[18F]Fluoride uptake in various bone types and soft tissues in rat
ConclusionUnderstanding the pharmacokinetics of [18F]fluoride in various bones and soft tissues is highly useful for assessing18F-labelled radiotracers that release [18F]fluoride. (Source: EJNMMI Research)
Source: EJNMMI Research - March 13, 2023 Category: Radiology Source Type: research

The impact of specific pulmonary arterial hypertension therapy on cardiac fluorodeoxyglucose distribution in PET/MRI hybrid imaging –follow-up study
ConclusionsPAH therapy escalation may influence RV glucose metabolism, what seems to be related with patients ’ prognosis. PET/MRI assessment may predict clinical deterioration regardless of previous clinical course, however its clinical significance in PAH requires further studies. Importantly, even mild alterations of RV glucose metabolism predict clinical deterioration in long follow-up.Clinical Trial Registration ClinicalTrials.gov, NCT03688698, 05/01/2016,https://clinicaltrials.gov/ct2/show/study/NCT03688698?term=NCT03688698&draw=2&rank=1 (Source: EJNMMI Research)
Source: EJNMMI Research - March 9, 2023 Category: Radiology Source Type: research

Correction: [18F]FE-PE2I PET is a feasible alternative to [123I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism
(Source: EJNMMI Research)
Source: EJNMMI Research - March 1, 2023 Category: Radiology Source Type: research

APOE- ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
ConclusionCUAPOE- ε4 carriers with a positive A β PET VR in regions known to accumulate amyloid at later stages of the Alzheimer’s disease (AD) continuum exhibited a steeper cognitive decline. This work supports the contention that regional VR of Aβ PET might convey prognostic information about future cognitive decline in individuals at highe r risk of developing AD.ClinicalTrials.gov Identifier: NCT02485730. Registered 20 June 2015https://clinicaltrials.gov/ct2/show/NCT02485730 and ClinicalTrials.gov Identifier:NCT02685969. Registered 19 February 2016https://clinicaltrials.gov/ct2/show/NCT02685969. (Source: EJNMMI Research)
Source: EJNMMI Research - March 1, 2023 Category: Radiology Source Type: research

Engineering a modular 44Ti/44Sc generator: eluate evaluation in preclinical models and estimation of human radiation dosimetry
ConclusionsA clinical-scale44Ti/44Sc generator system with a modular design was developed to supply44ScCl3 in 0.05  M HCl, which is suitable for further radiolabeling and in vivo use. Our data demonstrated that free44ScCl3 remained in the circulation for extended periods, which resulted in approximately 10 times greater radiation burden than stably chelated44Sc. Stable44Sc/47Sc-complexation will be more favorable for in vivo use and for clinical utility. (Source: EJNMMI Research)
Source: EJNMMI Research - February 28, 2023 Category: Radiology Source Type: research

Correction: [18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer ’s disease pathology in APP/PS1 mice
(Source: EJNMMI Research)
Source: EJNMMI Research - February 27, 2023 Category: Radiology Source Type: research

[18F] FDG uptake in patients with spondyloarthritis: correlation with serum inflammatory biomarker levels
ConclusionFDG uptake in untreated pSpA correlated significantly with serum inflammatory biomarker levels. (Source: EJNMMI Research)
Source: EJNMMI Research - February 15, 2023 Category: Radiology Source Type: research

Prognostic value of 18F-FDG PET/CT-based radiomics combining dosiomics and dose volume histogram for head and neck cancer
ConclusionMultidimensional model of radiomics features combining dosiomics features and DVH features showed high prognostic performance for predicting OS in patients with HNC. (Source: EJNMMI Research)
Source: EJNMMI Research - February 13, 2023 Category: Radiology Source Type: research

Relevance of 18F-DOPA visual and semi-quantitative PET metrics for the diagnostic of Parkinson disease in clinical practice: a machine learning-based inference study
ConclusionVisual expert analysis remains the most relevant parameter to predict IPD diagnosis at 11  months of median clinical follow-up in18F-FDOPA. The min SUV ratio appears interesting in the perspective of simple semi-automated diagnostic workflows. (Source: EJNMMI Research)
Source: EJNMMI Research - February 13, 2023 Category: Radiology Source Type: research

Correction: PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - February 10, 2023 Category: Radiology Source Type: research

Impact of framing scheme optimization and smoking status on binding potential analysis in dynamic PET with [11C]ABP688
ConclusionsBased on an [11C]ABP688 PET study in SZ patients, the results show that non-consistent BPND outcomes can be propagated by the framing scheme and that potential bias can be minimized using ‘Const Trues’ framing. (Source: EJNMMI Research)
Source: EJNMMI Research - February 9, 2023 Category: Radiology Source Type: research

Cost-effectiveness of 82-Rubidium PET myocardial perfusion imaging for the diagnosis of myocardial ischemia depending on the prevalence of coronary artery disease
ConclusionsRb-PET-MPI is cost-effective compared to Tc-SPECT-MPI for the detection of myocardial ischemia in patients with PTP  >  15% of obstructive coronary artery disease.Trial registrationRUBIS Trial registration: NCT01679886, Registered 03 September 2012,https://clinicaltrials.gov/ct2/show/NCT01679886. (Source: EJNMMI Research)
Source: EJNMMI Research - February 8, 2023 Category: Radiology Source Type: research

The potential application of MR-derived ADCmin values from 68Ga-DOTATATE and 18F-FDG dual tracer PET/MR as replacements for FDG PET in assessment of grade and stage of pancreatic neuroendocrine tumors
ConclusionsThis study highlights significant correlative relationships between FDG PET-derived parameters and ADCmin. ADCmin may offer utility as a tool for PNET staging and grading in lieu of FDG PET.68Ga-DOTATATE PET/MR alone may be a sufficient alternative to dual tracer PET/MR when conducting grading and staging of primary PNETs. (Source: EJNMMI Research)
Source: EJNMMI Research - February 8, 2023 Category: Radiology Source Type: research

A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients
ConclusionThe developed PBPK model adequately predicted tumor and organ uptake for this GEP-NET population. Relevant organ uptake differences between [68Ga]Ga-DOTATATE and [68Ga]Ga-HA-DOTATATE were caused by different affinity profiles, while tumor uptake was mainly affected by tumor blood flow and blood volume. Furthermore, tumor sink predictions showed that for the majority of patients a tumor sink effect is not expected to be clinically relevant. (Source: EJNMMI Research)
Source: EJNMMI Research - February 3, 2023 Category: Radiology Source Type: research

Direct reconstruction for simultaneous dual-tracer PET imaging based on multi-task learning
ConclusionsThe proposed Multi-task CNN could effectively reconstruct the dynamic activity images of two single tracers from the dual-tracer dynamic sinogram, which was potential in the direct reconstruction for real simultaneous dual-tracer PET imaging data in future. (Source: EJNMMI Research)
Source: EJNMMI Research - January 31, 2023 Category: Radiology Source Type: research