Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11 C-UCB-J
Conclusions11C-UCB-J dosimetry in adults is consistent with those for many carbon-11-labeled ligands. Overall,11C-UCB-J can be used safely in adolescents, as in adults, to measure synaptic density in various neuropsychiatric and other relevant disorders. (Source: EJNMMI Research)
Source: EJNMMI Research - July 14, 2020 Category: Radiology Source Type: research

Detection limit of 89 Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI
ConclusionThe results show the feasibility of detecting [89Zr]Zr(oxinate)4-labeled Jurkat T cells on clinical PET systems. The results provide a best-case scenario, as in vivo detection using PET/CT or PET/MRI will be affected by cell number, specific activity per cell, the density of cells within the target volume, and non-specific signal. This work has important implications for cell labeling studies in patients, particularly when using radiosensitive cells (e.g., T cells), which require detection of low cell numbers while minimizing radiation dose per cell. (Source: EJNMMI Research)
Source: EJNMMI Research - July 14, 2020 Category: Radiology Source Type: research

Value of 18 F-FDG PET/CT-based radiomics model to distinguish the growth patterns of early invasive lung adenocarcinoma manifesting as ground-glass opacity nodules
ConclusionPET/CT-based radiomics model shows good performance in predicting intermediate-high risk growth patterns in early IAC. This model provides a useful method for risk stratification, clinical management, and personalized treatment. (Source: EJNMMI Research)
Source: EJNMMI Research - July 13, 2020 Category: Radiology Source Type: research

FDG PET versus CT radiomics to predict outcome in malignant pleural mesothelioma patients
ConclusionWe were able to build a successful FDG PET radiomics model for the prediction of PFS in MPM. Radiomics could serve as a tool to aid clinical decision support systems for treatment of MPM in future. (Source: EJNMMI Research)
Source: EJNMMI Research - July 13, 2020 Category: Radiology Source Type: research

Radiobiological and dosimetric assessment of DNA-intercalated 99m Tc-complexes bearing acridine orange derivatives
Conclusions99mTc might not be the ideal radionuclide for Auger therapy but can be useful to validate the design of new classes of Auger-electron emitting radioconjugates. In this context, our results highlight the crucial importance of the distance of Auger electron emitters to the target DNA and encourage the development of strategies for the fine tuning of the distance to DNA for other medical radionuclides (e.g.,111In or161Tb) in order to enhance their radiotherapeutic effects within the Auger therapy of cancer. (Source: EJNMMI Research)
Source: EJNMMI Research - July 13, 2020 Category: Radiology Source Type: research

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake
In this study, we have investigated whether pharmacological intervention with selective serotonin reuptake inhibitors (SSRIs) may prevent radiotoxic MIBG uptake in platelets without affecting neuroblastoma tumor uptake.MethodsTo determine the transport kinetics of SERT for [125I]MIBG, HEK293 cells were transfected with SERT and uptake assays were conducted. Next, a panel of seven SSRIs was tested in vitro for their inhibitory potency on the uptake of [125I]MIBG in isolated human platelets and in cultured neuroblastoma cells. We investigated in vivo the efficacy of the four best performing SSRIs on the accumulation of [125I...
Source: EJNMMI Research - July 8, 2020 Category: Radiology Source Type: research

Kinfitr  — an open-source tool for reproducible PET modelling: validation and evaluation of test-retest reliability
ConclusionsIn summary, we showed excellent agreement between the open-source R packagekinfitr, and the widely used commercial application PMOD. We, therefore, conclude thatkinfitr is a valid and reliable tool for kinetic modelling of PET data. (Source: EJNMMI Research)
Source: EJNMMI Research - July 8, 2020 Category: Radiology Source Type: research

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis
ConclusionSkeletal muscle of SOD1G93A mice reproduces the increased FDG uptake observed in ALS patients. This finding reflects the selective activation of the ER-PPP in response to significant redox stress associated with alterations of mitochondrial ultrastructure, networking, and connection with the ER itself. This scenario is less severe in cardiomyocytes suggesting a relevant role for either communication with synaptic plaque or contraction dynamics. (Source: EJNMMI Research)
Source: EJNMMI Research - July 7, 2020 Category: Radiology Source Type: research

