Alteration of neuroinflammation detected by 18F-GE180 PET imaging in place-conditioned rats with morphine withdrawal
ConclusionIn morphine-dependent rats, Neuroinflammation (NI) became more severe in the addiction-involved brain regions but remitted in the sensory-related brain regions after the administration of naloxone, and this NI induced by withdrawal was further aggravated after conditioned aversion formation thus may help to consolidate the withdrawal memory. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
Rationale for MYC imaging and targeting in pancreatic cancer
AbstractThe incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summar...
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
Retraction Note to: Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
Correction to: Biokinetics, dosimetry and radiation risk in infants after 99mTc-MAG3 scans
(Source: EJNMMI Research)
Source: EJNMMI Research - October 11, 2021 Category: Radiology Source Type: research
The prognostic significance of [18F]FDG PET/CT in multiple myeloma according to novel interpretation criteria (IMPeTUs)
ConclusionSeveral parameters utilized in IMPeTUs predict PFS in MM patients, suggesting the potentially significant role of the new criteria in patient stratification and response assessment. Additional studies are warranted for the further evaluation of IMPeTUs in the direction of establishment of robust cut-off values with a prognostic significance in the disease. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2021 Category: Radiology Source Type: research
Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity
ConclusionsWe successfully obtained functional images of focal ROS generation during the early period of excitotoxic injury, and microglial ROS generation and mitochondrial dysfunction were observed during the progression of the inflammatory response. Both ex vivo DHE imaging and in vivo18F-BCPP-EF-PET were sufficiently sensitive to detect the respective processes of QA-induced brain damage. Our study contributes to the functional imaging of multiple events during the pathological process. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2021 Category: Radiology Source Type: research
Automated liver lesion detection in 68Ga DOTATATE PET/CT using a deep fully convolutional neural network
ConclusionDeep neural networks can automatically detect hepatic lesions in68Ga-DOTATATE PET. Ongoing improvements in data annotation methods, increasing sample sizes and training methods are anticipated to further improve detection performance. (Source: EJNMMI Research)
Source: EJNMMI Research - October 2, 2021 Category: Radiology Source Type: research
In vivo quantitative assessment of therapeutic response to bortezomib therapy in disseminated animal models of multiple myeloma with [18F]FDG and [64Cu]Cu-LLP2A PET
Conclusion[64Cu]Cu-LLP2A is a promising tracer for timely in vivo assessment of therapeutic response in disseminated models of MM. (Source: EJNMMI Research)
Source: EJNMMI Research - September 29, 2021 Category: Radiology Source Type: research
Lung shunt fraction calculation using 99mTc-MAA SPECT/CT imaging for 90Y microsphere selective internal radiation therapy of liver tumors
ConclusionsThis study demonstrates that LSF calculation using planar imaging can be significantly overestimated while calculation using SPECT/CT imaging and appropriate segmentation tools can be more accurate. Minimizing the errors in obtaining the LSF can lead to more effective90Y SIRT treatment planning for hepatic tumors while ensuring the lung dose will not exceed the standard acceptable safety thresholds. (Source: EJNMMI Research)
Source: EJNMMI Research - September 28, 2021 Category: Radiology Source Type: research
The effect of eating on the uptake of PSMA ligands in the salivary glands
ConclusionsEating only slightly increases uptake of [18F]DCFPyl in the parotid glands. We nonetheless recommend refraining from gustatory stimulation during the administration and early biodistribution phase of radionuclide therapy with PSMA-ligands to reduce the risk of avoidable additional toxicity. (Source: EJNMMI Research)
Source: EJNMMI Research - September 26, 2021 Category: Radiology Source Type: research
Imaging modalities for diagnosis and monitoring of cancer cachexia
AbstractCachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily implicates lean body mass, caused by an aberrant metabolism and systemic inflammation. This may lead to disease aggravation, poorer quality of life, and increased mortality. Timely detection is, therefore, crucial, as is the careful monitoring of cancer progression, in an effort to improve management, facilitate individual treatment and minimize disease complications. A detailed analysis of body composition and t...
Source: EJNMMI Research - September 23, 2021 Category: Radiology Source Type: research
Benefits and harms of implementing [18F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study
Conclusion[18F]FDG-PET/CT provided a high posterior probability of positive test, and a negative test was able to rule out distant metastases in women with clinically suspected recurrent breast cancer. One-fifth of patients examined for incidental findings detected on [18F]FDG-PET/CT were diagnosed with clinically relevant conditions. Further examinations of false-positive incidental findings in one of six women should be weighed against the high accuracy for diagnosing metastatic breast cancer.Trial registration Clinical.Trials.gov. NCT03358589. Registered 30 November 2017 —Retrospectively registered,http://www.Clinical...
Source: EJNMMI Research - September 22, 2021 Category: Radiology Source Type: research
[123I]MIBG is a better early marker of anthracycline cardiotoxicity than [18F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study
ConclusionThis longitudinal study precises that after doxorubicin treatment, cardiac [123I]MIBG uptake is significantly reduced as early as 2 weeks followed by the decrease of the LV end-diastolic volume and [18F]FDG uptake at 4 weeks and finally by the increase of LV end-systolic volume and decrease of LV ejection fraction at 6 weeks. Cardiac innervation imaging should thus be considered as an early key feature of anthracycline cardiac toxicity. (Source: EJNMMI Research)
Source: EJNMMI Research - September 20, 2021 Category: Radiology Source Type: research
CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [18F]FDG PET, T1 and FLAIR MRI, and CT images available for research
We describe the acquisition parameters, the image processing pipeline and provide participants ’ individual demographics (mean age 38 ± 11.5 years, range 23–65, 20 women). Volumetric analysis of the 37 T1 MRIs showed results in line with the literature. A leave-one-out assessment of the 37 FDG images using Statistical Parametric Mapping (SPM) yielded a low number of false positives after exclusion of artefacts. The database is stored in three different formats, following the BIDS common specification: (1) DICOM (data not processed), (2) NIFTI (multimodal images coregistered to PET subject space), (3) NIFTI normal...
Source: EJNMMI Research - September 16, 2021 Category: Radiology Source Type: research
Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma
ConclusionsqPET and ∆SUVmax identify large fractions of PTCL patients destined to experience treatment failure. qPET may be preferred because it requires a single PET scan, halving the diagnostic effort. (Source: EJNMMI Research)
Source: EJNMMI Research - September 14, 2021 Category: Radiology Source Type: research
