The assessment of left ventricular volume and function in gated small animal 18F-FDG PET/CT imaging: a comparative study of three commercially available software tools
ConclusionsAll three commercially available software tools are feasible in small animal cardiac volume assessment in gated18F-FDG PET/CT imaging. However, due to software-related differences in agreement analysis for cardiac volumes and function, PMOD, MIM, and QGS cannot be used interchangeably in murine research. (Source: EJNMMI Research)
Source: EJNMMI Research - August 12, 2023 Category: Radiology Source Type: research
Diagnostic accuracy of cerebral [18F]FDG PET in atypical parkinsonism
ConclusionsOur results support the additional use of [18F]FDG PET for the clinical diagnosis of AP with moderate to high sensitivity and specificity. Use of [18F]FDG PET may be beneficial for prognosis and supportive treatment of the patients and useful for future clinical treatment trials. (Source: EJNMMI Research)
Source: EJNMMI Research - August 12, 2023 Category: Radiology Source Type: research
Comparative in vivo biodistribution of cells labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS using PET
ConclusionThe [89Zr]Zr-DFO-NCS labelled cells suggest a prolonged accumulation in the lungs, while [89Zr]Zr-(oxinate)4 suggests quicker clearance of the lungs followed by accumulation in the liver. Accumulation of radiolabelled cells in the liver corresponds to other cell-tracking methods. Further studies are required to determine the actual location of the [89Zr]Zr-DFO-NCS labelled cell. (Source: EJNMMI Research)
Source: EJNMMI Research - August 8, 2023 Category: Radiology Source Type: research
Lymphoscintigraphy findings in patients with chylothorax: influence of biochemical parameters
ConclusionLymphoscintigraphy technique is a dependable diagnostic tool for the qualitative assessment of chylous pleural effusion. Higher pleural effusion triglyceride level and pleural effusion triglyceride/serum triglyceride ratio indicate a positive result in patients with chylothorax on lymphoscintigraphy, with the cutoff values of 2.870 mmol/L and 4.625 aiding in the diagnosis. (Source: EJNMMI Research)
Source: EJNMMI Research - August 3, 2023 Category: Radiology Source Type: research
Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex
ConclusionsOur findings indicate subtle but distinct metabolic patterns in bvFTD and PPD, most strongly in the dACC. The degree of frontotemporal and cingulate hypometabolism was related to impaired social cognition, compulsiveness and executive dysfunctioning. Our findings suggest that the dACC might be an important region to differentiate between bvFTD and PPD but needs further validation. (Source: EJNMMI Research)
Source: EJNMMI Research - July 26, 2023 Category: Radiology Source Type: research
Radiomics predictive modeling from dual-time-point FDG PET Ki parametric maps: application to chemotherapy response in lymphoma
ConclusionsOur results demonstrate significant value in harmonization of radiomics features as well as combining DTP and static radiomics models for predicting response to chemotherapy in lymphoma patients. (Source: EJNMMI Research)
Source: EJNMMI Research - July 26, 2023 Category: Radiology Source Type: research
Early prediction of treatment outcome for lenvatinib using 18F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma refractory to radioiodine treatment: a prospective, multicentre, non-randomised study
ConclusionsThe therapeutic effects of lenvatinib were detected earlier than those of CT because of decreased FDG uptake on PET/CT. PET/CT examination 1 week after the initiation of lenvatinib treatment may predict treatment outcomes in patients with DTC.Trial registration: This trial was registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (number UMIN000022592) on 6 June, 2016. (Source: EJNMMI Research)
Source: EJNMMI Research - July 17, 2023 Category: Radiology Source Type: research
Automatic healthy liver segmentation for holmium-166 radioembolization dosimetry
Conclusions166Ho –99mTc dual-isotope protocol can automatically segment the healthy liver without hampering the166Ho dosimetry assessment.Trial registration: ClinicalTrials.gov, NCT02067988. Registered 20 February 2014.https://clinicaltrials.gov/ct2/show/NCT02067988 (Source: EJNMMI Research)
Source: EJNMMI Research - July 15, 2023 Category: Radiology Source Type: research
Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis
Conclusion[18F]1 was synthesized with good radiochemical yield and high radiochemical purity. In PET imaging studies, [18F]1 displayed CXCR3-specific uptake in the atherosclerotic aorta in ApoE KO mice. [18F]1 visualized CXCR3 expression in different regions in mice aligned with the tissue histology studies. Taken together, [18F]1 is a potential PET radiotracer for imaging CXCR3 in atherosclerosis. (Source: EJNMMI Research)
Source: EJNMMI Research - July 13, 2023 Category: Radiology Source Type: research
Sub-minute acquisition with deep learning-based image filter in the diagnosis of colorectal cancers using total-body 18F-FDG PET/CT
ConclusionsThe DL filter can significantly improve the image quality of total-body18F-FDG PET/CT ultrafast acquisition. Deep learning-based image filtering methods can significantly reduce the noise of ultrafast acquisition, making them suitable for clinical diagnosis possible. (Source: EJNMMI Research)
Source: EJNMMI Research - July 10, 2023 Category: Radiology Source Type: research
Investigation of the structure-activity relationship at the N-terminal part of minigastrin analogs
ConclusionWe could demonstrate that a substitution ofd- γ-Glu-Ala-Tyr-Gly by PEG spacers simplified the peptide structure of DOTA-MGS5 while high CCK-2R affinity and favorable lipophilicity were maintained. Nevertheless, further optimization with regard to metabolic stability must be carried out for these minigastrin analogs. (Source: EJNMMI Research)
Source: EJNMMI Research - July 8, 2023 Category: Radiology Source Type: research
Impact of non-regional lymph node metastases accurately revealed on 18F-PSMA-1007 PET/CT in the clinical management of metastatic hormone-sensitive prostate cancer
ConclusionNRLN metastases could be accurately revealed by18F-PSMA-1007 PET/CT, which should be considered a high-volume feature, especially concomitant with bone metastases. Furthermore, patients with low-volume plus NRLN metastases may be suitable for more intensive treatment, such as early docetaxel chemotherapy. (Source: EJNMMI Research)
Source: EJNMMI Research - July 6, 2023 Category: Radiology Source Type: research
Predictive value of 99mTc-MAA-based dosimetry in personalized 90Y-SIRT planning for liver malignancies
ConclusionThis study supports the strong correlation between absorbed dose metrics from simulation and therapy dosimetry based on90Y SPECT/CT, highlighting the predictive ability of99mTc-MAA, not only in terms of mean absorbed dose but also of the dose distribution. (Source: EJNMMI Research)
Source: EJNMMI Research - July 3, 2023 Category: Radiology Source Type: research
Accuracy of dynamic sentinel lymph node biopsy for inguinal lymph node staging in cN0 penile cancer
ConclusionDNSB is a safe diagnostic procedure with a good detection rate and in particular high negative predictive value. It can therefore prevent overtreatment of patients with negative inguinal groins on clinical examination and DSNB examination. Finally, DSNB enables an early detection of occult metastases which would not be visualized with standardized imaging modalities. (Source: EJNMMI Research)
Source: EJNMMI Research - June 23, 2023 Category: Radiology Source Type: research
The effect of butylscopolamine on [18F]FDG uptake in the gastrointestinal tract is negligible and regionally variable
ConclusionsButylscopolamine reduces gastrointestinal FDG accumulation only in selected segments and, despite a significant effect, only to a small extent. A general recommendation for the use of butylscopolamine cannot be derived from these results, its use for specific issues could be considered individually. (Source: EJNMMI Research)
Source: EJNMMI Research - June 20, 2023 Category: Radiology Source Type: research
