The joint use of 99m Tc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning
ConclusionThe joint use of99mTc-MAA-SPECT/CT and CBCT optimizes dosimetric planning for RE procedures, enabling a more accurate personalized approach. (Source: EJNMMI Research)
Source: EJNMMI Research - March 4, 2021 Category: Radiology Source Type: research

99m Tc-labelled PSMA ligand for radio-guided surgery in nodal metastatic prostate cancer: proof of principle
AbstractPurposeIntraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier we demonstrated excellent performance of the111In-labelled PSMA ligand DKFZ-617 ([111In]In-PSMA-617) in RGS for ex situ distinction of LN vs LNM at lymphadenectomy (LA) at a single LN level. In comparison with indium-111, technetium-99m has better physical properties for γ-probe measurements, better availability and lower radiation exposure for patients and medical personnel. Against this b...
Source: EJNMMI Research - March 4, 2021 Category: Radiology Source Type: research

Evaluation of [ 68 Ga]Ga-PSMA PET/CT images acquired with a reduced scan time duration in prostate cancer patients using the digital biograph vision
ConclusionsHigh agreement at 3.5-fold reduction of scan time in terms of per-region detection (98% of regions) and image quantification (mean deviation  ≤ 10%) was demonstrated; however, small lesions can be missed in about 10% of patients leading to downstaging (T1N0M0 instead of T1N1M0) in 5% of patients. Our results suggest that a reduction of scan time duration or administered [68Ga]Ga-PSMA-11 activities can be considered in metastatic patients, where missing small lesions would not impact patient management. Limitations include the small and heterogeneous sample size and the lack of follow-up. (Source: EJNMMI Research)
Source: EJNMMI Research - February 28, 2021 Category: Radiology Source Type: research

Preoperative prediction of pathological grade in pancreatic ductal adenocarcinoma based on 18 F-FDG PET/CT radiomics
ConclusionThe model developed is capable of predicting pathological differentiation grade of PDAC based on preoperative18F-FDG PET/CT radiomics features. (Source: EJNMMI Research)
Source: EJNMMI Research - February 25, 2021 Category: Radiology Source Type: research

Detection and therapy of neuroblastoma minimal residual disease using [ 64/67 Cu]Cu-SARTATE in a preclinical model of hepatic metastases
ConclusionsClinical experiences of peptide-receptor radionuclide therapy for metastatic disease have been encouraging. This study demonstrates the potential for a theranostic approach using [64/67Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblastoma MRD. (Source: EJNMMI Research)
Source: EJNMMI Research - February 25, 2021 Category: Radiology Source Type: research

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review
ConclusionWhile publications on FAP-specific PET for non-malignant indications are mostly limited to case reports and incidental findings, the first retrospective and prospective studies present promising results for IgG4-related as well as cardiovascular disease that warrant further research. Several currently recruiting trials will add to the body evidence in the next few years. (Source: EJNMMI Research)
Source: EJNMMI Research - February 19, 2021 Category: Radiology Source Type: research

Yttrium-90 radioembolization of isolated hepatic adrenocortical carcinoma metastases with negative surgical pathology
ConclusionsThis case continues to add to the literature supporting90Y radioembolization as an effective treatment for isolated hepatic ACC metastases. Our case is the first to demonstrate surgically proven negative pathology after radioembolization. Further prospective study is warranted to better establish efficacy as well as safety of SIRT for ACC liver metastases. (Source: EJNMMI Research)
Source: EJNMMI Research - February 18, 2021 Category: Radiology Source Type: research

Comparison of 6-[ 18 F]FDOPA PET with Nigrosome 1 detection in patients with parkinsonism
Conclusions6-[18F]FDOPA PET and Nigrosome 1 evaluation had an overall good intermodality agreement. Diagnostic agreement was very good in cases of clinically suspected idiopathic Parkinson syndrome and fair in atypical parkinsonian syndromes, but poor in patients with non-parkinsonian disorders. 6-[18F]FDOPA PET showed higher sensitivity, specificity and accuracy in discriminating parkinsonian syndromes from non-parkinsonian disorders than the N1 evaluation. In summary, the additional benefit of N1 assessment in patients with APS or parkinsonism without dopaminergic deficit needs to be proven by prospective studies. (Source: EJNMMI Research)
Source: EJNMMI Research - February 15, 2021 Category: Radiology Source Type: research

