Head-to-head comparison of image quality between brain 18 F-FDG images recorded with a fully digital versus a last-generation analog PET camera
ConclusionsOn normal brain18F-FDG images and compared with a last-generation analog PET, the fully digital PET camera offers marked improvements in image noise and contrast, as well as significant potential for further enhancing spatial resolution. (Source: EJNMMI Research)
Source: EJNMMI Research - July 12, 2019 Category: Radiology Source Type: research

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [ 18 F]DiFA and comparison with [ 18 F]FMISO
Conclusion[18F]DiFA is well tolerated, and its radiation dose is comparable to those of other hypoxia tracers. [18F]DiFA is very rapidly cleared via the urinary system. [18F]DiFA PET generated comparable images to [18F]FMISO PET in hypoxia imaging with shorter waiting time, demonstrating the promising potential of [18F]DiFA PET for hypoxia imaging and for a multicenter trial. (Source: EJNMMI Research)
Source: EJNMMI Research - July 5, 2019 Category: Radiology Source Type: research

Diagnostic performance of regional cerebral blood flow images derived from dynamic PIB scans in Alzheimer ’s disease
ConclusionrCBF images were suggested to be a good surrogate for FDG scans for diagnostic purposes considering an adjusted threshold value. (Source: EJNMMI Research)
Source: EJNMMI Research - July 4, 2019 Category: Radiology Source Type: research

Repeatability of tumor blood flow quantification with 82 Rubidium PET/CT in prostate cancer  — a test-retest study
ConclusionDynamic82Rb PET/CT with kinetic modeling measures TBF in prostate cancer with high repeatability, which allows identification of blood flow changes of 32%. Static late-uptake82Rb PET/CT is inferior, and only intra-individual blood flow changes above 51% can hence be recognized. (Source: EJNMMI Research)
Source: EJNMMI Research - July 4, 2019 Category: Radiology Source Type: research

Direct comparison of [ 11 C] choline and [ 18 F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients
Conclusions[18F] FET was more accurate than [11C] choline for detecting glioma infiltration. Highest accuracy was found for [18F] FET TBR for the interval 60 –90 min post-injection. (Source: EJNMMI Research)
Source: EJNMMI Research - June 28, 2019 Category: Radiology Source Type: research

Radiation dosimetry of [ 18 F]-PSS232 —a PET radioligand for imaging mGlu5 receptors in humans
Conclusion[18F]-PSS232, a novel [18F]-labeled mGlu5 tracer, showed favorable dosimetry values. Additionally, the tracer was safe and well tolerated. (Source: EJNMMI Research)
Source: EJNMMI Research - June 25, 2019 Category: Radiology Source Type: research

Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis —an animal experimental prospective cohort study
This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18F]FDG-PET/CT and CE-CT) in experimental human xenograft tumors with modifiable vascularization and compared results to histology. Tumor xenografts with modifiable vascularization were established in 71 athymic nude rats by subcutaneous transplantation of human non-small-cell lung cancer (NSCLC) cells. Four different groups were transplanted with two different tumor cell lines (either A549 or H1299) alone or tumors co-...
Source: EJNMMI Research - June 21, 2019 Category: Radiology Source Type: research

Quantification of pulmonary disease activity in sarcoidosis measured with 18 F-FDG PET/CT: SUVmax versus total lung glycolysis
ConclusionSUVmax and TLuG are equal in determining the response to infliximab in pulmonary sarcoidosis patients. Furthermore, SUVmax and TLuG at initiation of infliximab can predict change in lung function after treatment. Since TLuG is a more time-consuming tool, we recommend to use SUVmax of the lung parenchyma for response monitoring in pulmonary sarcoidosis. (Source: EJNMMI Research)
Source: EJNMMI Research - June 13, 2019 Category: Radiology Source Type: research

