Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction
ConclusionThe decrease in the metabolic rate of glucose in the infarcted tissue suggests that inflammatory cells may be affected by glucose suppression through heparin injection and lipid infusion. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2023 Category: Radiology Source Type: research
Value of 18F-FDG-PET/CT radiomics combined with clinical variables in the differential diagnosis of malignant and benign vertebral compression fractures
ConclusionsThe PET/CT-based radiomics and clinical –radiomics models showed good performance in distinguishing between malignant and benign VCFs. The radiomics method may be valuable for treatment decision-making. (Source: EJNMMI Research)
Source: EJNMMI Research - October 11, 2023 Category: Radiology Source Type: research
Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols
ConclusionOur CNN-based outcome predictions are affected by the applied reconstruction protocols, yet in a predictable manner. Image-based harmonization is a suitable approach to harmonize CNN predictions across image reconstruction protocols. (Source: EJNMMI Research)
Source: EJNMMI Research - September 28, 2023 Category: Radiology Source Type: research
Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography
ConclusionsSWPs varied widely in low end accuracy based on measurement of rMBF in regions of known TMS. 3D PET using82Rb and HeartSee software accurately (0.26 mL/min/g, consistent with established values) and precisely (COV = 0.07) quantified rMBF in regions of TMS. The Emory-Ottawa software yielded the next-best accuracy (0.37 mL/min/g), though rMBF was higher than established gold-standard values in ~ 5% of the resting scans. 4DM, 4DM-FDV, Ceda rs and Emory-Votaw SWP consistently resulted values higher than the established gold standard (0.71, 0.41, 0.66, 0.51 mL/min/g, respectively), with higher interscan var...
Source: EJNMMI Research - September 27, 2023 Category: Radiology Source Type: research
Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements
ConclusionThe high correspondence of simultaneously intra- and extracorporeally determined AIFs and resulting model parameters establishes a feasible framework for extracorporeal dispersion correction. This should allow more precise and accurate kinetic modelling in small animal experiments. (Source: EJNMMI Research)
Source: EJNMMI Research - September 26, 2023 Category: Radiology Source Type: research
Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction
ConclusionsRMI conferred relatively decreased hematopoietic-inflammatory activation compared with PMI. Patients with RMI presented subsequent enlarged myocardial scar, worsened cardiac dysfunction, aggravated remodeling, and worse outcomes than that in PMI patients. (Source: EJNMMI Research)
Source: EJNMMI Research - September 25, 2023 Category: Radiology Source Type: research
CYP3A4 inhibitors do not influence [68Ga]Ga-DOTA-TATE uptake in liver tissue
(Source: EJNMMI Research)
Source: EJNMMI Research - September 22, 2023 Category: Radiology Source Type: research
Threshold for defining PSMA-positivity prior to 177Lu-PSMA therapy: a comparison of [68Ga]Ga-PSMA-11 and [18F]F-DCFPyL in metastatic prostate cancer
ConclusionsOur data showed that [18F]F-DCFPyl-PET and [68Ga]Ga-PSMA-11-PET provide comparable tumour-to-liver and tumour-to-mediastinum ratios. Therefore, a tumour uptake of [18F]F-DCFPyL above the liver background, like using [68Ga]Ga-PSMA-11, can be considered as equally suitable for defining PSMA-positivity by a semiquantitative assessment based on the liver background, e. g. prior to radioligand therapy with177Lu-labelled PSMA ligands. In addition, our data suggest a tending advantage of [18F]F-DCFPyL in terms of lesion detectability. (Source: EJNMMI Research)
Source: EJNMMI Research - September 20, 2023 Category: Radiology Source Type: research
Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus
Conclusions[11C]MRB PET may be used as an in vivo biomarker of noradrenaline concentrations in the hippocampus of the neurodegenerating brain. Further studies appear warranted to extend its applicability to AD studies. (Source: EJNMMI Research)
Source: EJNMMI Research - September 15, 2023 Category: Radiology Source Type: research
Fc-engineered monoclonal antibodies to reduce off-target liver uptake
ConclusionAntibodies with reduced binding to Fc γR display lower liver accumulation and better tumor-to-liver ratios. These findings need to be taken into account to improve antibody-based theragnostic approaches. (Source: EJNMMI Research)
Source: EJNMMI Research - September 11, 2023 Category: Radiology Source Type: research
3D-printed dual holder system for simultaneous rat PET scanning: design and influence on quantification
ConclusionsOur results showed that simultaneous scans of two rats in INVEON do not affect quantification. The dual support system will allow us to reduce protocol costs and duration. (Source: EJNMMI Research)
Source: EJNMMI Research - September 7, 2023 Category: Radiology Source Type: research
Impact of brain segmentation methods on regional metabolism quantification in 18F-FDG PET/MR analysis
ConclusionsDifferent segmentation methods may have impact on the calculation of brain metabolism in basal ganglia nuclei and specific cerebral cortexes. The AI-based approach offers improved efficiency and is recommended for its enhanced performance. (Source: EJNMMI Research)
Source: EJNMMI Research - September 5, 2023 Category: Radiology Source Type: research
First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study
ConclusionsIn first individual cases, iRIT with [177Lu]Lu-6A10-Fab appears to be feasible and safe, without therapy-related side effects. A confirmatory multicenter phase-I-trial was recently opened and is currently recruiting. (Source: EJNMMI Research)
Source: EJNMMI Research - September 4, 2023 Category: Radiology Source Type: research
A dual-tracer approach using [11C]CH and [18F]FDG in HCC clinical decision making
ConclusionsOur study favours a dual-tracer approach in HCC staging in high-risk patients or when conventional imaging is non-conclusive. (Source: EJNMMI Research)
Source: EJNMMI Research - August 29, 2023 Category: Radiology Source Type: research
In reply to Cheng et al. (DOI: 10.1186/s13550-023-00965-8)
(Source: EJNMMI Research)
Source: EJNMMI Research - August 17, 2023 Category: Radiology Source Type: research