Quantitation of cancer treatment response by 2-[ 18 F]FDG PET/CT: multi-center assessment of measurement variability using AUTO-PERCIST ™
ConclusionQuantitative tumor [18F]FDG SULpeak changes measured across multiple global sites and readers utilizing Auto-PERCIST ™ show very high correlation. Harmonization of methods to single software, Auto-PERCIST™, resulted in virtually identical extraction of quantitative tumor response data from [18F]FDG PET images when the readers select the same target tumor. (Source: EJNMMI Research)
Source: EJNMMI Research - February 12, 2021 Category: Radiology Source Type: research

Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA
ConclusionsThe strong organ selectivity and high target-to-background acquisition of NIS-RNA lipoplexes indicate the feasibility of small animal PET/MRI to quantify organ-specific delivery of RNA. (Source: EJNMMI Research)
Source: EJNMMI Research - February 10, 2021 Category: Radiology Source Type: research

Interim 4 ′-[methyl- 11 C]-thiothymidine PET for predicting the chemoradiotherapeutic response in head and neck squamous cell carcinoma: comparison with [ 18 F]FDG PET
AbstractPurposeWe investigated the potential of interim 4 ′-[methyl-11C]thiothymidine ([11C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET.MethodsA total of 32 patients with HNSCC who underwent both [11C]4DST and [18F]FDG PET/CT before therapy (baseline) and at approximately 40  Gy point during chemoradiotherapy (interim) were available for a retrospective analysis of prospectively collected data. The baseline was treatment-naïve PET/CT scan as part of staging. The maximum standa...
Source: EJNMMI Research - February 10, 2021 Category: Radiology Source Type: research

Potential synergy between PSMA uptake and tumour blood flow for prediction of human prostate cancer aggressiveness
AbstractBackgroundBoth prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressiveness. The aim of the present study was to evaluate the potential synergistic benefit of combining the two physiologic parameters for separating significant PCa from insignificant findings.MethodsFrom previous studies of [82Rb]Rb positron emission tomography (PET) TBF in PCa, the 43 patients that underwent clinical [68Ga]Ga-PSMA-11 PET were selected for this retrospective study. Tumours were delineate...
Source: EJNMMI Research - February 9, 2021 Category: Radiology Source Type: research

A PSMA-targeted theranostic approach is unlikely to be efficient in serous ovarian cancers
ConclusionThe present work demonstrates that PSMA expression is negligible and a fortiori non-sufficient to ensure its usefulness as a prognosticator or a target for a theranostic strategy in ovarian cancers. (Source: EJNMMI Research)
Source: EJNMMI Research - February 9, 2021 Category: Radiology Source Type: research

Increased [ 18 F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors
In this study, we evaluated whether MRP1 activity affected [18F]FMISO PET imaging.MethodsFaDu human pharyngeal squamous cell carcinoma cells were pretreated with MRP1 inhibitors (cyclosporine A, lapatinib, or MK-571) for 1  h, incubated with [18F]FMISO for 4  h under hypoxia, and their radioactivity was then measured. FaDu tumor-bearing mice were intravenously injected with [18F]FMISO, and PET/CT images were acquired at 4  h post-injection (1st PET scan). Two days later, the same mice were pretreated with MRP1 inhibitors (cyclosporine A, lapatinib, or MK-571) for 1 h, and PET/CT images were acquired (2n...
Source: EJNMMI Research - January 25, 2021 Category: Radiology Source Type: research

Preliminary study of AI-assisted diagnosis using FDG-PET/CT for axillary lymph node metastasis in patients with breast cancer
ConclusionsIt is expected that AI using deep-learning technologies will be useful in diagnosing axillary LN metastasis using 2-[18F]FDG-PET/CT. Even if the diagnostic performance of AI is not better than that of clinicians, taking AI diagnoses into consideration may positively impact the overall diagnostic accuracy. (Source: EJNMMI Research)
Source: EJNMMI Research - January 25, 2021 Category: Radiology Source Type: research

A preliminary clinical trial to evaluate 64 Cu-NOTA-Trastuzumab as a positron emission tomography imaging agent in patients with breast cancer
Conclusions64Cu-NOTA-Trastuzumab showed a specific uptake at the HER2-expressing tumors, thus making it a feasible and safe monitoring tool of HER2 tumor status in patients with breast cancer.Trial registrationCRIS, KCT0002790. Registered 02 February 2018,https://cris.nih.go.kr (Source: EJNMMI Research)
Source: EJNMMI Research - January 21, 2021 Category: Radiology Source Type: research