Internal radiation dosimetry of a 152 Tb-labeled antibody in tumor-bearing mice
ConclusionsMicroPET-based dosimetry of152Tb is feasible, and the comparison with organ harvesting resulted in acceptable dose discrepancies for body districts that can be segmented on CT. These encouraging results warrant additional validation using radiolabeled biomolecules with a different biodistribution pattern. (Source: EJNMMI Research)
Source: EJNMMI Research - June 11, 2019 Category: Radiology Source Type: research

Elimination of tumor hypoxia by eribulin demonstrated by 18 F-FMISO hypoxia imaging in human tumor xenograft models
ConclusionsUsing18F-FMISO, we demonstrated the elimination of the tumor hypoxic condition by eribulin treatment, concomitantly with the increase in microvessel density. These findings indicate that PET imaging using18F-FMISO may provide the possibility to detect the early treatment response in clinical patients undergoing eribulin treatment. (Source: EJNMMI Research)
Source: EJNMMI Research - June 3, 2019 Category: Radiology Source Type: research

Comparison of the radiolabeled PSMA-inhibitor 111 In-PSMA-617 and the radiolabeled GRP-R antagonist 111 In-RM2 in primary prostate cancer samples
ConclusionPSMA and GRP-R based imaging might have complementary performances for the initial characterization of prostatic tumors. Prospective clinical studies comparing the two tracers in this setting are needed. (Source: EJNMMI Research)
Source: EJNMMI Research - June 3, 2019 Category: Radiology Source Type: research

Correlation between 18 F-1-amino-3-fluorocyclobutane-1-carboxylic acid ( 18 F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer
AbstractPurposeTo evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) which is approved for the detection of recurrent PCa.MethodsTwenty-five hormone-na ïve patients with histologically confirmed PCa underwent PET/CT before prostatectomy. Dynamic imaging was performed immediately after injection of 368 ± 10 MBq of18F-fluciclovine and the uptake in PCa was expressed as SUVmax at six sequential 4-min time fram...
Source: EJNMMI Research - May 31, 2019 Category: Radiology Source Type: research

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
AbstractBackgroundPretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfortunately, these systems led to immunogenic responses in patients. The inverse electron demand Diels-Alder (IEDDA) reaction between a radiolabelled tetrazine (Tz) and atrans-cyclooctene (TCO)-functionalized targeting vector is a promising alternative for clinical pretargeted imaging due to its fast reaction kinetics. This strategy w...
Source: EJNMMI Research - May 28, 2019 Category: Radiology Source Type: research

Instant kit preparation of 68 Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [ 68 Ga]Ga-DATA-TOC
Conclusion[68Ga]Ga-DATA-TOC was prepared, to a quality appropriate for in vivo use, following a highly efficient kit type process. Furthermore, the novel radiopharmaceutical was comparable or better than [68Ga]Ga-DOTA-TOC in all preclinical tests, achieving a higher tumour-to-liver contrast in a NET-patient. The results illustrate the potential of the DATA-chelator to facilitate the access to and preparation of68Ga-radiotracers in a routine clinical radiopharmacy setting. (Source: EJNMMI Research)
Source: EJNMMI Research - May 23, 2019 Category: Radiology Source Type: research

PET imaging of hepatocellular carcinoma with anti-1-amino-3-[ 18 F]fluorocyclobutanecarboxylic acid in comparison with l -[ S -methyl- 11 C]methionine
ConclusionBoth [18F]FACBC and [11C]Met showed uptake in HCC through the use of a clinically relevant animal model of woodchuck HCC. The uptake and retention of [18F]FACBC and [11C]Met depend on their metabolism and also rely on the distribution of their principal amino acid transporters. (Source: EJNMMI Research)
Source: EJNMMI Research - May 22, 2019 Category: Radiology Source Type: research