Development and validation of a prognostic model incorporating [ 18 F]FDG PET/CT radiomics for patients with minor salivary gland carcinoma
AbstractObjectivesThe aim of this study was to develop and validate a prognostic model incorporating [18F]FDG PET/CT radiomics for patients of minor salivary gland carcinoma (MSGC).MethodsWe retrospectively reviewed the pretreatment [18F]FDG PET/CT images of 75 MSGC patients treated with curative intent. Using a 1.5:1 ratio, the patients were randomly divided into a training and validation group. The main outcome measurements were overall survival (OS) and relapse-free survival (RFS). All of the patients were followed up for at least 30  months or until death. Following segmentation of tumors and lymph nodes on PET ...
Source: EJNMMI Research - July 6, 2020 Category: Radiology Source Type: research

Combined PET/CT with thoracic contrast-enhanced CT in assessment of primary cardiac tumors in adult patients
This study sought to retrospectively evaluate whether combined18F-FDG PET/CT with thoracic contrast-enhanced CT (CECT) helps in assessing primary cardiac tumors in adult patients, compared with CECT or PET/CT alone.MethodsForty-six consecutive patients who were diagnosed as primary cardiac tumors were enrolled. All patients underwent18F-FDG PET/CT followed by thoracic CECT before biopsy or surgery. Visual qualitative interpretation and quantitative analysis were performed, and diagnostic performance was evaluated.ResultsMore than half (16/29) of benign tumors exhibited with mild18F-FDG uptake. There were significant differ...
Source: EJNMMI Research - July 6, 2020 Category: Radiology Source Type: research

Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe 3 O 4 @Al(OH) 3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution
ConclusionWe present the application of novel18F-labeled Fe3O4@Al(OH)3 NPs as safe cell tracking agents for simultaneous PET/MRI. Combining both modalities allows fast and easy NP and mMSC localization and quantification using PET at early time points, while MRI provides high-resolution, anatomic background information and long-term NP follow-up, hereby overcoming limitations of the individual imaging modalities. (Source: EJNMMI Research)
Source: EJNMMI Research - June 30, 2020 Category: Radiology Source Type: research

[ 18 F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection
The objective of this study was to investigate the prognostic value of 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake of bone marrow (BM) and metabolic parameters of primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer.MethodsPretreatment [18F]FDG PET/CT images of 345 breast cancer patients were retrospectively evaluated. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of primary breast cancer and bone marrow-to-liver uptake ratio (BLR) on PET/CT were measured. A Cox proportional hazard reg...
Source: EJNMMI Research - June 30, 2020 Category: Radiology Source Type: research

Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader
ConclusionsIn our preclinical studies, dose-dependent inhibition of FES tumoral uptake confirmed target engagement of SAR439859 to ER α. FES-PET thus appears as a relevant imaging biomarker for measuring non-invasively the impact of SAR439859 on tumor estrogen receptor occupancy. This study further validates the use of FLT-PET to directly visualize the anti-proliferative tumor effect of the palbociclib CDK 4/6 inhibitor alone and in combination with SAR439859. (Source: EJNMMI Research)
Source: EJNMMI Research - June 29, 2020 Category: Radiology Source Type: research

Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm
ConclusionsThe reconstructed xQ and xB images were more accurate than those reconstructed conventionally using F3D. The xB for bone SPECT imaging offered essentially unchanged spatial resolution even when the numbers of iterations did not converge. The xB reconstruction further enhanced SPECT image quality using CT data. Our findings provide important information for understanding the performance characteristics of the novel xQ and xB algorithms. (Source: EJNMMI Research)
Source: EJNMMI Research - June 29, 2020 Category: Radiology Source Type: research

A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts
ConclusionsThis protocol can provide high contrast images of tumors expressing ER or HER2 within 3  days from injection of 4FMFES to final scan of89Zr-T and, hence, provides a basis for future dual-tracer combinations that include antibodies. (Source: EJNMMI Research)
Source: EJNMMI Research - June 26, 2020 Category: Radiology Source Type: research