Nanobody: a promising toolkit for molecular imaging and disease therapy
AbstractNanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseases. As imaging tracers, nanobodies allow an early acquisition of high-quality images, provide a comprehensive evaluation of the disease, and subsequently enable a personalized precision therapy. As therapeutic agents, nanobodies enable a targeted therapy by lesion-specific delivery of drugs and effecto...
Source: EJNMMI Research - January 19, 2021 Category: Radiology Source Type: research

Comparison of metabolic and functional parameters using cardiac 18F-FDG-PET in early to mid-adulthood male and female mice
ConclusionIn this study of serial cardiac PET scans, we provide insight for basic murine research models, showing that mice gender and age show distinct cardiac metabolisms. These physiologic alterations need to be considered when planning in vivo injury models to avoid potential pitfalls. (Source: EJNMMI Research)
Source: EJNMMI Research - January 19, 2021 Category: Radiology Source Type: research

The role of [ 68  Ga]Ga-DOTATATE PET/CT in wild-type KIT / PDGFRA gastrointestinal stromal tumours (GIST)
ConclusionsOur data suggest that SSTR2 is not a diagnostic or therapeutic target in wtGIST. [68 Ga]Ga-DOTATATE PET/CT may have specific diagnostic utility in differentiating wtGIST from other primary tumours such as paraganglioma in patients with sporadic and hereditary forms of wtGIST. (Source: EJNMMI Research)
Source: EJNMMI Research - January 14, 2021 Category: Radiology Source Type: research

The significance of equivocal bone findings in staging PSMA imaging in the preoperative setting: validation of the PSMA-RADS version 1.0
ConclusionsIn intermediate and high-risk patients staged prior to radical prostatectomy, the majority of PSMA-RADS 3B lesions are of no clinical relevance. Bone lesions judged as being highly suspicious for metastases (PSMA-RADS 4/5) were all validated as true positives. (Source: EJNMMI Research)
Source: EJNMMI Research - January 6, 2021 Category: Radiology Source Type: research

Repeatability of two semi-automatic artificial intelligence approaches for tumor segmentation in PET
ConclusionThe semi-automatic AI-based segmentation approaches used in this study provided better repeatability than conventional segmentation approaches. Moreover, both algorithms lead to accurate segmentations for both primary tumors as well as metastasis and are therefore good candidates for PET tumor segmentation. (Source: EJNMMI Research)
Source: EJNMMI Research - January 6, 2021 Category: Radiology Source Type: research

Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [ 18 F]DCFPyL-PET: comparison to [ 18 F]fluorocholine-PET
ConclusionsDIL was detected with good sensitivity and specificity using 22-min dynamic [18F]DCFPyL PET and avoids the need for delayed post-injection imaging timepoints. The dissimilar in vivo kinetic behaviour of [18F]DCFPyL and [18F]FCH could explain their different SUV images.Clinical Trial Registration NCT04009174 (ClinicalTrials.gov). (Source: EJNMMI Research)
Source: EJNMMI Research - January 4, 2021 Category: Radiology Source Type: research

Clinical implementation of PLANET ® Dose for dosimetric assessment after [ 177 Lu]Lu-DOTA-TATE: comparison with Dosimetry Toolkit® and OLINDA/EXM® V1.0
ConclusionsThe ADs to organs at risk obtained with the new workstation PLANET ® Dose are concordant with those calculated with the currently used software and in agreement with the literature. These results validate the use of PLANET® Dose in clinical routine for patient dosimetry after targeted radiotherapy with [177Lu]Lu-DOTA-TATE. (Source: EJNMMI Research)
Source: EJNMMI Research - January 4, 2021 Category: Radiology Source Type: research

Evaluation of image quality with four positron emitters and three preclinical PET/CT systems
ConclusionsThe systems performed most optimal in terms of NEMA image quality parameters when using18F, where11C and89Zr performed slightly worse than18F. The performance was least optimal when using68Ga, due to large positron range. The large quantification differences prompt optimization not only by terms of image quality but also quantification. Further investigation should be performed to find an appropriate calibration and harmonization protocol and the evaluation should be conducted on a multi-scanner and multi-center level. (Source: EJNMMI Research)
Source: EJNMMI Research - December 10, 2020 Category: Radiology Source Type: research

FLT-PET for the assessment of systemic sarcoidosis including cardiac and CNS involvement: a prospective study with comparison to FDG-PET
AbstractBackground2-deoxy-2-[18F]fluoro-d-glucose ’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for patients and lead to incomplete cardiac suppression in many cases. Furthermore, FDG PET is limited in the detection of n eurosarcoidosis due to an inability to suppress high level of physiological uptake within the brain. 3′-deoxy-3′-[18F]fluorothymidine (FLT) has been shown to accumulate in sarcoidosis lesions and this tracer lacks significant physiological myocardial and brain up...
Source: EJNMMI Research - December 10, 2020 Category: Radiology Source Type: research