A phase 0 study of the pharmacokinetics, biodistribution, and dosimetry of 188 Re-liposome in patients with metastatic tumors
ConclusionThis phase 0 exploratory IND study shows that nanocarrier188Re-liposome achieves favorable tumor accumulation and tumor to normal organ uptake ratios for a subset of cancer patients. The clinical pharmacokinetic, biodistribution, and dosimetry results justify a further dose-escalating phase 1 clinical trial.Trial registrationTaiwan FDA MA1101G0 (Jan 31, 2012). (Source: EJNMMI Research)
Source: EJNMMI Research - May 22, 2019 Category: Radiology Source Type: research

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans
ConclusionEvaluating the biodistribution of89Zr-AlbudAb in healthy volunteers using a low radioactivity dose was successful (total subject exposure ~  10 mSv). Results indicated rapid formation of reversible, but stable, complexes between AlbudAb and albumin upon dosing.89Zr-AlbudAb demonstrated albumin-like pharmacokinetics, including limited renal elimination. This novel organ-specific distribution data for AlbudAbs in humans will facilitate a better selection of drug targets to prosecute using the AlbudAb platform and significantly contribute to modeling work optimizing dosing of therapeutic AlbudAbs in the ...
Source: EJNMMI Research - May 21, 2019 Category: Radiology Source Type: research

Correction to: 3D skeletal uptake of 18 F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer
Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct. (Source: EJNMMI Research)
Source: EJNMMI Research - May 20, 2019 Category: Radiology Source Type: research

Initial biological evaluations of 18 F-KS1, a novel ascorbate derivative to image oxidative stress in cancer
ConclusionThis work demonstrates the strong preliminary support of18F-KS1, both in vitro and in vivo for imaging ROS in cancer. If successful, this work will provide a new paradigm to directly probe real-time oxidative stress levels in vivo. Our work could enhance precision medicine approaches to treat cancer, as well as neurodegenerative and cardiovascular diseases affected by ROS. (Source: EJNMMI Research)
Source: EJNMMI Research - May 17, 2019 Category: Radiology Source Type: research

Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47 Sc
Conclusions47Sc can be produced via the48Ti( γ,p)47Sc reaction and separated from natural Ti targets with a yield and radiochemical purity suitable for radiolabeling of peptides for in vitro studies. The data in this work supports the potential use of eLINACs for studies of photonuclear production of medical radionuclides and the future development of high-intensity eLINAC facilities capable of producing relevant quantities of carrier-free radionuclides currently inaccessible via routine production pathways or limited due to costly enriched targets. (Source: EJNMMI Research)
Source: EJNMMI Research - May 16, 2019 Category: Radiology Source Type: research

Optimising quantitative 90 Y PET imaging: an investigation into the effects of scan length and Bayesian penalised likelihood reconstruction
This study aimed to quantitatively optimise90Y PET imaging using a new Bayesian penalised likelihood (BPL) reconstruction algorithm (Q.Clear, GE Healthcare). The length of time per bed was also investigated to study its impact on quantification accuracy.MethodsA NEMA IQ phantom with an 8:1 sphere-to-background ratio was scanned overnight on a GE Discovery 710 PET/CT scanner. Datasets were rebinned into varying lengths of time (5 –60 min); the 15-min rebins were reconstructed using BPL reconstruction with a range of noise penalisation weighting factors (beta values). The metrics of contrast recovery (CR), backgro...
Source: EJNMMI Research - May 10, 2019 Category: Radiology Source Type: research

99m Tc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study
Conclusion99mTc-HYNIC-IL-2 scintigraphy proved to be a good technique to detect grade 2 and 3 acute rejection in a small sample population of patients after lung transplantation. Larger studies are necessary to really show the added value of this non-invasive specific imaging technique over transbronchial biopsy. Alternatively, imaging with the PET tracer18F-IL-2 may be useful for this purpose. (Source: EJNMMI Research)
Source: EJNMMI Research - May 10, 2019 Category: Radiology Source Type: research

