cognitive functioning is high.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Dregan, A., Wolfe, C. D. A., Gulliford, M. C. Tags: Clinical Sciences Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

Risk of incident stroke in patients with Alzheimer disease or vascular dementia
Conclusions: Patients with VD, but not AD, have a markedly higher risk of developing an ischemic stroke than those without dementia. In patients with AD, but not VD, use of atypical antipsychotic drugs was associated with an increased risk of TIA.
Source: Neurology - September 2, 2013 Category: Neurology Authors: Imfeld, P., Bodmer, M., Schuerch, M., Jick, S. S., Meier, C. R. Tags: All Cerebrovascular disease/Stroke, Alzheimer's disease, Vascular dementia, Case control studies, Incidence studies ARTICLE Source Type: research

CCL11 (Eotaxin-1) Levels Predict Long-Term Functional Outcomes in Patients Following Ischemic Stroke
AbstractCirculating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer ’s disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypothesized that circulating CCL11 levels would increase following ischemic stroke in mice and humans, and that higher CCL11 levels would correlate with poor long-term recovery in patients. As predic ted, circulating levels of CCL11 in both young and aged mice increased significantly 24 h after experime...
Source: Translational Stroke Research - June 21, 2017 Category: Neurology Source Type: research

Modeling Mixed Vascular and Alzheimer ’s Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice
AbstractSubcortical white matter ischemic lesions are increasingly recognized to have pathologic overlap in individuals with Alzheimer ’s disease (AD). The interaction of white matter ischemic lesions with amyloid pathology seen in AD is poorly characterized. We designed a novel mouse model of subcortical white matter ischemic stroke and AD that can inform our understanding of the cellular and molecular mechanisms of mixed vascul ar and AD dementia. Subcortical white matter ischemic stroke underlying forelimb motor cortex was induced by local stereotactic injection of an irreversible eNOS inhibitor. Subcortical white mat...
Source: Translational Stroke Research - February 20, 2020 Category: Neurology Source Type: research

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid- β Formation
AbstractStroke and Alzheimer ’s disease (AD) are cerebral pathologies with high socioeconomic impact that can occur together and mutually interact. Vascular factors predisposing to cerebrovascular disease have also been specifically associated with development of AD, and acute stroke is known to increase the risk to develop d ementia.Despite the apparent association, it remains unknown how acute cerebrovascular disease and development of AD are precisely linked and act on each other. It has been suggested that this interaction is strongly related to vascular deposition of amyloid- β (Aβ), i.e., cerebral amyloid angiopa...
Source: Translational Stroke Research - November 27, 2019 Category: Neurology Source Type: research

Prevalence and cognitive impact of medial temporal atrophy in a hospital stroke service: retrospective cohort study
ConclusionsMedial temporal lobe atrophy is common and has an independent impact on cognitive function in a stroke service population, independent of confounding factors including age and magnetic resonance imaging markers of cerebrovascular disease. Medial temporal lobe atrophy is independently related to verbal memory and nominal skills, while small vessel pathology also contributes to speed and attention, and executive and perceptual functions.
Source: International Journal of Stroke - June 1, 2015 Category: Neurology Authors: Valeria Kebets, Simone M. Gregoire, Andreas Charidimou, Josephine Barnes, Khadija Rantell, Martin M. Brown, Hans R. Jäger, Lisa Cipolotti, David J. Werring Tags: Research Source Type: research