[18F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer
ConclusionsWe found a comparable heterogeneity between patients with up to five lesions and plurimetastic patients, while patients with up to three lesions were less heterogeneous than plurimetastatic patients, featuring different cells phenotypes in the two groups. Our results supported the use of a 3-lesion threshold to define oligometastatic PCa. (Source: EJNMMI Research)
Source: EJNMMI Research - November 27, 2021 Category: Radiology Source Type: research

Receptor depletion and recovery in small-intestinal neuroendocrine tumors and normal tissues after administration of a single intravenous dose of octreotide measured by 68Ga-DOTATOC PET/CT
This study was performed to investigate the time-dependent extended effect (7  h) of a single intravenous dose of 400 µg short-acting octreotide on the tumor versus normal tissue uptake of68Ga-DOTATOC.MethodsPatients with small-intestinal NETs received a single intravenous dose of 400  µg octreotide and underwent dynamic abdominal68Ga-DOTATOC-PET/CT at three sessions (0, 3 and 6  h) plus static whole-body (WB) PET/CT (1, 4 and 7 h), starting each PET/CT session by administering 167 ± 21 MBq, 23.5 ± 4.2 µg (mean &plusm...
Source: EJNMMI Research - November 25, 2021 Category: Radiology Source Type: research

Value of 18F-FDG PET/CT for predicting axillary pathologic complete response following neoadjuvant systemic therapy in breast cancer patients: emphasis on breast cancer subtype
ConclusionsPredicting axillary response following NST with baseline18F-FDG PET/CT can be performed when focusing on breast cancer subtypes. The easily computed PET-parameter SUVmax can predict axillary response in HER2-positive and TN breast cancer. This study adds to the accumulating evidence that studies investigating the value of18F-FDG PET/CT in breast cancer should always take subtypes into account. (Source: EJNMMI Research)
Source: EJNMMI Research - November 22, 2021 Category: Radiology Source Type: research

Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
ConclusionBone plasma clearance measured from static WB scans correlates with clearance data measured by dynamic analysis. Static [18F]NaF PET/CT scans can be applied in future studies to measure Ki in patients with CKD-MBD, but the results should not be compared uncritically with results obtained by dynamic scan analysis. (Source: EJNMMI Research)
Source: EJNMMI Research - November 22, 2021 Category: Radiology Source Type: research

Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
AbstractRecent advancements in the field of immune-oncology have led to a significant increase in life expectancy of patients with diverse forms of cancer, such as hematologic malignancies, melanoma and lung cancer. Unfortunately, these encouraging results are not observed in the majority of patients, who remain unresponsive and/or encounter adverse events. Currently, researchers are collecting more insight into the cellular and molecular mechanisms that underlie these variable responses. As an example, the human lymphocyte activation gene-3 (huLAG-3), an inhibitory immune checkpoint receptor, is increasingly studied as a ...
Source: EJNMMI Research - November 2, 2021 Category: Radiology Source Type: research

Dose escalation biodistribution, positron emission tomography/computed tomography imaging and dosimetry of a highly specific radionuclide-labeled non-blocking nanobody
Conclusion68Ga-NOTA-Nb109 showed specific accumulation in hPD-L1 xenografts in ex vivo biodistribution studies and monkey PET/CT imaging. The dose escalation distribution data provided a recommended dose range for further use, and the safety of the tracer was confirmed in dosimetry studies. (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2021 Category: Radiology Source Type: research

[68Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation
ConclusionThe results highlight the potential of [68Ga]Ga-4HMSA as an interesting alternative to [68Ga]Ga-citrate for inflammation imaging by PET. The new PET tracer also offers additional advantages than [68Ga]Ga-citrate in term of dosimetry and lower overall background activity. (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2021 Category: Radiology Source Type: research

Semi-quantitative measurements of chemokine receptor 4-targeted 68Ga-pentixafor PET/CT in response assessment of Waldenstr öm macroglobulinemia/lymphoplasmacytic lymphoma
ConclusionsThe semi-quantitative measurements of68Ga-pentixafor PET/CT outperformed18F-FDG PET/CT in response assessment of WM/LPL. (Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research

More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research

Response to letter: More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research