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation
ConclusionsThese results demonstrated that cessation of anti-VLA-4 mAb treatment for 4  days caused a transient rebound increase in neuroinflammation. This highlights the usefulness of serial TSPO imaging in thefDTH-EAE model to better understand the rebound phenomenon. (Source: EJNMMI Research)
Source: EJNMMI Research - May 9, 2019 Category: Radiology Source Type: research

[ 18 F]FMISO PET/CT as a preoperative prognostic factor in patients with pancreatic cancer
Conclusions[18F]FMISO PET/CT has the possibility to be a preoperative prognostic factor in patients with pancreatic cancer. (Source: EJNMMI Research)
Source: EJNMMI Research - May 9, 2019 Category: Radiology Source Type: research

Diagnostic performance of the specific uptake size index for semi-quantitative analysis of I-123-FP-CIT SPECT: harmonized multi-center research setting versus typical clinical single-camera setting
ConclusionsThe SUSI is particularly useful in MULTI settings. SPECT images should be stereotactically normalized prior to SUSI analysis. The putaminal SUSI provides better diagnostic performance than the SUSI of the whole striatum. Errors of the estimate of non-displaceable count density in the reference region can cause misclassification by both SUSI and SBR, particularly in borderline cases. These cases might be identified by visual checking FP-CIT uptake in the reference region for particularly high variability. (Source: EJNMMI Research)
Source: EJNMMI Research - May 7, 2019 Category: Radiology Source Type: research

A comparative study of standardized quantitative and visual assessment for predicting tumor volume and outcome in newly diagnosed diffuse large B-cell lymphoma staged with 18F-FDG PET/CT
ConclusionPredictions of outcome after first-line treatment for DLBCL were surprisingly good when left to the unsupervised, subjective judgment of experienced readers of lymphoma 18F-FDG-PET/CT. The study highlights the importance of non-standardized clinical judgments and shows potential loss of valuable prognostic information when relying solely on semi-automated MTV measurements. (Source: EJNMMI Research)
Source: EJNMMI Research - May 3, 2019 Category: Radiology Source Type: research

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines
(Source: EJNMMI Research)
Source: EJNMMI Research - April 16, 2019 Category: Radiology Source Type: research

Intratumoral 18 F-FLT infusion in metabolic targeted radiotherapy
ConclusionConsidering the biochemical stability of18F-FLT and the physical properties of localized18F, this study shows that TRT via intratumoral infusion of18F-FLT and 5FU could provide a new effective treatment option for solid tumors. Using this approach in a colorectal tumor model, the tumor and its metastases could be efficiently irradiated locally with much lower doses absorbed by healthy tissues than withi.t. administration of18F-FDG or conventional EBRT. (Source: EJNMMI Research)
Source: EJNMMI Research - April 11, 2019 Category: Radiology Source Type: research

Determination of a pharmacokinetic model for [ 11 C]-acetate in brown adipose tissue
ConclusionFor healthy men, a three-tissue model with four kinetic parameters, similar to a heart [11C]-palmitate model seems the most appropriate based on model stability and its ability to describe the main [11C]-acetate pathways in BAT cells. Further studies are required to validate this model in women and people with metabolic disorders. (Source: EJNMMI Research)
Source: EJNMMI Research - March 27, 2019 Category: Radiology Source Type: research

Optimized dual-time-window protocols for quantitative [ 18 F]flutemetamol and [ 18 F]florbetaben PET studies
ConclusionsThe length of the interval inversely correlates with the accuracy of the BPND estimates. Consequently, a dual-time-window protocol of 0 –30 and 90–110 min (=maximum of 60 min interval) allows for accurate estimation of BPND values for both tracers.[18F]flutemetamol: EudraCT 2007-000784-19, registered 8 February 2007, [18F]florbetaben: EudraCT 2006-003882-15, registered 2006. (Source: EJNMMI Research)
Source: EJNMMI Research - March 27, 2019 Category: Radiology Source Type: research

