Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease
DiscussionneuroAD™ Therapy System provides a low-risk therapeutic benefit for patients with milder AD (baseline ADAS-Cog ≤30) beyond pharmacologic SOC. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 24, 2019 Category: Geriatrics Source Type: research

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease
We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 24, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment
DiscussionGd does not accumulate in brains of older individuals with a BBB breakdown in the hippocampus. Thus, Gd agents can be used without risk of brain retention within a ∼2-year follow-up to study BBB in the aging human brain in relation to cognition and/or other pathologies. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: December 2019Source: Alzheimer's & Dementia, Volume 15, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Stratifying risk for dementia onset using large-scale electronic health record data: a retrospective cohort study
DiscussionA cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8 years before diagnosis. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 18, 2019 Category: Geriatrics Source Type: research

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 10, 2019 Category: Geriatrics Source Type: research

Neuropsychological decline up to 20 years before incident mild cognitive impairment
DiscussionThe preclinical duration of cognitive and behavioral changes approaches the earliest reported biomarker changes. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube
DiscussionThis integrated real-world AD data overview provides an intuitive visual model that facilitates initial assessment and identification of gaps in relevant outcomes data to inform future prospective data collection and matching of data sources and outcomes against research protocols. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Comorbid amyloid-β pathology affects clinical and imaging features in VCD
DiscussionComorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study
DiscussionMR found robust evidence of a causal association between alcohol consumption and an earlier AAOS, but not alcohol intake and LOAD risk. The protective effect of alcohol dependence is potentially due to survivor bias. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Incidence of dementia in the oldest-old and its relationship with age: The Monzino 80-plus population-based study
ConclusionDementia incidence also keeps rising in nonagenarians and centenarians. Slowing down in growing risk of developing dementia with age is mainly attributable to increasing competing risk of death and resulting selective survival of individuals at lower risk of dementia. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 29, 2019 Category: Geriatrics Source Type: research

Incidence of frontotemporal disorders in Olmsted County: A population-based study
Publication date: Available online 26 November 2019Source: Alzheimer's & DementiaAuthor(s): Pierpaolo Turcano, Cole D. Stang, Michelle M. Mielke, Peter R. Martin, Sudhindra G. Upadhyaya, Keith A. Josephs, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Rodolfo SavicaAbstractIntroductionFrontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort.MethodsUsing a records-linkage system, we identified all patients with a diagnostic code for deme...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 27, 2019 Category: Geriatrics Source Type: research

Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration
We examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 MAPT, GRN, and C9orf72 family members, including 102 non–mutation carriers, 103 asymptomatic carriers, 43 mildly/questionably symptomatic carriers, and 72 carriers with dementia.ResultsAsymptomatic carriers showed similar scores on all clinical measures compared with noncarriers but reduced frontal and temporal volumes. Those with mild/questionable impairment showed decreased verbal recall, fluency, and Trail Making Test performance and impaired mood and self-monitoring. Dementia was associated with impairment in...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 27, 2019 Category: Geriatrics Source Type: research

Tau-positron emission tomography correlates with neuropathology findings
DiscussionElevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 27, 2019 Category: Geriatrics Source Type: research

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD
DiscussionEarly “subtle cognitive decline” among Aβ+ CN on a sensitive cognitive composite demonstrably increases risk for imminent clinical disease progression and functional impairment. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 21, 2019 Category: Geriatrics Source Type: research

A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL-INCA)
Publication date: Available online 20 November 2019Source: Alzheimer's & DementiaAuthor(s): Hector M. González, Wassim Tarraf, Myriam Fornage, Kevin A. González, Albert Chai, Marston Youngblood, Maria de los Angeles Abreu, Donglin Zeng, Sonia Thomas, Gregory A. Talavera, Linda C. Gallo, Robert Kaplan, Martha L. Daviglus, Neil SchneidermanAbstractHispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 21, 2019 Category: Geriatrics Source Type: research

Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions
DiscussionOur findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 21, 2019 Category: Geriatrics Source Type: research

Corrigendum to “AMYPAD Diagnostic and Patient Management Study: Rationale and design” [Alzheimer's & Dementia 2019;15:388-99]
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Research Roundtable Considers Novel Treatment Approaches for Alzheimer's Disease
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): Stacie Weninger, Bjorn Sperling, Lisa J. Bain, Maria C. Carillo (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: November 2019Source: Alzheimer's & Dementia, Volume 15, Issue 11Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study
DiscussionThe Cognigram was well liked in waiting rooms of primary care settings. Assistance from a trained adult and clinic endorsement were keys to success. How the Cognigram performs in a geographically compact, population-dense global setting, such as Brooklyn with high vascular disease risk and a plethora of health disparities, is being tested. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2019 Category: Geriatrics Source Type: research

Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results
DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 18, 2019 Category: Geriatrics Source Type: research

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study
DiscussionCMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 10, 2019 Category: Geriatrics Source Type: research