Extravasation of [ 177 Lu]Lu-DOTATOC: case report and discussion
ConclusionsThe treatment of extravasation was successful, and the redistribution of the drug can be easily verified through measurement of the dose rate at contact with the skin. From the results of dosimetry, it was assessed that no change of the treatment course was necessary to compensate for a possibly incomplete treatment as a result of the extravasation. (Source: EJNMMI Research)
Source: EJNMMI Research - June 23, 2020 Category: Radiology Source Type: research

PET imaging of soluble epoxide hydrolase in non-human primate brain with [ 18 F]FNDP
AbstractPurposeSoluble epoxide hydrolase (sEH) is a promising candidate positron emission tomography (PET) imaging biomarker altered in various disorders, including vascular cognitive impairment (VCI), Alzheimer ’s disease (AD), Parkinson’s disease (PD), stroke, and depression, known to regulate levels of epoxyeicosatrienoic acids (EETs) and play an important role in neurovascular coupling. [18F]FNDP, a PET radiotracer for imaging sEH, was evaluated through quantitative PET imaging in the baboon brain, radiometabolite analysis, and radiation dosimetry estimate.MethodsBaboon [18F]FNDP dynamic PET studies were pe...
Source: EJNMMI Research - June 22, 2020 Category: Radiology Source Type: research

In vivo absolute quantification of striatal and extrastriatal D 2/3 receptors with [ 123 I]epidepride SPECT
ConclusionA partial saturation method allowed the robust quantification of D2/3 receptors in striatal and extrastriatal D2/3 receptors with a single-scan approach. This approach may be applied in the mapping of the D2/3 receptor in translational biological studies and potentially, in clinical SPECT imaging. (Source: EJNMMI Research)
Source: EJNMMI Research - June 16, 2020 Category: Radiology Source Type: research

Tumour-to-liver ratio determined by [ 68 Ga]Ga-DOTA-TOC PET/CT as a prognostic factor of lanreotide efficacy for patients with well-differentiated gastroenteropancreatic-neuroendocrine tumours
AbstractBackgroundLanreotide is a long-acting somatostatin analogue with proven antitumour effects against well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumours (GEP-NETs). However, there are no globally established prognostic factors associated with the efficacy of lanreotide as a treatment for GEP-NETs. We investigated the prognostic value of [68Ga]Ga-DOTA-TOC positron emission tomography (PET)/computed tomography (CT) somatostatin receptor imaging for patients with WD GEP-NETs treated with lanreotide.MethodsIn this retrospective study, we included 31 patients with unresectable or metastatic WD GEP-NETs ...
Source: EJNMMI Research - June 15, 2020 Category: Radiology Source Type: research

Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer ’s disease pathology: a clinicopathological study
The objective of this study was to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.MethodsPatients with dementia (two with clinical diagnosis of AD, one undetermined), nearing the end of life, underwent 20-min PET, beginning 80  min after an injection of ~370 mBq flortaucipir [18F]. Neocortical, basal ganglia, and limbic tissue samples were obtained bilaterally from 19 regions at autopsy and subject-specific PET regions of interest corresponding to the 19 sampled target tissue regions in each hemisphere were hand drawn o...
Source: EJNMMI Research - June 15, 2020 Category: Radiology Source Type: research

Cerenkov luminescence imaging is an effective preclinical tool for assessing colorectal cancer PD-L1 levels in vivo
ConclusionsThere is a great potential for131I-PD-L1-Mab noninvasive Cerenkov luminescence imaging to assess the status of tumor PD-L1 expression and select patients for anti-PD-L1 targeted therapy. (Source: EJNMMI Research)
Source: EJNMMI Research - June 15, 2020 Category: Radiology Source Type: research