Correction to: Comparison of three-parameter kinetic model analysis to standard Patlak ’s analysis in 18 F-FDG PET imaging of lung cancer patients
Following publication of the original article [1], the authors flagged that the author affiliations detailed in the article are incorrect for the authors M. L. Calcagni and A. Giordano. (Source: EJNMMI Research)
Source: EJNMMI Research - March 26, 2019 Category: Radiology Source Type: research

An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [ 18 F]FDG PET/CT  —the inference from a juvenile porcine model
AbstractPurposeTo examine parameters affecting the detection of osteomyelitis (OM) by [18F]FDG PET/CT and to reduce tracer activity in a pig model.Background[18F]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Early diagnosis and initiation of therapy are therefore essential. We have previously demonstrated that [18F]FDG PET/CT is promising in juvenileStaphylococcus aureus (S. aureus) OM of peripheral bones in a pig model, not failing even small lesions. When using imaging in children, radia...
Source: EJNMMI Research - March 22, 2019 Category: Radiology Source Type: research

Transcriptional effects of 177 Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice
AbstractBackground177Lu-octreotate is used for therapy of somatostatin receptor expressing neuroendocrine tumors with promising results, although complete tumor remission is rarely seen. Previous studies on nude mice bearing the human small intestine neuroendocrine tumor, GOT1, have shown that a priming injection of177Lu-octreotate 24  h before the main injection of177Lu-octreotate resulted in higher177Lu concentration in tumor, resulting in increased absorbed dose, volume reduction, and time to regrowth. To our knowledge, the cellular effects of a priming treatment schedule have not yet been studied. The aim of thi...
Source: EJNMMI Research - March 20, 2019 Category: Radiology Source Type: research

No significant difference found in PET/MRI CBF values reconstructed with CT-atlas-based and ZTE MR attenuation correction
ConclusionThe CBF images from AB- and ZTE-MRAC reconstruction showed no significant differences in regional values, although the parietal region tended to show greater values in AB-MRAC reconstruction. Quantitative values in the skull base region were very close, and almost the same IDIFs were obtained. (Source: EJNMMI Research)
Source: EJNMMI Research - March 19, 2019 Category: Radiology Source Type: research

Bone SPECT-based segmented attenuation correction for quantitative analysis of bone metastasis (B-SAC): comparison with CT-based attenuation correction
ConclusionsThe results of this preliminary study suggest the potential for B-SAC to improve the quantitation of bone metastases in bone SPECT when X-ray CT or transmission CT data are not available. Considering the small but unignorable differences of lesional SUVs between CTAC and B-SAC, SUVs obtained with the current version of B-SAC seem difficult to be directly compared with those obtained with CTAC. (Source: EJNMMI Research)
Source: EJNMMI Research - March 19, 2019 Category: Radiology Source Type: research

HYNIC and DOMA conjugated radiolabeled bombesin analogs as receptor-targeted probes for scintigraphic detection of breast tumor
ConclusionConsidering its most improved pharmacological characteristics, BN4 is thus considered as most promising probes for early non-invasive diagnosis of GRP receptor-positive breast tumors. (Source: EJNMMI Research)
Source: EJNMMI Research - March 18, 2019 Category: Radiology Source Type: research

Optimal respiratory-gated [ 18 F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma
ConclusionsCorrection for respiratory motion artifacts using ORG impacts the quantification of metabolic parameters in PDAC lesions. The correlation of metabolic parameters with OS was significantly affected, in particular parameters that describe intra-tumor heterogeneity. Therefore, interpretation of single-voxel or average metabolic parameters in relation to clinical outcome should be done cautiously. Furthermore, ORG is a valuable tool to improve quantification of intra-tumoral heterogeneity in PDAC. (Source: EJNMMI Research)
Source: EJNMMI Research - March 13, 2019 Category: Radiology Source Type: research