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis
Publication date: Available online 6 November 2019Source: Alzheimer's & DementiaAuthor(s): Martin Tolar, Susan Abushakra, Marwan SabbaghAbstractDevelopment of disease-modifying treatments for Alzheimer's disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, providing important validation of amyloid as a therapeutic target. However, the inconsistent results observed with aducanumab may be...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 7, 2019 Category: Geriatrics Source Type: research

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease
DiscussionThese results raise the possibility that C99, rather than Aβ plaques, is responsible for the death of nerve cells in AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 1, 2019 Category: Geriatrics Source Type: research

Individualized clinical management of patients at risk for Alzheimer's dementia
Publication date: Available online 31 October 2019Source: Alzheimer's & DementiaAuthor(s): Richard S. Isaacson, Hollie Hristov, Nabeel Saif, Katherine Hackett, Suzanne Hendrix, Juan Melendez, Joseph Safdieh, Matthew Fink, Madhav Thambisetty, George Sadek, Sonia Bellara, Paige Lee, Cara Berkowitz, Aneela Rahman, Josefina Meléndez-Cabrero, Emily Caesar, Randy Cohen, Pei-lin Lu, Samuel P. Dickson, Mu Ji HwangAbstractIntroductionMultidomain intervention for Alzheimer's disease (AD) risk reduction is an emerging therapeutic paradigm.MethodsPatients were prescribed individually tailored interventions (education/pharma...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 1, 2019 Category: Geriatrics Source Type: research

Intact global cognitive and olfactory ability predicts lack of transition to dementia
We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia.MethodsIn an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed.ResultsIn covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among part...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 30, 2019 Category: Geriatrics Source Type: research

Secular trends in cognitive trajectories of diverse older adults
This study aimed to determine if later birth year influences trajectory of age-related cognitive decline across racial/ethnic groups and to test whether years of school, childhood socioeconomic status, and cardiovascular disease burden explain such secular trends.MethodsWe compared cognitive trajectories of global cognition and subdomains in two successive racially/ethnically and educationally diverse birth cohorts of a prospective cohort study.ResultsLater birth year was associated with higher initial cognitive levels for Whites and Blacks, but not Hispanics. Later birth year was also associated with less rapid rate of de...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 29, 2019 Category: Geriatrics Source Type: research

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease
We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes.MethodsThe four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline.ResultsVoxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (tempor...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 29, 2019 Category: Geriatrics Source Type: research

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias
DiscussionBiomarkers of synapse and neurodegeneration differentiate HC subjects from neurodegenerative dementias and between AD, FTD, and CJD. NF-L and 14-3-3 performed similar to total tau when AT(N) system was applied. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 26, 2019 Category: Geriatrics Source Type: research

Amyloid pathology–produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites
DiscussionOverall, abnormal Ca2+ homeostasis in AD has an age dependency that comprises multiple mechanisms, including compensatory processes. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 26, 2019 Category: Geriatrics Source Type: research

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures
DiscussionNew personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavor...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2019 Category: Geriatrics Source Type: research

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin
We examined, in a community-based population (N = 777, aged 50–95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays.ResultsMultiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T-tau had the strongest association with cognition in ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2019 Category: Geriatrics Source Type: research

Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes
DiscussionWe confirm that accelerometry can provide relevant information about challenging behaviors. We extended previous studies by differentiating various types of agitated behaviors and applying long-term measurements in a real-world setting. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2019 Category: Geriatrics Source Type: research

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
Publication date: Available online 22 October 2019Source: Alzheimer's & DementiaAuthor(s): Chih Hung Lo, Colin Kin-Wye Lim, Zhipeng Ding, Sanjula P. Wickramasinghe, Anthony R. Braun, Karen H. Ashe, Elizabeth Rhoades, David D. Thomas, Jonathan N. SachsAbstractObjectiveUnderstanding the heterogeneous pathology in Alzheimer's disease and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease-modifying therapies. Through monitoring ensembles of toxic and nontoxic tau oligomers spontaneously formed in cells, our biosensor technology can identify tool compounds that mod...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2019 Category: Geriatrics Source Type: research

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology
We present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in which detailed clinical and neuropsychological assessments are performed, biofluid samples are collected, and magnetic resonance imaging scans are performed using a standard protocol.DiscussionThese data and samples, which are available to interested investigators worldwide, will facilitate planning for upcoming disease-modifying therapeutic trials in f-FTLD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 20, 2019 Category: Geriatrics Source Type: research

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study
This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer's disease (AD) and Parkinson's disease (PD) subjects from the network of the European, Innovative Medicines Initiative–funded project AETIONOMY.MethodsA total of 227 samples from the studies/centres AETIONOMY, ICEBERG, and IDIBAPS were used to analyse 21 selected immunity biomarkers in CSF. Results were compared to data of an independent cohort of 399 subjects previously published.ResultsImmunity markers were predominantly and reproducibly associated with pathological levels of tau isoforms, but also with amyloid levels, aging, sex,...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 18, 2019 Category: Geriatrics Source Type: research

Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
DiscussionOur results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research