Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease
DiscussionneuroAD™ Therapy System provides a low-risk therapeutic benefit for patients with milder AD (baseline ADAS-Cog ≤30) beyond pharmacologic SOC. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 24, 2019 Category: Geriatrics Source Type: research

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease
We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 24, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment
DiscussionGd does not accumulate in brains of older individuals with a BBB breakdown in the hippocampus. Thus, Gd agents can be used without risk of brain retention within a ∼2-year follow-up to study BBB in the aging human brain in relation to cognition and/or other pathologies. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Stratifying risk for dementia onset using large-scale electronic health record data: a retrospective cohort study
DiscussionA cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8 years before diagnosis. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 10, 2019 Category: Geriatrics Source Type: research

Neuropsychological decline up to 20 years before incident mild cognitive impairment
DiscussionThe preclinical duration of cognitive and behavioral changes approaches the earliest reported biomarker changes. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube
DiscussionThis integrated real-world AD data overview provides an intuitive visual model that facilitates initial assessment and identification of gaps in relevant outcomes data to inform future prospective data collection and matching of data sources and outcomes against research protocols. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Comorbid amyloid-β pathology affects clinical and imaging features in VCD
DiscussionComorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study
DiscussionMR found robust evidence of a causal association between alcohol consumption and an earlier AAOS, but not alcohol intake and LOAD risk. The protective effect of alcohol dependence is potentially due to survivor bias. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Incidence of dementia in the oldest-old and its relationship with age: The Monzino 80-plus population-based study
ConclusionDementia incidence also keeps rising in nonagenarians and centenarians. Slowing down in growing risk of developing dementia with age is mainly attributable to increasing competing risk of death and resulting selective survival of individuals at lower risk of dementia. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research