Disease activity and response to therapy monitored by [ 18 F]FDG PET/CT using volume-based indices in IgG4-related disease
AbstractPurposeThe efficiency of [18F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).MethodsA total of 17 patients with IgG4-RD were examined with [18F]FDG PET/CT before and during treatment. The lesion boundary was determined using a fixed threshold of standardized uptake value (SUV) ≥ 2.5. The highest maximum SUV (SUVmax) among all affected lesions was calculated for individual patients. We summed metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of each affected lesion to genera...
Source: EJNMMI Research - December 9, 2020 Category: Radiology Source Type: research

18 F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography
ConclusionThe rapid clearance of18F-C2Am from the blood pool and low kidney retention allowed the spatial distribution of cell death in a tumor to be imaged during the course of therapy, providing a rapid assessment of tumor treatment response.18F-C2Am has the potential to be used in the clinic to assess early treatment response in tumors. (Source: EJNMMI Research)
Source: EJNMMI Research - December 9, 2020 Category: Radiology Source Type: research

Relationship between tumor mutational burden and maximum standardized uptake value in 2-[ 18 F]FDG PET (positron emission tomography) scan in cancer patients
We report the relationship between TMB and SUVmax, linking these two important parameters.MethodsIn this pilot study, we analyzed 1923 patients with diverse cancers and available TMB values. Overall, 273 patients met our eligibility criteria in that they had no systemic treatment prior to imaging/biopsy, and also had 2-[18F]FDG PET/CT within 6  months prior to the tissue biopsy, to ensure acceptable temporal correlation between imaging and genomic evaluation.ResultsWe found a linear correlation between TMB and SUVmax (p 
Source: EJNMMI Research - December 9, 2020 Category: Radiology Source Type: research

Application of the PET ligand [ 11 C]ORM-13070 to examine receptor occupancy by the α 2C -adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain
ConclusionsORM-12741 is a selective α2C-AR antagonist which penetrates the rat and human brain to occupy α2C-ARs in a manner consistent with its receptor pharmacology.Trialregistrationnumberanddateofregistration: ClinicalTrial.cov NCT00829907. Registered 11 December 2008.https://clinicaltrials.gov/. (Source: EJNMMI Research)
Source: EJNMMI Research - December 9, 2020 Category: Radiology Source Type: research

Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease
AbstractObjectiveExpression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity of the second-generation TSPO PET radioligand, [11C]PBR28, and to generate simplified PET protocols in patients with inflammatory joint disease (IJD) in this pilot study.MethodsThree IJD patients (two rheumatoid arthritis and one osteoarthritis) with knee involvement underwent dynamic [11C]PBR28-PET scans before and after administration of 90  mg of oral emapunil (XBD-173), a TSPO ligand the sam...
Source: EJNMMI Research - December 7, 2020 Category: Radiology Source Type: research

Preclinical comparison of four [ 18 F, nat Ga]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics
Conclusion[18F,natGa]rhPSMA-7.3 has been selected as a lead compound for clinical development of a [18F]rhPSMA-based candidate. The intraindividual differential uptake and excretion analysis in vivo allowed for an accurate comparison and assessment of radiopharmaceuticals. (Source: EJNMMI Research)
Source: EJNMMI Research - December 7, 2020 Category: Radiology Source Type: research

[ 18 F]-Fluciclovine PET discrimination of recurrent intracranial metastatic disease from radiation necrosis
ConclusionsFluciclovine PET may play an important role in distinguishing active intracranial metastatic lesions from radiation necrosis in patients previously treated with SRS but needs to be validated in larger studies. (Source: EJNMMI Research)
Source: EJNMMI Research - December 7, 2020 Category: Radiology Source Type: research

Evaluation of [ 13 N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain
ConclusionThe [13N]ammonia PET method was unable to reliably estimate GS activity in the human brain but may provide an alternative index of CBF. (Source: EJNMMI Research)
Source: EJNMMI Research - December 3, 2020 Category: Radiology Source Type: research