Interobserver variability of image-derived arterial blood SUV in whole-body FDG PET
ConclusionThe present investigation demonstrates that the image-based manual determination of BSUV in the aorta is sufficiently reproducible across different observers and delineation tools which is a prerequisite for accurate SUR determination. This finding is in line with the already demonstrated superior prognostic value of SUR in comparison to SUV in the first clinical studies. (Source: EJNMMI Research)
Source: EJNMMI Research - March 4, 2019 Category: Radiology Source Type: research

High-speed scanning of planar images showing 123 I-MIBG uptake using a whole-body CZT camera: a phantom and clinical study
ConclusionsIn planar images with a whole-body CZT-based camera, the HMRs of patients with LBD were significantly lower than those without. HMRs with the collection time of 50  s and longer showed good consistency with those of 300 s in the ICC analysis. These findings indicate a clinical utility of this novel scanner for HMR measurements and potential time reductions. (Source: EJNMMI Research)
Source: EJNMMI Research - February 26, 2019 Category: Radiology Source Type: research

Diffusion-weighted magnetic resonance imaging using a preclinical 1  T PET/MRI in healthy and tumor-bearing rats
AbstractBackgroundHybrid positron emission tomography and magnetic resonance imaging (PET/MRI) scanners are increasingly used for both clinical and preclinical imaging. Especially functional MRI sequences such as diffusion-weighted imaging (DWI) are of great interest as they provide information on a molecular level, thus, can be used as surrogate biomarkers. Due to technical restrictions, MR sequences need to be adapted for each system to perform reliable imaging. There is, to our knowledge, no suitable DWI protocol for 1  Tesla PET/MRI scanners. We aimed to establish such DWI protocol with focus on the choice ofb val...
Source: EJNMMI Research - February 22, 2019 Category: Radiology Source Type: research

223 Ra-dichloride therapy of bone metastasis: optimization of SPECT images for quantification
ConclusionsAbsolute quantitative223Ra SPECT imaging appears feasible once the dimension of the target is determined. Further evaluation should be needed to apply the calibration factor-based quantitation to clinical223Ra SPECT/CT imaging. This will open the possibility for patient-specific223Ra treatment planning and therapeutic outcome prediction in patients. (Source: EJNMMI Research)
Source: EJNMMI Research - February 21, 2019 Category: Radiology Source Type: research

Multi-modal image analysis for semi-automatic segmentation of the total liver and liver arterial perfusion territories for radioembolization
ConclusionThis methodology can be used for pre-treatment dosimetry and for SIRT planning including the determination of the activity that should be administered to achieve the therapeutical goal. The inclusion of perfusion CBCT enables perfusion-based definition of the liver lobes, which was shown to be markedly different from the anatomical definition in some of the patients. (Source: EJNMMI Research)
Source: EJNMMI Research - February 20, 2019 Category: Radiology Source Type: research

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death
AbstractPurposeWe have previously developed the caspase-based radiotracer,18F-ICMT-11, for PET imaging to monitor treatment response. We further validated18F-ICMT-11 specificity in a murine melanoma death-switch tumour model with conditional activation of caspase-3 induced by doxycycline.MethodsCaspase-3/7 activity and cellular uptake of18F-ICMT-11,18F-ML-10 and18F-FDG were assessed in B16ova and B16ovaRevC3 cells after death-switch induction.Death-switch induction was confirmed in vivo in xenograft tumours, and18F-ICMT-11 and18F-ML-10 biodistribution was assessed byex vivo gamma counting of select tissues. PET imaging was...
Source: EJNMMI Research - February 19, 2019 Category: Radiology Source Type: research

First-in-class positron emission tomography tracer for the glucagon receptor
Conclusion[68Ga]Ga-DO3A-S01-GCG thus constitutes a first-in-class PET tracer targeting the GCG receptor, with suitable properties for clinical development. This tool has potential to provide direct quantitative evidence of GCG receptor occupancy in humans. (Source: EJNMMI Research)
Source: EJNMMI Research - February 15, 2019 Category: Radiology Source Type: research