Human biodistribution and internal dosimetry of 4-[ 18 F ]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart
ConclusionsThe radiation dose associated with an administration of F-DEX is comparable to that of other18F labelled tracers such as FDG (19.0 μSv/MBq) and lower than tracers used for SPECT imaging of muscarinic receptors (I-DEX 28.5 μSv/MBq). Clinical use would likely result in an effective dose less than 4mSv for the ICRP 133 standard phantoms after dose optimisation allowing justification for numerous follow-up procedures. Recent results from first in-human studies and a comparatively low radiation dose make F-DEX an attractive option for future applications of imaging muscarinic receptors in the brain. Further inv...
Source: EJNMMI Research - June 12, 2020 Category: Radiology Source Type: research

Voxel-based comparison of [ 68 Ga]Ga-RM2-PET/CT and [ 68 Ga]Ga-PSMA-11-PET/CT with histopathology for diagnosis of primary prostate cancer
ConclusionsQualitative and quantitative findings in this preliminary study with 8 patients indicate that RM2-PET and PSMA-PET partially show not only the same, but also distinct regions of prostate cancer. Patients with pPCa might profit from information given by tracers targeting GRPR and PSMA simultaneously, in terms of a better delineation of the gross tumor volume. (Source: EJNMMI Research)
Source: EJNMMI Research - June 12, 2020 Category: Radiology Source Type: research

Regional SUV quantification in hybrid PET/MR, a comparison of two atlas-based automatic brain segmentation methods
AbstractBackgroundQuantitative analysis of brain positron-emission tomography (PET) depends on structural segmentation, which can be time-consuming and operator-dependent when performed manually. Previous automatic segmentation usually registered subjects ’ images onto an atlas template (defined as RSIAT here) for group analysis, which changed the individuals’ images and probably affected regional PET segmentation. In contrast, we could register atlas template to subjects’ images (RATSI), which created an individual atlas template and may be mo re accurate for PET segmentation. We segmented two representa...
Source: EJNMMI Research - June 8, 2020 Category: Radiology Source Type: research

Synthesis of a novel 89 Zr-labeled HER2 affibody and its application study in tumor PET imaging
ConclusionThe novel HER2 affibody for PET imaging was easily prepared with satisfactory labeling yield and radiochemical purity. [89Zr]Zr-DFO-MAL-Cys-MZHER2 is a potential candidate for detecting HER2 expression. It may play specific roles in clinical cancer theranostics. (Source: EJNMMI Research)
Source: EJNMMI Research - June 3, 2020 Category: Radiology Source Type: research

Quantification and reliability of [ 11 C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung — a test-retest PET study in control subjects
The objectives of the present study in control subjects were to advance the methodology for quantification of [11C]VC-002 binding in lung and to examine the reliability using a test-retest paradigm. This work constituted a self-standing preparatory step in a larger clinical trial aiming at estimating mAChR occupancy in the human lungs following inhalation of mAChR antagonists.MethodsPET measurements using [11C]VC-002 and the GE Discovery 710 PET/CT system were performed in seven control subjects at two separate occasions, 2 –19 days apart. One subject discontinued the study after the first measurement.Radioligand bin...
Source: EJNMMI Research - June 3, 2020 Category: Radiology Source Type: research

Use of static and dynamic [ 18 F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression
AbstractBackgroundStatic [18F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence/progression as well as assess further relationships with patient outcome.MethodsFifty-one consecutive patients who underwent an [18F]-F-DOPA PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively inc...
Source: EJNMMI Research - May 29, 2020 Category: Radiology Source Type: research

The flow-metabolism ratio might predict treatment response and survival in patients with locally advanced esophageal squamous cell carcinoma
AbstractBackgroundPerfusion CT can offer functional information about tumor angiogenesis, and18F-FDG PET/CT quantifies the glucose metabolic activity of tumors. This prospective study aims to investigate the value of biologically relevant imaging biomarkers for predicting treatment response and survival outcomes in patients with locally advanced esophageal squamous cell cancer (LA ESCC).MethodsTwenty-seven patients with pathologically proven ESCC were included. All patients had undergone perfusion CT and18F-FDG PET/CT using separate imaging systems before receiving definitive chemoradiotherapy (dCRT). The perfusion paramet...
Source: EJNMMI Research - May 29, 2020 Category: Radiology Source Type: research