Inter- and intraobserver agreement of the quantitative assessment of [ 99m Tc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer
ConclusionGood to excellent inter- and intraobserver agreement of the quantitative assessment of [99mTc]NM-01 SPECT/CT in NSCLC was demonstrated in this study, including T:BP which has been shown to correlate with PD-L1 status. [99mTc]NM-01 SPECT/CT has the potential to reliably and non-invasively assess PD-L1 expression.Clinical trial registrationClinicalTrials.gov identifier no. NCT02978196. Registered 30th November 2016. (Source: EJNMMI Research)
Source: EJNMMI Research - December 1, 2020 Category: Radiology Source Type: research

Clinical impact of digital and conventional PET control databases for semi-quantitative analysis of brain 18 F-FDG digital PET scans
AbstractPurposeDigital PET cameras markedly improve sensitivity and spatial resolution of brain18F-FDG PET images compared to conventional cameras. Our study aimed to assess whether specific control databases are required to improve the diagnostic performance of these recent advances.MethodsWe retrospectively selected two groups of subjects, twenty-seven Alzheimer's Disease (AD) patients and twenty-two healthy control (HC) subjects. All subjects underwent a brain18F-FDG PET on a digital camera (Vereos, Philips ®). These two group (AD and HC) are compared, using a Semi-Quantitative Analysis (SQA), to two age and sex mat...
Source: EJNMMI Research - November 30, 2020 Category: Radiology Source Type: research

18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy
ConclusionWe studied in vivo18F-Fluciclovine uptake in human prostate cancer orthograft models following acute and chronic ADT.18F-Fluciclovine uptakes highlight tumour heterogeneity that may explain castration resistance and can be exploited as a clinical biomarker. (Source: EJNMMI Research)
Source: EJNMMI Research - November 25, 2020 Category: Radiology Source Type: research

Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography
ConclusionTLC coupled with autoradiography is a good alternative to high-performance liquid chromatography for radio-metabolite correction. The advantages of requiring only small blood samples (~  100 μL) and of analyzing multiple samples simultaneously, make the method suitable for individual dynamic PET studies. (Source: EJNMMI Research)
Source: EJNMMI Research - November 23, 2020 Category: Radiology Source Type: research

KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver
ConclusionThe correlations observed after applying the described corrections show potential for assigning probabilities for theKRAS missense mutation status in CLM using 2-[18F]FDG PET images. (Source: EJNMMI Research)
Source: EJNMMI Research - November 23, 2020 Category: Radiology Source Type: research

Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [ 11 C]UCB-J PET study in a model of obsessive –compulsive disorder-like behaviour
AbstractBackgroundCurrently, the  evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) provides the opportunity to visualize synaptic density changes in vivo, by targeting the synaptic vesicle protein 2A (SV2A). Here, we aim to evaluate such alterations in the brain of the SAP90/PSD-95-associated protein 3 (Sapap3) knockout (ko) mouse model, showing an abnormal ...
Source: EJNMMI Research - November 13, 2020 Category: Radiology Source Type: research

Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients
ConclusionsFreehand SPECT using a prototype SiPM-based gamma camera demonstrates high sensitivity for detection of SLNs in a preoperative setting. Camera fhSPECT is a potential means for efficiently obtaining real-time 3D activity distribution maps in applications such as image-guided percutaneous biopsy, and surgical SLN biopsy or radioguided tumor excision. (Source: EJNMMI Research)
Source: EJNMMI Research - November 11, 2020 Category: Radiology Source Type: research

The value of 18 F-PSMA-1007 PET/CT in identifying non-metastatic high-risk prostate cancer
In this study, we aimed to investigate the value of18F-PSMA-1007 in identifying non-metastatic high-risk PCa.MethodsA total of 101 patients with primary non-metastatic PCa who underwent18F-PSMA-1007 PET/CT were retrospectively analyzed. According to the European Association of Urology guidelines on PCa, patients were classified into intermediate-risk (IR) group or high-risk (HR) group. The maximum standardized uptake values (SUVmax) of the primary prostate tumor were measured on PET/CT images. The diagnostic performance of PET/CT for IR and HR PCa was calculated, and the relationship between the SUVmax of primary prostate ...
Source: EJNMMI Research - November 10, 2020 Category: Radiology Source Type: research

Striatal dopamine transporter SPECT quantification: head-to-head comparison between two three-dimensional automatic tools
ConclusionsBoth Datquant ® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT. (Source: EJNMMI Research)
Source: EJNMMI Research - November 7, 2020 Category: Radiology Source Type: research