Intraindividual comparison of [68  Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 in prostate cancer patients: a retrospective single-center analysis
AbstractBackgroundThe analysis aimed to compare the radiotracers [68Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging and presumable unspecific lesions retrospectively as used in routine clinical practice.MethodsA retrospective analysis of 46 prostate cancer patients (median age: 71  years) who underwent consecutive [68Ga]-Ga-PSMA-11- and [18F]-F-PSMA-1007-PET/CT or PET/MRI within a mean of 12  ± 8.0 days was performed. MiTNM staging was performed in both studies by two nuclear medicine physicians who were blinded to the res...
Source: EJNMMI Research - October 19, 2021 Category: Radiology Source Type: research

Short-duration dynamic [18F]DCFPyL PET and CT perfusion imaging to localize dominant intraprostatic lesions in prostate cancer: validation against digital histopathology and comparison to [18F]DCFPyL PET/MR at 120 minutes
AbstractPurposeLocalized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy through more precise targeting of biopsy, radiotherapy and focal ablative therapies. The goal of this study is to validate the performance of [18F]DCFPyL PET and CT perfusion (CTP) for detecting and localizing DIL against digital histopathological images.MethodsMulti-modality image sets: in vivo T2-weighted (T2w)-MRI, 22-min dynamic [18F]DCFPyL PET/CT, CTP, and 2-h post-injection PET/MR were acquired in ...
Source: EJNMMI Research - October 15, 2021 Category: Radiology Source Type: research

Predicting the nature of pleural effusion in patients with lung adenocarcinoma based on 18F-FDG PET/CT
ConclusionsOur predictive model based on18F-FDG PET/CT showed good diagnostic performance for PE, which was helpful to differentiate MPE from BPE in patients with lung adenocarcinoma. (Source: EJNMMI Research)
Source: EJNMMI Research - October 15, 2021 Category: Radiology Source Type: research

Convolutional neural network-based automatic heart segmentation and quantitation in 123I-metaiodobenzylguanidine SPECT imaging
AbstractBackgroundSince three-dimensional segmentation of cardiac region in123I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (CNN) with123I-MIBG single photon emission computed tomography (SPECT) imaging, to calculate heart counts and washout rates (WR) automatically and to compare with conventional quantitation based on planar imaging.MethodsWe assessed 48 patients (aged 68.4  ± 11.7 years) with heart and neurological diseases, including chronic heart failure, dementia with Lewy bodies, and Parki...
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
ConclusionsNovel radiopharmaceuticals targeting a number of different integrins, above all, αvβ6, have proven their clinical potential and will play an increasingly important role in future theranostics. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research

Alteration of neuroinflammation detected by 18F-GE180 PET imaging in place-conditioned rats with morphine withdrawal
AbstractBackgroundAccumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted18F-flutriciclamide (GE180) positron emission tomography (PET) imaging to investigate the conversion of NI during drug withdrawal and conditioning-induced aversion by measuring the change in microglial activation with18F-GE180.MethodsTwelve male adult Sprague –Dawley rats were subjected to morphine withdrawal by the administration of naloxone, and six of them were used to model conditioned place aversion (CPA).18F-GE18...
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research

Rationale for MYC imaging and targeting in pancreatic cancer
AbstractThe incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summar...
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research

Retraction Note to: Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research

Correction to: Biokinetics, dosimetry and radiation risk in infants after 99mTc-MAG3 scans
(Source: EJNMMI Research)
Source: EJNMMI Research - October 11, 2021 Category: Radiology Source Type: research

The prognostic significance of [18F]FDG PET/CT in multiple myeloma according to novel interpretation criteria (IMPeTUs)
ConclusionSeveral parameters utilized in IMPeTUs predict PFS in MM patients, suggesting the potentially significant role of the new criteria in patient stratification and response assessment. Additional studies are warranted for the further evaluation of IMPeTUs in the direction of establishment of robust cut-off values with a prognostic significance in the disease. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2021 Category: Radiology Source Type: research

Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity
ConclusionsWe successfully obtained functional images of focal ROS generation during the early period of excitotoxic injury, and microglial ROS generation and mitochondrial dysfunction were observed during the progression of the inflammatory response. Both ex vivo DHE imaging and in vivo18F-BCPP-EF-PET were sufficiently sensitive to detect the respective processes of QA-induced brain damage. Our study contributes to the functional imaging of multiple events during the pathological process. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2021 Category: Radiology Source Type: research

Automated liver lesion detection in 68Ga DOTATATE PET/CT using a deep fully convolutional neural network
ConclusionDeep neural networks can automatically detect hepatic lesions in68Ga-DOTATATE PET. Ongoing improvements in data annotation methods, increasing sample sizes and training methods are anticipated to further improve detection performance. (Source: EJNMMI Research)
Source: EJNMMI Research - October 2, 2021 Category: Radiology Source Type: research

