The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology
We present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in which detailed clinical and neuropsychological assessments are performed, biofluid samples are collected, and magnetic resonance imaging scans are performed using a standard protocol.DiscussionThese data and samples, which are available to interested investigators worldwide, will facilitate planning for upcoming disease-modifying therapeutic trials in f-FTLD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 20, 2019 Category: Geriatrics Source Type: research

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study
This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer's disease (AD) and Parkinson's disease (PD) subjects from the network of the European, Innovative Medicines Initiative–funded project AETIONOMY.MethodsA total of 227 samples from the studies/centres AETIONOMY, ICEBERG, and IDIBAPS were used to analyse 21 selected immunity biomarkers in CSF. Results were compared to data of an independent cohort of 399 subjects previously published.ResultsImmunity markers were predominantly and reproducibly associated with pathological levels of tau isoforms, but also with amyloid levels, aging, sex,...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 18, 2019 Category: Geriatrics Source Type: research

Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
DiscussionOur results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Longitudinal study of self-reported hearing loss and subjective cognitive function decline in women
DiscussionSelf-reported hearing loss was associated with higher risk of incident subjective cognitive function decline in women. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people
Publication date: Available online 13 October 2019Source: Alzheimer's & DementiaAuthor(s): Catherine M. Calvin, Tim Wilkinson, John M. Starr, Cathie Sudlow, Saskia P. Hagenaars, Sarah E. Harris, Christian Schnier, Gail Davies, Chloe Fawns-Ritchie, Catharine R. Gale, John Gallacher, Ian J. DearyAbstractIntroductionProspective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation.MethodsWe used UK Biobank baseline cognitive data (...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors
DiscussionAβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 12, 2019 Category: Geriatrics Source Type: research

Sex/gender differences in cognitive trajectories vary as a function of race/ethnicity
This study takes an important first step in understanding interactions between race/ethnicity and sex/gender on cognitive trajectories by demonstrating variability in sex/gender differences across race/ethnicity. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 11, 2019 Category: Geriatrics Source Type: research

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics
DiscussionThese results suggest that additional genetic variation in the APOE region influences AD risk beyond APOE E2/E3/E4. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 11, 2019 Category: Geriatrics Source Type: research

Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos
Publication date: Available online 9 October 2019Source: Alzheimer's & DementiaAuthor(s): Alberto R. Ramos, Wassim Tarraf, Benson Wu, Susan Redline, Jianwen Cai, Martha L. Daviglus, Linda Gallo, Yasmin Mossavar-Rahmani, Krista M. Perreira, Phyllis Zee, Donglin Zeng, Hector M. GonzalezAbstractIntroductionTo determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247).MethodsThe exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 11, 2019 Category: Geriatrics Source Type: research

Association between enrollment factors and incident cognitive impairment in Blacks and Whites: Data from the Alzheimer's Disease Center
We examined the influence of enrollment factors demonstrated to differ by race on incident mild cognitive impairment and dementia using Alzheimer's Disease Center data.MethodsDifferences in rates of incident impairment between non-Latino Whites and Blacks (n = 12,242) were examined with age-at-progression survival models. Models included race, sex, education, source of recruitment, health factors, and family history of dementia.ResultsNo significant race differences in progression were observed in cognitively unimpaired participants. In those with mild cognitive impairment at baseline, Whites evidenced greater ri...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 8, 2019 Category: Geriatrics Source Type: research

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project
The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort.MethodsWe calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in post–positron emission tomography diagnosis and management change between “AUC-consistent” and “AUC-inconsistent” patients.ResultsAlmost half (250/507) of patients were AUC-consistent. In both AUC-consistent and AUC-in...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 6, 2019 Category: Geriatrics Source Type: research

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults
DiscussionLTPA both throughout life and later in life are associated with lower risk of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 4, 2019 Category: Geriatrics Source Type: research

Declining incidence of dementia: A national registry-based study over 20 years
DiscussionThis is the first study to report continuous time trends of incidence and prevalence in an entire national population. The incidence rate has declined steadily since 2003, while the total prevalence is still increasing. Future health care planning on prevention and treatment of dementia should take these findings into account. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 4, 2019 Category: Geriatrics Source Type: research

Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial
DiscussionS-CitAD will provide information about a practical, immediately available approach to treating agitation in patients with AD. S-CitAD may become a model of how to evaluate and predict treatment response in patients with AD and agitation as a neuropsychiatric symptom (ClinicalTrials.gov Identifier: NCT03108846). (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 4, 2019 Category: Geriatrics Source Type: research

Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?
Publication date: Available online 26 September 2019Source: Alzheimer's & DementiaAuthor(s): Kevin McRae-McKee, Chinedu T. Udeh-Momoh, Geraint Price, Sumali Bajaj, Celeste A. de Jager, David Scott, Christoforos Hadjichrysanthou, Emily McNaughton, Luc Bracoud, Sara Ahmadi-Abhari, Frank de Wolf, Roy M. Anderson, Lefkos T. Middleton, Alzheimer's Disease Neuroimaging InitiativeAbstractThe 2018 National Institute on Aging and the Alzheimer's Association (NIA-AA) research framework recently redefined Alzheimer's disease (AD) as a biological construct, based on in vivo biomarkers reflecting key neuropathologic features. ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 27, 2019 Category: Geriatrics Source Type: research

Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent
DiscussionResults highlight the importance of considering sex and age when assessing APOE-ε4–associated vulnerability to cognitive decline. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 25, 2019 Category: Geriatrics Source Type: research

Differences in service utilization at an urban tribal health organization before and after Alzheimer's disease or related dementia diagnosis: A cohort study
DiscussionThis is the only study quantifying changes in healthcare service utilization before and after ADRD diagnosis among ANAI people, which is crucial for tailoring geriatric care for ANAI populations. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 25, 2019 Category: Geriatrics Source Type: research

Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status
DiscussionMI alone or in combination with omega-3 fatty acids was associated with improved primary cognitive outcome in subjects with positive amyloid status.Trial RegistrationClinicalTrials.gov Identifier: NCT01513252. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 25, 2019 Category: Geriatrics Source Type: research

Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait?
Publication date: Available online 20 September 2019Source: Alzheimer's & DementiaAuthor(s): Ríona Mc Ardle, Brook Galna, Paul Donaghy, Alan Thomas, Lynn RochesterAbstractObjectiveWe aimed to refine the hypothesis that dementia has a unique signature of gait impairment reflective of underlying pathology by considering two dementia subtypes, Alzheimer's disease (AD) and Lewy body disease (LBD), and exploring the role of cognition in disease-specific gait impairments.BackgroundAccurately differentiating AD and LBD is important for treatment and disease management. Early evidence suggests gait could be a marker of ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 20, 2019 Category: Geriatrics Source Type: research

Paul Greengard, Ph.D. (1925-2019)
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): Sam Gandy, Toshiharu Suzuki (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Epilepsy and Alzheimer's disease: Overlapping mechanisms and therapeutic opportunities
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): Alzheimer's (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: September 2019Source: Alzheimer's & Dementia, Volume 15, Issue 9Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 19, 2019 Category: Geriatrics Source Type: research

Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study
DiscussionPoor performance on several independent gait domains precedes cognitive decline and incident dementia. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 11, 2019 Category: Geriatrics Source Type: research

The Alzheimer's Disease Exposome
DiscussionWe propose the “AD exposome” to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions. (Source: Alzheimer's and Dementi...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 11, 2019 Category: Geriatrics Source Type: research

A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials
DiscussionThe harmonized database is an optimum resource to design AD prevention trials decades before symptomatic onset. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 8, 2019 Category: Geriatrics Source Type: research

Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
This study aimed to systematically review any previous studies that involved resilient APOE ε4 homozygotes and to identify possible modifying or protective genetic factors.ResultsFifteen studies met our inclusion criteria and reported genetic factors contributing to reduced risk. We found that only two single nucleotide polymorphisms, CASP7 rs10553596 and SERPINA3 rs4934-A/A, had strong evidence.DiscussionWe found a paucity of studies adequately designed to discover protective genetic factors against LOAD. Many studies combined APOE ε4 homozygotes and heterozygotes together because of small sample sizes and...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 8, 2019 Category: Geriatrics Source Type: research

