Repeatability of [15O]H2O PET imaging for lower extremity skeletal muscle perfusion: a test –retest study
ConclusionParametric images and volume-of-interest-based methods demonstrated comparable resting perfusion values in the lower legs and feet of healthy individuals. The largest variation was seen between individuals, whereas a smaller variation was seen between muscle groups. Repeated measurements of resting blood flow yielded a strong overall correlation for all methods. (Source: EJNMMI Research)
Source: EJNMMI Research - January 31, 2024 Category: Radiology Source Type: research
ParaPET: non-invasive deep learning method for direct parametric brain PET reconstruction using histoimages
ConclusionWe proposed a direct non-invasive DL-based reconstruction method and produced high-quality parametric maps of the brain. The use of histoimages holds promising potential for enhancing the estimation of parametric images, an area that has not been extensively explored thus far. The proposed method can be applied to subject-specific dynamic PET data alone. (Source: EJNMMI Research)
Source: EJNMMI Research - January 30, 2024 Category: Radiology Source Type: research
Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer ’s disease and amnestic mild cognitive impairment using integrated PET/MR
ConclusionASL could detect similar aberrant patterns of abnormalities compared to18F-FDG PET in patients with AD compared with NC participants but not in aMCI. The diagnostic efficiency of18F-FDG-PET for AD and aMCI patients remained higher to ASL. Our findings support that applying18F-FDG PET may be preferable for diagnosing AD and aMCI. (Source: EJNMMI Research)
Source: EJNMMI Research - January 25, 2024 Category: Radiology Source Type: research
18F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation
ConclusionsOur results suggest that nAChR imaging with18F-ASEM has potential as a noninvasive diagnostic method for peripheral nervous system disorders. (Source: EJNMMI Research)
Source: EJNMMI Research - January 22, 2024 Category: Radiology Source Type: research
Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490
Conclusionɑ7nAChR is highly expressed in human macrophages and showed proliferation and hypoxia-driven expression in human endothelial cells. While NS14490 imaging displays a pattern that coincides with vessel formation, macrophage infiltration and fibrovascular encapsulation in the sponge model, this is not the case in the MI model where the ɑ7nAChR imaging signal was strongly associated with extracellular matrix deposition which could be explained by ɑ7nAChR expression in fibroblasts. Overall, these findings support the involvement of ɑ7nAChR across several processes central to cardiac repair, wit h fibrosis most clo...
Source: EJNMMI Research - January 11, 2024 Category: Radiology Source Type: research
Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients
ConclusionsAn irreversible tracer kinetic model is appropriate for dynamic analysis of68Ga-PSMA-11 PET images. Kinetic parameters estimated by Patlak graphical analysis or full compartmental analysis can distinguish tumor from normal prostate tissue. (Source: EJNMMI Research)
Source: EJNMMI Research - January 10, 2024 Category: Radiology Source Type: research
Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice
ConclusionsDeep anaesthesia and prolonged low anaesthesia should be avoided during renal scintigraphy because they result in prolonged blood clearance half-life, delayed renal influx and/or later Tmax. Vice versa, low anaesthesia with high respiratory rates of 80 –90 rpm and short duration (≤ 20 min) should be preferred to obtain representative data with low variance. (Source: EJNMMI Research)
Source: EJNMMI Research - January 5, 2024 Category: Radiology Source Type: research
ImmunoPET provides a novel way to visualize the CD103+ tissue-resident memory T cell to predict the response of immune checkpoint inhibitors
ConclusionCD103 ImmunoPET is a promising method for determining tumor-infiltrating lymphocytes (TILs) load and response to ICIs, thereby addressing the lack of reliable biomarkers in cancer immunotherapy. Compared to general T cell markers, CD103 is a specific marker for tissue-resident memory T cells, which number increases during successful ICI therapy. ImmunoPET offers noninvasive, dynamic imaging of specific markers, complemented by detailed molecular information from immunohistochemistry (IHC). Radiomics can extract quantitative features from traditional imaging methods, while near-infrared fluorescence (NIRF) imaging...
Source: EJNMMI Research - January 5, 2024 Category: Radiology Source Type: research
PSMA imaging as a non-invasive tool to monitor inducible gene expression in vivo
(Source: EJNMMI Research)
Source: EJNMMI Research - January 4, 2024 Category: Radiology Source Type: research
[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis
Conclusion[68 Ga]Ga-FAPI-04 uptake at baseline were significantly higher in early responders than those in non-responders.Trial registration ClinicalTrials. NCT04514614. Registered 13 August 2020,https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000A4PN&selectaction=Edit&uid=U0001JRW&ts=2&cx=-x9t7cp (Source: EJNMMI Research)
Source: EJNMMI Research - January 4, 2024 Category: Radiology Source Type: research
A short 18F-FDG imaging window triple injection neuroimaging protocol for parametric mapping in PET
ConclusionThe proposed 24-min triple injection protocol enables parametric18F-FDG neuroimaging with noninvasive estimation of the AIF from cardiac images using a standard field of view PET scanner. (Source: EJNMMI Research)
Source: EJNMMI Research - January 2, 2024 Category: Radiology Source Type: research
Advancements in theranostic applications: exploring the role of fibroblast activation protein inhibition tracers in enhancing thyroid health assessment
ConclusionThe utilization of fibroblast activating protein inhibitors in thyroid cancer holds significant promise, offering clinicians valuable insights for more precise diagnose choices and treatments strategies in the future. (Source: EJNMMI Research)
Source: EJNMMI Research - December 22, 2023 Category: Radiology Source Type: research
[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
ConclusionsFDOPA is superior to DOTATOC for localization of PCC. In contrast to DOTATOC, FDOPA also identified all PGL but with a limited number of patient cases. (Source: EJNMMI Research)
Source: EJNMMI Research - December 18, 2023 Category: Radiology Source Type: research
Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells
ConclusionTargeting of DGCR2 is a promising approach for in vivo detection of stem-cell-derived islets grafts by molecular imaging. The synthesis of [18F]ZDGCR2:AM106 was successfully performed via a pretargeting method to label a site-specific covalently bonded fluorine-18 to the Affibody molecule. However, the rapid washout of [18F]ZDGCR2:AM106 from the stem-cell-derived islets graft indicates that dissociation kinetics can be improved. Further studies using alternative binders of similar classes with improved binding potential are warranted. (Source: EJNMMI Research)
Source: EJNMMI Research - December 15, 2023 Category: Radiology Source Type: research
Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat
ConclusionThese data demonstrate early signs of hypercholesterolemia, high levels of bile acids, the development of atherosclerotic lesions, and macrophage accumulation inapoE−/− rats. Therefore, this model shows promise for atherosclerosis imaging studies. (Source: EJNMMI Research)
Source: EJNMMI Research - December 11, 2023 Category: Radiology Source Type: research