High uptake of 68 Ga-PSMA and 18 F-DCFPyL in the peritumoral area of rat gliomas due to activated astrocytes
ConclusionsHigh uptake of68Ga-PSMA and18F-DCFPyL in the peritumoral area of all glioma models is presumably caused by activated astrocytes. This may represent a limitation for the clinical application of PSMA ligands in gliomas. (Source: EJNMMI Research)
Source: EJNMMI Research - May 25, 2020 Category: Radiology Source Type: research

Independent attenuation correction of whole body [ 18 F]FDG-PET using a deep learning approach with Generative Adversarial Networks
ConclusionIndependent AC of whole body [18F]FDG-PET is feasible using the proposed deep learning approach yielding satisfactory PET quantification accuracy. Further clinical validation is necessary prior to implementation in clinical routine applications. (Source: EJNMMI Research)
Source: EJNMMI Research - May 24, 2020 Category: Radiology Source Type: research

Comparison of diagnostic sensitivity of [ 18 F]fluoroestradiol and [ 18 F]fluorodeoxyglucose positron emission tomography/computed tomography for breast cancer recurrence in patients with a history of estrogen receptor-positive primary breast cancer
ConclusionsThe restaging of patients who had ER-positive primary breast cancer and present with recurrent disease may include [18F]FES PET/CT as an initial test when standard imaging studies are equivocal or suspicious. (Source: EJNMMI Research)
Source: EJNMMI Research - May 24, 2020 Category: Radiology Source Type: research

Neuron-specific enolase has potential value as a biomarker for [ 18 F]FDG/[ 68 Ga]Ga-PSMA-11 PET mismatch findings in advanced mCRPC patients
AbstractBackgroundPSMA-targeted radioligand therapy (PSMA-RLT) yielded impressive results in the metastasized castration-resistant prostate carcinoma (mCRPC) setting. High expression of PSMA is essential for successful PSMA-RLT. However, some patients develop [18F]FDG-avid lesions with low or no PSMA expression ([18F]FDG/[68Ga]Ga-PSMA-11 mismatch findings on PET/CT) in the course of treatment. Those lesions are not affected by PSMA-RLT and a change in therapy management is needed. To enable early mismatch detection, possible blood parameters as indicators for the occurrence of [18F]FDG/[68Ga]Ga-PSMA-11 mismatch findings on...
Source: EJNMMI Research - May 24, 2020 Category: Radiology Source Type: research

PD-L1 expression correlation with metabolic parameters of FDG PET/CT and clinicopathological characteristics in non-small cell lung cancer
ConclusionsPD-L1 expression of NSCLC was related to SUVmax, TLG, man, smoking, and central location. However, only SUVmax was an independent predictor of PD-L1 positivity, which could help to explore the existence of immune checkpoints. (Source: EJNMMI Research)
Source: EJNMMI Research - May 19, 2020 Category: Radiology Source Type: research

Long-term Ashtanga yoga practice decreases medial temporal and brainstem glucose metabolism in relation to years of experience
AbstractBackgroundYoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing experienced yoga practitioners to yoga-naive healthy subjects using a multiparametric 2 × 2 design with simultaneous positron emission tomography/magnetic resonance (PET/MR) imaging.Methods18F-FDG PET, morphometric and diffusion tensor imaging, resting state fMRI, and MR spectroscopy were acqui...
Source: EJNMMI Research - May 14, 2020 Category: Radiology Source Type: research

Fluorescence labeling of a Na V 1.7-targeted peptide for near-infrared nerve visualization
ConclusionsFluorescent NaV1.7-targeted tracers have the potential to be adopted clinically for the intraoperative visualization of peripheral nerves during surgery, providing guidance for the surgeon and potentially improving the standard of care. (Source: EJNMMI Research)
Source: EJNMMI Research - May 14, 2020 Category: Radiology Source Type: research

VEGF receptor targeted imaging of angiogenic response to limb ischemia in diabetic vs. non-diabetic Yucatan minipigs
ConclusionVEGF receptor targeted imaging showed the effects of diabetes to suppress angiogenesis in response to occlusion of the anterior femoral artery of purpose bred diabetic Yucatan minipigs and indicates potential applicability as a marker to follow efficacy of novel therapies to improve blood flow by stimulating angiogenesis in diabetic PAD. (Source: EJNMMI Research)
Source: EJNMMI Research - May 12, 2020 Category: Radiology Source Type: research

