Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis
ConclusionsWe developed and evaluated a new radiotracer, [64Cu]Cu-NOTA-CD4, for immunoPET imaging of murine CD4+ T cells. [64Cu]Cu-NOTA-CD4 was successfully synthesized by F(ab) ’2 fragments of R-anti-mouse CD4 antibodies conjugated to a chelator and radiolabeled with copper-64. We found that our novel CD4 PET tracer can be used for noninvasive visualization of murine CD4+ T cells. (Source: EJNMMI Research)
Source: EJNMMI Research - September 16, 2022 Category: Radiology Source Type: research
Respiratory motion correction in F-18-FDG PET/CT impacts lymph node assessment in lung cancer patients
ConclusionsPET motion correction resulted in significantly higher lymph node assessment scores of expert readers. Significant effects on quantitative PET parameters were seen; however, subjective reader certainty was not improved. (Source: EJNMMI Research)
Source: EJNMMI Research - September 15, 2022 Category: Radiology Source Type: research
PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer
ConclusionConsidering the radio-cytotoxic effect in the tumour tissue and a delay on tumour doubling time, [125I]PARPi-01 presents a potential radiotherapeutics for treatment of TNBC. Improvements to overcome the suboptimal pharmacokinetics are necessary for its potential clinical application. (Source: EJNMMI Research)
Source: EJNMMI Research - September 14, 2022 Category: Radiology Source Type: research
Effect of steroid treatment on the diagnostic yield of baseline 18f-fluorodeoxyglucose positron emission tomography in aggressive B cell lymphoma
AbstractAggressive B cell lymphoma often requires prompt steroid treatment, even before baseline18f-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and definitive treatment, to alleviate symptoms or prevent organ damage. Since lymphoma is a steroid-sensitive malignancy, there are concerns that steroids might affect the results of FDG PET/CT and decrease its diagnostic yield. The aim of the current study was to evaluate the effect of steroids administered before baseline PET/CT on the maximum standardized uptake value (SUVmax) and additional PET/CT parameters. Retrospective review of the d...
Source: EJNMMI Research - September 14, 2022 Category: Radiology Source Type: research
External validation: a simulation study to compare cross-validation versus holdout or external testing to assess the performance of clinical prediction models using PET data from DLBCL patients
ConclusionIn case of small datasets, it is not advisable to use a holdout or a very small external dataset with similar characteristics. A single small testing dataset suffers from a large uncertainty. Therefore, repeated CV using the full training dataset is preferred instead. Our simulations also demonstrated that it is important to consider the impact of differences in patient population between training and test data, which may ask for adjustment or stratification of relevant variables. (Source: EJNMMI Research)
Source: EJNMMI Research - September 11, 2022 Category: Radiology Source Type: research
Short-time-window Patlak imaging using a population-based arterial input function and optimized Bayesian penalized likelihood reconstruction: a feasibility study
ConclusionsShort-time-window Ki images with a population-based IF reconstructed using the BPL algorithm and a high beta value were closely correlated with long-time-window Ki images generated with an individual patient-based IF. Short-time-window Ki images using a population-based IF and BPL reconstruction might represent practical alternatives to long-time-window Ki images generated using an individual patient-based IF. (Source: EJNMMI Research)
Source: EJNMMI Research - September 8, 2022 Category: Radiology Source Type: research
[18F]FE-PE2I PET is a feasible alternative to [123I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism
ConclusionsThe high correspondence of [18F]FE-PE2I PET compared to reference standard [123I]FP-CIT SPECT establishes [18F]FE-PE2I PET as a feasible PET tracer for clinical use with favourable scan logistics. (Source: EJNMMI Research)
Source: EJNMMI Research - September 7, 2022 Category: Radiology Source Type: research
Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study
ConclusionsIn the early phase of aMCI, presence of amyloid pathology at baseline strongly predicted amyloid accumulation during follow-up, which was further paralleled by cognitive declines. Inversely, some of our patients remained amyloid negative also at the end of the study without significant change in18F-Flutemetamol uptake or cognition. Future studies with longer follow-up are needed to distinguish whether the underlying pathophysiology of aMCI in such patients is other than AD. (Source: EJNMMI Research)
Source: EJNMMI Research - September 5, 2022 Category: Radiology Source Type: research
Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study
ConclusionInclusion of a blood sample and PET scan at 24 h p.i. improves accuracy and precision of Patlak results for89Zr-immuno-PET; the exact timing of the two later time points is not critical. (Source: EJNMMI Research)
Source: EJNMMI Research - September 5, 2022 Category: Radiology Source Type: research
Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1
ConclusionThe GluN2B-specific radioligand(R)-[11C]Me-NB1 was well-tolerated without reported side effects. Effective dose was estimated to 1.8 mSv when using 300 MBq of presented radioligand. The critical organ was the urinary bladder. Due to the low effective dose coefficient of this radioligand, longitudinal studies for drug development and treatment monitoring of neuropsychiatric disorders including neurodegenerative diseases are pos sible.Trial registration Registered on 11th of June 2019 athttps://www.basg.gv.at (EudraCT: 2018-002933-39). (Source: EJNMMI Research)
Source: EJNMMI Research - August 26, 2022 Category: Radiology Source Type: research
A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma
Conclusions68 Ga-PSMA-617 PET/CT is a valuable imaging modality for the detection of ACC and combining with18F-FDG PET/CT will achieve a higher detection efficiency. PSMA RLT may be a promising treatment for ACC and is worth of further investigation.Trial registration: Diagnosis of Adenoid Cystic Carcinoma on68 Ga-PSMA-617 PET-CT and Therapy With177Lu-EB-PSMA-617 (NCT04801264, Registered 16 March 2021, retrospectively registered).URL of registry:https://clinicaltrials.gov/ct2/show/NCT04801264. (Source: EJNMMI Research)
Source: EJNMMI Research - August 19, 2022 Category: Radiology Source Type: research
Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT
ConclusionsMPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT. (Source: EJNMMI Research)
Source: EJNMMI Research - August 17, 2022 Category: Radiology Source Type: research
Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent
ConclusionHere, we report the first radiofluorination of an ATM inhibitor and its in vitro and in vivo biological evaluations, revealing the benefits but also some limitations of18F-labelled ATM inhibitors. (Source: EJNMMI Research)
Source: EJNMMI Research - August 13, 2022 Category: Radiology Source Type: research
A guideline proposal for mice preparation and care in 18F-FDG PET imaging
AbstractThe experimental outcomes of small-animal positron emission tomography (PET) imaging with18F-labelled fluorodeoxyglucose (18F-FDG) can be particularly compromised by animal preparation and care. Several works intend to improve research reporting and amplify the quality and reliability of published research. Though these works provide valuable information to plan and conduct animal studies, manuscripts describe different methodologies —standardization does not exist. Consequently, the variation in details reported can explain the difference in the experimental results found in the literature. Additionally, the res...
Source: EJNMMI Research - August 13, 2022 Category: Radiology Source Type: research
Changes of regional cerebral blood flow after deep brain stimulation in cervical dystonia
ConclusionsClinical improvement of cervical dystonia after GPi DBS may be accompanied by rCBF changes in several brain areas of the cortico-basal ganglia-cerebellar network which are important for sensorimotor integration. (Source: EJNMMI Research)
Source: EJNMMI Research - August 9, 2022 Category: Radiology Source Type: research