Differences in [ 18 F]FDG uptake in BAT of UCP1 −/− and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis
Conclusions[18F]FDG uptake within adrenergically stimulated BAT of wild-type and UCP1-knockout mice can significantly vary such that an [18F]FDG uptake threshold cannot be used to differentiate wild-type from UCP1-knockout mice. However, while an increase in BAT [18F]FDG uptake during adrenergic stimulation is consistently observed in wild-type mice, in UCP1-knockout mice [18F]FDG uptake in BAT seems to be independent of β3-adrenergic stimulation of non-shivering thermogenesis. (Source: EJNMMI Research)
Source: EJNMMI Research - November 7, 2020 Category: Radiology Source Type: research

[ 68 Ga]Ga-PSMA-11 PET before and after initial long-term androgen deprivation in patients with newly diagnosed prostate cancer: a retrospective single-center study
AbstractPurposeThe study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation to the PSA concentration by comparing qualitative and quantitative parameters: SUVmax, SUVmean, PSMA-derived tumor volume (PSMA-TV), total lesion PSMA (TL-PSMA) and molecular imaging (mi)PSMA score.MethodsRetrospective analysis of 21 therapy-na ïve patients with oligometastatic prostate cancer (median age 70 years) who underwent either [68Ga]Ga-PSMA-11-PET/CT or -PET/MRI before initiation of (T1) as well as during ADT (T2). The median duration of ADT was 155  days (range 61–28...
Source: EJNMMI Research - November 6, 2020 Category: Radiology Source Type: research

Asphericity of tumor FDG uptake in non-small cell lung cancer: reproducibility and implications for harmonization in multicenter studies
AbstractBackgroundAsphericity (ASP) of the primary tumor ’s metabolic tumor volume (MTV) in FDG-PET/CT is independently predictive for survival in patients with non-small cell lung cancer (NSCLC). However, comparability between PET systems may be limited. Therefore, reproducibility of ASP was evaluated at varying image reconstruction and acquisition tim es to assess feasibility of ASP assessment in multicenter studies.MethodsThis is a retrospective study of 50 patients with NSCLC (female 20; median age 69  years) undergoing pretherapeutic FDG-PET/CT (median 3.7 MBq/kg; 180 s/bed position). Reconstructi...
Source: EJNMMI Research - November 2, 2020 Category: Radiology Source Type: research

Tracking a TGF- β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
AbstractPurposeAs a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemoresistance, metastasis and tumor cell stemness, as well as epithelial-mesenchymal transition. The novel positron emission tomography (PET) radiopharmaceutical Ga-68-Triveoctin for in vivo mapping of αvβ8-integrin expression might enhance the prognosis of certain tumor entities, as well as support and augment TGF-β-targeted therapeutic approaches.MethodsMonomeric a...
Source: EJNMMI Research - October 31, 2020 Category: Radiology Source Type: research

Day-to-day variability of [ 68 Ga]Ga-PSMA-11 accumulation in primary prostate cancer: effects on tracer uptake and visual interpretation
ConclusionResults of test-retest [68Ga]Ga-PSMA-11 PET/CT scans in a 4-week interval show that [68Ga]Ga-PSMA-11 uptake is repeatable, with a clinical irrelevant variation in tumor and physiological distribution. Based on the presented repeatable uptake, [68Ga]Ga-PSMA-11 PET/CT scans can potentially be used for disease surveillance and therapy response monitoring. Changes in uptake larger than the RC are therefore likely to reflect actual biological changes in PSMA expression.Trial registration NL8263 at Trialregister.nl retrospectively registered on 03-01-2020.https://www.trialregister.nl/trial/8263 (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2020 Category: Radiology Source Type: research

Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson ’s disease: a longitudinal study
AbstractBackgroundWith the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson ’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with18F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD.MethodsAge-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent18F-FDG PET scans. The DBS patients were followed longitudinally to investigate the alternat...
Source: EJNMMI Research - October 29, 2020 Category: Radiology Source Type: research

[ 177 Lu]Lu-DOTA-ZOL bone pain palliation in patients with skeletal metastases from various cancers: efficacy and safety results
Conclusion[177Lu]Lu-DOTA-ZOL shows promising results and is an effective radiopharmaceutical in the treatment of bone pain due to skeletal metastases from various cancers. (Source: EJNMMI Research)
Source: EJNMMI Research - October 28, 2020 Category: Radiology Source Type: research

Correction to: Neurologically asymptomatic cerebral oligometastatic prostate carcinoma metastasis identified on [Ga]Ga-THP-PSMA PET/CT
An amendment to this paper has been published and can be accessed via the original article. (Source: EJNMMI Research)
Source: EJNMMI Research - October 27, 2020 Category: Radiology Source Type: research