Targeted beta therapy of prostate cancer with 177 Lu-labelled Miltuximab ® antibody against glypican-1 (GPC-1)
ConclusionThese findings demonstrate the potential utility of Miltuximab ® as a PET imaging agent ([89Zr]Zr-DFO-Miltuximab ®) and a beta therapy ([177Lu]Lu-DOTA-Miltuximab ®) in patients with PCa or other GPC-1 expressing tumours. (Source: EJNMMI Research)
Source: EJNMMI Research - May 7, 2020 Category: Radiology Source Type: research

Head and neck tumors angiogenesis imaging with 68 Ga-NODAGA-RGD in comparison to 18 F-FDG PET/CT: a pilot study
ConclusionAll HNSCC tumors were detected with both tracers with higher uptake with18F-FDG, however.68Ga-NODAGA-RGD has a different spatial distribution than18F-FDG bringing different tumor information.Trial registrationNCT,NCT02666547. Registered 12.8.2012. (Source: EJNMMI Research)
Source: EJNMMI Research - May 7, 2020 Category: Radiology Source Type: research

Diagnostic value of PET/CT with 11 C-methionine (MET) and 18 F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification
AbstractBackgroundThe molecular features ofisocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3 ′-deoxy-3′-[18F]fluorothymidine (FLT) has been used to evaluate tumour grade and proliferative activity and compared withl-[methyl-11C]-methionine (MET) in glioma patients. Herein, we evaluated tracer uptakes of MET-PET/CT and FLT-PET/CT for differentiating glioma based on the 2016 WHO classification espe...
Source: EJNMMI Research - May 7, 2020 Category: Radiology Source Type: research

[ 99cm Tc]Tc-PSMA-I & amp;S-SPECT/CT: experience in prostate cancer imaging in an outpatient center
Conclusions[99mTc]Tc-PSMA-I&S-SPECT/CT was useful in PSMA-targeted imaging of PCa at various clinical stages. At low PSA levels ( 4 ng/ml) [99mTc]Tc-PSMA-I&S-SPECT/CT provides high detection rates in BCR. [99mTc]Tc-PSMA-I&S-SPECT/CT can also be used for primary staging and for restaging of advanced recurrent PCa. However, further studies are needed to assess the clinical value in these indications. (Source: EJNMMI Research)
Source: EJNMMI Research - May 7, 2020 Category: Radiology Source Type: research

Double-strand breaks in lymphocyte DNA of humans exposed to [ 18 F]fluorodeoxyglucose and the static magnetic field in PET/MRI
ConclusionThere is no evidence of a synergism between [18F]FDG and the SMF that may be of relevance for risk assessment of PET/MRI. (Source: EJNMMI Research)
Source: EJNMMI Research - April 28, 2020 Category: Radiology Source Type: research

Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [ 177 Lu]Lu-DOTA-TATE in Lewis rats
ConclusionRenal scintigraphy is a highly sensitive tool for the detection of renal function impairment after a combination of everolimus and PRRT. Additional treatment with everolimus does not increase renal and haematological toxicity of PRRT with [177Lu]Lu-DOTA-TATE. (Source: EJNMMI Research)
Source: EJNMMI Research - April 25, 2020 Category: Radiology Source Type: research

A pan-cancer analysis of the clinical and genetic portraits of somatostatin receptor expressing tumor as a potential target of peptide receptor imaging and therapy
ConclusionA broad range of SST2 expression was observed across diverse cancer subtypes. The SST2 expression level showed a significant association with genomic and clinical aspects across cancers, especially in LGG and BRCA. These findings extend our knowledge base to diversify the indications for PRRT as well as SST imaging. (Source: EJNMMI Research)
Source: EJNMMI Research - April 25, 2020 Category: Radiology Source Type: research

