18F-FDG PET/CT-based deep learning radiomics predicts 5-years disease-free survival after failure to achieve pathologic complete response to neoadjuvant chemotherapy in breast cancer
ConclusionThe integrated model combining radiomic and depth features extracted from PET/CT images can accurately predict 5-year DFS in non-pCR patients. It can help identify patients with a high risk of recurrence and strengthen adjuvant therapy to improve survival. (Source: EJNMMI Research)
Source: EJNMMI Research - December 6, 2023 Category: Radiology Source Type: research
Single time point quantitation of cerebral glucose metabolism by FDG-PET without arterial sampling
ConclusionsThe observed interrelationships between pharmacokinetic parameters in the IDIF measured during the PET recording support quantitation of FDG-Ki in brain using a single averaged frame from the interval 52 –67 min post-injection, with minimal error relative to calculation from the complete dynamic sequences. (Source: EJNMMI Research)
Source: EJNMMI Research - November 30, 2023 Category: Radiology Source Type: research
[18F]FDG PET-MR characterization of aortitis in the IL1rn −/− mouse model of giant-cell arteritis
ConclusionsIn addition to the involvement of interleukin-1 β and -6 inIL1rn−/− mouse aortitis, this study seems to validate [18F]FDG PET-MR as a useful tool for noninvasive monitoring of aortitis in this preclinical model. (Source: EJNMMI Research)
Source: EJNMMI Research - November 29, 2023 Category: Radiology Source Type: research
Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies
ConclusionOverall, [64Cu][Cu(ATSM)] imaging and proteomic results showed the presence of hypoxia and protein expression changes linked to hypoxia and oxidative stress in BM, which are more pronounced in cortical BM compared to striatal BM. Moreover, it emphasized the interest of [64Cu][Cu(ATSM)] PET to characterize TME of BM and depict inter-metastasis heterogeneity that could be useful to guide treatments. (Source: EJNMMI Research)
Source: EJNMMI Research - November 25, 2023 Category: Radiology Source Type: research
Biological efficacy of simulated radiolabeled Lipiodol ® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors
ConclusionsThis study showed a higher ability of Lipiodol ® ultra-fluid to penetrate the tumor that translated into a higher EUBED. This study confirms90Y as a good candidate for radioembolization, although32P,166Ho, and188Re can achieve similar results. (Source: EJNMMI Research)
Source: EJNMMI Research - November 23, 2023 Category: Radiology Source Type: research
Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET
Conclusion[89Zr]Zr-hCD103.Fab01A demonstrated a relatively low background and high xenograft uptake in scans as early as 6 h post-injection and could be explored for repeat imaging during immunotherapy in clinical trials.18F or64Cu could be explored as alternative to68Ga in optimizing half-life and radiation burden of the tracer. (Source: EJNMMI Research)
Source: EJNMMI Research - November 20, 2023 Category: Radiology Source Type: research
Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer
ConclusionPSMA expression and PSMA-ligand uptake show marked heterogeneity. Prostate carcinoma with GP 4 showed significantly higher uptake compared with non-neoplastic prostate tissue. Our analyses extend the scope of applications of radiolabeled PSMA-ligands to ARG for identifying high-grade disease and using its signal as a noninvasive biomarker in prostate cancer. (Source: EJNMMI Research)
Source: EJNMMI Research - November 16, 2023 Category: Radiology Source Type: research
Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example
ConclusionsAs expected, global and regional data characteristics are database specific. However, our work shows the value of increasing database size and suggests ways in which database differences can be overcome. This may inform analysis via traditional statistics or machine learning, and clinical implementation. (Source: EJNMMI Research)
Source: EJNMMI Research - November 15, 2023 Category: Radiology Source Type: research
An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?
ConclusionImprovements in PET scanner technology and software for automated IDIF extraction may allow to solve some of the major limitations associated with IDIF, such as partial volume effects and poor temporal sampling, with the exciting potential for accurate estimation of single kinetic rates. Nevertheless, until individualized radiometabolite correction can be performed effectively, IDIF approaches remain confined at best to a few tracers. (Source: EJNMMI Research)
Source: EJNMMI Research - November 10, 2023 Category: Radiology Source Type: research
Adenosine-induced splenic switch-off on [15O]H2O PET perfusion for the assessment of vascular vasodilatation
ConclusionsSSO can be quantified from [15O]H2O PET perfusion and used as a marker for adequate adenosine-induced vasodilatation response. In contrary to other PET perfusion tracers, adenosine-induced SSO is time dependent with [15O]H2O. (Source: EJNMMI Research)
Source: EJNMMI Research - November 9, 2023 Category: Radiology Source Type: research
The remodeling of metabolic brain pattern in patients with extracranial diffuse large B-cell lymphoma
ConclusionsThe proposed DLBCLRP would lay the foundation for further investigating the cerebral dysfunction related to DLBCL itself and/or treatments. Besides, the expression of DLBCLRP was associated with the tumor burden of lymphoma, implying a potential biomarker for prognosis. (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2023 Category: Radiology Source Type: research
Effects of novel androgen receptor signaling inhibitors on PSMA PET signal intensity in patients with castrate-resistant prostate cancer: a prospective exploratory serial imaging study
ConclusionsOur prospective trial involving 9 mCRPC patients initiating ARSi did not show significant modulation of PSMA expression measured on WB-PSMA PET at 1-week. This study was registered on clinicaltrials.gov (NCT04279561). (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2023 Category: Radiology Source Type: research
Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
Conclusion[18F]flortaucipir and [18F]florbetapir showed similar R1 estimates in cortical regions. This finding, put together with previous studies, indicates that R1 could be considered a surrogate for relative cerebral blood flow (rCBF) in the cortex and may be used interchangeably, but with caution, regardless of the choice of these two tracers. (Source: EJNMMI Research)
Source: EJNMMI Research - October 27, 2023 Category: Radiology Source Type: research
Baseline 18F-FDG PET/CT radiomics for prognosis prediction in diffuse large B cell lymphoma
ConclusionsRadiomics signatures derived from PET images showed the high predictive power for progression in patients with DLBCL. The combination of radiomics signatures, clinical factors, and metabolic parameters may not significantly improve predictive value beyond that of radiomics signatures alone. (Source: EJNMMI Research)
Source: EJNMMI Research - October 26, 2023 Category: Radiology Source Type: research
Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma
ConclusionsUsing the EARL2 method for PET image reconstruction resulted in higher SUVmax and SURmax compared to EARL1, with nodal upstaging in a significant number of patients. (Source: EJNMMI Research)
Source: EJNMMI Research - October 25, 2023 Category: Radiology Source Type: research
