Assessment of early metabolic progression in melanoma patients under immunotherapy: an 18F-FDG PET/CT study
ConclusionPET/CT, performed already after administration of two ICIs ’ cycles, can identify the majority of non-responders in melanoma immunotherapy. In order to tackle however, the non-negligible phenomenon of pseudoprogression, another follow-up PET/CT, the usage of novel response criteria and vigilance over emergence of radiological irAEs are recommended. Moreov er, the investigation of spleen glucose metabolism may offer further prognostic information in melanoma patients under ICIs. (Source: EJNMMI Research)
Source: EJNMMI Research - September 8, 2021 Category: Radiology Source Type: research
The effects of molar activity on [18F]FDOPA uptake in patients with neuroendocrine tumors
Conclusion[18F]FDOPA-H provides a higher activity yield, offering the possibility to scan more patients with one single production. Minor differences were observed in SUV ’s, with slight increases in uptake of [18F]FDOPA-H in comparison to [18F]FDOPA-L. This finding is not a concern for clinical practice, but could be of importance when quantifying follow-up scans while introducing new production methods with a higher molar activity of [18F]FDOPA. (Source: EJNMMI Research)
Source: EJNMMI Research - September 8, 2021 Category: Radiology Source Type: research
A novel read methodology to evaluate the optimal dose of 68Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial
ConclusionsBinary visual reading, which was associated with a low inter-reader variability, has further supported that the optimal administered radioactivity of68Ga-satoreotide trizoxetan was 100 –200 MBq with a peptide mass up to 50 µg.Trial registration ClinicalTrials.gov, NCT03220217. Registered 18 July 2017,https://clinicaltrials.gov/ct2/show/NCT03220217 (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research
Quantitative SPECT/CT parameters of myocardial 99mTechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake in suspected cardiac transthyretin amyloidosis
ConclusionQuantitative SPECT/CT parameters of cardiac Tc-DPD uptake are robust, enabling separation of patients with grades 2 and 3 cardiac uptake from grades 0 and 1. Larger patient cohorts will determine the incremental value of SPECT/CT quantification for ATTR management. (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research
EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases
AbstractInflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. In vivo molecular imaging enables us to study molecular targets and to measure biochemical processes non-invasively and longitudinally, providing information on disease processes and potential therapeutic strategies, e.g. efficacy of...
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research
The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis
ConclusionOur results suggest that an MTV TLR 2.0 on PET/CT reflects pathological N stage in local patients with CRC. (Source: EJNMMI Research)
Source: EJNMMI Research - September 6, 2021 Category: Radiology Source Type: research
Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted
AbstractCorrelation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is an urgent need to improve histopathological evaluation in animal model-based research to expedite translation into clinical applications. While different other fields of translational science were standardized over the last years, little was done to improve the pipeline of experimental pathology to ensure reproducibility based on pathological expertise in experimental animal models with respect to defined guid...
Source: EJNMMI Research - August 28, 2021 Category: Radiology Source Type: research
Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes
ConclusionOur study demonstrates that human megakaryocytes cultured in vitro are capable of MIBG uptake. Moreover, the SSRI citalopram selectively inhibits MIBG uptake via the serotonin transporter. The concomitant administration of citalopram to neuroblastoma patients during [131I]MIBG therapy might be a promising strategy to prevent the onset of thrombocytopenia. (Source: EJNMMI Research)
Source: EJNMMI Research - August 23, 2021 Category: Radiology Source Type: research
Sex correction improves the accuracy of clinical dopamine transporter imaging
ConclusionsA considerable number of elderly healthy male subjects can be interpreted to be dopaminergically abnormal if no sex correction of DAT binding is performed. Sex differences in striatal dopaminergic function should be taken into account when DAT imaging is used to assist clinical diagnostics in patients with suspected neurological disorders. (Source: EJNMMI Research)
Source: EJNMMI Research - August 23, 2021 Category: Radiology Source Type: research
Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review
ConclusionBoth methodologies were useful in the preoperative assessment of patients scheduled for liver interventions, especially in combination, but nuclear imaging demonstrated better predictive value for postoperative mortality and LF in a few trials. The overall technical and methodological heterogeneity of the included studies complicates the ability to directly compare the clinical utility of the two imaging techniques. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
[18F]FDG-PET/CT in prone compared to supine position for optimal axillary staging and treatment in clinically node-positive breast cancer patients with neoadjuvant systemic therapy
ConclusionsAxillary staging with FDG-PET/CT in prone compared to supine position did not result in concordant up- or downstaging. Therefore, FDG-PET/CT in supine position only can be considered sufficient for axillary staging. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [64/67Cu]Cu-SARTATE
AbstractIn a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [64/67Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblastoma lesions in pediatric patients whose widespread metastases survive initial therapy as minimal residual disease (MRD). MRD may be detected by [64Cu]Cu-SARTATE and subsequently treated by [67Cu]Cu-SARTATE. Since therapeutic dosimetry estimation of the latter agent from the uptake of the former one in the initial diagnostic scan was not addressed, the present theoretical commentary proposes the derivation o...
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging
ConclusionsA PET-based radiomics model using a standardized, multi-centre dataset to predict EFS in locally advanced NSCLC was successfully established and validated with good performance. Prediction models with robust feature preselection were unsuccessful, indicating the need for a standardized imaging protocol. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example
ConclusionThe example for89Zr-trastuzumab illustrates the potential to assess target expression. The pitfall of false-positive findings depends on the cut-off to define clinical target positivity (i.e., IHC 3) and the administered mass dose. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
PSMA-ligand uptake can serve as a novel biomarker in primary prostate cancer to predict outcome after radical prostatectomy
ConclusionPreoperative miTNM classification from68Ga-PSMA-11 PET correlates with postoperative GS, surgical margin status and time to BCR. The association between miTNM staging and outcome proposes68Ga-PSMA-11 PET as a novel non-invasive imaging biomarker and potentially serves for ancillary pre-treatment stratification. (Source: EJNMMI Research)
Source: EJNMMI Research - August 21, 2021 Category: Radiology Source Type: research