18 F-FLT PET/MRI for bone marrow failure syndrome-initial experience
Conclusion18F-FLT PET can be used to noninvasively assess whole-body bone marrow proliferative activity and DWI may reflect the different aspects of bone marrow pathophysiology from18F-FLT PET.18F-FLT PET/MRI is useful for the diagnosis and monitoring of BMFS, except for the differentiation between non-severe AA and hypo-MDS, and the prediction of progression to leukemia. (Source: EJNMMI Research)
Source: EJNMMI Research - February 15, 2019 Category: Radiology Source Type: research

Personalised insulin calculator enables safe and effective correction of hyperglycaemia prior to FDG PET/CT
AbstractBackgroundHyperglycaemia can influence18F-fluorodeoxyglucose (FDG) uptake due to competition for glucose transport and phosphorylation by hexokinase. Major international nuclear medicine societies recommend blood glucose level (BGL)  10 mmol/L) prior to FDG PET/CT at the Peter MacCallum Cancer Centre over a 2-year period. Cohort 1 comprised a 12-month period (April 1, 2014–March 31, 2015) using the department’s established empiric-dose insulin protocol, and Cohort 2 the 12 months (April 1, 2015–March 31, 2016) followi ng introduction of a personalised insulin calculator protocol. ...
Source: EJNMMI Research - February 8, 2019 Category: Radiology Source Type: research

Repeatability of [ 18 F]FDG PET/CT total metabolic active tumour volume and total tumour burden in NSCLC patients
ConclusionsThis study suggests that under some circumstances TMATV and TTB repeatability are significantly affected by the lesion delineation method used. Performing the delineation with a majority vote approach improves reliability and does not hamper repeatability, regardless of acquisition and reconstruction settings. It is therefore concluded that by using a majority vote based tumour segmentation approach, TMATV and TTB in NSCLC patients can be measured with high reliability and precision. (Source: EJNMMI Research)
Source: EJNMMI Research - February 7, 2019 Category: Radiology Source Type: research

Concomitant 177 Lu-DOTATATE and capecitabine therapy in malignant paragangliomas
ConclusionsOur data confirm that177Lu-DOTATATE-capecitabine therapy is effective in achieving an objective response in 28% and symptomatic response in 43% patients. In comparison to published PRRT monotherapy outcomes in PGL, we did not observe any great advantage of concomitant therapy; however, it could be due to under-powered study. We recommend a large randomized trial to prove or disprove the utility of capecitabine as a radiosensitizer for PRRT in PGL patients. (Source: EJNMMI Research)
Source: EJNMMI Research - February 6, 2019 Category: Radiology Source Type: research

Partial-volume correction in dynamic PET-CT: effect on tumor kinetic parameter estimation and validation of simplified metrics
AbstractBackgroundPartial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) for accurate quantification. However, investigation of PVC in dynamic oncological PET studies to date is scarce. The aim of this study was to investigate PVC ’s impact on tumor kinetic parameter estimation from dynamic PET-CT acquisitions and subsequent validation of simplified semi-quantitative metrics. Ten patients with EGFR-mutated non-small cell lung cancer underwent dynamic18F-fluorothymidine PET-CT before, 7  days after, and 28&nbs...
Source: EJNMMI Research - February 4, 2019 Category: Radiology Source Type: research

Phase analysis single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) detects dyssynchrony in myocardial scar and increases specificity of MPI
ConclusionThe use of PA entropy significantly improved the specificity of SPECT MPI and could influence the labeling of a patient as having or not having myocardial scar and thereby may influence not only diagnostic reporting but also potentially prognostic determination and therapeutic decision-making. (Source: EJNMMI Research)
Source: EJNMMI Research - January 31, 2019 Category: Radiology Source Type: research