Impact of administered amount of peptide on tumor dosimetry at the first cycle of peptide receptor radionuclide therapy (PRRT) in relation to total tumor somatostatin receptor expression
ConclusionIn this retrospective analysis, no correlation between the amount of administered peptide in the177Lu-DOTATATE preparation and the absorbed radiation doses in tumors and normal tissues was demonstrated in relation to the total tumor SSTR expression. (Source: EJNMMI Research)
Source: EJNMMI Research - May 19, 2023 Category: Radiology Source Type: research
Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications
ConclusionImaging of treatment targets with PET tracers may provide a more reliable precision medicine tool to find the right treatment for the right patient at the right time. In addition to visualization of the target of treatment, theranostic trials with alpha- or beta-emitting isotopes provide a future treatment option for patients with metastatic breast cancer. (Source: EJNMMI Research)
Source: EJNMMI Research - May 17, 2023 Category: Radiology Source Type: research
[99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression
ConclusionThis study is the first to report PD-L1 expression of the heart that can be quantified non-invasively without invasive myocardial biopsy, with high reliability and specificity. This technique can be applied to investigate myocardial PD-L1 expression in ICI-associated myocarditis and cardiomyopathies.Clinical trial registration PD-L1 Expression in Cancer (PECan) study (NCT04436406).https://clinicaltrials.gov/ct2/show/NCT04436406 June 18th, 2020. (Source: EJNMMI Research)
Source: EJNMMI Research - May 17, 2023 Category: Radiology Source Type: research
Visualizing GABA transporters in vivo: an overview of reported radioligands and future directions
AbstractBy clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biomarker for various psychiatric and neurological disorders. Not surprisingly, in recent years several research attempts to develop a radioligand have been conducted, but so far none have led to suitable radioligands that allow imaging of GATs. Here, we provide an overview of the radioligands that were developed with a focus on GAT1, since this is the most abundant transporter and most of the research concerns th...
Source: EJNMMI Research - May 12, 2023 Category: Radiology Source Type: research
Influence of corticosteroid treatment on CXCR4 expression in DLBCL
ConclusionOverall, corticosteroid treatment (Dex/Pred) consistently induced an upregulation of CXCR4 expression DBLCL cells in vitro, albeit in a very cell line-dependent manner. For the cell line with the most pronounced Dex-induced CXCR4 upregulation, OCI-LY1, the in vitro findings were corroborated by an in vivo biodistribution study. This confirms that at least the corticosteroid component of stabilizing chemotherapy regimens in DLBCL patients prior to [177Lu]Lu-PentixaTher RLT does not lead to downregulation of the molecular target CXCR4 and may even have a beneficiary effect. However, further studies are needed to in...
Source: EJNMMI Research - May 10, 2023 Category: Radiology Source Type: research
Correction: The association of DAT gene methylation with striatal DAT availability in healthy subjects
(Source: EJNMMI Research)
Source: EJNMMI Research - May 10, 2023 Category: Radiology Source Type: research
Molecular imaging of fibroblast activation in multiple non-ischemic cardiomyopathies
ConclusionFAPI PET/CT presents a potential value for in vivo visualization and quantification of fibroblast activation on the molecular level. Further study is warranted for investigating the theranostic and prognostic value of elevated FAP signal. (Source: EJNMMI Research)
Source: EJNMMI Research - May 8, 2023 Category: Radiology Source Type: research
Peptide-based PET imaging agent of tumor TIGIT expression
Conclusion68Ga-DOTA-DTBP-3 holds potential for non-invasively detect tumor TIGIT expression and for timely assessment of the therapeutic effect of immune checkpoint blockade. (Source: EJNMMI Research)
Source: EJNMMI Research - May 2, 2023 Category: Radiology Source Type: research
In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
ConclusionsWe demonstrated that18F-FIMP has affinity not only for LAT1, but also for ATB0,+. Our results may be helpful for understanding the mechanisms of the whole-body distribution and tumor accumulation of18F-FIMP. (Source: EJNMMI Research)
Source: EJNMMI Research - April 28, 2023 Category: Radiology Source Type: research
Semi-quantitative analysis of visually normal 123I-FP-CIT across three large databases revealed no difference between control and patients
ConclusionSBR values distribution from visually normal scans were not different from the existing reference database, enabling this method to create a reference database by expert nuclear physicians. In addition, it showed a rarely described age-gender interaction related to its size. The proposed post-reconstruction harmonization method can also facilitate the use of semi-quantitative analysis. (Source: EJNMMI Research)
Source: EJNMMI Research - April 28, 2023 Category: Radiology Source Type: research
Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma
Conclusions89Zr- αGPC3 avidly accumulated in GPC3+ tumors with minimal off-target sequestration.89Zr- αGPC3 immuno-PET yielded a sensitivity of 100% and detected sub-millimeter tumors. This technology may improve diagnostic sensitivity of small HCC and select GPC3+ tumors for targeted therapy. Human trials are warranted to assess its impact. (Source: EJNMMI Research)
Source: EJNMMI Research - April 27, 2023 Category: Radiology Source Type: research
Detecting localised prostate cancer using radiomic features in PSMA PET and multiparametric MRI for biologically targeted radiation therapy
ConclusionsMachine learning classifiers using radiomic features from PSMA PET and mpMRI show promise for predicting IPLs and differentiating between high-grade and low-grade disease, which could be used to inform biologically targeted radiation therapy planning. (Source: EJNMMI Research)
Source: EJNMMI Research - April 26, 2023 Category: Radiology Source Type: research
CMR validation of left ventricular volumes and ejection fraction measured by the IQ-SPECT system in patients with small heart size
ConclusionWith CMR as the standard, IQ-SPECT yields more reliable LVEF values than conventional SPECT for populations with small heart size. The best reconstruction parameters from IQ-SPECT were 5 S and 12 I for patients with small hearts. (Source: EJNMMI Research)
Source: EJNMMI Research - April 24, 2023 Category: Radiology Source Type: research
A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides
ConclusionsThis study demonstrated ACE2 selectivity for all radiopeptides. [67Ga]Ga-HBED-CC-DX600 was revealed as the most promising candidate due to its favorable tissue distribution profile. Importantly, the HBED-CC chelator enabled67Ga-labeling at high molar activity, which would be essential to obtain images with high signal-to-background contrast to detect (patho)physiological ACE2 expression levels in patients. (Source: EJNMMI Research)
Source: EJNMMI Research - April 19, 2023 Category: Radiology Source Type: research
Multiparametric dynamic whole-body PSMA PET/CT using [68Ga]Ga-PSMA-11 and [18F]PSMA-1007
ConclusionD-WB PET/CT is feasible for both PSMA tracers allowing for direct reconstruction of parametricKi images. The use of multiparametric PSMA images increased TBR but did not lead to the detection of more lesions. For quantitative whole-bodyKi imaging, [18F]PSMA-1007 should be preferred over [68Ga]Ga-PSMA-11 due to its irreversible kinetics in organs and lesions. (Source: EJNMMI Research)
Source: EJNMMI Research - April 15, 2023 Category: Radiology Source Type: research
