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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study
DISCUSSION: Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.PMID:37157186 | DOI:10.1002/alz.13122
Source: The Journal of Alzheimers Association - May 9, 2023 Category: Psychiatry Authors: Wansi Zhong Hui Chen Xiaoxian Gong Lusha Tong Xin Xu Geng Zong Changzheng Yuan Min Lou Source Type: research
The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
In this study, we employed hypoxia/reoxygenation conditions for primary cortical neuronal cell cultures as an in vitro model of stroke as well as the in vivo model of rat focal middle cerebral artery occlusion (MCAO). Our data showed that when primary neuronal cultures were first subjected to hypoxic conditions (0.3%, 24 h) followed by reoxygenation (21%, 24-48 h), the cell viability was greatly reduced. In the animal model of stroke (MCAO), we found that 2 h ischemia followed by 4 days reperfusion resulted in an infarct of 47.42 ± 9.86% in sections 6 mm from the frontal pole. Using taurine greatly increased cell viabilit...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Gharibani PM, Modi J, Pan C, Menzie J, Ma Z, Chen PC, Tao R, Prentice H, Wu JY Tags: Adv Exp Med Biol Source Type: research
Depression, stroke, and dementia in patients with myocardial infarction.
In conclusion, we found that preceding depression was associated with moderately increased mortality after MI, and that
was associated with an increased risk of stroke and vascular dementia, but not dementia from other causes.
PMID: 29619929 [PubMed - in process]
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research
Preventing dementia by preventing stroke: The Berlin Manifesto
This article summarizes the evidence for translation into action.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research
Stroke as a cause of death in death certificates of patients with dementia: a cohort study from the Swedish Dementia Registry.
CONCLUSIONS: There was relatively high number of patients that died from IS in their death certificate but had not been registered in Riksstroke in the year before death. This creates concerns on the accuracy of death certificate stroke diagnoses, particularly for deaths taking place outside of hospitals.
PMID: 30280666 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - October 2, 2018 Category: Neurology Authors: Subic A, Zupanic E, von Euler M, Norrving B, Cermakova P, Religa D, Winblad B, Kramberger MG, Eriksdotter M, Garcia-Ptacek S Tags: Curr Alzheimer Res Source Type: research
High Prevalence of Social Cognition Disorders and Mild Cognitive Impairment Long Term After Stroke.
CONCLUSIONS: The study demonstrates the high frequency of social cognition impairment 3 years after the first-ever stroke in young patients. Doctors and nurses should be sensitized to cognitive handicap after stroke because of difficulties for rehabilitation and returning to work.
PMID: 31633560 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Stroke and Alzheimer ’s Disease: A Mendelian Randomization Study
In conclusion, different types of stroke, including AS, AIS, LAS, and CES, would not be causally associated with AD risk.
Source: Frontiers in Genetics - July 13, 2020 Category: Genetics & Stem Cells Source Type: research
Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study
Conclusion: Elevated stroke risk at midlife is associated with accelerated cognitive decline over 10 years. Aggregation of risk factors may be especially important in this association.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 30, 2012 Category: Geriatrics Authors: Sara Kaffashian, Aline Dugravot, Eric J. Brunner, Séverine Sabia, Joël Ankri, Mika Kivimäki, Archana Singh-Manoux Tags: Featured Articles Source Type: research
Impact of Stroke on A{beta}1-40 and A{beta}1-42 Plasmatic Levels (P1.105)
Conclusion. Aβ1-40 levels depend mainly on stroke characteristics, especially delay after onset, vascular risk factors and ischemic subtype, but not by PCoI. Aβ1-42 levels are not influenced by stroke, but their relationship with the cognitive status is more difficult to interpret.Disclosure: Dr. Moulin has nothing to disclose. Dr. Leys has received personal compensation in an editorial capacity for Lancet and Lancet Neurology. Dr. Leys has received research support from Bayer Pharmaceuticals Corp., Sanofi-Aventis Pharmaceuticals Inc., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Schraen-Maschke has nothing ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Moulin, S., Leys, D., Schraen-Maschke, S., Bordet, R. Tags: Cerebrovascular Disease and Interventional Neurology: Translational Science Source Type: research
Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study
Conclusion Elevated stroke risk at midlife is associated with accelerated cognitive decline over 10 years. Aggregation of risk factors may be especially important in this association.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2014 Category: Geriatrics Source Type: research
The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort.
CONCLUSIONS:: Although the modified Framingham Stroke Risk Profile in late-life predicts rate of decline on selective neurocognitive measures in previously normal elderly individuals, age appears to be the strongest risk factor for cognitive impairment in this population. History of stroke independently influences rate of cognitive decline in these individuals.
PMID: 25626633 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - February 1, 2016 Category: Neurology Authors: Matthew Traylor, Poneh Adib‐Samii, Denise Harold, , , Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, , Tags: Research Article Source Type: research
Shared genetic contribution to ischemic stroke and Alzheimer's disease
ObjectiveIncreasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases.
MethodsUsing genome‐wide association study (GWAS) data from METASTROKE + (15,916 IS cases and 68,826 controls) and the International Genomics of Alzheimer's Project (IGAP; 17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype‐level data (4,610 IS cases, 1,281 AD cases, and 14,320 controls), we estimat...
Source: Annals of Neurology - March 29, 2016 Category: Neurology Authors: Matthew Traylor, Poneh Adib‐Samii, Denise Harold, , Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, Tags: Research Article Source Type: research
