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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

Neuroprotective Effects of Ginkgolide B against Ischemic Stroke: a Review of Current Literature.
Abstract Extensive evidences have shown the promising effects of Ginkgo biloba consumption on several diseases such as Alzheimer, Parkinson, ischemic stroke, etc. Several studies also reported its beneficial role on motor activity and cognitive function. This species contain unique class of diterpene, namely Ginkgolide B, which possess several pharmacological activities such as protective effect against cardiovascular disease; the most important causes of death worldwide. The promising effects of Ginkgolide B on stroke, both ischemic and hemorrhagic, are suggested by an overwhelming body of scientific evidences. M...
Source: Current Topics in Medicinal Chemistry - June 10, 2015 Category: Chemistry Authors: Nabavi SM, Habtemariam S, Daglia M, Braidy N, Loizzo MR, Tundis R, Nabavi SF Tags: Curr Top Med Chem Source Type: research

Tyrosine Kinase Inhibitor as a new Therapy for Ischemic Stroke and other Neurologic Diseases: is there any Hope for a Better Outcome?
Abstract The relevance of tyrosine kinase inhibitors (TKIs) in the treatment of malignancies has been already defined. Aberrant activation of tyrosine kinase signaling pathways has been causally linked not only to cancers but also to other non-oncological diseases. This review concentrates on the novel plausible usage of this group of drugs in neurological disorders, such as ischemic brain stroke, subarachnoid hemorrhage, Alzheimer's disease, multiple sclerosis. The drugs considered here are representatives of both receptor and non-receptor TKIs. Among them imatinib and masitinib have the broadest spectrum of ther...
Source: Current Neuropharmacology - November 26, 2015 Category: Drugs & Pharmacology Authors: Gagalo I, Rusiecka I, Kocic I Tags: Curr Neuropharmacol Source Type: research

Decline of microtubule-associated protein tau after experimental stroke in differently aged wild-type and 3xTg mice with Alzheimer-like alterations
In conclusion, microtubule-associated protein tau was robustly identified as a highly sensitive cytoskeletal constitute under ischemic conditions, suggesting a pivotal role during the transition process toward long-lasting tissue damage. Consequently, cytoskeletal elements appear as promising targets for novel therapeutic approaches with the objective to impede ischemia-induced irreversible cellular degradation.
Source: Neuroscience - June 3, 2016 Category: Neuroscience Source Type: research

Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionsAdministration of SSRIs may improve gross motor function, reduce disability and enhance QOL for patients recovering from stroke.
Source: Clinical Drug Investigation - July 29, 2017 Category: Drugs & Pharmacology Source Type: research

Visualization of ischemic stroke-related changes on 18 F-THK-5351 positron emission tomography
Conclusion18F-THK-5351 PET imaging provides a potential tool for in vivo visualization of the widespread ischemia-related changes associated with a microstructural disruption in recent ischemic stroke patients.
Source: EJNMMI Research - July 16, 2018 Category: Radiology Source Type: research

Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.
Abstract Remyelination has been widely noticed as an important repair mechanism triggered after a stroke-induced white matter injury, but it often fails due to the lack of recruitment of the oligodendrocyte progenitor cells (OPCs) to the demyelinated area and the inadequate differentiation of OPCs. Racemic dl-3-n-butylphthalide (dl-NBP) has been reported to improve the functional recovery in animal models of vascular dementia, Alzheimer's disease (AD) and ischemic stroke. Dl-NBP (70 mg/kg) by oral gavage for two weeks from day 7 after a stroke was administered in the study, the treatment promoted differentiation a...
Source: Brain Research - April 11, 2019 Category: Neurology Authors: Zhao C, Cheng X, Wang H, Liu C, Zhong S, Niu X, Zhang X, Qi R, Zhao S, Zhang X, Qu H Tags: Brain Res Source Type: research

Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology.
Conclusion: AT had a therapeutic effect for ischemic via multicomponent, multitarget, and multisignal pathway, which provided a novel research aspect for AT against IS. PMID: 33178313 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - November 13, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Gut dysbiosis in stroke and its implications on Alzheimer's disease-like cognitive dysfunction.
Abstract Various neurological disorders, such as stroke and Alzheimer's disease (AD), involve neuroinflammatory responses. The advent of the gut-brain axis enhances our understanding of neurological disease progression and secondary cell death. Gut microbiomes, especially those associated with inflammation, may reflect the dysbiosis of both the brain and the gut, opening the possibility to utilize inflammatory microbiomes as biomarkers and therapeutic targets. The gut-brain axis may serve as a contributing factor to disease pathology and offer innovative approaches in cell-based regenerative medicine for the treat...
Source: CNS Neuroscience and Therapeutics - January 19, 2021 Category: Neuroscience Authors: Cho J, Park YJ, Gonzales-Portillo B, Saft M, Cozene B, Sadanandan N, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Everyday Abilities Scale for India in Screening for Poststroke Dementia Among Young Stroke Survivors
Introduction: Cognitive dysfunction after stroke is an important concern. We explored the utility of everyday abilities scale for India (EASI) for screening for dementia among young stroke survivors. Methods: We interviewed 150 young stroke survivors and caregivers. Vascular dementia was diagnosed according to American Heart Association-American Stroke Association (ASA-AHA) criteria. EASI was administered to all caregivers. Receiver operating characteristic curve analysis was used to determine the area under the curve and optimum cut-points for EASI for the identification of dementia. Results: Median EASI...
Source: Alzheimer Disease and Associated Disorders - July 1, 2021 Category: Geriatrics Tags: Brief Reports Source Type: research

Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Cancer Control - March 19, 2022 Category: Cancer & Oncology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research