Value of 18F-FDG PET/CT for predicting axillary pathologic complete response following neoadjuvant systemic therapy in breast cancer patients: emphasis on breast cancer subtype
ConclusionsPredicting axillary response following NST with baseline18F-FDG PET/CT can be performed when focusing on breast cancer subtypes. The easily computed PET-parameter SUVmax can predict axillary response in HER2-positive and TN breast cancer. This study adds to the accumulating evidence that studies investigating the value of18F-FDG PET/CT in breast cancer should always take subtypes into account. (Source: EJNMMI Research)
Source: EJNMMI Research - November 22, 2021 Category: Radiology Source Type: research
Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
ConclusionBone plasma clearance measured from static WB scans correlates with clearance data measured by dynamic analysis. Static [18F]NaF PET/CT scans can be applied in future studies to measure Ki in patients with CKD-MBD, but the results should not be compared uncritically with results obtained by dynamic scan analysis. (Source: EJNMMI Research)
Source: EJNMMI Research - November 22, 2021 Category: Radiology Source Type: research
Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
AbstractRecent advancements in the field of immune-oncology have led to a significant increase in life expectancy of patients with diverse forms of cancer, such as hematologic malignancies, melanoma and lung cancer. Unfortunately, these encouraging results are not observed in the majority of patients, who remain unresponsive and/or encounter adverse events. Currently, researchers are collecting more insight into the cellular and molecular mechanisms that underlie these variable responses. As an example, the human lymphocyte activation gene-3 (huLAG-3), an inhibitory immune checkpoint receptor, is increasingly studied as a ...
Source: EJNMMI Research - November 2, 2021 Category: Radiology Source Type: research
Dose escalation biodistribution, positron emission tomography/computed tomography imaging and dosimetry of a highly specific radionuclide-labeled non-blocking nanobody
Conclusion68Ga-NOTA-Nb109 showed specific accumulation in hPD-L1 xenografts in ex vivo biodistribution studies and monkey PET/CT imaging. The dose escalation distribution data provided a recommended dose range for further use, and the safety of the tracer was confirmed in dosimetry studies. (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2021 Category: Radiology Source Type: research
[68Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation
ConclusionThe results highlight the potential of [68Ga]Ga-4HMSA as an interesting alternative to [68Ga]Ga-citrate for inflammation imaging by PET. The new PET tracer also offers additional advantages than [68Ga]Ga-citrate in term of dosimetry and lower overall background activity. (Source: EJNMMI Research)
Source: EJNMMI Research - October 30, 2021 Category: Radiology Source Type: research
Semi-quantitative measurements of chemokine receptor 4-targeted 68Ga-pentixafor PET/CT in response assessment of Waldenstr öm macroglobulinemia/lymphoplasmacytic lymphoma
ConclusionsThe semi-quantitative measurements of68Ga-pentixafor PET/CT outperformed18F-FDG PET/CT in response assessment of WM/LPL. (Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research
More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research
Response to letter: More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer
(Source: EJNMMI Research)
Source: EJNMMI Research - October 29, 2021 Category: Radiology Source Type: research
Intraindividual comparison of [68 Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 in prostate cancer patients: a retrospective single-center analysis
ConclusionIn terms of miTNM staging, both tracers appeared widely exchangeable, as no tracer relevantly outperformed the other. The differences between the two tracers were far more common in presumable unspecific lesions than in malignant spots. A routinely performed two-tracer study could not be shown to be superior. Since it seems at least challenging for most nuclear medicine departments to provide both [18F]-F-PSMA-1007 and [68Ga]-Ga-PSMA-11, it appears reasonable to choose the PSMA radiotracer depending on local availability with attention to the greater occurrence of nonspecific bone findings with [18F]-F-PSMA-1007....
Source: EJNMMI Research - October 19, 2021 Category: Radiology Source Type: research
Short-duration dynamic [18F]DCFPyL PET and CT perfusion imaging to localize dominant intraprostatic lesions in prostate cancer: validation against digital histopathology and comparison to [18F]DCFPyL PET/MR at 120 minutes
ConclusionsWe have validated using co-registered digital histopathological images that parameters from kinetic analysis of 22-min dynamic [18F]DCFPyL PET can accurately localize DILs in PCa for targeting of biopsy, radiotherapy, and focal ablative therapies. Short-duration dynamic [18F]DCFPyL PET was not inferior to SUVLate in this diagnostic task.Clinical trial registration number: NCT04009174 (ClinicalTrials.gov). (Source: EJNMMI Research)
Source: EJNMMI Research - October 15, 2021 Category: Radiology Source Type: research
Predicting the nature of pleural effusion in patients with lung adenocarcinoma based on 18F-FDG PET/CT
ConclusionsOur predictive model based on18F-FDG PET/CT showed good diagnostic performance for PE, which was helpful to differentiate MPE from BPE in patients with lung adenocarcinoma. (Source: EJNMMI Research)
Source: EJNMMI Research - October 15, 2021 Category: Radiology Source Type: research
Convolutional neural network-based automatic heart segmentation and quantitation in 123I-metaiodobenzylguanidine SPECT imaging
ConclusionsThe CNN could create segmentation from SPECT images, and average heart counts and WR were reliably calculated three-dimensionally, which might be a novel approach to quantifying SPECT images of innervation. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
ConclusionsNovel radiopharmaceuticals targeting a number of different integrins, above all, αvβ6, have proven their clinical potential and will play an increasingly important role in future theranostics. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
Alteration of neuroinflammation detected by 18F-GE180 PET imaging in place-conditioned rats with morphine withdrawal
ConclusionIn morphine-dependent rats, Neuroinflammation (NI) became more severe in the addiction-involved brain regions but remitted in the sensory-related brain regions after the administration of naloxone, and this NI induced by withdrawal was further aggravated after conditioned aversion formation thus may help to consolidate the withdrawal memory. (Source: EJNMMI Research)
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
Rationale for MYC imaging and targeting in pancreatic cancer
AbstractThe incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summar...
Source: EJNMMI Research - October 12, 2021 Category: Radiology Source Type: research