Visual and quantitative evaluation of [ 18 F]FES and [ 18 F]FDHT PET in patients with metastatic breast cancer: an interobserver variability study
ConclusionVisual and quantitative evaluation of [18F]FES PET showed high interobserver agreement. These results support the use of [18F]FES PET in clinical practice. In contrast, visual agreement for [18F]FDHT PET was relatively low due to low tumour-background ratios, but quantitative agreement was good. This underscores the relevance of quantitative analysis of [18F]FDHT PET in breast cancer.Trial registrationClinicalTrials.gov, NCT01988324. Registered 20 November 2013,https://clinicaltrials.gov/ct2/show/NCT01988324?term=FDHT+PET&draw=1&rank=2. (Source: EJNMMI Research)
Source: EJNMMI Research - April 19, 2020 Category: Radiology Source Type: research

Impaired brain glucose metabolism and presynaptic dopaminergic functioning in a mouse model of schizophrenia
ConclusionsDopamine D2 mutant animals show reduced glucose metabolism and impaired presynaptic dopaminergic functioning, in line with reports from human studies. This mouse line may be a valuable model of schizophrenia, useful to test novel tracers for PET scanning diagnostic. (Source: EJNMMI Research)
Source: EJNMMI Research - April 17, 2020 Category: Radiology Source Type: research

A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18 F-positron emitting tomography and fluorescence
ConclusionThe superior imaging properties of IR783-AMBF3 could lead to enhanced accuracy in the treatment of patients and would assist surgeons in non-invasively diagnosing diseases of the CNS. (Source: EJNMMI Research)
Source: EJNMMI Research - April 16, 2020 Category: Radiology Source Type: research

Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
ConclusionTRNT using177Lu-AbN44v6 proved efficient in stalling spheroid growth in a dose-dependent and antigen-dependent manner, and PM2 treatment demonstrated a growth inhibitory effect as a monotherapy. Moreover, by combining TRNT with PM2-based therapy, therapeutic effects of TRNT were potentiated in a 3D multicellular tumor spheroid model. This proof-of-concept study exemplifies the strength and possibility of combining TRNT targeting CD44v6 with PM2-based therapy. (Source: EJNMMI Research)
Source: EJNMMI Research - April 16, 2020 Category: Radiology Source Type: research

Comparative evaluation of 68 Ga-labelled TATEs: the impact of chelators on imaging
Conclusion68Ga-NOTA-TATE and68Ga-DOTA-TATE demonstrated comparable tumour uptake in an AR42J mouse model. An initial clinical study revealed that68Ga-NOTA-TATE may have reduced background uptake in the major organs such as the liver. Although the subject numbers were limited, further investigation of68Ga-NOTA-TATE is warranted for detecting SSTR2-positive neuroendocrine tumours. (Source: EJNMMI Research)
Source: EJNMMI Research - April 15, 2020 Category: Radiology Source Type: research

[ 18 F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action
ConclusionsThe improved ruthenium-mediated18F-deoxyfluorination procedure overcomes previous hurdles such as the addition of salt additives, the drying steps, or the use of different solvent mixtures at different phases of the process, which increases its practical use, and may allow faster translation to clinical settings. Based on tissue uptake evaluations, [18F]atorvastatin showed the potential to be used as a tool for the understanding of the mechanism of action of statins. Further knowledge of the in vivo biodistribution of [18F]atorvastatin may help to better understand the origin of off-target effects and potentiall...
Source: EJNMMI Research - April 15, 2020 Category: Radiology Source Type: research

PRRT of neuroendocrine tumors: individualized dosimetry or fixed dose scheme?
AbstractGreat efforts have been made in dosimetry for individualizing PRRT. However, many centers do not use dosimetry and its results hardly influence treatment. A reason for that is that reliable thresholds for organs-at-risk, kidneys and bone marrow, and treatment response are lacking. The nuclear medicine community must provide solid data from large trials delivering reliable thresholds, which then help to tailor PRRT according to organ doses (in order to reduce toxicity or increase treatment activity) or tumor doses (in order to increase activity to meet the response-threshold). Otherwise, development of radionuclide ...
Source: EJNMMI Research - April 15, 2020 Category: Radiology Source Type: research