Cognitive function after surgery with regional or general anesthesia: A population-based study
Publication date: Available online 5 September 2019Source: Alzheimer's & DementiaAuthor(s): Juraj Sprung, Phillip J. Schulte, David S. Knopman, Michelle M. Mielke, Ronald C. Petersen, Toby N. Weingarten, David P. Martin, Andrew C. Hanson, Darrell R. Schroeder, David O. WarnerAbstractIntroductionOur aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA).MethodsLongitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative
DiscussionNP criteria produced a reversion rate that is consistent with, albeit modestly improved from, reversion rates in meta-analyses. Reverters’ biomarker profiles and progression rates suggest that NP criteria accurately tracked with underlying pathophysiologic status. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid
Publication date: Available online 5 September 2019Source: Alzheimer's & DementiaAuthor(s): Petros Takousis, Angélique Sadlon, Jessica Schulz, Inken Wohlers, Valerija Dobricic, Lefkos Middleton, Christina M. Lill, Robert Perneczky, Lars BertramAbstractIntroductionSeveral microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case-control studies remains inconclusive.MethodsA systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal f...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
DiscussionThe results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals
DiscussionCorrelation patterns between tau burden and atrophy in the amyloid-β–negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 6, 2019 Category: Geriatrics Source Type: research

Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries
DiscussionAscertainment of etiologic dementia subtype may inform hereditary risk and facilitate financial and care planning. Use of dementia specialty care was low, particularly for Hispanics and Asians, and associated with more detection of etiological subtype. Dementia-related professional development for nonspecialists is urgent given their central role in dementia diagnosis and care. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 5, 2019 Category: Geriatrics Source Type: research

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium
DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 31, 2019 Category: Geriatrics Source Type: research

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
DiscussionThe regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 29, 2019 Category: Geriatrics Source Type: research

Reply to “Down Syndrome Cognitive Marker's Significance in Alzheimer's Disease and Dementia Management”
Publication date: Available online 23 August 2019Source: Alzheimer's & DementiaAuthor(s): Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Tamara Al-Janabi, Kin Y. Mok, John Hardy, Andre Strydom (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 24, 2019 Category: Geriatrics Source Type: research

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Publication date: Available online 18 August 2019Source: Alzheimer's & DementiaAuthor(s): Binyin Li, Yixi He, Jianfang Ma, Pei Huang, Juanjuan Du, Li Cao, Yan Wang, Qin Xiao, Huidong Tang, Shengdi ChenAbstractObjectiveGut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia.BackgroundAD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 18, 2019 Category: Geriatrics Source Type: research

Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Longfei Jia, Qiongqiong Qiu, Heng Zhang, Lan Chu, Yifeng Du, Jiewen Zhang, Chunkui Zhou, Furu Liang, Shengliang Shi, Shan Wang, Wei Qin, Qi Wang, Fangyu Li, Qigeng Wang, Yan Li, Luxi Shen, Yiping Wei, Jianping JiaAbstractIntroductionNeuronal-derived exosomal Aβ42, T-tau, and P-T181-tau have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has assessed the association of Aβ42, T-tau, and P-T181-tau between exosomes and CSF.MethodsThis was a multicenter study with two-stage design. The subj...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Lucidity in dementia: A perspective from the NIA
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Basil A. Eldadah, Elena M. Fazio, Kristina A. McLindenAbstractIn this issue of Alzheimer's & Dementia, Mashour et al. propose the intriguing hypothesis that some manifestations of late-stage dementia are reversible, albeit transiently. Calling this phenomenon paradoxical lucidity, their paper follows a 2018 workshop sponsored by the National Institute on Aging that assessed the state of knowledge on lucidity in dementia and identified areas ripe for further study. The National Institute on Aging has since released two funding ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Recommendations for a new perioperative cognitive impairment nomenclature
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Lisbeth Evered, Brendan Silbert, David A. Scott, Roderic G. Eckenhoff (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Down syndrome cognitive marker's significance in Alzheimer's disease and dementia management
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Ranjeet Singh Mahla (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research