In vivo quantitative assessment of therapeutic response to bortezomib therapy in disseminated animal models of multiple myeloma with [18F]FDG and [64Cu]Cu-LLP2A PET
AbstractBackgroundMultiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-4 (VLA4, CD49d/CD29) is overexpressed in MM cells. Here, we evaluated [18F]FDG and VLA4 targeted [64Cu]Cu-LLP2A for quantitative PET imaging in disseminated MM models of variable VLA4 expression, following bortezomib therapy.MethodsIn vitro and ex vivo VLA4 expression was evaluated by flow cytometry. Human MM cells, MM.1S-CG and U266-CG (C: luciferase and G: green fluorescent protein), were injected ...
Source: EJNMMI Research - September 29, 2021 Category: Radiology Source Type: research

Lung shunt fraction calculation using 99mTc-MAA SPECT/CT imaging for 90Y microsphere selective internal radiation therapy of liver tumors
AbstractBackground99mTc-macroaggregated albumin (99mTc-MAA) scintigraphy is utilized in treatment planning for Yttrium-90 (90Y) Selective Internal Radiation Therapy (SIRT) of liver tumors to evaluate hepatopulmonary shunting by calculating the lung shunt fraction (LSF). The purpose of this study was to evaluate if LSF calculation using SPECT/CT instead of planar gamma camera imaging is more accurate and if this can potentially lead to more effective treatment planning of hepatic lesions while avoiding excessive pulmonary irradiation.ResultsLSF calculation was obtained using two different methodologies in 85 cases from cons...
Source: EJNMMI Research - September 28, 2021 Category: Radiology Source Type: research

The effect of eating on the uptake of PSMA ligands in the salivary glands
AbstractRationalePSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of177Lu/225Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xerostomia and potentially severe effect on the quality of life. Gustatory stimulation is an approach that has commonly been used in radioactive iodine therapy to reduce accumulation in the salivary glands. However, based on theoretical differences in biodistribution, it was hypothesized that this could potentially lead to adverse increased toxicity for PSMA-ligand therapy. The primary objective of this ...
Source: EJNMMI Research - September 26, 2021 Category: Radiology Source Type: research

Imaging modalities for diagnosis and monitoring of cancer cachexia
AbstractCachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily implicates lean body mass, caused by an aberrant metabolism and systemic inflammation. This may lead to disease aggravation, poorer quality of life, and increased mortality. Timely detection is, therefore, crucial, as is the careful monitoring of cancer progression, in an effort to improve management, facilitate individual treatment and minimize disease complications. A detailed analysis of body composition and t...
Source: EJNMMI Research - September 23, 2021 Category: Radiology Source Type: research

Benefits and harms of implementing [18F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study
Conclusion[18F]FDG-PET/CT provided a high posterior probability of positive test, and a negative test was able to rule out distant metastases in women with clinically suspected recurrent breast cancer. One-fifth of patients examined for incidental findings detected on [18F]FDG-PET/CT were diagnosed with clinically relevant conditions. Further examinations of false-positive incidental findings in one of six women should be weighed against the high accuracy for diagnosing metastatic breast cancer.Trial registration Clinical.Trials.gov. NCT03358589. Registered 30 November 2017 —Retrospectively registered,http://www.Clin...
Source: EJNMMI Research - September 22, 2021 Category: Radiology Source Type: research

[123I]MIBG is a better early marker of anthracycline cardiotoxicity than [18F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study
ConclusionThis longitudinal study precises that after doxorubicin treatment, cardiac [123I]MIBG uptake is significantly reduced as early as 2  weeks followed by the decrease of the LV end-diastolic volume and [18F]FDG uptake at 4  weeks and finally by the increase of LV end-systolic volume and decrease of LV ejection fraction at 6 weeks. Cardiac innervation imaging should thus be considered as an early key feature of anthracycline cardiac toxicity. (Source: EJNMMI Research)
Source: EJNMMI Research - September 20, 2021 Category: Radiology Source Type: research

CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [18F]FDG PET, T1 and FLAIR MRI, and CT images available for research
We describe the acquisition parameters, the image processing pipeline and provide participants ’ individual demographics (mean age 38 ± 11.5 years, range 23–65, 20 women). Volumetric analysis of the 37 T1 MRIs showed results in line with the literature. A leave-one-out assessment of the 37 FDG images using Statistical Parametric Mapping (SPM) yielded a low number of false positives after exclusion of artefacts. The database is stored in three different formats, following the BIDS common specification: (1) DICOM (data not processed), (2) NIFTI (multimodal images coregistered to PET subj...
Source: EJNMMI Research - September 16, 2021 Category: Radiology Source Type: research

Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma
AbstractBackgroundInterim [18F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.MethodsInterim scans from 43 patients with anaplastic lymphoma kinase-negative PTCL from the ‘Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas’ trial were re-analyzed by qPET (relating residual lymphoma-related uptake to liver uptake) and ∆SUVmax (relating interim scan to baseline scan). The endpoint was progression-free survival.ResultsqPET and ∆SUVmax were closely correlated (Pearson ’sr&t...
Source: EJNMMI Research - September 14, 2021 Category: Radiology Source Type: research

Assessment of early metabolic progression in melanoma patients under immunotherapy: an 18F-FDG PET/CT study
ConclusionPET/CT, performed already after administration of two ICIs ’ cycles, can identify the majority of non-responders in melanoma immunotherapy. In order to tackle however, the non-negligible phenomenon of pseudoprogression, another follow-up PET/CT, the usage of novel response criteria and vigilance over emergence of radiological irAEs are recommended. Moreov er, the investigation of spleen glucose metabolism may offer further prognostic information in melanoma patients under ICIs. (Source: EJNMMI Research)
Source: EJNMMI Research - September 8, 2021 Category: Radiology Source Type: research

The effects of molar activity on [18F]FDOPA uptake in patients with neuroendocrine tumors
This study aimed to investigate whether the difference in molar activity affects the [18F]FDOPA uptake at physiological sites and in tumor lesions, in patients with NET. It was anticipated that the specific uptake of [18F]FDOPA-H would be equal to or higher than [18F]FDOPA-L.MethodsWe retrospectively analyzed 49 patients with pathologically confirmed NETs and stable disease who underwent PET scanning using both [18F]FDOPA-H and [18F]FDOPA-L within a time span of 5  years. A total of 98 [18F]FDOPA scans (49 [18F]FDOPA-L and 49 [18F]FDOPA-H with average molar activities of 8 and 107  GBq/mmol) were analyzed. The SU...
Source: EJNMMI Research - September 8, 2021 Category: Radiology Source Type: research

A novel read methodology to evaluate the optimal dose of 68Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial
ConclusionsBinary visual reading, which was associated with a low inter-reader variability, has further supported that the optimal administered radioactivity of68Ga-satoreotide trizoxetan was 100 –200 MBq with a peptide mass up to 50 µg.Trial registration ClinicalTrials.gov, NCT03220217. Registered 18 July 2017,https://clinicaltrials.gov/ct2/show/NCT03220217 (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research

Quantitative SPECT/CT parameters of myocardial 99mTechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake in suspected cardiac transthyretin amyloidosis
ConclusionQuantitative SPECT/CT parameters of cardiac Tc-DPD uptake are robust, enabling separation of patients with grades 2 and 3 cardiac uptake from grades 0 and 1. Larger patient cohorts will determine the incremental value of SPECT/CT quantification for ATTR management. (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research

EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases
AbstractInflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. In vivo molecular imaging enables us to study molecular targets and to measure biochemical processes non-invasively and longitudinally, providing information on disease processes and potential therapeutic strategies, e.g. efficacy of...
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research

The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis
ConclusionOur results suggest that an MTV TLR 2.0 on PET/CT reflects pathological N stage in local patients with CRC. (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research

Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted
AbstractCorrelation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is an urgent need to improve histopathological evaluation in animal model-based research to expedite translation into clinical applications. While different other fields of translational science were standardized over the last years, little was done to improve the pipeline of experimental pathology to ensure reproducibility based on pathological expertise in experimental animal models with respect to defined guid...
Source: EJNMMI Research - August 28, 2021 Category: Radiology Source Type: research

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes
ConclusionOur study demonstrates that human megakaryocytes cultured in vitro are capable of MIBG uptake. Moreover, the SSRI citalopram selectively inhibits MIBG uptake via the serotonin transporter. The concomitant administration of citalopram to neuroblastoma patients during [131I]MIBG therapy might be a promising strategy to prevent the onset of thrombocytopenia. (Source: EJNMMI Research)
Source: EJNMMI Research - August 23, 2021 Category: Radiology Source Type: research

Sex correction improves the accuracy of clinical dopamine transporter imaging
ConclusionsA considerable number of elderly healthy male subjects can be interpreted to be dopaminergically abnormal if no sex correction of DAT binding is performed. Sex differences in striatal dopaminergic function should be taken into account when DAT imaging is used to assist clinical diagnostics in patients with suspected neurological disorders. (Source: EJNMMI Research)
Source: EJNMMI Research - August 23, 2021 Category: Radiology Source Type: research

Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review
ConclusionBoth methodologies were useful in the preoperative assessment of patients scheduled for liver interventions, especially in combination, but nuclear imaging demonstrated better predictive value for postoperative mortality and LF in a few trials. The overall technical and methodological heterogeneity of the included studies complicates the ability to directly compare the clinical utility of the two imaging techniques. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

[18F]FDG-PET/CT in prone compared to supine position for optimal axillary staging and treatment in clinically node-positive breast cancer patients with neoadjuvant systemic therapy
AbstractPurposeAxillary staging before neoadjuvant systemic therapy in clinically node-positive breast cancer patients with tailored axillary treatment according to the Marking Axillary lymph nodes with radioactive iodine seeds (MARI)-protocol, a protocol developed at the Netherlands Cancer Institute, is performed with [18F] fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT). We aimed to assess the value of FDG-PET/CT in prone compared to standard supine position for axillary staging.MethodsWe selected patients with FDG-PET/CT in supine and prone position who underwent the MARI-protocol....
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [64/67Cu]Cu-SARTATE
AbstractIn a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [64/67Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblastoma lesions in pediatric patients whose widespread metastases survive initial therapy as minimal residual disease (MRD). MRD may be detected by [64Cu]Cu-SARTATE and subsequently treated by [67Cu]Cu-SARTATE. Since therapeutic dosimetry estimation of the latter agent from the uptake of the former one in the initial diagnostic scan was not addressed, the present theoretical commentary proposes the derivation o...
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging
ConclusionsA PET-based radiomics model using a standardized, multi-centre dataset to predict EFS in locally advanced NSCLC was successfully established and validated with good performance. Prediction models with robust feature preselection were unsuccessful, indicating the need for a standardized imaging protocol. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example
ConclusionThe example for89Zr-trastuzumab illustrates the potential to assess target expression. The pitfall of false-positive findings depends on the cut-off to define clinical target positivity (i.e., IHC 3) and the administered mass dose. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

PSMA-ligand uptake can serve as a novel biomarker in primary prostate cancer to predict outcome after radical prostatectomy
AbstractBackgroundThe prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is increasingly used for primary prostate cancer staging, and the molecular imaging TNM classification (miTNM) standardizes its reporting. We aimed to investigate the potential of PET-imaging to serve as a noninvasive imaging biomarker to predict disease outcome in primary prostate cancer after radical prostatectomy (RP).MethodsIn this retrospective analysis, 186 primary prostate cancer patients treated with...
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients
ConclusionSpleen [68Ga]Pentixafor uptake was not associated with stage of disease and clinical outcomes in solid tumor patients. We identified positively associated platelet and/or leukocyte counts with spleen [68Ga]Pentixafor uptake in neuroendocrine tumors, non-small cell lung cancer and small cell lung cancer, suggesting that splenic CXCR4 expression could possibly play a role in systemic immunity/inflammation in some types of solid tumors or a subgroup of patients within solid tumor entities. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research

Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
ConclusionOur study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively. (Source: EJNMMI Research)
Source: EJNMMI Research - August 16, 2021 Category: Radiology Source Type: research

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors
ConclusionsTo conclude, biodistribution of68Ga-DOTATATE was described with a whole-body PBPK model, where tissue distribution was mainly determined by variability in SSTR2 organ expression and differences in administered peptide amounts. (Source: EJNMMI Research)
Source: EJNMMI Research - August 16, 2021 Category: Radiology Source Type: research

Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease
Conclusions68Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis. (Source: EJNMMI Research)
Source: EJNMMI Research - August 14, 2021 Category: Radiology Source Type: research

[18F]FDG PET/MRI enables early chemotherapy response prediction in pancreatic ductal adenocarcinoma
ConclusionMultiparametric [18F]FDG PET/MRI-derived parameters, in particular indicators of a change in tumor glycolysis and cellularity, may enable very early chemotherapy response prediction. Further prospective studies in larger patient cohorts are recommended to their clinical impact. (Source: EJNMMI Research)
Source: EJNMMI Research - July 28, 2021 Category: Radiology Source Type: research